TWI351405B - Novel imidazopyridines as cyclin dependent kinase - Google Patents

Info

Publication number

TWI351405B

TWI351405B TW092125636A TW92125636A TWI351405B TW I351405 B TWI351405 B TW I351405B TW 092125636 A TW092125636 A TW 092125636A TW 92125636 A TW92125636 A TW 92125636A TW I351405 B TWI351405 B TW I351405B

Authority

TW

Taiwan

Prior art keywords

group

alkyl

compound

cycloalkyl

cancer

Prior art date

2002-09-19

Links

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• 102000003903 Cyclin-dependent kinases Human genes 0.000 title claims description 16
• 108090000266 Cyclin-dependent kinases Proteins 0.000 title claims description 16
• 150000005232 imidazopyridines Chemical class 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 106
• 125000000217 alkyl group Chemical group 0.000 claims description 86
• 125000003118 aryl group Chemical group 0.000 claims description 69
• -1 -NR5R6 Chemical group 0.000 claims description 68
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 45
• 125000001072 heteroaryl group Chemical group 0.000 claims description 38
• 150000003839 salts Chemical class 0.000 claims description 32
• 125000000623 heterocyclic group Chemical group 0.000 claims description 31
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 30
• OAKJQQAXSVQMHS-UHFFFAOYSA-N hydrazine group Chemical group NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims description 29
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 24
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• 229910052794 bromium Inorganic materials 0.000 claims description 21
• 229910052799 carbon Inorganic materials 0.000 claims description 19
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 17
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 17
• 201000010099 disease Diseases 0.000 claims description 16
• 229910052736 halogen Inorganic materials 0.000 claims description 16
• 150000002367 halogens Chemical group 0.000 claims description 16
• 239000000460 chlorine Substances 0.000 claims description 15
• 229910052731 fluorine Inorganic materials 0.000 claims description 14
• 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 claims description 13
• 229910052739 hydrogen Inorganic materials 0.000 claims description 13
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