PE20040959A1 - Derivados de acido acetico sustituido con cicloalquilmetoxi y procedimientos para su preparacion - Google Patents
Derivados de acido acetico sustituido con cicloalquilmetoxi y procedimientos para su preparacionInfo
- Publication number
- PE20040959A1 PE20040959A1 PE2004000206A PE2004000206A PE20040959A1 PE 20040959 A1 PE20040959 A1 PE 20040959A1 PE 2004000206 A PE2004000206 A PE 2004000206A PE 2004000206 A PE2004000206 A PE 2004000206A PE 20040959 A1 PE20040959 A1 PE 20040959A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- cycloalkyl
- acetic acid
- cycloalkylmetoxi
- procedures
- Prior art date
Links
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 108010016731 PPAR gamma Proteins 0.000 abstract 1
- 102100038831 Peroxisome proliferator-activated receptor alpha Human genes 0.000 abstract 1
- 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 150000001242 acetic acid derivatives Chemical group 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
SE REFIERE A DERIVADOS DE ACIDO ACETICO SUSTITUIDO CON CICLOALQUILMETOXI DONDE EL ANILLO A ES CICLOALCANODIILO C3-C8, CICLOALQUENODIILO C3-C8 DONDE EN LOS ANILLOS CICLOALCANODIILO O CICLOALQUENODIILO PUEDEN HABER UNO O MAS ATOMOS DE C REEMPLAZADOS POR ATOMOS DE O; R1, R2 SON H, FL Cl, Br, CF3, OCF3, ALQUILO C1-C6, ENTRE OTROS; R3 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C8, ALQUILO(C1-C3)CICLOALQUILO(C3-C8), FENILO, ENTRE OTROS; W ES CH, N SI o ES 1; W ES O, S, NR10 SI o ES O; X ES ALCANODIILO C1-C6; Y1 ES (CR13R14)p; p ES 1 o 2; Y2 ES CH2, S, SO, SO2 ENTRE OTROS; n ES 0-2; R4 ES H, ALQUILO C1-C6; R5 ES H, ALQUILO C1-C6 SI Y2 NO ES O, NR9; R6 ES H, ALQUILO C1-C6, F SI n NO ES O; R7 ES H, F, ALQUILO C1-C6, ALCOXI C1-C6, ENTRE OTROS; R6 Y R7 JUNTO AL ATOMO DE C AL QUE ESTAN UNIDOS FORMAN CICLOALQUILO C3-C8; R8 ES H, ALQUILO C1-C6; R9 ES H, ALQUILO C1-C6, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. SON COMPUESTOS PREFERIDOS ACIDO 2-[CIS-3-(5-METIL-2-p-TOLILOXAZOL-4-ILMETOXI)CICLOHEXILMETOXI]-PENTANOICO, 1-[CIS-3-(5-METIL-2-p-TOLILOXAZOL-4-ILMETOXI)CICLOHEXILMETOXI]-PENTANOICO, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS ACTIVAN LOS RECEPTORES PPAR-alfa y PPAR-gamma Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS METABOLICOS, DIABETES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10308355A DE10308355A1 (de) | 2003-02-27 | 2003-02-27 | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040959A1 true PE20040959A1 (es) | 2005-01-17 |
Family
ID=32920629
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000206A PE20040959A1 (es) | 2003-02-27 | 2004-02-27 | Derivados de acido acetico sustituido con cicloalquilmetoxi y procedimientos para su preparacion |
| PE2004000205A PE20050293A1 (es) | 2003-02-27 | 2004-02-27 | Derivados de aminoacidos sustituidos con cicloalquilo, procedimiento para su preparacion y su uso como medicamentos |
| PE2004000203A PE20050292A1 (es) | 2003-02-27 | 2004-02-27 | Derivados de acido alcanoico sustituidos con aril-cicloalquilo, procedimientos para su obtencion y su empleo como medicamentos |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2004000205A PE20050293A1 (es) | 2003-02-27 | 2004-02-27 | Derivados de aminoacidos sustituidos con cicloalquilo, procedimiento para su preparacion y su uso como medicamentos |
| PE2004000203A PE20050292A1 (es) | 2003-02-27 | 2004-02-27 | Derivados de acido alcanoico sustituidos con aril-cicloalquilo, procedimientos para su obtencion y su empleo como medicamentos |
Country Status (34)
| Country | Link |
|---|---|
| US (5) | US7259177B2 (es) |
| EP (3) | EP1599452B1 (es) |
| JP (3) | JP2006519193A (es) |
| KR (3) | KR20050106461A (es) |
| CN (3) | CN100398526C (es) |
| AR (3) | AR043427A1 (es) |
| AT (3) | ATE365159T1 (es) |
| AU (3) | AU2004215673B2 (es) |
| BR (3) | BRPI0407758A (es) |
| CA (3) | CA2517381A1 (es) |
| CL (2) | CL2004000392A1 (es) |
| CO (2) | CO5690580A2 (es) |
