ZA200407535B - Bioadhesive drug delivery system - Google Patents
Bioadhesive drug delivery system Download PDFInfo
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- ZA200407535B ZA200407535B ZA200407535A ZA200407535A ZA200407535B ZA 200407535 B ZA200407535 B ZA 200407535B ZA 200407535 A ZA200407535 A ZA 200407535A ZA 200407535 A ZA200407535 A ZA 200407535A ZA 200407535 B ZA200407535 B ZA 200407535B
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- ZA
- South Africa
- Prior art keywords
- agents
- composition
- therapeutically active
- phase
- active drug
- Prior art date
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- 238000012377 drug delivery Methods 0.000 title claims description 31
- 239000000227 bioadhesive Substances 0.000 title description 2
- 239000003814 drug Substances 0.000 claims description 125
- 229940079593 drug Drugs 0.000 claims description 117
- 239000000203 mixture Substances 0.000 claims description 68
- 230000002378 acidificating effect Effects 0.000 claims description 50
- 239000003795 chemical substances by application Substances 0.000 claims description 35
- 239000000839 emulsion Substances 0.000 claims description 31
- 230000007935 neutral effect Effects 0.000 claims description 29
- -1 spermicides Substances 0.000 claims description 25
- 239000002245 particle Substances 0.000 claims description 16
- 239000006172 buffering agent Substances 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 6
- 229920001282 polysaccharide Polymers 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 5
- 229960000282 metronidazole Drugs 0.000 claims description 5
- VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 230000009471 action Effects 0.000 claims description 4
- 210000004877 mucosa Anatomy 0.000 claims description 4
- 239000005017 polysaccharide Substances 0.000 claims description 4
- 208000013464 vaginal disease Diseases 0.000 claims description 4
- 229920002101 Chitin Polymers 0.000 claims description 3
- 229920001503 Glucan Polymers 0.000 claims description 3
- 239000003085 diluting agent Substances 0.000 claims description 3
- 239000003995 emulsifying agent Substances 0.000 claims description 3
- 239000003381 stabilizer Substances 0.000 claims description 3
- 208000004926 Bacterial Vaginosis Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
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- 230000007803 itching Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
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- 230000003204 osmotic effect Effects 0.000 claims 6
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 claims 4
- 229910002651 NO3 Inorganic materials 0.000 claims 4
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- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
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- MQHLMHIZUIDKOO-OKZBNKHCSA-N (2R,6S)-2,6-dimethyl-4-[(2S)-2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine Chemical compound C1=CC(C(C)(C)CC)=CC=C1C[C@H](C)CN1C[C@@H](C)O[C@@H](C)C1 MQHLMHIZUIDKOO-OKZBNKHCSA-N 0.000 claims 2
- AFNXATANNDIXLG-SFHVURJKSA-N 1-[(2r)-2-[(4-chlorophenyl)methylsulfanyl]-2-(2,4-dichlorophenyl)ethyl]imidazole Chemical compound C1=CC(Cl)=CC=C1CS[C@H](C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 AFNXATANNDIXLG-SFHVURJKSA-N 0.000 claims 2
