AR046133A1 - Derivados de benzazepina como inhibidores de mao-b, procesos para su obtencion, composiciones farmaceuticas que los contienen y su utilizacion en la fabricacion de medicamentos para el tratamiento de trastornos neurologicos - Google Patents

Derivados de benzazepina como inhibidores de mao-b, procesos para su obtencion, composiciones farmaceuticas que los contienen y su utilizacion en la fabricacion de medicamentos para el tratamiento de trastornos neurologicos

Info

Publication number
AR046133A1
AR046133A1 ARP040103808A ARP040103808A AR046133A1 AR 046133 A1 AR046133 A1 AR 046133A1 AR P040103808 A ARP040103808 A AR P040103808A AR P040103808 A ARP040103808 A AR P040103808A AR 046133 A1 AR046133 A1 AR 046133A1
Authority
AR
Argentina
Prior art keywords
alkyl
ch2c
son
compound
formula
Prior art date
Application number
ARP040103808A
Other languages
English (en)
Inventor
Synese Jolidon
Sarmiento Rosa Maria Rodriguez
Andrew William Thomas
Wolfgang Wostl
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR046133A1 publication Critical patent/AR046133A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
    • C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nutrition Science (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente se refiere a derivados de benzazepina como inhibidores de MAO-B., composiciones farmacéuticas que contienen a dichos derivados y a su utilización para la fabricación de medicamentos útiles para la prevención y tratamiento de enfermedades en las que desempena un papel o está implicada la inhibición selectiva de la actividad de la monoamina oxidasa B. Reivindicación 1: Un compuesto de la fórmula (1) en la que R1 es H o metilo; R2 es H, alquilo C1-3, -CH2C(O)NH2, -CH(CH3)C(O)NH2, - S(O)2CH3 o -C(O)R6; R3, R4 y R5 con independencia entre si son H, halógeno, ciano, alquilo C1-3 u -O-alquilo C1-3-; R6 es H, -CH3, -CH2OCH3, -C(O)NH2, -CH2C(O)NH2, -OCH3, -NH2 o -NHCH2CH3, X-X´es-CH2-CH2-, -CH=CH- o -CH2-C(O)-; y Y-Y´ es -CH2-CH2-; - CH=CH- o -CH2-C(O)-; o X-X´ es -CH2- e Y-Y´ es -CH2-CH2-C(O)-; en la que cuando uno de X-X´e Y-Y´es -CH2-CH2- y el otro es -CH=CH-, o cuando los dos X-X´e Y-Y´son -CH=CH-, entonces R2 es -S(O)2CH3 o -C(O)R6; o cuando X-X´e Y-Y´son -CH2-C(O)- entonces R2 es H, alquilo C1-3, -CH2C(O)NH2 o -CH(CH3)C(O)NH2; y las sales farmacéuticamente aceptables de los mismos. Reivindicación 15: Un proceso de obtención de un compuesto de la fórmula (1) según la reivindicación 1 en la que R1 es H o metilo; R2 es H, R3, R4 y R5 con independencia entre si son H, halógeno, ciano, alquilo C1-3 u -O-alquilo C1-3; X-X´es-CH2-CH2-, -CH=CH- o -CH2-C(O)-; y Y-Y´ es -CH2-CH2-; -CH=CH- o -CH2-C(O)-; o X-X´ es -CH2- e Y-Y´ es -CH2-CH2-C(O)-; en la que cuando uno de X-X´e Y-Y´es -CH2-CH2- y el otro es -CH=CH-, o cuando los dos X-X´e Y-Y´son -CH=CH-, entonces R2 es -S(O)2CH3 o -C(O)R6; o cuando X-X´e Y-Y´son -CH2-C(O)- entonces R2 es H, alquilo C1-3, -CH2C(O)NH2 o -CH(CH3)C(O)NH2; que consiste en eliminar un grupo protector de un compuesto de la fórmula (2) en la que p1 es un grupo protector, elegido entre un grupo tert-butoxicarbonilo, metoxicarbonilo y 9-fluorenil-metoxi-carbonilo. Reivindicación 16: Un proceso de obtención de un compuesto de la fórmula (1) según la reivindicación 1 en la que: R1 es H o metilo; R2 es H, alquilo C1-3, -CH2C(O)NH2, -CH(CH3)C(O)NH2, -S(O)2CH3 o -C(O)R6; R3, R4 y R5 con independencia entre si son H, halógeno, ciano, alquilo C1-3 u -O-alquilo C1- 3-; R6 es H, -CH3, -CH2OCH3, -C(O)NH2, -CH2C(O)NH2, -OCH3, -NH2 o -NHCH2CH3, X-X´es-CH2-CH2-, -CH=CH- o -CH2-C(O)-; y Y-Y´ es -CH2-CH2-; -CH=CH- o -CH2-C(O)-; o X-X´ es -CH2- e Y-Y´ es -CH2-CH2-C(O)-; en la que cuando uno de X-X´e Y-Y´es -CH2-CH2- y el otro es -CH=CH-, o cuando los dos X-X´e Y-Y´son -CH=CH-, entonces R3 es -S(O)2CH3 o -C(O)R6; o cuando X-X´e Y-Y´son -CH2-C(O)- entonces R3 es H, alquilo C1-3, -CH2C(O)NH2 o -CH(CH3)C(O)NH2; que consiste en hacer reaccionar un compuesto de la fórmula (39 con un compuesto de la fórmula (4) en las que Z es OH, o cuando R2 es -S(O)2CH3 o -C(O)R6, entonces Z puede ser halógeno o un resto ácido sulfónico.
ARP040103808A 2003-10-23 2004-10-21 Derivados de benzazepina como inhibidores de mao-b, procesos para su obtencion, composiciones farmaceuticas que los contienen y su utilizacion en la fabricacion de medicamentos para el tratamiento de trastornos neurologicos AR046133A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03024297 2003-10-23

