ZA200504972B - Condensed furan compounds - Google Patents
Condensed furan compounds Download PDFInfo
- Publication number
- ZA200504972B ZA200504972B ZA200504972A ZA200504972A ZA200504972B ZA 200504972 B ZA200504972 B ZA 200504972B ZA 200504972 A ZA200504972 A ZA 200504972A ZA 200504972 A ZA200504972 A ZA 200504972A ZA 200504972 B ZA200504972 B ZA 200504972B
- Authority
- ZA
- South Africa
- Prior art keywords
- trans
- pyridine
- chloropyridin
- furo
- carboxamide
- Prior art date
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- 150000002240 furans Chemical class 0.000 title 1
- -1 furan compound Chemical class 0.000 claims description 118
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 75
- IAWZRPDZTOHTPZ-UHFFFAOYSA-N furo[3,2-b]pyridine-2-carboxamide Chemical compound C1=CC=C2OC(C(=O)N)=CC2=N1 IAWZRPDZTOHTPZ-UHFFFAOYSA-N 0.000 claims description 65
- 150000003839 salts Chemical class 0.000 claims description 59
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 52
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 52
- 125000000623 heterocyclic group Chemical group 0.000 claims description 48
- 125000000217 alkyl group Chemical group 0.000 claims description 44
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 44
- 229910052739 hydrogen Inorganic materials 0.000 claims description 24
- 239000001257 hydrogen Substances 0.000 claims description 24
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 19
- 150000001875 compounds Chemical class 0.000 claims description 18
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 17
- 125000001424 substituent group Chemical group 0.000 claims description 16
- 150000003857 carboxamides Chemical class 0.000 claims description 15
- 125000002252 acyl group Chemical group 0.000 claims description 14
- 150000002431 hydrogen Chemical class 0.000 claims description 14
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims description 13
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 13
- 125000004103 aminoalkyl group Chemical group 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims description 10
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- GBJNZGDNTWILNB-UHFFFAOYSA-N furo[3,2-c]pyridine-2-carboxamide Chemical compound N1=CC=C2OC(C(=O)N)=CC2=C1 GBJNZGDNTWILNB-UHFFFAOYSA-N 0.000 claims description 9
- 229910052757 nitrogen Inorganic materials 0.000 claims description 9
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- JFYLKLRQPTZVAW-UHFFFAOYSA-N furo[3,2-b]pyridine-5-carboxylic acid Chemical compound OC(=O)C1=CC=C2OC=CC2=N1 JFYLKLRQPTZVAW-UHFFFAOYSA-N 0.000 claims description 7
- 125000005936 piperidyl group Chemical group 0.000 claims description 7
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 6
- QJCVZTNALQUPPP-UHFFFAOYSA-N furo[3,2-b]pyridine-2,5-dicarboxamide Chemical compound O1C(=CC2=NC(=CC=C21)C(=O)N)C(=O)N QJCVZTNALQUPPP-UHFFFAOYSA-N 0.000 claims description 6
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 claims description 6
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 6
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- LEIAZUKOBVWTEH-UHFFFAOYSA-N pyridine-2,5-dicarboxamide Chemical compound NC(=O)C1=CC=C(C(N)=O)N=C1 LEIAZUKOBVWTEH-UHFFFAOYSA-N 0.000 claims description 5
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 4
- 125000005842 heteroatom Chemical group 0.000 claims description 4
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 4
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 4
- 125000006518 morpholino carbonyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])N(C(*)=O)C1([H])[H] 0.000 claims description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 4
- 125000005415 substituted alkoxy group Chemical group 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 125000004434 sulfur atom Chemical group 0.000 claims description 4
