MXPA05008988A - Derivados de acido 3-(2-fenil-oxazol-4-ilmetoxi) ciclohexilmetoxiacetico y compuestos relacionados utilizados como moduladores de ppar para tratar diabetes de tipo 2 y arterioesclerosis. - Google Patents

Derivados de acido 3-(2-fenil-oxazol-4-ilmetoxi) ciclohexilmetoxiacetico y compuestos relacionados utilizados como moduladores de ppar para tratar diabetes de tipo 2 y arterioesclerosis.

Info

Publication number
MXPA05008988A
MXPA05008988A MXPA05008988A MXPA05008988A MXPA05008988A MX PA05008988 A MXPA05008988 A MX PA05008988A MX PA05008988 A MXPA05008988 A MX PA05008988A MX PA05008988 A MXPA05008988 A MX PA05008988A MX PA05008988 A MXPA05008988 A MX PA05008988A
Authority
MX
Mexico
Prior art keywords
acetic acid
acid derivatives
cyclohexylmethoxy
oxazol
arteriosclerosis
Prior art date
Application number
MXPA05008988A
Other languages
English (en)
Inventor
Falk Eugene
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of MXPA05008988A publication Critical patent/MXPA05008988A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

La invencion se refiere a derivados del acido acetico sustituidos con cicloalquil-metoxi, ademas de sus sales compatibles fisiologicamente y a derivados funcionales fisiologicamente. La invencion se refiere a compuestos de formula (I), en la cual los grupos estan definidos como se cita en la descripcion, ademas de sus sales compatibles fisiologicamente y a un metodo para su produccion. Los compuestos son adecuados para, por ejemplo, tratar y/o prevenir desordenes del metabolismo de los acidos grasos y desordenes de la utilizacion de la glucosa ademas de desordenes en los cuales la resistencia a la insulina juega una parte.
MXPA05008988A 2003-02-27 2004-02-19 Derivados de acido 3-(2-fenil-oxazol-4-ilmetoxi) ciclohexilmetoxiacetico y compuestos relacionados utilizados como moduladores de ppar para tratar diabetes de tipo 2 y arterioesclerosis. MXPA05008988A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10308355A DE10308355A1 (de) 2003-02-27 2003-02-27 Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel
PCT/EP2004/001579 WO2004076427A1 (de) 2003-02-27 2004-02-19 3-(2-phenyl-oxazol-4- ylmethoxy)-cyclohexylmethoxy -essigsäure derivate und verwandte verbindungen als ppar modulatoren zur behandlung von typ 2 diabetes und atherosklerose

Publications (1)

Publication Number Publication Date
MXPA05008988A true MXPA05008988A (es) 2005-10-18

Family

ID=32920629

Family Applications (3)

Application Number Title Priority Date Filing Date
MXPA05008951A MXPA05008951A (es) 2003-02-27 2004-02-19 Derivados de acido 3-metil -2-(3- (2-fenil -oxazol-4 -ilmetoxi) -ciclohexanocarbonil -aminobutirico y compuestos relacionados como moduladores de ppar para el tratamiento de diabetes de tipo 2 y aterosclerosis.
MXPA05008988A MXPA05008988A (es) 2003-02-27 2004-02-19 Derivados de acido 3-(2-fenil-oxazol-4-ilmetoxi) ciclohexilmetoxiacetico y compuestos relacionados utilizados como moduladores de ppar para tratar diabetes de tipo 2 y arterioesclerosis.
MXPA05008995A MXPA05008995A (es) 2003-02-27 2004-02-19 Derivados de acido 4 - (3-(2-feniloxazol - 4 - ilmetoxi) ciclohexiloxi) - butanoico y compuestos relacionados como moduladores de ppar para tratar la diabetes tipo 2 y la aterosclerosis.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MXPA05008951A MXPA05008951A (es) 2003-02-27 2004-02-19 Derivados de acido 3-metil -2-(3- (2-fenil -oxazol-4 -ilmetoxi) -ciclohexanocarbonil -aminobutirico y compuestos relacionados como moduladores de ppar para el tratamiento de diabetes de tipo 2 y aterosclerosis.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MXPA05008995A MXPA05008995A (es) 2003-02-27 2004-02-19 Derivados de acido 4 - (3-(2-feniloxazol - 4 - ilmetoxi) ciclohexiloxi) - butanoico y compuestos relacionados como moduladores de ppar para tratar la diabetes tipo 2 y la aterosclerosis.