Publications (1)

Publication Number Publication Date
AR046133A1 true AR046133A1 (es) 2005-11-23

Family

ID=34486095

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040103808A AR046133A1 (es) 2003-10-23 2004-10-21 Derivados de benzazepina como inhibidores de mao-b, procesos para su obtencion, composiciones farmaceuticas que los contienen y su utilizacion en la fabricacion de medicamentos para el tratamiento de trastornos neurologicos

Country Status (19)

Country Link
US (2) US7173023B2 (es)
EP (1) EP1680127B1 (es)
JP (1) JP2007509094A (es)
KR (1) KR100856141B1 (es)
CN (1) CN100441188C (es)
AR (1) AR046133A1 (es)
AT (1) ATE411027T1 (es)
AU (1) AU2004283452A1 (es)
BR (1) BRPI0415842A (es)
CA (1) CA2543287A1 (es)
CO (1) CO5680409A2 (es)
DE (1) DE602004017206D1 (es)
IL (1) IL174845A0 (es)
MX (1) MXPA06004307A (es)
NO (1) NO20061907L (es)
RU (1) RU2006117366A (es)
TW (1) TWI254707B (es)
WO (1) WO2005039591A1 (es)
ZA (1) ZA200603177B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2423353C1 (ru) 2002-12-20 2011-07-10 Глэксо Груп Лимитед Новые производные бензазепина
GB0408083D0 (en) * 2004-04-08 2004-05-12 Glaxo Group Ltd Novel compounds
US20070293475A1 (en) * 2006-06-20 2007-12-20 Alcon Manufacturing Ltd. Aryl and heteroaryl tetrahydrobenzazepine derivatives and their use for treating glaucoma
FR2932800B1 (fr) * 2008-06-20 2015-02-20 Servier Lab Nouveau procede de synthese de la 7,8-dimethoxy-1,3-dihydro- 2h-3-benzazepin-2-one, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable
KR101220182B1 (ko) * 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
JP6346658B2 (ja) 2013-03-14 2018-06-20 ダート・ニューロサイエンス・（ケイマン）・リミテッド Ｍａｏ阻害剤としての置換ナフチリジン及びキノリン化合物
CN114437068A (zh) * 2022-02-21 2022-05-06 深圳市儿童医院 一种萘啶衍生物及其作为单胺氧化酶抑制剂的用途