- LEZWWPYKPKIXLL-UHFFFAOYSA-N 1-{2-(4-chlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound C1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 LEZWWPYKPKIXLL-UHFFFAOYSA-N 0.000 claims 2
- QXHHHPZILQDDPS-UHFFFAOYSA-N 1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}imidazole Chemical compound S1C=CC(COC(CN2C=NC=C2)C=2C(=CC(Cl)=CC=2)Cl)=C1Cl QXHHHPZILQDDPS-UHFFFAOYSA-N 0.000 claims 2
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 claims 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 claims 2
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- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- MQJKPEGWNLWLTK-UHFFFAOYSA-N Dapsone Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 MQJKPEGWNLWLTK-UHFFFAOYSA-N 0.000 claims 2
- 229930182566 Gentamicin Natural products 0.000 claims 2
- CEAZRRDELHUEMR-URQXQFDESA-N Gentamicin Chemical compound O1[C@H](C(C)NC)CC[C@@H](N)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](NC)[C@@](C)(O)CO2)O)[C@H](N)C[C@@H]1N CEAZRRDELHUEMR-URQXQFDESA-N 0.000 claims 2
- CTETYYAZBPJBHE-UHFFFAOYSA-N Haloprogin Chemical compound ClC1=CC(Cl)=C(OCC#CI)C=C1Cl CTETYYAZBPJBHE-UHFFFAOYSA-N 0.000 claims 2
- 108060003100 Magainin Proteins 0.000 claims 2
- JNTOCHDNEULJHD-UHFFFAOYSA-N Penciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(CCC(CO)CO)C=N2 JNTOCHDNEULJHD-UHFFFAOYSA-N 0.000 claims 2
- 229930182555 Penicillin Natural products 0.000 claims 2
- NCXMLFZGDNKEPB-UHFFFAOYSA-N Pimaricin Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCC(C)OC(=O)C=CC2OC2CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 NCXMLFZGDNKEPB-UHFFFAOYSA-N 0.000 claims 2
- KGZHFKDNSAEOJX-WIFQYKSHSA-N Ramoplanin Chemical compound C([C@H]1C(=O)N[C@H](CCCN)C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](C(=O)O[C@@H]([C@@H](C(N[C@@H](C(=O)N[C@H](CCCN)C(=O)N[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)[C@H](C)O)C=1C=CC(O)=CC=1)C=1C=CC(O)=CC=1)[C@@H](C)O)C=1C=CC(O)=CC=1)=O)NC(=O)[C@H](CC(N)=O)NC(=O)\C=C/C=C/CC(C)C)C(N)=O)C=1C=C(Cl)C(O)=CC=1)C=1C=CC(O)=CC=1)[C@@H](C)O)C=1C=CC(O[C@@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O[C@@H]2[C@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=CC=1)C1=CC=CC=C1 KGZHFKDNSAEOJX-WIFQYKSHSA-N 0.000 claims 2
- 239000004098 Tetracycline Substances 0.000 claims 2
- HDOVUKNUBWVHOX-QMMMGPOBSA-N Valacyclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCOC(=O)[C@@H](N)C(C)C)C=N2 HDOVUKNUBWVHOX-QMMMGPOBSA-N 0.000 claims 2
- UFUVLHLTWXBHGZ-MGZQPHGTSA-N [(2r,3r,4s,5r,6r)-6-[(1s,2s)-2-chloro-1-[[(2s,4r)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate Chemical compound CN1C[C@H](CCC)C[C@H]1C(=O)N[C@H]([C@H](C)Cl)[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@@H](SC)O1 UFUVLHLTWXBHGZ-MGZQPHGTSA-N 0.000 claims 2
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- 229960003942 amphotericin b Drugs 0.000 claims 2
- 229960003348 anidulafungin Drugs 0.000 claims 2
- JHVAMHSQVVQIOT-MFAJLEFUSA-N anidulafungin Chemical compound C1=CC(OCCCCC)=CC=C1C1=CC=C(C=2C=CC(=CC=2)C(=O)N[C@@H]2C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@H](C(=O)N[C@H](C(=O)N3C[C@H](C)[C@H](O)[C@H]3C(=O)N[C@H](O)[C@H](O)C2)[C@@H](C)O)[C@H](O)[C@@H](O)C=2C=CC(O)=CC=2)[C@@H](C)O)=O)C=C1 JHVAMHSQVVQIOT-MFAJLEFUSA-N 0.000 claims 2
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- ABJKWBDEJIDSJZ-UHFFFAOYSA-N butenafine Chemical compound C=1C=CC2=CC=CC=C2C=1CN(C)CC1=CC=C(C(C)(C)C)C=C1 ABJKWBDEJIDSJZ-UHFFFAOYSA-N 0.000 claims 2