- 125000004945 acylaminoalkyl group Chemical group 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 2
- 125000004450 alkenylene group Chemical group 0.000 claims description 2
- 125000002070 alkenylidene group Chemical group 0.000 claims description 2
- 125000003545 alkoxy group Chemical group 0.000 claims description 2
- 125000002947 alkylene group Chemical group 0.000 claims description 2
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 2
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000001188 haloalkyl group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 125000002632 imidazolidinyl group Chemical group 0.000 claims description 2
- 125000002757 morpholinyl group Chemical group 0.000 claims description 2
- 125000004193 piperazinyl group Chemical group 0.000 claims description 2
- 125000003072 pyrazolidinyl group Chemical group 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 125000000383 tetramethylene group Chemical group [H]C([H])([*:1])C([H])([H])C([H])([H])C([H])([H])[*:2] 0.000 claims description 2
- 125000005505 thiomorpholino group Chemical group 0.000 claims description 2
- IBBMAWULFFBRKK-UHFFFAOYSA-N picolinamide Chemical compound NC(=O)C1=CC=CC=N1 IBBMAWULFFBRKK-UHFFFAOYSA-N 0.000 claims 17
- 125000004938 5-pyridyl group Chemical group N1=CC=CC(=C1)* 0.000 claims 1
- LKRLLQLNJOTFOM-RZDIXWSQSA-N C1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](CC2)N2C(COCC2)=O)C2=NC=CC=C2O1 Chemical compound C1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](CC2)N2C(COCC2)=O)C2=NC=CC=C2O1 LKRLLQLNJOTFOM-RZDIXWSQSA-N 0.000 claims 1
- SGGJQKMRYMBGEJ-UAPYVXQJSA-N N1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](CC2)N2C(COCC2)=O)C2=NC(N3CCOCC3)=CC=C2O1 Chemical compound N1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](CC2)N2C(COCC2)=O)C2=NC(N3CCOCC3)=CC=C2O1 SGGJQKMRYMBGEJ-UAPYVXQJSA-N 0.000 claims 1
- VUWLZYKWCBNHNY-JCNLHEQBSA-N N1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](CC2)N2CCCC2)C2=CN=CC=C2O1 Chemical compound N1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](CC2)N2CCCC2)C2=CN=CC=C2O1 VUWLZYKWCBNHNY-JCNLHEQBSA-N 0.000 claims 1
- MLTNYSUODACDHB-KOMQPUFPSA-N N1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](CC2)N2CCCC2)C2=NC(Cl)=CC=C2O1 Chemical compound N1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)[C@@H]2CC[C@H](CC2)N2CCCC2)C2=NC(Cl)=CC=C2O1 MLTNYSUODACDHB-KOMQPUFPSA-N 0.000 claims 1
- XRQQRJRCOSUAPR-KOMQPUFPSA-N O=C([C@@H]1CC[C@H](CC1)N1C(COCC1)=O)NC=1C2=NC(OC)=CC=C2OC=1C(=O)NC1=CC=C(Cl)C=N1 Chemical compound O=C([C@@H]1CC[C@H](CC1)N1C(COCC1)=O)NC=1C2=NC(OC)=CC=C2OC=1C(=O)NC1=CC=C(Cl)C=N1 XRQQRJRCOSUAPR-KOMQPUFPSA-N 0.000 claims 1
- 125000005117 dialkylcarbamoyl group Chemical group 0.000 claims 1
- MVILWLLYYQVYNH-UHFFFAOYSA-N pyridine-2-carboxamide Chemical compound NC(=O)C1=CC=CC=N1.NC(=O)C1=CC=CC=N1 MVILWLLYYQVYNH-UHFFFAOYSA-N 0.000 description 16
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- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 125000006264 diethylaminomethyl group Chemical group [H]C([H])([H])C([H])([H])N(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000006222 dimethylaminomethyl group Chemical group [H]C([H])([H])N(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000006534 ethyl amino methyl group Chemical group [H]N(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
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- 239000003527 fibrinolytic agent Substances 0.000 description 1
- 230000003480 fibrinolytic effect Effects 0.000 description 1
- RLBRZMUOZZGMQL-UHFFFAOYSA-N furo[2,3-b]pyridine-2-carboxamide Chemical compound NC(=O)c1cc2cccnc2o1 RLBRZMUOZZGMQL-UHFFFAOYSA-N 0.000 description 1
- 208000031169 hemorrhagic disease Diseases 0.000 description 1
