ZA200502791B - Sulfonylamino-acetic derviatives and their use as orexin receptor antagonists. - Google Patents
Sulfonylamino-acetic derviatives and their use as orexin receptor antagonists. Download PDFInfo
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- ZA200502791B ZA200502791B ZA200502791A ZA200502791A ZA200502791B ZA 200502791 B ZA200502791 B ZA 200502791B ZA 200502791 A ZA200502791 A ZA 200502791A ZA 200502791 A ZA200502791 A ZA 200502791A ZA 200502791 B ZA200502791 B ZA 200502791B
- Authority
- ZA
- South Africa
- Prior art keywords
- amino
- acetamide
- ethyl
- pyridin
- mixtures
- Prior art date
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- 150000001875 compounds Chemical class 0.000 claims abstract description 78
- 238000000034 method Methods 0.000 claims abstract description 21
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
- 239000004480 active ingredient Substances 0.000 claims abstract 4
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- 239000000203 mixture Substances 0.000 claims description 92
- 125000000217 alkyl group Chemical group 0.000 claims description 54
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 52
- 150000003839 salts Chemical class 0.000 claims description 48
- DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims description 38
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 30
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- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 claims description 16
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- KPVVJIFMIQQGGP-UHFFFAOYSA-N n-benzyl-n-ethyl-2-(2-methoxy-n-(3-methylpyridin-2-yl)sulfonylanilino)acetamide Chemical compound C=1C=CC=C(OC)C=1N(S(=O)(=O)C=1C(=CC=CN=1)C)CC(=O)N(CC)CC1=CC=CC=C1 KPVVJIFMIQQGGP-UHFFFAOYSA-N 0.000 claims description 2
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Classifications
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- C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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CN (1) | CN1332942C (fr) |
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FR2896798A1 (fr) | 2006-01-27 | 2007-08-03 | Sanofi Aventis Sa | Derives de sulfonamides, leur preparation et leur application en therapeutique |
FR2896799B1 (fr) * | 2006-02-02 | 2008-03-28 | Sanofi Aventis Sa | Derives de sulfonamides, leur preparation et leur application en therapeutique |
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WO2007118854A1 (fr) * | 2006-04-13 | 2007-10-25 | Euro-Celtique S.A. | Composés à base de benzènesulfonamide et leur utilisation |
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JP5847087B2 (ja) | 2009-10-23 | 2016-01-20 | ヤンセン ファーマシューティカ エヌ.ベー. | オレキシン受容体調節因子としての縮合複素環式化合物 |
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WO2012145581A1 (fr) | 2011-04-20 | 2012-10-26 | Janssen Pharmaceutica Nv | Octahydropyrrolo [3,4-c] pyrroles disubstitués utilisés comme modulateurs du récepteur de l'orexine |
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JP2002537376A (ja) | 1999-02-26 | 2002-11-05 | マーク・アンド・カンパニー・インコーポレイテッド | 新規スルホンアミドおよびそれらの使用 |
US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
MXPA02008797A (es) | 2000-03-14 | 2005-09-08 | Actelion Pharmaceuticals Ltd | Derivados de 1,2,3,4-tetrahidroisoquinolina. |
JP2001261649A (ja) * | 2000-03-15 | 2001-09-26 | Sankyo Co Ltd | スルホンアミド誘導体 |
CA2408343A1 (fr) * | 2000-05-11 | 2002-11-07 | Banyu Pharmaceutical Co., Ltd. | Derives n-acyltetrahydroisoquinoline |
PT1289955E (pt) | 2000-06-16 | 2005-08-31 | Smithkline Beecham Plc | Piperidinas para utilizacao como antagonistas dos receptores da orexina |
