ZA200505765B - 4(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butane acid derivatives and related compounds as ppar modulators for treating diabetes of type 2 and atherosclerosis - Google Patents

4(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butane acid derivatives and related compounds as ppar modulators for treating diabetes of type 2 and atherosclerosis Download PDF

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Publication number
ZA200505765B
ZA200505765B ZA200505765A ZA200505765A ZA200505765B ZA 200505765 B ZA200505765 B ZA 200505765B ZA 200505765 A ZA200505765 A ZA 200505765A ZA 200505765 A ZA200505765 A ZA 200505765A ZA 200505765 B ZA200505765 B ZA 200505765B
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South Africa
Prior art keywords
alkyl
phenyl
compounds
formula
substituted
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ZA200505765A
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English (en)
Inventor
Christian Stapper
Stefanie Keil
Heiner Glombik
Eugen Falk
Dirk Gretzke
Hans-Ludwig Schaefer
Jochen Goerlitzer
Wolfgang Wendler
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Sanofi Aventis Deutschland
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Publication of ZA200505765B publication Critical patent/ZA200505765B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
ZA200505765A 2003-02-27 2005-07-19 4(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butane acid derivatives and related compounds as ppar modulators for treating diabetes of type 2 and atherosclerosis ZA200505765B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10308355A DE10308355A1 (de) 2003-02-27 2003-02-27 Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
ZA200505765B true ZA200505765B (en) 2006-05-31

Family

ID=32920629

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200505765A ZA200505765B (en) 2003-02-27 2005-07-19 4(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butane acid derivatives and related compounds as ppar modulators for treating diabetes of type 2 and atherosclerosis
ZA200505768A ZA200505768B (en) 2003-02-27 2005-07-19 3-(2-Phenyl-oxazol-4-ylmethoxy) cyclohexylmethoxy acetic acid derivatives and related compounds usedas ppar modulators for treating type 2 diabetes a nd arteriosclerosis.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ZA200505768A ZA200505768B (en) 2003-02-27 2005-07-19 3-(2-Phenyl-oxazol-4-ylmethoxy) cyclohexylmethoxy acetic acid derivatives and related compounds usedas ppar modulators for treating type 2 diabetes a nd arteriosclerosis.

Country Status (34)

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US (5) US7365084B2 (es)
EP (3) EP1599455B1 (es)
JP (3) JP2006519194A (es)
KR (3) KR20050106461A (es)
CN (3) CN100398526C (es)
AR (3) AR043427A1 (es)
AT (3) ATE365159T1 (es)
AU (3) AU2004215673B2 (es)
BR (3) BRPI0407907A (es)
CA (3) CA2516620A1 (es)
CL (2) CL2004000392A1 (es)
CO (2) CO5690580A2 (es)
DE (4) DE10308355A1 (es)
DK (3) DK1599452T3 (es)
EC (2) ECSP055985A (es)
ES (3) ES2287700T3 (es)
HR (3) HRP20050744A2 (es)
IL (2) IL170314A (es)
MA (3) MA27737A1 (es)
MX (3) MXPA05008995A (es)
NO (3) NO20054398L (es)
OA (2) OA13034A (es)
PA (1) PA8596801A1 (es)
PE (3) PE20050292A1 (es)
PL (3) PL378437A1 (es)
PT (3) PT1599453E (es)
RS (1) RS20050594A (es)
RU (3) RU2005129995A (es)
SA (1) SA04250153A (es)
TN (2) TNSN05204A1 (es)
TW (3) TW200510352A (es)
UY (2) UY28209A1 (es)
WO (3) WO2004076427A1 (es)
ZA (2) ZA200505765B (es)

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DE102004039509B4 (de) 2004-08-14 2006-09-21 Sanofi-Aventis Deutschland Gmbh Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE102004039533B4 (de) * 2004-08-14 2006-09-28 Sanofi-Aventis Deutschland Gmbh Essigsäurederivate mit Cyclohexylmethoxy-Substituenten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
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CN103360290B (zh) * 2008-02-29 2015-04-01 日产化学工业株式会社 噻吩化合物及其中间体的制造方法
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KR20050106461A (ko) 2005-11-09
AU2004215672A1 (en) 2004-09-10
ECSP055986A (es) 2006-01-16
CA2517386A1 (en) 2004-09-10
NO20054396D0 (no) 2005-09-22
HRP20050744A2 (en) 2006-09-30
PL377735A1 (pl) 2006-02-20
ES2326418T3 (es) 2009-10-09
DE502004004139D1 (de) 2007-08-02
UY28210A1 (es) 2004-09-30
TNSN05204A1 (en) 2007-06-11
DK1599453T3 (da) 2009-08-24
OA13034A (en) 2006-11-10
AR043433A1 (es) 2005-07-27
US20050101637A1 (en) 2005-05-12
RU2005129992A (ru) 2006-02-10
RU2005130002A (ru) 2006-01-27
CN1753881A (zh) 2006-03-29
PL378130A1 (pl) 2006-03-06
JP2006519199A (ja) 2006-08-24
CN100439347C (zh) 2008-12-03
DK1599452T3 (da) 2007-10-01
DE10308355A1 (de) 2004-12-23
PT1599453E (pt) 2009-07-14
MXPA05008988A (es) 2005-10-18
CN1753879A (zh) 2006-03-29
CA2517381A1 (en) 2004-09-10
BRPI0407907A (pt) 2006-02-14
PE20050293A1 (es) 2005-05-24
MXPA05008995A (es) 2005-10-18
RS20050594A (en) 2007-12-31
MA27736A1 (fr) 2006-02-01
RU2005129995A (ru) 2006-01-27
PT1599452E (pt) 2007-09-12
EP1599455A1 (de) 2005-11-30
NO20054398L (no) 2005-11-02
IL170314A (en) 2010-11-30
TNSN05206A1 (en) 2007-06-11
DK1599455T3 (da) 2009-11-09
US7365084B2 (en) 2008-04-29
MA27742A1 (fr) 2006-02-01
AU2004215673B2 (en) 2009-10-01
NO20054398D0 (no) 2005-09-22
PE20040959A1 (es) 2005-01-17
ATE435217T1 (de) 2009-07-15
ZA200505768B (en) 2005-11-23
MXPA05008951A (es) 2005-11-04
PT1599455E (pt) 2009-09-29
MA27737A1 (fr) 2006-02-01
OA13035A (en) 2006-11-10
CO5690580A2 (es) 2006-10-31
AU2004215673A1 (en) 2004-09-10
US7259177B2 (en) 2007-08-21
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ATE365159T1 (de) 2007-07-15
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US20050215596A1 (en) 2005-09-29
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WO2004076428A1 (de) 2004-09-10
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