ZA200501537B - Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics - Google Patents
Derivatives of dioxane-2-alkyl carbamates, preparation method thereof and application of same in therapeutics Download PDFInfo
- Publication number
- ZA200501537B ZA200501537B ZA200501537A ZA200501537A ZA200501537B ZA 200501537 B ZA200501537 B ZA 200501537B ZA 200501537 A ZA200501537 A ZA 200501537A ZA 200501537 A ZA200501537 A ZA 200501537A ZA 200501537 B ZA200501537 B ZA 200501537B
- Authority
- ZA
- South Africa
- Prior art keywords
- dioxan
- trans
- general formula
- naphthalen
- propylcarbamate
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title description 8
- 239000003814 drug Substances 0.000 title description 5
- 150000001875 compounds Chemical class 0.000 claims description 74
- -1 trifluoromethoxy, benzyloxy Chemical group 0.000 claims description 50
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 25
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 20
- 125000003545 alkoxy group Chemical group 0.000 claims description 19
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- YNTOKMNHRPSGFU-UHFFFAOYSA-N n-Propyl carbamate Chemical compound CCCOC(N)=O YNTOKMNHRPSGFU-UHFFFAOYSA-N 0.000 claims description 16
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 15
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 15
- 125000005843 halogen group Chemical group 0.000 claims description 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 15
- 150000001412 amines Chemical class 0.000 claims description 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
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- OGKKHZMANPWMSD-UHFFFAOYSA-N (2-amino-2-oxoethyl) n-[3-[5-(6-methoxynaphthalen-1-yl)-1,3-dioxan-2-yl]propyl]carbamate Chemical compound C=1C=CC2=CC(OC)=CC=C2C=1C1COC(CCCNC(=O)OCC(N)=O)OC1 OGKKHZMANPWMSD-UHFFFAOYSA-N 0.000 claims description 2
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FR0210707A FR2843964B1 (fr) | 2002-08-29 | 2002-08-29 | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
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EP (2) | EP1840125B1 (de) |
JP (2) | JP4585854B2 (de) |
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BR (1) | BR0313846A (de) |
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DE (2) | DE60323754D1 (de) |
DK (2) | DK1840125T3 (de) |
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ES (2) | ES2329181T3 (de) |
FR (1) | FR2843964B1 (de) |
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MA (1) | MA27390A1 (de) |
ME (2) | MEP24208A (de) |
MX (1) | MXPA05002319A (de) |
NO (2) | NO331165B1 (de) |
NZ (1) | NZ538404A (de) |
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PT (2) | PT1840125E (de) |
RS (2) | RS51085B (de) |
SI (2) | SI1840125T1 (de) |
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UA (1) | UA82847C2 (de) |
WO (1) | WO2004020430A2 (de) |
ZA (1) | ZA200501537B (de) |
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Publication number | Priority date | Publication date | Assignee | Title |
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FR2843964B1 (fr) * | 2002-08-29 | 2004-10-01 | Sanofi Synthelabo | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
KR20050088992A (ko) * | 2002-10-07 | 2005-09-07 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 아난드아미드 가수분해 차단을 통한 불안감의 조절 |
FR2854633B1 (fr) * | 2003-05-07 | 2005-06-24 | Sanofi Synthelabo | Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique |
FR2865205B1 (fr) * | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
FR2866886B1 (fr) | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
FR2866888B1 (fr) * | 2004-02-26 | 2006-05-05 | Sanofi Synthelabo | Derives de alkylpiperazine- et alkylhomopiperazine- carboxylates, leur preparation et leur application en therapeutique |
FR2866884B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-piperidinecarboxylates, leur preparation et leur application en therapeutique |
FR2866885B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives de piperidinylalkylcarbamates, leur prepation et leur application en therapeutique |
US7269708B2 (en) * | 2004-04-20 | 2007-09-11 | Rambus Inc. | Memory controller for non-homogenous memory system |
WO2005115370A2 (en) * | 2004-04-23 | 2005-12-08 | The Regents Of The University Of California | Compounds and methods for treating non-inflammatory pain using pparalpha agonists |
DE102004039326A1 (de) * | 2004-08-12 | 2006-02-16 | Abbott Gmbh & Co. Kg | Neue medizinische Verwendungen und Verfahren |
ES2433290T3 (es) | 2005-02-17 | 2013-12-10 | Astellas Pharma Inc. | Derivados de piperazina para el tratamiento de la incontinencia urinaria y el dolor |
FR2885364B1 (fr) | 2005-05-03 | 2007-06-29 | Sanofi Aventis Sa | Derives d'alkyl-, alkenyl-et alkynylcarbamates, leur preparation et leur application en therapeutique |