Country Status (34)

Country Link
US (5) US7259177B2 (es)
EP (3) EP1599452B1 (es)
JP (3) JP2006519193A (es)
KR (3) KR20050106461A (es)
CN (3) CN100398526C (es)
AR (3) AR043427A1 (es)
AT (3) ATE365159T1 (es)
AU (3) AU2004215673B2 (es)
BR (3) BRPI0407758A (es)
CA (3) CA2517381A1 (es)
CL (2) CL2004000392A1 (es)
CO (2) CO5690580A2 (es)
DE (4) DE10308355A1 (es)
DK (3) DK1599455T3 (es)
EC (2) ECSP055985A (es)
ES (3) ES2326418T3 (es)
HR (3) HRP20050743A2 (es)
IL (2) IL170316A (es)
MA (3) MA27736A1 (es)
MX (3) MXPA05008951A (es)
NO (3) NO20054408L (es)
OA (2) OA13035A (es)
PA (1) PA8596801A1 (es)
PE (3) PE20040959A1 (es)
PL (3) PL378437A1 (es)
PT (3) PT1599455E (es)
RS (1) RS20050594A (es)
RU (3) RU2005129992A (es)
SA (1) SA04250153A (es)
TN (2) TNSN05204A1 (es)
TW (3) TW200508210A (es)
UY (2) UY28210A1 (es)
WO (3) WO2004076428A1 (es)
ZA (2) ZA200505765B (es)

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Also Published As

Publication number Publication date
PT1599453E (pt) 2009-07-14
CO5690578A2 (es) 2006-10-31
ES2287700T3 (es) 2007-12-16
AR043432A1 (es) 2005-07-27
ATE365159T1 (de) 2007-07-15
JP2006519194A (ja) 2006-08-24
AU2004215677B2 (en) 2010-01-07
OA13035A (en) 2006-11-10
ES2326418T3 (es) 2009-10-09
CL2004000391A1 (es) 2005-01-07
PL378437A1 (pl) 2006-04-03
TW200500349A (en) 2005-01-01
RS20050594A (en) 2007-12-31
BRPI0407758A (pt) 2006-02-14
PT1599455E (pt) 2009-09-29
HRP20050742A2 (en) 2006-09-30
MXPA05008951A (es) 2005-11-04
UY28209A1 (es) 2004-09-30
BRPI0407907A (pt) 2006-02-14
NO20054408L (no) 2005-11-23
PA8596801A1 (es) 2004-09-16
EP1599453A1 (de) 2005-11-30
AR043433A1 (es) 2005-07-27
ZA200505765B (en) 2006-05-31
CL2004000392A1 (es) 2005-04-22
EP1599455A1 (de) 2005-11-30
JP2006519199A (ja) 2006-08-24
US7335671B2 (en) 2008-02-26
RU2005130002A (ru) 2006-01-27
EP1599453B1 (de) 2009-05-06
MXPA05008995A (es) 2005-10-18
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RU2005129992A (ru) 2006-02-10
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JP2006519193A (ja) 2006-08-24
OA13034A (en) 2006-11-10
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US20050101637A1 (en) 2005-05-12
ATE435217T1 (de) 2009-07-15
NO20054396L (no) 2005-11-11
PT1599452E (pt) 2007-09-12
MA27736A1 (fr) 2006-02-01
EP1599452B1 (de) 2007-06-20
DE502004004139D1 (de) 2007-08-02
CN1753881A (zh) 2006-03-29
HRP20050744A2 (en) 2006-09-30
US7365084B2 (en) 2008-04-29
CN100439347C (zh) 2008-12-03
KR20050106461A (ko) 2005-11-09
SA04250153A (ar) 2005-12-03
US7259177B2 (en) 2007-08-21
DE502004009453D1 (de) 2009-06-18
PE20050292A1 (es) 2005-05-24
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US20080167354A1 (en) 2008-07-10
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ZA200505768B (en) 2005-11-23
KR20050105492A (ko) 2005-11-04
HRP20050743A2 (en) 2006-08-31
IL170316A (en) 2010-11-30
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DE502004009690D1 (de) 2009-08-13
CN100439345C (zh) 2008-12-03
WO2004076428A1 (de) 2004-09-10
WO2004076426A1 (de) 2004-09-10
TNSN05206A1 (en) 2007-06-11
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AU2004215672A1 (en) 2004-09-10
CA2517381A1 (en) 2004-09-10
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AU2004215672B2 (en) 2010-01-07
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MA27737A1 (fr) 2006-02-01
PE20040959A1 (es) 2005-01-17
ATE430738T1 (de) 2009-05-15
AR043427A1 (es) 2005-07-27
EP1599455B1 (de) 2009-07-01
US20050215596A1 (en) 2005-09-29
UY28210A1 (es) 2004-09-30
MA27742A1 (fr) 2006-02-01
PL378130A1 (pl) 2006-03-06
NO20054398L (no) 2005-11-02
CN100398526C (zh) 2008-07-02
US7872034B2 (en) 2011-01-18
KR20050106462A (ko) 2005-11-09
CO5690580A2 (es) 2006-10-31
AU2004215673B2 (en) 2009-10-01
AU2004215677A1 (en) 2004-09-10
NO20054396D0 (no) 2005-09-22
TW200510352A (en) 2005-03-16
RU2005129995A (ru) 2006-01-27
NO20054408D0 (no) 2005-09-22
ES2329366T3 (es) 2009-11-25
TW200508210A (en) 2005-03-01
NO20054398D0 (no) 2005-09-22
DK1599455T3 (da) 2009-11-09
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US20080015238A1 (en) 2008-01-17

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