ZA200500133B - 1H-1,2,4-triazole-3-carboxamide derivatives as ca nnabinoid- CB, receptor ligands. - Google Patents
1H-1,2,4-triazole-3-carboxamide derivatives as ca nnabinoid- CB, receptor ligands. Download PDFInfo
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- ZA200500133B ZA200500133B ZA200500133A ZA200500133A ZA200500133B ZA 200500133 B ZA200500133 B ZA 200500133B ZA 200500133 A ZA200500133 A ZA 200500133A ZA 200500133 A ZA200500133 A ZA 200500133A ZA 200500133 B ZA200500133 B ZA 200500133B
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Classifications
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
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- Pharmacology & Pharmacy (AREA)
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- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
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- Neurosurgery (AREA)
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- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02078966 | 2002-09-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200500133B true ZA200500133B (en) | 2005-11-01 |
Family
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Family Applications (1)
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| ZA200500133A ZA200500133B (en) | 2002-09-19 | 2005-01-06 | 1H-1,2,4-triazole-3-carboxamide derivatives as ca nnabinoid- CB, receptor ligands. |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7319110B2 (fr) |
| EP (1) | EP1542678B1 (fr) |
| JP (1) | JP2006501275A (fr) |
| KR (1) | KR100996828B1 (fr) |
| CN (1) | CN1319529C (fr) |
| AR (1) | AR041268A1 (fr) |
| AT (1) | ATE458479T1 (fr) |
| AU (1) | AU2003299024B2 (fr) |
| BR (1) | BR0312020A (fr) |
| CA (1) | CA2491394C (fr) |
| DE (1) | DE60331444D1 (fr) |
| DK (1) | DK1542678T3 (fr) |
| ES (1) | ES2341540T3 (fr) |
| HK (1) | HK1078796A1 (fr) |
| HR (1) | HRP20050053A2 (fr) |
| IL (1) | IL165611A (fr) |
| MX (1) | MXPA05002862A (fr) |
| NO (1) | NO20051870L (fr) |
| PL (1) | PL375020A1 (fr) |
| PT (1) | PT1542678E (fr) |
| RU (1) | RU2325382C2 (fr) |
| SI (1) | SI1542678T1 (fr) |
| UA (1) | UA80298C2 (fr) |
| WO (1) | WO2004026301A1 (fr) |
| ZA (1) | ZA200500133B (fr) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897240B2 (en) * | 2002-05-08 | 2005-05-24 | The Regents Of The University Of California | Thio semicarbazone and semicarbazone inhibitors of cysteine proteases and methods of their use |
| WO2004094407A1 (fr) * | 2003-04-21 | 2004-11-04 | Daiichi Pharmaceutical Co. Ltd. | Derive heterocyclique a cinq chainons |
| US7223780B2 (en) * | 2003-05-19 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors |
| MXPA06004434A (es) * | 2003-10-24 | 2006-06-20 | Solvay Pharm Gmbh | Usos medicos novedosos de compuestos que muestran actividad antagonista cb1 y tratamiento de combinacion que involucra tales compuestos. |
| US7829552B2 (en) * | 2003-11-19 | 2010-11-09 | Metabasis Therapeutics, Inc. | Phosphorus-containing thyromimetics |
| US20060025448A1 (en) | 2004-07-22 | 2006-02-02 | Cadila Healthcare Limited | Hair growth stimulators |
| FR2874012B1 (fr) | 2004-08-09 | 2008-08-22 | Sanofi Synthelabo | Derives de pyrrole, leur preparation et leur utlisation en therapeutique |