| DE (4) | DE10308355A1 (es) |
| DK (3) | DK1599455T3 (es) |
| EC (2) | ECSP055985A (es) |
| ES (3) | ES2326418T3 (es) |
| HR (3) | HRP20050743A2 (es) |
| IL (2) | IL170316A (es) |
| MA (3) | MA27736A1 (es) |
| MX (3) | MXPA05008951A (es) |
| NO (3) | NO20054408L (es) |
| OA (2) | OA13035A (es) |
| PA (1) | PA8596801A1 (es) |
| PE (3) | PE20040959A1 (es) |
| PL (3) | PL378437A1 (es) |
| PT (3) | PT1599455E (es) |
| RS (1) | RS20050594A (es) |
| RU (3) | RU2005129992A (es) |
| SA (1) | SA04250153A (es) |
| TN (2) | TNSN05204A1 (es) |
| TW (3) | TW200508210A (es) |
| UY (2) | UY28210A1 (es) |
| WO (3) | WO2004076428A1 (es) |
| ZA (2) | ZA200505765B (es) |
Families Citing this family (17)
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|---|---|---|---|---|
| US7576131B2 (en) | 1999-06-04 | 2009-08-18 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia |
| US6262118B1 (en) * | 1999-06-04 | 2001-07-17 | Metabolex, Inc. | Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia |
| US7399777B2 (en) * | 2001-08-31 | 2008-07-15 | Sanofi-Aventis Deutschland Gmbh | Diarylcycloalkyl derivatives, processes for their preparation and their use as pharmceuticals |
| DE10308353A1 (de) * | 2003-02-27 | 2004-12-02 | Aventis Pharma Deutschland Gmbh | Diarylcycloalkylderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102004038403B4 (de) * | 2004-08-07 | 2006-08-31 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung der enantiomeren Formen von cis-konfigurierten 3-Hydroxycyclohexancarbonsäure-Derivaten |
| DE102004039532B4 (de) * | 2004-08-14 | 2006-09-21 | Sanofi-Aventis Deutschland Gmbh | Cyclohexyl-methyloxy substituierte Essigsäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| DE102004039533B4 (de) * | 2004-08-14 | 2006-09-28 | Sanofi-Aventis Deutschland Gmbh | Essigsäurederivate mit Cyclohexylmethoxy-Substituenten, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel |
| DE102004039509B4 (de) * | 2004-08-14 | 2006-09-21 | Sanofi-Aventis Deutschland Gmbh | Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DE102004060227B3 (de) | 2004-12-15 | 2006-07-20 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von Oxazolen durch Kondensation von aromatischen Aldehyden mit α-Ketoximen zu N-Oxiden und nachfolgende Reaktion mit aktivierten Säurederivaten |
| GT200600218A (es) * | 2005-06-10 | 2007-03-28 | Formulación y proceso de compresión directa | |
| BRPI0617207A2 (pt) | 2005-09-29 | 2011-07-19 | Sanofi Aventis | derivados de fenil-1,2,4-oxadiazolona, processos para sua preparação e seu uso como produtos farmacêuticos |
| US8128969B2 (en) | 2006-08-10 | 2012-03-06 | Mimozax Co., Ltd. | Hypoglycemic composition containing acacia bark derivative |
| CN101801906A (zh) | 2007-08-16 | 2010-08-11 | 索尔维公司 | 制备4-氟取代的3-氧代-烷酸酯的方法 |
| CN103435593B (zh) | 2008-02-29 | 2015-01-28 | 日产化学工业株式会社 | 噻吩化合物及其中间体的制造方法 |
| US7615661B2 (en) * | 2008-03-12 | 2009-11-10 | International Flavors & Fragrances Inc. | Thioester compounds and their use in fragrance or flavor applications |
| CN116224736A (zh) | 2017-12-13 | 2023-06-06 | 佳能株式会社 | 盒与图像形成装置 |
| CN109810071B (zh) * | 2019-03-28 | 2023-04-21 | 中国科学院成都生物研究所 | 一种miRNA生物合成抑制剂 |
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| PE20021091A1 (es) | 2001-05-25 | 2003-02-04 | Aventis Pharma Gmbh | Derivados de fenilurea sustituidos con carbonamida y procedimiento para su preparacion |
| PL367077A1 (en) * | 2001-06-07 | 2005-02-21 | Eli Lilly And Company | Modulators of peroxisome proliferator activated receptors (ppar) |
| DE10154689A1 (de) | 2001-11-09 | 2003-05-22 | Probiodrug Ag | Substituierte Aminoketonverbindungen |
| WO2003005025A1 (en) | 2001-07-03 | 2003-01-16 | Biovitrum Ab | Methods for identifying compounds modulating the activity of ppar-gamma |
| FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
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2003
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