CA2423933A1 (fr) | 2000-10-17 | 2002-04-25 | Applied Research Systems Ars Holding N.V. | Derives de sulfanilide actifs du point de vue pharmaceutique |
EP1353918B1 (fr) * | 2000-11-28 | 2005-01-12 | Smithkline Beecham Plc | Derives de la morpholine utilises comme antagonistes des recepteurs de l'orexine |
WO2002051232A2 (fr) | 2000-12-27 | 2002-07-04 | Actelion Pharmaceuticals Ltd. | Nouvelles benzazepines et derives heterocycliques associes |
US20040192673A1 (en) | 2001-05-05 | 2004-09-30 | Pascale Gaillard | N-aroyl cyclic amine derivatives as orexin receptor antagonists |
US7432270B2 (en) | 2001-05-05 | 2008-10-07 | Smithkline Beecham P.L.C. | N-aroyl cyclic amines |
EP1399441B1 (fr) | 2001-06-28 | 2006-07-05 | Smithkline Beecham Plc | Derives d'amine cycliques n-aroyle utilises comme antagonistes du recepteur de l'orexine |
GB0115862D0 (en) | 2001-06-28 | 2001-08-22 | Smithkline Beecham Plc | Compounds |
GB0124463D0 (en) | 2001-10-11 | 2001-12-05 | Smithkline Beecham Plc | Compounds |
GB0126292D0 (en) | 2001-11-01 | 2002-01-02 | Smithkline Beecham Plc | Compounds |
GB0127145D0 (en) | 2001-11-10 | 2002-01-02 | Smithkline Beecham | Compounds |
GB0130393D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
GB0130388D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
GB0130335D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
GB0130341D0 (en) | 2001-12-19 | 2002-02-06 | Smithkline Beecham Plc | Compounds |
-
2003
- 2003-10-06 CN CNB2003801011037A patent/CN1332942C/zh not_active Expired - Fee Related
- 2003-10-06 MX MXPA05003295A patent/MXPA05003295A/es unknown
- 2003-10-06 WO PCT/EP2003/011021 patent/WO2004033418A2/fr active Application Filing
- 2003-10-06 KR KR1020057005712A patent/KR20050043988A/ko not_active Application Discontinuation
- 2003-10-06 AT AT03785607T patent/ATE496884T1/de not_active IP Right Cessation
- 2003-10-06 BR BR0315115-8A patent/BR0315115A/pt not_active IP Right Cessation
- 2003-10-06 NZ NZ538749A patent/NZ538749A/en unknown
- 2003-10-06 CA CA2498091A patent/CA2498091C/fr not_active Expired - Fee Related
- 2003-10-06 DE DE60335891T patent/DE60335891D1/de not_active Expired - Lifetime
- 2003-10-06 US US10/529,637 patent/US7279578B2/en not_active Expired - Fee Related
- 2003-10-06 JP JP2004542433A patent/JP4528125B2/ja not_active Expired - Fee Related
- 2003-10-06 RU RU2005114486/04A patent/RU2334735C2/ru not_active IP Right Cessation
- 2003-10-06 EP EP03785607A patent/EP1554239B1/fr not_active Expired - Lifetime
- 2003-10-06 AU AU2003294671A patent/AU2003294671A1/en not_active Abandoned
-
2005
- 2005-03-01 NO NO20051102A patent/NO20051102L/no not_active Application Discontinuation
- 2005-04-06 ZA ZA200502791A patent/ZA200502791B/en unknown
-
2007
- 2007-05-31 US US11/756,008 patent/US7435815B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CN1703397A (zh) | 2005-11-30 |
RU2005114486A (ru) | 2006-01-20 |
RU2334735C2 (ru) | 2008-09-27 |
NO20051102L (no) | 2005-05-04 |
WO2004033418A3 (fr) | 2004-06-03 |
US7435815B2 (en) | 2008-10-14 |
KR20050043988A (ko) | 2005-05-11 |
CA2498091A1 (fr) | 2004-04-22 |
AU2003294671A1 (en) | 2004-05-04 |
ATE496884T1 (de) | 2011-02-15 |
US20060014783A1 (en) | 2006-01-19 |
BR0315115A (pt) | 2005-08-16 |
DE60335891D1 (de) | 2011-03-10 |
US7279578B2 (en) | 2007-10-09 |
US20070244156A1 (en) | 2007-10-18 |
WO2004033418A2 (fr) | 2004-04-22 |
CN1332942C (zh) | 2007-08-22 |
CA2498091C (fr) | 2011-03-22 |
JP2006502209A (ja) | 2006-01-19 |
JP4528125B2 (ja) | 2010-08-18 |
NZ538749A (en) | 2006-11-30 |
EP1554239B1 (fr) | 2011-01-26 |
EP1554239A2 (fr) | 2005-07-20 |
MXPA05003295A (es) | 2005-07-05 |
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