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1003753B (de) 1953-11-07 1957-03-07 Dr Karl Kindler Verfahren zur Herstellung von N-Dialkylaminoacylaminophenolaethern
US3719669A (en) * 1972-03-27 1973-03-06 Pennwalt Corp Amino(or amido)-phenyl-alkyl-benzazepine analgesics and narcotic antagonists
US4210749A (en) * 1974-11-12 1980-07-01 Pennwalt Corporation Substituted 1,2,4,5-tetrahydro-3H,3 benzazepines
US4348393A (en) * 1978-06-09 1982-09-07 Delalande S.A. N-Aryl oxazolidinones, oxazolidinethiones, pyrrolidinones, pyrrolidines and thiazolidinones
FR2500831A1 (fr) 1981-02-27 1982-09-03 Delalande Sa Nouvelles n-aryl-oxazolidinones et -pyrrolidinones
US4524206A (en) * 1983-09-12 1985-06-18 Mead Johnson & Company 1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives
CA1261335A (en) * 1984-08-29 1989-09-26 Hoffmann-La Roche Limited/Hoffmann-La Roche Limitee Ethylenediamine monoamide derivatives
HUT43322A (en) * 1985-09-24 1987-10-28 Schering Ag Compositions with herbicidal effect comprising imidazolinyl derivatives as active substance and process for preparing the active substances
JPS6259973U (es) 1985-10-04 1987-04-14
CA1332151C (en) 1988-01-28 1994-09-27 Roman Amrein Use of a benzamide to treat cognitive disorder
DE3834861A1 (de) * 1988-10-13 1990-04-19 Basf Ag Arylalkoxycumarine, verfahren zu ihrer herstellung und diese enthaltende therapeutische mittel
JPH02142774A (ja) 1988-11-25 1990-05-31 Mitsui Toatsu Chem Inc ２−（４−置換フェニル）イミダゾリノン類、その製造法、およびそれらを有効成分として含有する除草剤
FR2645019A1 (es) 1989-03-30 1990-10-05 Fournier Innovation Synergie
IL94466A (en) 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
CA2090857A1 (en) 1990-09-17 1992-03-18 David A. Clark 5-trifluoroacylamino-2-aryloxazoles 2-aryl-5-trifluoroacylaminooxazoles
JPH04295470A (ja) 1991-03-22 1992-10-20 Wakamoto Pharmaceut Co Ltd モノアミンオキシダーゼ−ｂ酵素阻害活性を有する１，２，４−オキサジアゾール誘導体及びその製造法
GB9119467D0 (en) * 1991-09-12 1991-10-23 Smithkline Beecham Corp Chemical compounds
TW219935B (es) * 1991-12-25 1994-02-01 Mitsubishi Chemicals Co Ltd
JPH05262718A (ja) 1992-03-23 1993-10-12 Taisho Pharmaceut Co Ltd ５−置換アミノ−２−フェノキシスルホンアニリド化合物
US5317017A (en) * 1992-09-30 1994-05-31 Merck & Co., Inc. N-biphenyl-3-amido substituted benzolactams stimulate growth hormone release
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
GB9313365D0 (en) * 1993-06-29 1993-08-11 Roussel Lab Ltd Chemical compounds
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US6137002A (en) * 1993-07-22 2000-10-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
IL110172A (en) 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
US6448269B1 (en) * 1993-07-22 2002-09-10 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
ES2098186B1 (es) 1995-02-09 1998-02-01 Consejo Superior Investigacion Composiciones farmaceuticas a base de aminometilindoles para su aplicacion terapeutica como neuroprotectores en las enfermedades de parkinson y alzheimer.
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
GB9515412D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
EP0906090A1 (en) 1996-03-15 1999-04-07 Somerset Pharmaceuticals, Inc. Method for preventing and treating peripheral neurophathy by administering selegiline
TW498067B (en) * 1996-07-19 2002-08-11 Hoffmann La Roche 4-hydroxy-piperidine derivatives
EP1005470B1 (en) 1997-08-22 2007-08-01 AstraZeneca AB Oxindolylquinazoline derivatives as angiogenesis inhibitors
EP2201944B1 (en) 1997-11-21 2012-05-23 Purdue Neuroscience Company Use of substituted 2-aminoacetamides for treating, preventing or ameliorating manic depression
GB9727521D0 (en) 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
EP1073623B1 (en) 1998-04-20 2007-04-11 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as erythropoietin mimetics
DE19841895A1 (de) 1998-09-11 2000-03-23 Degussa Neues Verfahren zur Herstellung von 3-Amino-2-oxo-pyrrolidinen, neue Zwischenprodukte und deren Verwendung
US6294694B1 (en) 1999-06-04 2001-09-25 Wisconsin Alumni Research Foundation Matrix metalloproteinase inhibitors and method of using same
DE19952146A1 (de) 1999-10-29 2001-06-07 Boehringer Ingelheim Pharma Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AU1359801A (en) 1999-11-05 2001-06-06 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome
US6306911B1 (en) 2000-02-07 2001-10-23 Ortho-Mcneil Pharmaceutical, Inc. Substituted amino acids as neutral sphingomyelinase inhibitors
US6667327B2 (en) * 2002-02-04 2003-12-23 Hoffmann-La Roche Inc. Pyridine amido derivatives
US6660736B2 (en) * 2002-03-27 2003-12-09 Hoffmann-La Roche Inc. Phthalimido derivatives and a process for their preparation
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
JP4322685B2 (ja) * 2002-04-26 2009-09-02 エフ．ホフマン−ラ ロシュ アーゲー イソキノリン誘導体
WO2003099763A1 (en) * 2002-05-29 2003-12-04 F. Hoffmann-La Roche Ag N-acylaminobenzene dervatives as selective monoamine oxidase b inhibitors
RU2423353C1 (ru) * 2002-12-20 2011-07-10 Глэксо Груп Лимитед Новые производные бензазепина
WO2005042491A1 (en) * 2003-10-22 2005-05-12 Arena Pharmaceuticals, Inc. Benzazepine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases

Also Published As

Publication number Publication date
IL174845A0 (en) 2006-08-20
EP1680127A1 (en) 2006-07-19
KR20060061390A (ko) 2006-06-07
CN100441188C (zh) 2008-12-10
TWI254707B (en) 2006-05-11
KR100856141B1 (ko) 2008-09-03
US20070117791A1 (en) 2007-05-24
CN1871013A (zh) 2006-11-29
US7173023B2 (en) 2007-02-06
MXPA06004307A (es) 2006-06-05
RU2006117366A (ru) 2007-12-10
NO20061907L (no) 2006-07-12
BRPI0415842A (pt) 2007-01-02
WO2005039591A1 (en) 2005-05-06
AU2004283452A1 (en) 2005-05-06
EP1680127B1 (en) 2008-10-15
JP2007509094A (ja) 2007-04-12
ZA200603177B (en) 2007-09-26
CO5680409A2 (es) 2006-09-29
CA2543287A1 (en) 2005-05-06
US20050107360A1 (en) 2005-05-19
TW200524875A (en) 2005-08-01
ATE411027T1 (de) 2008-10-15
DE602004017206D1 (de) 2008-11-27

Similar Documents

Publication Publication Date Title
AR020727A1 (es) Uso de compuestos derivados 3-amino-4-aril-maleimidas para la preparacion de medicamentos para condiciones asociadas a una necesidad de inhibicion de lagsk-3, dichos compuestos, procedimiento para su preparacion y composiciones farmaceuticas que los comprenden
UY27333A1 (es) Nucleótidos 4` sustituidos
UY26872A1 (es) Derivados de la 4- fenil piridina
AR063706A1 (es) Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden.
BR0010555A (pt) Inibidores de neuraminidases
ECSP024399A (es) Derivados de benzotiazol
BR0312513A (pt) Derivados de glicosìdeo de tiofeno, processos para a produção dos mesmos, medicamentos que contêm esses compostos e uso dos mesmos
ES2158778B1 (es) Compuestos de sales de paroxetina, su preparacion y uso, y composiciones farmaceuticas que los contienen.
BR0109011A (pt) Composto, processo para preparação e uso do mesmo, método para produzir um efeito inibidor de ibat em um animal de sangue quente, e, composição farmacêutica
AR072233A1 (es) Derivados de acido lipoico y composiciones farmaceuticas que los contienen y metodos para tratar una enfermedad
BR0113234A (pt) Polimorfos de um análogo de epotilona
ECSP045469A (es) El uso de cianopirrolidinas sustituidas y preparaciones de combinacion que las contienen para tratar hiperlipidemia y enfermedades asociadas
ES2038172T3 (es) Procedimiento para preparar carboxamidas heterociclicas.
FR2836917B1 (fr) Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif
BRPI0409465A (pt) derivados de carboxamida como agentes antidiabéticos
AR018139A1 (es) Un compuesto n-[3-hidroxi-5[(1,4,5,6-tetrahidro-5-hidroxi-2-pirimidinil)amino]benzoil]glici-3-(3-halo-5-halo-2-hidroxifenil)-beta alanina, composicionfarmaceutica y uso del mismo en la fabricacion de un medicamento.
AR052413A1 (es) Nuevos derivados de piridotienopiriidina
UY27786A1 (es) Derivados de isoquinolina.
AR046133A1 (es) Derivados de benzazepina como inhibidores de mao-b, procesos para su obtencion, composiciones farmaceuticas que los contienen y su utilizacion en la fabricacion de medicamentos para el tratamiento de trastornos neurologicos
AR065297A1 (es) Formulaciones biodisponibles de compuestos heterociclicos
JP2010024243A (ja) 緑内障および近視を処置するためのベンゾ［ｇ］キノリン誘導体
BRPI0413384A (pt) inibidores da proteìna farnesil transferase como agentes antitumores
KR910000607A (ko) 새로운 에스테르
AR001769A1 (es) Benzamida enterocinética composiciones farmacéuticas que las contienen procedimiento para la preparación de dichas composiciones farmacéuticas el uso de dichos compuestos para la manufactura de medicamentos y un procedimiento para su preparación
KR970706251A (ko) 항종양제 및 항바이러스제로서의 비스-(2-할로에틸)아미노페닐 치환된 디스타마이신 유도체(Bis-(2-haloethyl)aminophenyl substituted distamycin derivatives as antitumor and antiviral agents)

Legal Events

Date Code Title Description
FB Suspension of granting procedure