ZA200502278B - Imidazopyridines as cyclin dependent kinase inhibitors - Google Patents

Info

Publication number

ZA200502278B

ZA200502278B ZA200502278A ZA200502278A ZA200502278B ZA 200502278 B ZA200502278 B ZA 200502278B ZA 200502278 A ZA200502278 A ZA 200502278A ZA 200502278 A ZA200502278 A ZA 200502278A ZA 200502278 B ZA200502278 B ZA 200502278B

Authority

ZA

South Africa

Prior art keywords

aryl

alkyl

group

compound

unsubstituted

Prior art date

2002-09-19

Links

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• 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title description 7
• 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title description 3
• 150000005232 imidazopyridines Chemical class 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims description 131
• 125000000217 alkyl group Chemical group 0.000 claims description 115
• 125000003118 aryl group Chemical group 0.000 claims description 89
• -1 arylalkyt Chemical group 0.000 claims description 73
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 53
• 125000001072 heteroaryl group Chemical group 0.000 claims description 52
• 238000000034 method Methods 0.000 claims description 49
• 229910052794 bromium Inorganic materials 0.000 claims description 43
• 239000000203 mixture Substances 0.000 claims description 42
• 150000003839 salts Chemical class 0.000 claims description 41
• 125000000623 heterocyclic group Chemical group 0.000 claims description 38
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 37
• 102000003903 Cyclin-dependent kinases Human genes 0.000 claims description 32
• 108090000266 Cyclin-dependent kinases Proteins 0.000 claims description 32
• 229910052801 chlorine Inorganic materials 0.000 claims description 32
• 238000011282 treatment Methods 0.000 claims description 32
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 30
• 229910052736 halogen Inorganic materials 0.000 claims description 29
• 150000002367 halogens Chemical class 0.000 claims description 29
• 239000012453 solvate Substances 0.000 claims description 29
• 229910052731 fluorine Inorganic materials 0.000 claims description 27
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 25
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