| ES2255834B1 (es) * | 2004-09-14 | 2008-01-16 | Laboratorios Del Dr. Esteve, S.A. | Nuevos derivados 1,2,4-triazol-3-carboxamida. |
| CA2581945C (fr) * | 2004-10-01 | 2011-01-18 | Henrietta Dehmlow | Derives d'ether substitues par du hexafluoroisopropanol |
| WO2006045799A2 (fr) | 2004-10-25 | 2006-05-04 | Solvay Pharmaceuticals Gmbh | Compositions pharmaceutiques contenant des antagonistes des recepteurs cannabinoides et des agents d'ouverture de canaux potassiques dans le traitement du diabete insulino-dependant, de l'obesite et des etats associes |
| US7494985B2 (en) * | 2004-11-03 | 2009-02-24 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis, and use |
| ES2329614T3 (es) * | 2005-04-29 | 2009-11-27 | Janssen Pharmaceutica Nv | Derivados de benzotriazol como antagonistas de los receptores cannabinoides. |
| US7923465B2 (en) | 2005-06-02 | 2011-04-12 | Glenmark Pharmaceuticals S.A. | Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation |
| PL1902034T3 (pl) | 2005-06-02 | 2011-09-30 | Glenmark Pharmaceuticals Sa | Nowe ligandy receptorów kanabinoidowych, kompozycja farmaceutyczna je zawierająca oraz proces ich wytwarzania |
| US7632837B2 (en) | 2005-06-17 | 2009-12-15 | Bristol-Myers Squibb Company | Bicyclic heterocycles as cannabinoid-1 receptor modulators |
| TW200726765A (en) * | 2005-06-17 | 2007-07-16 | Bristol Myers Squibb Co | Triazolopyridine cannabinoid receptor 1 antagonists |
| US20090012127A1 (en) * | 2005-06-29 | 2009-01-08 | Astrazeneca Ab | Thiophene-2-Carboxamide Derivatives as Alpha 7 Nicotinic Receptor Modulators |
| NZ564759A (en) | 2005-06-30 | 2011-08-26 | Prosidion Ltd | GPCR agonists |
| FR2894579B1 (fr) | 2005-12-12 | 2008-01-18 | Sanofi Aventis Sa | Derives diaryltriazolmethylamine, leur preparation et leur application en therapeutique. |
| CA2657247A1 (fr) | 2006-07-28 | 2008-01-31 | Boehringer Ingelheim International Gmbh | Composes modulant le recepteur cb2 |
| WO2008033572A1 (fr) * | 2006-09-15 | 2008-03-20 | Xenoport, Inc. | Promédicaments à base de carbamate d'acyloxyalkyle, procédés de synthèse et utilisation |
| BRPI0806498A2 (pt) | 2007-01-04 | 2014-04-22 | Prosidion Ltd | Agonistas gpcr piperidina |
| GB0700122D0 (en) | 2007-01-04 | 2007-02-14 | Prosidion Ltd | GPCR agonists |
| WO2008081208A1 (fr) | 2007-01-04 | 2008-07-10 | Prosidion Limited | Agonistes de gpcr pipéridiniques |
| CL2008000017A1 (es) | 2007-01-04 | 2008-08-01 | Prosidion Ltd | Compuestos derivados de heterociclos de nitrogeno y oxigeno, agonistas de gpcr; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de la obesidad, diabetes, sindrome metabolico, hiperlipidemia, toleranci |
| PE20081659A1 (es) | 2007-01-04 | 2008-10-24 | Prosidion Ltd | Agonistas de gpcr |
| CN101302200B (zh) * | 2007-05-09 | 2011-04-20 | 上海医药工业研究院 | 制备n-哌啶子基-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基吡唑-3-甲酰胺的方法 |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| GB0720389D0 (en) | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| WO2009061652A1 (fr) | 2007-11-07 | 2009-05-14 | Boehringer Ingelheim International Gmbh | Composés modulant le récepteur cb2 |
| JP5496918B2 (ja) | 2008-02-21 | 2014-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節するアミン化合物及びエーテル化合物 |
