ZA200602544B - The use of a polyphenol for the treatment of a cancerous or pre-cancerous lesion of the skin - Google Patents
The use of a polyphenol for the treatment of a cancerous or pre-cancerous lesion of the skin Download PDFInfo
- Publication number
- ZA200602544B ZA200602544B ZA200602544A ZA200602544A ZA200602544B ZA 200602544 B ZA200602544 B ZA 200602544B ZA 200602544 A ZA200602544 A ZA 200602544A ZA 200602544 A ZA200602544 A ZA 200602544A ZA 200602544 B ZA200602544 B ZA 200602544B
- Authority
- ZA
- South Africa
- Prior art keywords
- gallate
- use according
- epigallocatechol
- epicatechol
- group
- Prior art date
Links
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- 150000005206 1,2-dihydroxybenzenes Chemical class 0.000 claims description 26
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Classifications
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- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
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- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Veterinary Medicine (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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US51010103P | 2003-10-09 | 2003-10-09 |
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ZA200602544A ZA200602544B (en) | 2003-10-09 | 2004-10-08 | The use of a polyphenol for the treatment of a cancerous or pre-cancerous lesion of the skin |
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US (3) | US7910138B2 (ru) |
EP (2) | EP2292226A3 (ru) |
AR (1) | AR045865A1 (ru) |
AU (1) | AU2004281525B2 (ru) |
BR (1) | BRPI0415215B8 (ru) |
CA (1) | CA2541405C (ru) |
ES (1) | ES2391561T3 (ru) |
IL (1) | IL174434A0 (ru) |
MX (1) | MXPA06003404A (ru) |
NZ (1) | NZ546323A (ru) |
RU (1) | RU2366447C2 (ru) |
WO (1) | WO2005037300A1 (ru) |
ZA (1) | ZA200602544B (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003043628A1 (de) * | 2001-11-19 | 2003-05-30 | Medigene Aktiengesellschaft | Arzneimittel zur behandlung von viralen haut- und tumorerkrankungen |
US20050079235A1 (en) * | 2003-10-09 | 2005-04-14 | Eggert Stockfleth | Use of a polyphenol for the treatment of actinic keratosis |
NZ560633A (en) * | 2005-03-11 | 2011-08-26 | Neuprotect Pty Ltd | Flavonoid compounds and uses thereof |
JP6855240B2 (ja) | 2013-09-27 | 2021-04-07 | メビオン・メディカル・システムズ・インコーポレーテッド | 粒子ビーム走査 |
WO2015090853A1 (en) * | 2013-12-20 | 2015-06-25 | Unilever N.V. | Sunless tanning |
US10675487B2 (en) | 2013-12-20 | 2020-06-09 | Mevion Medical Systems, Inc. | Energy degrader enabling high-speed energy switching |
US9962560B2 (en) | 2013-12-20 | 2018-05-08 | Mevion Medical Systems, Inc. | Collimator and energy degrader |
US9661736B2 (en) | 2014-02-20 | 2017-05-23 | Mevion Medical Systems, Inc. | Scanning system for a particle therapy system |
US10786689B2 (en) | 2015-11-10 | 2020-09-29 | Mevion Medical Systems, Inc. | Adaptive aperture |
EP3906968A1 (en) | 2016-07-08 | 2021-11-10 | Mevion Medical Systems, Inc. | Treatment planning |
US11103730B2 (en) | 2017-02-23 | 2021-08-31 | Mevion Medical Systems, Inc. | Automated treatment in particle therapy |