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- 201000004332 intermediate coronary syndrome Diseases 0.000 description 1
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- 125000006533 methyl amino methyl group Chemical group [H]N(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- XGVXMRJHBWALBK-UHFFFAOYSA-N n-(5-chloropyridin-2-yl)-3-[(1-pyridin-4-ylpiperidine-4-carbonyl)amino]furo[3,2-b]pyridine-2-carboxamide Chemical compound N1=CC(Cl)=CC=C1NC(=O)C1=C(NC(=O)C2CCN(CC2)C=2C=CN=CC=2)C2=NC=CC=C2O1 XGVXMRJHBWALBK-UHFFFAOYSA-N 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 description 1
- WSHYKIAQCMIPTB-UHFFFAOYSA-M potassium;2-oxo-3-(3-oxo-1-phenylbutyl)chromen-4-olate Chemical compound [K+].[O-]C=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 WSHYKIAQCMIPTB-UHFFFAOYSA-M 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
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- 229960000883 warfarin potassium Drugs 0.000 description 1
Classifications
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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JP2003003536 | 2003-01-09 | ||
JP2003334598A JP2005104838A (ja) | 2003-01-09 | 2003-09-26 | 縮合フラン化合物 |
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ZA200504972B true ZA200504972B (en) | 2006-04-26 |
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Family Applications (1)
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ZA200504972A ZA200504972B (en) | 2003-01-09 | 2005-06-20 | Condensed furan compounds |
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Country | Link |
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US (2) | US7514449B2 (fr) |
EP (1) | EP1582521A4 (fr) |
JP (2) | JP2005104838A (fr) |
KR (2) | KR100827263B1 (fr) |
CN (1) | CN100344632C (fr) |
AR (1) | AR042827A1 (fr) |
AU (1) | AU2004204003B2 (fr) |
BR (1) | BRPI0406721A (fr) |
CA (1) | CA2510519C (fr) |
IL (1) | IL169193A0 (fr) |
MX (1) | MXPA05007408A (fr) |
MY (1) | MY139461A (fr) |
NO (1) | NO20053762L (fr) |
NZ (1) | NZ541198A (fr) |
PL (1) | PL378249A1 (fr) |
RU (1) | RU2302422C2 (fr) |
TW (1) | TWI328588B (fr) |
WO (1) | WO2004063202A1 (fr) |
ZA (1) | ZA200504972B (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI322806B (en) * | 2003-06-30 | 2010-04-01 | Mitsubishi Tanabe Pharma Corp | Process of preparating 3-acylaminobenzofuran-2-carboxylic acid derivatives |
TW200512181A (en) * | 2003-09-26 | 2005-04-01 | Tanabe Seiyaku Co | Amide-type carboxamide derivatives |
TW200524915A (en) | 2003-09-26 | 2005-08-01 | Tanabe Seiyaku Co | Carbamoyl-type benzofuran derivatives |
JP4710445B2 (ja) * | 2004-07-08 | 2011-06-29 | 田辺三菱製薬株式会社 | 医薬組成物 |
EP1630163A1 (fr) * | 2004-08-25 | 2006-03-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Dihydropteridinones, procédés de préparation et leur utilisation en tant que médicaments |
JP4900238B2 (ja) * | 2005-02-02 | 2012-03-21 | 味の素株式会社 | 新規ベンズアミジン化合物 |
JP2006298909A (ja) * | 2005-03-25 | 2006-11-02 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
WO2006137350A1 (fr) * | 2005-06-22 | 2006-12-28 | Kissei Pharmaceutical Co., Ltd. | Nouveau dérivé de furopyridine, composition pharmaceutique comprenant le dérivé et utilisation du dérivé ou de la composition |
WO2007027855A2 (fr) * | 2005-09-01 | 2007-03-08 | Array Biopharma Inc. | Composes inhibiteurs de la raf kinase et procedes d'utilisation de ceux-ci |
CN100376582C (zh) * | 2006-04-26 | 2008-03-26 | 浙江大学 | 一种六氢呋喃[3,2-c]喹啉衍生物的制备方法 |
CA2660546A1 (fr) * | 2006-08-21 | 2008-02-28 | Genentech, Inc. | Composes aza-benzofuranyle et leurs procedes d'utilisation |
JP5349306B2 (ja) | 2006-08-21 | 2013-11-20 | ジェネンテック, インコーポレイテッド | アザベンゾチオフェニル化合物および使用方法 |
RU2448111C2 (ru) * | 2006-08-21 | 2012-04-20 | Дженентек, Инк. | Соединения азабензофуранила и способ их применения |
TW200900408A (en) * | 2007-03-02 | 2009-01-01 | Kyowa Hakko Kogyo Kk | Fused pyridine derivative |