| US8178568B2 (en) | 2008-07-10 | 2012-05-15 | Boehringer Ingelheim International Gmbh | Sulfone compounds which modulate the CB2 receptor |
| WO2010036630A2 (fr) | 2008-09-25 | 2010-04-01 | Boehringer Ingelheim International Gmbh | Composés modulant sélectivement le récepteur cb2 |
| JP5583694B2 (ja) | 2009-01-05 | 2014-09-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節するピロリジン化合物 |
| WO2010079241A1 (fr) | 2009-01-12 | 2010-07-15 | Fundacion Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion | Utilisation d'antagonistes et/ou d'agonistes inverses des récepteurs cb1 pour la préparation de médicaments qui augmentent l'excitabilité des motoneurones |
| JP5705748B2 (ja) | 2009-02-18 | 2015-04-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を変調する複素環化合物 |
| US8299103B2 (en) | 2009-06-15 | 2012-10-30 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| WO2010147791A1 (fr) | 2009-06-16 | 2010-12-23 | Boehringer Ingelheim International Gmbh | Dérivés d'azétidine 2-carboxamide qui modulent le récepteur cb2 |
| US8383651B2 (en) | 2009-09-22 | 2013-02-26 | Boehringer Ingelheim International Gmbh | Compounds which selectively modulate the CB2 receptor |
| EP2523936A1 (fr) | 2010-01-15 | 2012-11-21 | Boehringer Ingelheim International GmbH | Composés qui modulent le récepteur cb2 |
| US8329735B2 (en) | 2010-03-05 | 2012-12-11 | Boehringer Ingelheim International Gmbh | Tetrazole compounds which selectively modulate the CB2 receptor |
| JP5746764B2 (ja) | 2010-07-22 | 2015-07-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃｂ２受容体を調節する化合物 |
| CN102558157B (zh) * | 2010-12-20 | 2014-04-30 | 中国科学院上海药物研究所 | 羟乙基三唑类化合物或氨乙基三唑类化合物及其制备方法和用途 |
| CN102731418B (zh) * | 2012-07-15 | 2015-03-11 | 浙江大学 | 1-取代-1h-1,2,4-三氮唑-甲酰胺衍生物及其制备和用途 |
| JP6027244B2 (ja) * | 2012-09-17 | 2016-11-16 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | トリアゾールカルボキサミド誘導体 |
| EP2803668A1 (fr) | 2013-05-17 | 2014-11-19 | Boehringer Ingelheim International Gmbh | Nouveau (cyano-dimethyl-methyl)-isoxazoles et - [1,3,4] thiadiazoles |
| RU2705800C2 (ru) | 2014-06-06 | 2019-11-12 | Рисерч Трайэнгл Инститьют | Агонисты рецептора апелина (apj) и их применение |
| RS62862B1 (sr) | 2015-01-30 | 2022-02-28 | Neurocrine Biosciences Inc | Supstituisani triazoli i postupci koji se odnose na njih |
| WO2017100558A1 (fr) | 2015-12-09 | 2017-06-15 | Research Triangle Institute | Agonistes améliorés du récepteur de l'apéline (apj) et leurs utilisations |
| MA46540A (fr) * | 2016-10-12 | 2019-08-21 | Res Triangle Inst | Agonistes du récepteur de l'apéline (apj) hétérocyclique et leurs utilisations |
| US11655238B2 (en) | 2018-11-20 | 2023-05-23 | Shanghaitech University | MMPL3 inhibitors, compositions and uses thereof |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58194866A (ja) * | 1982-05-07 | 1983-11-12 | Kureha Chem Ind Co Ltd | トリアゾ−ル誘導体及び該誘導体を含有する除草剤 |
| DE3316300A1 (de) * | 1982-05-07 | 1983-11-24 | Kureha Kagaku Kogyo K.K., Tokyo | Heribizide zusammensetzung mit einem gehalt an einem derivat des 1,2,4-triazols als wirkstoff |
| DE3817192A1 (de) * | 1988-05-20 | 1989-11-30 | Hoechst Ag | 1,2,4-triazolderivate enthaltende pflanzenschuetzende mittel sowie neue derivate des 1,2,4-triazols |