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
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Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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US10/101,014 US6899890B2 (en) | 2002-03-20 | 2002-03-20 | Bioadhesive drug delivery system |
Publications (1)
Publication Number | Publication Date |
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ZA200407535B true ZA200407535B (en) | 2006-06-28 |
Family
ID=22282669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200407535A ZA200407535B (en) | 2002-03-20 | 2004-09-17 | Bioadhesive drug delivery system |
Country Status (17)
Country | Link |
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US (1) | US6899890B2 (zh) |
EP (1) | EP1494630A4 (zh) |
JP (1) | JP4462818B2 (zh) |
KR (2) | KR20030076159A (zh) |
CN (3) | CN101045034A (zh) |
AR (1) | AR039037A1 (zh) |
AU (2) | AU2002300175B2 (zh) |
BR (1) | BR0202767A (zh) |
CA (1) | CA2392473C (zh) |
FR (1) | FR2837389A1 (zh) |
HU (1) | HUP0203102A3 (zh) |
IT (1) | ITMI20021660A1 (zh) |
MX (1) | MXPA02006943A (zh) |
PT (1) | PT102854B (zh) |
RU (1) | RU2320322C2 (zh) |
WO (1) | WO2003079981A2 (zh) |
ZA (1) | ZA200407535B (zh) |
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2002
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- 2002-06-28 CA CA002392473A patent/CA2392473C/en not_active Expired - Lifetime
- 2002-07-10 KR KR1020020039940A patent/KR20030076159A/ko not_active Application Discontinuation
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- 2002-07-18 BR BR0202767-4A patent/BR0202767A/pt not_active IP Right Cessation
- 2002-07-26 IT IT2002MI001660A patent/ITMI20021660A1/it unknown
- 2002-07-29 CN CNA2007101048008A patent/CN101045034A/zh active Pending
- 2002-07-29 CN CN02127087A patent/CN1444926A/zh active Pending
- 2002-07-29 CN CN2010105156408A patent/CN102048689A/zh active Pending
- 2002-09-12 JP JP2002266381A patent/JP4462818B2/ja not_active Expired - Fee Related
- 2002-09-18 HU HU0203102A patent/HUP0203102A3/hu unknown
- 2002-10-15 PT PT102854A patent/PT102854B/pt not_active IP Right Cessation
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2003
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- 2003-03-19 EP EP03714226A patent/EP1494630A4/en not_active Ceased
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ITMI20021660A1 (it) | 2004-01-26 |
AU2003218233A1 (en) | 2003-10-08 |
FR2837389A1 (fr) | 2003-09-26 |
CN1444926A (zh) | 2003-10-01 |
HU0203102D0 (zh) | 2002-11-28 |
BR0202767A (pt) | 2004-05-25 |
JP4462818B2 (ja) | 2010-05-12 |
CN101045034A (zh) | 2007-10-03 |
AR039037A1 (es) | 2005-02-02 |
US6899890B2 (en) | 2005-05-31 |
MXPA02006943A (es) | 2004-12-13 |
AU2002300175B2 (en) | 2004-04-22 |
WO2003079981A3 (en) | 2003-11-06 |
WO2003079981A2 (en) | 2003-10-02 |
CA2392473A1 (en) | 2003-09-20 |
EP1494630A2 (en) | 2005-01-12 |
RU2320322C2 (ru) | 2008-03-27 |
KR20080098576A (ko) | 2008-11-11 |
AU2003218233A8 (en) | 2003-10-08 |
RU2004130870A (ru) | 2005-06-10 |
EP1494630A4 (en) | 2007-03-14 |
PT102854A (pt) | 2003-09-30 |
AU2002300175A1 (en) | 2003-10-09 |
JP2003286193A (ja) | 2003-10-07 |
US20030180366A1 (en) | 2003-09-25 |
CA2392473C (en) | 2007-09-18 |
KR20030076159A (ko) | 2003-09-26 |
CN102048689A (zh) | 2011-05-11 |
PT102854B (pt) | 2004-02-27 |
HUP0203102A3 (en) | 2004-06-28 |
HUP0203102A2 (hu) | 2004-05-28 |
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