WO2019006253A1 (en) | 2017-06-30 | 2019-01-03 | Mevion Medical Systems, Inc. | CONFIGURABLE COLLIMATOR CONTROLLED BY LINEAR MOTORS |
EP3934751A1 (en) | 2019-03-08 | 2022-01-12 | Mevion Medical Systems, Inc. | Collimator and energy degrader for a particle therapy system |
IT201900003843A1 (it) * | 2019-03-15 | 2020-09-15 | Lo Li Pharma Srl | Trattamento di fibromi con vitamina D e un agente come l'epigallocatechina gallato (EGCG) |
Family Cites Families (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4002775A (en) | 1973-07-09 | 1977-01-11 | Kabara Jon J | Fatty acids and derivatives of antimicrobial agents |
JPS55105677A (en) | 1979-02-07 | 1980-08-13 | Norin Suisansyo Chiyagiyou Shikenjo | Production of catechins |
US4306568A (en) * | 1979-12-04 | 1981-12-22 | Torre Douglas P | Method and apparatus for congelation cryometry in cryosurgery |
EP0087161A3 (en) | 1982-02-24 | 1984-04-04 | Key Pharmaceuticals, Inc. | Isopropylmyristate 4-alkyl-2,6-(bis-tert-butyl)-phenol medicament |
JPS59219384A (ja) | 1983-05-30 | 1984-12-10 | Mitsui Norin Kk | 天然抗酸化剤の製造方法 |
JPS6013780A (ja) | 1983-07-05 | 1985-01-24 | Mitsui Norin Kk | 茶カテキン類の製造方法 |
JPS61238728A (ja) | 1985-04-16 | 1986-10-24 | Mitsui Norin Kk | 茶葉抽出物と活性水酸化アルミニウムとの抗潰瘍性複合体 |
US4672810A (en) | 1985-10-15 | 1987-06-16 | Marlowe Christian P | Hydraulic transmission device and method of using it |
SE462894B (sv) | 1985-10-28 | 1990-09-17 | Biogram Ab | Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning |
US4863970A (en) | 1986-11-14 | 1989-09-05 | Theratech, Inc. | Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols |
US5204089A (en) | 1989-08-30 | 1993-04-20 | Mitsui Norin Co., Ltd. | Method of preventing the formation or aggrevation of dental plaque and method for reducing cariogenesis |
JP2727471B2 (ja) | 1989-09-14 | 1998-03-11 | 三井農林株式会社 | インフルエンザウィルス感染予防剤 |
JP2888554B2 (ja) | 1989-09-20 | 1999-05-10 | 三井農林株式会社 | マイコプラズマ感染予防剤 |
US5318986A (en) | 1989-10-19 | 1994-06-07 | Mitsui Norin Co., Ltd. | Method of inhibiting the activity of α-amylase |
US5063787A (en) * | 1989-11-22 | 1991-11-12 | General Electric Company | Venturi arrangement |
US5358713A (en) | 1990-02-23 | 1994-10-25 | Mitsui Norin Co., Ltd. | Method of preventing the transmission of infection caused by methicillin-resistant Staphylococcus aureus |
JP3019996B2 (ja) | 1990-03-01 | 2000-03-15 | 三井農林株式会社 | 白癬治療剤 |
JPH04253918A (ja) | 1991-02-05 | 1992-09-09 | Mitsui Norin Kk | 血糖上昇抑制剤 |
US5303486A (en) * | 1992-05-04 | 1994-04-19 | Dell Gay D | Quilting hoop |
DK0644766T3 (da) | 1992-06-08 | 1999-10-11 | Pitmy Int Nv | Dinitrogenoxid-holdigt dermatologisk præparat |
US5306486A (en) | 1993-03-01 | 1994-04-26 | Elizabeth Arden Co., Division Of Conopco, Inc. | Cosmetic sunscreen composition containing green tea and a sunscreen |
JP3333584B2 (ja) | 1993-04-19 | 2002-10-15 | 三井農林株式会社 | 歯質の耐酸性強化組成物 |
US5670154A (en) | 1994-01-10 | 1997-09-23 | Mitsui Norin Co., Ltd. | Reducing tyrosinase activity |
FR2718022B1 (fr) | 1994-04-01 | 1996-04-26 | Roussel Uclaf | Compositions cosmétiques ou dermatologiques et leur préparation. |