| FR2692575B1 (fr) * | 1992-06-23 | 1995-06-30 | Sanofi Elf | Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant. |
| DE4225778A1 (de) * | 1992-08-04 | 1994-02-17 | Hoechst Ag | 1,2,4-Triazolyl-3-carbonsäure-4-aminopiperidide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel, insbesondere Fungizide |
| FR2741621B1 (fr) * | 1995-11-23 | 1998-02-13 | Sanofi Sa | Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant |
| FR2789079B3 (fr) * | 1999-02-01 | 2001-03-02 | Sanofi Synthelabo | Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant |
| EP1224173B1 (fr) | 1999-10-18 | 2005-10-12 | The University Of Connecticut | Derives de pyrazole comme antagonistes des recepteurs des cannabinoides |
| US6653304B2 (en) | 2000-02-11 | 2003-11-25 | Bristol-Myers Squibb Co. | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
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2003
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- 2003-09-16 AR ARP030103347A patent/AR041268A1/es unknown
- 2003-09-17 EP EP03797318A patent/EP1542678B1/fr not_active Expired - Lifetime
- 2003-09-17 PT PT03797318T patent/PT1542678E/pt unknown
- 2003-09-17 RU RU2005103244/04A patent/RU2325382C2/ru not_active IP Right Cessation
- 2003-09-17 JP JP2004537155A patent/JP2006501275A/ja active Pending
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- 2003-09-17 AT AT03797318T patent/ATE458479T1/de active
- 2003-09-17 PL PL03375020A patent/PL375020A1/xx not_active Application Discontinuation
- 2003-09-17 SI SI200331803T patent/SI1542678T1/sl unknown
- 2003-09-17 WO PCT/EP2003/050628 patent/WO2004026301A1/fr active Application Filing
- 2003-09-17 ES ES03797318T patent/ES2341540T3/es not_active Expired - Lifetime
- 2003-09-17 KR KR1020057004584A patent/KR100996828B1/ko not_active IP Right Cessation
- 2003-09-17 CA CA2491394A patent/CA2491394C/fr not_active Expired - Fee Related
- 2003-09-17 UA UAA200503704A patent/UA80298C2/uk unknown
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2005
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Also Published As
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| JP2006501275A (ja) | 2006-01-12 |
| IL165611A0 (en) | 2006-01-15 |
| AR041268A1 (es) | 2005-05-11 |
| WO2004026301A1 (fr) | 2004-04-01 |
| RU2005103244A (ru) | 2005-06-27 |
| EP1542678B1 (fr) | 2010-02-24 |
| SI1542678T1 (sl) | 2010-07-30 |
| ES2341540T3 (es) | 2010-06-22 |
| EP1542678A1 (fr) | 2005-06-22 |
| PT1542678E (pt) | 2010-05-25 |
| KR20050057399A (ko) | 2005-06-16 |
| BR0312020A (pt) | 2005-03-22 |
| UA80298C2 (en) | 2007-09-10 |
| DE60331444D1 (de) | 2010-04-08 |
| CA2491394C (fr) | 2010-06-15 |
| HRP20050053A2 (en) | 2005-04-30 |
| ATE458479T1 (de) | 2010-03-15 |
| HK1078796A1 (en) | 2006-03-24 |
| DK1542678T3 (da) | 2010-06-07 |
| CN1319529C (zh) | 2007-06-06 |
| AU2003299024A1 (en) | 2004-04-08 |
| KR100996828B1 (ko) | 2010-11-29 |
| PL375020A1 (en) | 2005-11-14 |
| RU2325382C2 (ru) | 2008-05-27 |
| CN1671377A (zh) | 2005-09-21 |
| US20040106614A1 (en) | 2004-06-03 |
| CA2491394A1 (fr) | 2004-04-01 |
| US7319110B2 (en) | 2008-01-15 |
| AU2003299024B2 (en) | 2008-03-06 |
| NO20051870L (no) | 2005-06-03 |
| MXPA05002862A (es) | 2005-05-27 |
| IL165611A (en) | 2010-04-15 |
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