EP2054055A2 (de) * | 2006-08-18 | 2009-05-06 | N.V. Organon | Kombination aus faah-hemmer und analgetikum, entzündungshemmer oder antipyretikum |
US20080089845A1 (en) * | 2006-09-07 | 2008-04-17 | N.V. Organon | Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo |
US20090099240A1 (en) * | 2006-10-02 | 2009-04-16 | N.V. Organon | Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity |
EP2096915A1 (de) * | 2006-11-20 | 2009-09-09 | N.V. Organon | Metabolisch stabilisierte hemmer der fettsäureamidhydrolase |
US8207226B1 (en) | 2008-06-03 | 2012-06-26 | Alcon Research, Ltd. | Use of FAAH antagonists for treating dry eye and ocular pain |
FR2941696B1 (fr) * | 2009-02-05 | 2011-04-15 | Sanofi Aventis | Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
TW201044234A (en) * | 2009-06-08 | 2010-12-16 | Chunghwa Picture Tubes Ltd | Method of scanning touch panel |
AU2010293429B2 (en) | 2009-09-09 | 2015-12-17 | Sumitomo Dainippon Pharma Co., Ltd. | 8-oxodihydropurine derivative |
US8274566B2 (en) * | 2009-10-09 | 2012-09-25 | John Mezzalingua Associates, Inc. | Modulation analyzer and level measurement device |
EP2545914A1 (de) | 2011-07-11 | 2013-01-16 | Sanofi | 2-Amino-2-oxoethyl-trrans-3-[5-(6-methoxy-naphtalen-yl)-1,3-dioxan-2-yl]propyl-carbamat zur Verwendung bei der Behandlung von anhaltendem Krebsschmerz |
EP2545915A1 (de) | 2011-07-11 | 2013-01-16 | Sanofi | 2-Amino-2-oxoethyl-trrans-3-[5-(6-methoxy-naphtalen-yl)-1,3-dioxan-2-yl]propyl-carbamat zur Verwendung bei der Behandlung von anhaltendem Krebsschmerz |
PL2800565T3 (pl) * | 2012-01-06 | 2020-09-21 | Lundbeck La Jolla Research Center, Inc. | Związki karbaminianowe i sposoby ich wytwarzania oraz zastosowanie |
CN114835726B (zh) * | 2022-03-24 | 2024-01-26 | 上海诺精生物科技有限公司 | 一类抑制肿瘤细胞干性的化合物及用途 |
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DK0461958T3 (da) * | 1990-06-15 | 1995-02-20 | Synthelabo | 2-(aminoalkyl)-5-(arylalkyl)-1,3-dioxanderivater, fremgangsmåde til fremstilling deraf og anvendelse deraf i terapien |
US5173506A (en) * | 1990-08-16 | 1992-12-22 | Schering Corporation | N-(mercaptoalkyl)ureas and carbamates |
FR2742152B1 (fr) * | 1995-12-06 | 1998-01-16 | Synthelabo | Derives de 5-naphtalen-1-yl-1,3-dioxanes, leur preparation et leur application en therapeutique |
AT403579B (de) * | 1995-12-07 | 1998-03-25 | Agrolinz Melamin Gmbh | Verfahren zur herstellung von hochreinem melamin |
AU8025198A (en) | 1997-06-05 | 1998-12-21 | Sanofi-Synthelabo | 5-naphthalen-1-yl-1,3-dioxane derivatives, preparation and therapeutic application |
CA2328234C (en) * | 1998-04-16 | 2009-03-17 | Texas Biotechnology Corporation | Compounds that inhibit the binding of integrins to their receptors |
FR2816938B1 (fr) | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
FR2843964B1 (fr) * | 2002-08-29 | 2004-10-01 | Sanofi Synthelabo | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
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2004
- 2004-03-11 ME MEP-2008-242A patent/ME00108B/me unknown
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2005
- 2005-02-14 IL IL166882A patent/IL166882A/en not_active IP Right Cessation
- 2005-02-17 IS IS7699A patent/IS2733B/is unknown
- 2005-02-22 US US11/062,541 patent/US7119116B2/en not_active Expired - Lifetime
- 2005-02-24 CO CO05017682A patent/CO5700820A2/es active IP Right Grant
- 2005-02-25 NO NO20051051A patent/NO331165B1/no not_active IP Right Cessation
- 2005-02-25 TN TNP2005000057A patent/TNSN05057A1/fr unknown
- 2005-02-28 MA MA28125A patent/MA27390A1/fr unknown
- 2005-02-28 HR HRP20050190AA patent/HRP20050190B1/hr not_active IP Right Cessation
- 2005-09-23 HK HK08101677.0A patent/HK1108157A1/xx not_active IP Right Cessation
- 2005-09-23 HK HK05108400A patent/HK1074445A1/xx not_active IP Right Cessation
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2006
- 2006-06-28 US US11/426,964 patent/US20060247290A1/en not_active Abandoned
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2008
- 2008-12-12 CY CY20081101445T patent/CY1108792T1/el unknown
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2009
- 2009-05-14 HR HRP20090270AA patent/HRP20090270B1/hr not_active IP Right Cessation
- 2009-07-28 US US12/510,326 patent/US7777057B2/en not_active Expired - Fee Related
- 2009-09-24 CY CY20091100995T patent/CY1109441T1/el unknown
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2010
- 2010-06-18 JP JP2010139427A patent/JP5244863B2/ja not_active Expired - Fee Related
- 2010-07-12 US US12/834,268 patent/US8119687B2/en not_active Expired - Fee Related
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2011
- 2011-04-15 NO NO20110598A patent/NO335866B1/no not_active IP Right Cessation
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