IL115156A (en) | 1994-09-06 | 2000-07-16 | Univ Georgia | Pharmaceutical compositions for the treatment of cancer comprising 1-(2-hydroxymethyl-1,3-dioxolan-4-yl) cytosines |
JP2718653B2 (ja) | 1995-01-31 | 1998-02-25 | 日本配合飼料株式会社 | 新規卵および卵質改良方法 |
IT1275905B1 (it) | 1995-03-14 | 1997-10-24 | Indena Spa | Frazioni polifenoliche di te', loro uso e formulazioni che le contengono |
GB2300578B (en) | 1995-05-11 | 1998-01-14 | Matsushita Seiko Kk | Gargling cup,antiviral mask,antiviral filter,antifungal,antibacterial,and antiviral filter air cleaner and air-cleaner-humidifier |
US5888527A (en) | 1995-05-11 | 1999-03-30 | Matsushita Seiko Co., Ltd. | Gargling cup, antiviral mask, antiviral filter, antifungal, antibacterial, and antiviral filter air cleaner and air-cleaner humidifier |
JPH09132532A (ja) | 1995-09-06 | 1997-05-20 | Mitsui Norin Kk | 抗生物質の抗菌力増強方法 |
US6127393A (en) | 1995-12-29 | 2000-10-03 | Novactyl, Inc. | Antiproliferative, antiinfective, antiinflammatory, autologous immunization agent and method |
US5804567A (en) | 1996-07-18 | 1998-09-08 | Cancer Institute (Hospital), Chinese Academy Of Medical Sciences | Method of increasing the effectiveness of anti-metabolites |
US6337320B1 (en) * | 1996-10-11 | 2002-01-08 | Thione International, Inc. | Reparatives for ultraviolet radiation skin damage |
AU729546B2 (en) | 1996-11-14 | 2001-02-01 | Lipomedica Ehf. | Topical formulations containing as a therapeutic active agent fatty acids or fatty alcohols or monoglyceride derivatives thereof for treating of mucosa infections |
JP3213557B2 (ja) | 1996-11-18 | 2001-10-02 | 三井農林株式会社 | 茶カテキンを有効成分として含有する尖圭コンジローマ治療剤 |
US5968973A (en) | 1996-11-18 | 1999-10-19 | Cancer Institute (Hospital), Chinese Academy Of Medical Sciences | Method for treating hyperplasia |
US6197808B1 (en) | 1996-11-18 | 2001-03-06 | Cancer Instititute (Hospital), Chinese Academy Of Medical Sciences | Methods for treating hyperplasia |
US20020198161A1 (en) * | 1997-02-20 | 2002-12-26 | Douglas E. Brash | Therapeutic uses of antioxidants |
JP3202938B2 (ja) | 1997-03-18 | 2001-08-27 | 三井農林株式会社 | チューインガム及びその製造法 |
US5910308A (en) | 1997-03-19 | 1999-06-08 | Sante International Inc. | Herbal extract composition containing gynostemma pentaphyllum, crataegus pinnatifida and camellia sinensis |
US6372234B1 (en) | 1997-05-27 | 2002-04-16 | Sembiosys Genetics Inc. | Products for topical applications comprising oil bodies |
US6696484B2 (en) | 1997-10-31 | 2004-02-24 | University Of Chicago Office Of Technology And Intellectual Property | Method and compositions for regulation of 5-alpha reductase activity |
JP4738592B2 (ja) | 1997-10-31 | 2011-08-03 | アーチ・デヴェロップメント・コーポレイション | 5α−還元酵素活性を調節するための方法及び組成物 |
CN1139382C (zh) | 1998-04-21 | 2004-02-25 | 三井农林株式会社 | 抗衣原体剂 |
US20020006447A1 (en) | 1998-04-21 | 2002-01-17 | Mitsui Norin Co., Ltd. | Anti-chlamydia agent |
DE19827624A1 (de) | 1998-06-20 | 1999-12-23 | Beiersdorf Ag | Verwendung von einem mit einem Gehalt an Catecinen oder einem Gehalt an Extrakt von grünem Tee in kosmetischen Zubereitungen zur Bräunung der Haut |
