ZA200505765B - 4(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butane acid derivatives and related compounds as ppar modulators for treating diabetes of type 2 and atherosclerosis - Google Patents

4(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butane acid derivatives and related compounds as ppar modulators for treating diabetes of type 2 and atherosclerosis Download PDF

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Publication number
ZA200505765B
ZA200505765B ZA200505765A ZA200505765A ZA200505765B ZA 200505765 B ZA200505765 B ZA 200505765B ZA 200505765 A ZA200505765 A ZA 200505765A ZA 200505765 A ZA200505765 A ZA 200505765A ZA 200505765 B ZA200505765 B ZA 200505765B
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South Africa
Prior art keywords
alkyl
phenyl
compounds
formula
substituted
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ZA200505765A
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English (en)
Inventor
Christian Stapper
Stefanie Keil
Heiner Glombik
Eugen Falk
Dirk Gretzke
Hans-Ludwig Schaefer
Jochen Goerlitzer
Wolfgang Wendler
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Sanofi Aventis Deutschland
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Publication of ZA200505765B publication Critical patent/ZA200505765B/en

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D263/00Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12Antidiuretics, e.g. drugs for diabetes insipidus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
ZA200505765A 2003-02-27 2005-07-19 4(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butane acid derivatives and related compounds as ppar modulators for treating diabetes of type 2 and atherosclerosis ZA200505765B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10308355A DE10308355A1 (de) 2003-02-27 2003-02-27 Aryl-cycloalkyl substituierte Alkansäurederivate, Verfahren zu ihrer Herstellung und ihre Anwendung als Arzneimittel

Publications (1)

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ZA200505765B true ZA200505765B (en) 2006-05-31

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200505768A ZA200505768B (en) 2003-02-27 2005-07-19 3-(2-Phenyl-oxazol-4-ylmethoxy) cyclohexylmethoxy acetic acid derivatives and related compounds usedas ppar modulators for treating type 2 diabetes a nd arteriosclerosis.
ZA200505765A ZA200505765B (en) 2003-02-27 2005-07-19 4(3- (2-phenyl-oxazol-4-ylmethoxy)-cyclohexyloxy)-butane acid derivatives and related compounds as ppar modulators for treating diabetes of type 2 and atherosclerosis

Family Applications Before (1)

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ZA200505768A ZA200505768B (en) 2003-02-27 2005-07-19 3-(2-Phenyl-oxazol-4-ylmethoxy) cyclohexylmethoxy acetic acid derivatives and related compounds usedas ppar modulators for treating type 2 diabetes a nd arteriosclerosis.

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UY (2) UY28210A1 (US07259177-20070821-C00218.png)
WO (3) WO2004076426A1 (US07259177-20070821-C00218.png)
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TNSN05204A1 (en) 2007-06-11
EP1599452B1 (de) 2007-06-20
TNSN05206A1 (en) 2007-06-11
US7335671B2 (en) 2008-02-26
US7259177B2 (en) 2007-08-21
EP1599453B1 (de) 2009-05-06
KR20050106461A (ko) 2005-11-09
AU2004215677B2 (en) 2010-01-07
CN100439347C (zh) 2008-12-03
KR20050105492A (ko) 2005-11-04
CA2516620A1 (en) 2004-09-10
NO20054398D0 (no) 2005-09-22
ZA200505768B (en) 2005-11-23
ATE430738T1 (de) 2009-05-15
PL377735A1 (pl) 2006-02-20
US20080167354A1 (en) 2008-07-10
OA13034A (en) 2006-11-10
AU2004215677A1 (en) 2004-09-10
CN1753879A (zh) 2006-03-29
EP1599455B1 (de) 2009-07-01
TW200508210A (en) 2005-03-01
NO20054396L (no) 2005-11-11
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HRP20050744A2 (en) 2006-09-30
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MA27737A1 (fr) 2006-02-01
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AR043433A1 (es) 2005-07-27
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EP1599453A1 (de) 2005-11-30
US20050215596A1 (en) 2005-09-29
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RS20050594A (en) 2007-12-31
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ATE435217T1 (de) 2009-07-15
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