US20100173828A1 (en) * | 2008-07-25 | 2010-07-08 | Abbott Gmbh & Co. Kg | Aß(X - 38 .. 43) oligomers, and processes, compositions, and uses thereof |
CN102675230A (zh) * | 2012-05-17 | 2012-09-19 | 盛世泰科生物医药技术(苏州)有限公司 | 一种3-氨基-2-氰基-6-溴吡嗪的制备方法 |
CA2890009C (fr) * | 2012-11-08 | 2017-11-28 | Pfizer Inc. | Composes heteroaromatiques et leur utilisation comme ligands de la dopamine d1 |
US9933880B2 (en) * | 2014-03-17 | 2018-04-03 | Tactual Labs Co. | Orthogonal signaling touch user, hand and object discrimination systems and methods |
RU2017119399A (ru) * | 2014-11-03 | 2018-12-05 | ТРОМБОЛИТИКС, ЭлЭлСи | Антифибринолитические соединения |
JP2021501582A (ja) | 2017-11-03 | 2021-01-21 | ウニヴェルシテ ド モントリオールUniversite De Montreal | 化合物及び幹細胞及び/又は前駆細胞の増殖におけるその使用 |
TW201938171A (zh) | 2017-12-15 | 2019-10-01 | 匈牙利商羅特格登公司 | 作為血管升壓素V1a受體拮抗劑之三環化合物 |
HU231206B1 (hu) | 2017-12-15 | 2021-10-28 | Richter Gedeon Nyrt. | Triazolobenzazepinek |
CN115747298B (zh) * | 2022-10-10 | 2023-10-27 | 浙江大学 | 昆虫烟酰胺酶抑制剂及鉴定方法及用于杀虫剂的用途 |
Family Cites Families (10)
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WO1994017075A1 (fr) * | 1993-01-20 | 1994-08-04 | A. Menarini Industrie Farmaceutiche Riunite S.R.L. | Derives de diazepine et compositions antivirales |
EP0712844A4 (fr) * | 1994-06-06 | 1996-11-06 | Green Cross Corp | Nouveau compose d'acide carboxylique a noyau fusionne ou sel de ce compose, et son utilisation en medecine |
US5597823A (en) * | 1995-01-27 | 1997-01-28 | Abbott Laboratories | Tricyclic substituted hexahydrobenz [e]isoindole alpha-1 adrenergic antagonists |
FR2761072B1 (fr) | 1997-03-20 | 1999-04-23 | Synthelabo | Derives de 2,3-dihydrofuro[3,2-b]pyridine, leur preparation et leur application en therapeutique |
EP0937711A1 (fr) | 1998-02-18 | 1999-08-25 | Roche Diagnostics GmbH | Thiobenzamides, procédé pour leur préparation et médicaments les contenant |
AU5261001A (en) * | 2000-04-27 | 2001-11-12 | Imperial Cancer Research Technology Ltd | Condensed heteroaryl derivatives |
AU2001277731A1 (en) * | 2000-08-09 | 2002-02-18 | Welfide Corporation | Fused bicyclic amide compounds and medicinal use thereof |
PT1489078E (pt) | 2002-03-28 | 2010-02-24 | Mitsubishi Tanabe Pharma Corp | Derivados de benzofurano |
JP4667867B2 (ja) * | 2002-08-02 | 2011-04-13 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換フロ[2,3−b]ピリジン誘導体 |
EP1678168B1 (fr) * | 2003-10-24 | 2012-07-11 | Exelixis, Inc. | Modulateurs des p70s6 kinases et procede d'utilisation |
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- 2004-01-08 JP JP2005507978A patent/JP4310437B2/ja not_active Expired - Fee Related
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KR100827263B1 (ko) | 2008-05-07 |
JP4310437B2 (ja) | 2009-08-12 |
NO20053762D0 (no) | 2005-08-08 |
AU2004204003B2 (en) | 2007-03-29 |
KR20070094818A (ko) | 2007-09-21 |
CA2510519A1 (fr) | 2004-07-29 |
IL169193A0 (en) | 2007-07-04 |
US7514449B2 (en) | 2009-04-07 |
PL378249A1 (pl) | 2006-03-20 |
US20060094724A1 (en) | 2006-05-04 |
AU2004204003A1 (en) | 2004-07-29 |
WO2004063202A1 (fr) | 2004-07-29 |
BRPI0406721A (pt) | 2005-12-20 |
KR20050091081A (ko) | 2005-09-14 |
US20090156803A1 (en) | 2009-06-18 |
MY139461A (en) | 2009-10-30 |
TWI328588B (en) | 2010-08-11 |
EP1582521A4 (fr) | 2007-09-19 |
CN100344632C (zh) | 2007-10-24 |
MXPA05007408A (es) | 2005-09-12 |
JPWO2004063202A1 (ja) | 2006-05-18 |
TW200413385A (en) | 2004-08-01 |
US7737161B2 (en) | 2010-06-15 |
RU2005125204A (ru) | 2006-01-27 |
CN1723210A (zh) | 2006-01-18 |
RU2302422C2 (ru) | 2007-07-10 |
CA2510519C (fr) | 2010-03-16 |
JP2005104838A (ja) | 2005-04-21 |
NZ541198A (en) | 2008-01-31 |
NO20053762L (no) | 2005-10-07 |
AR042827A1 (es) | 2005-07-06 |
EP1582521A1 (fr) | 2005-10-05 |
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