SE9803929D0 (sv) | 1998-11-18 | 1998-11-18 | Medivir Ab | Antiviral formulation |
KR100319973B1 (ko) | 1998-12-05 | 2002-04-22 | 이인수 | 녹차카테킨을 유효성분으로 하는 자궁경부 상피내종양 예방 또는 치료제 조성물 |
US6210679B1 (en) | 1999-01-07 | 2001-04-03 | Hauser, Inc. | Method for isolation of caffeine-free catechins from green tea |
DE19962369A1 (de) | 1999-12-23 | 2001-06-28 | Beiersdorf Ag | Kosmetische oder dermatologische Zubereitungen mit einem Gehalt an Catechinen oder einem Gehalt an Extrakt von grünem Tee und einem weiteren Gehalt an Ascorbinsäure |
US6248341B1 (en) * | 2000-01-14 | 2001-06-19 | Color Access, Inc. | Method of treating topical angiogenesis-related disorders |
US20020031535A1 (en) * | 2000-09-11 | 2002-03-14 | Sheffield Felix H. | Topical formulation to treat skin disorders |
US6713506B2 (en) * | 2000-10-11 | 2004-03-30 | University Of South Florida | Tea polyphenol esters and analogs thereof for cancer prevention and treatment |
WO2003043628A1 (de) | 2001-11-19 | 2003-05-30 | Medigene Aktiengesellschaft | Arzneimittel zur behandlung von viralen haut- und tumorerkrankungen |
US20030143165A1 (en) * | 2002-01-25 | 2003-07-31 | Allan Evans | NSAID-containing topical formulations that demonstrate chemopreventive activity |
US20030166583A1 (en) | 2002-02-22 | 2003-09-04 | Oliver Yoa-Pu Hu | Dermal cytochrome P450 1A inhibitors and enhancers |
US6723750B2 (en) * | 2002-03-15 | 2004-04-20 | Allergan, Inc. | Photodynamic therapy for pre-melanomas |
BRPI0204130B8 (pt) * | 2002-09-18 | 2021-05-25 | Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp | composição gel à base de extrato de pothomorphe umbellata, seus usos e método cosmético não-terapêutico. |
WO2004053097A2 (en) * | 2002-12-10 | 2004-06-24 | Medical College Of Georgia Research Institute, Inc. | Chemopreventive and therapeutic aspects of polyphenolic compositions and assays |
US6817511B2 (en) * | 2002-12-16 | 2004-11-16 | Dana Corporation | Method for joining axle components |
WO2004080293A2 (en) | 2003-03-13 | 2004-09-23 | 3M Innovative Properties Company | Methods for diagnosing skin lesions |
US20050079235A1 (en) | 2003-10-09 | 2005-04-14 | Eggert Stockfleth | Use of a polyphenol for the treatment of actinic keratosis |
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EP1684780B1 (en) | 2012-07-25 |
EP2292226A2 (en) | 2011-03-09 |
AU2004281525A1 (en) | 2005-04-28 |
BRPI0415215B8 (pt) | 2021-05-25 |
AR045865A1 (es) | 2005-11-16 |
RU2006115603A (ru) | 2007-11-27 |
US9060998B2 (en) | 2015-06-23 |
RU2366447C2 (ru) | 2009-09-10 |
MXPA06003404A (es) | 2006-06-27 |
NZ546323A (en) | 2009-04-30 |
EP1684780A1 (en) | 2006-08-02 |
AU2004281525B2 (en) | 2010-01-28 |
US8455022B2 (en) | 2013-06-04 |
IL174434A0 (en) | 2006-08-01 |
EP2292226A3 (en) | 2011-08-10 |
US7910138B2 (en) | 2011-03-22 |
US20070059387A1 (en) | 2007-03-15 |
BRPI0415215A (pt) | 2006-12-05 |
CA2541405C (en) | 2014-07-29 |
CA2541405A1 (en) | 2005-04-28 |
WO2005037300A1 (en) | 2005-04-28 |
US20130245113A1 (en) | 2013-09-19 |
BRPI0415215B1 (pt) | 2021-02-23 |
ES2391561T3 (es) | 2012-11-27 |
US20110166219A1 (en) | 2011-07-07 |
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