AR056453A1 - Composiciones con estrogeno y metodos terapeuticos para su uso - Google Patents
Composiciones con estrogeno y metodos terapeuticos para su usoInfo
- Publication number
- AR056453A1 AR056453A1 ARP060103508A ARP060103508A AR056453A1 AR 056453 A1 AR056453 A1 AR 056453A1 AR P060103508 A ARP060103508 A AR P060103508A AR P060103508 A ARP060103508 A AR P060103508A AR 056453 A1 AR056453 A1 AR 056453A1
- Authority
- AR
- Argentina
- Prior art keywords
- composition
- estrogenic compound
- vulvovaginal
- compositions
- approximately
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Una composicion farmacéutica comprende por lo menos un compuesto estrogénico, donde la composicion está adaptada para su aplicacion en una dosis unitaria a una superficie vulvovaginal y que tiene por lo menos una fase interna no lipoide y por lo menos una fase externa lipoide que es bioadhesiva a la superficie vulvovaginal, donde el por lo menos un compuesto estrogénico está presente en una cantidad de aproximadamente entre 5 y 1000mg de estradiol equivalente por dosis unitaria de la composicion, y al aplicar la composicion a la superficie vulvovaginal el por lo menos un compuesto estrogénico se libera a lo largo de un período de aproximadamente entre 3 horas y 3 días. La composicion es util para administracion vulvovaginal para tratar la vaginitis atrofica o un trastorno asociada con la misma, por ejemplo en una mujer menopáusica o posmenopásusica. Un método para tratar una condicion relacionada con hipoestrogenismo del aparato urogenital de una paciente femenina comprende la administracion intravaginal de por lo menos un compuesto estrogénico de acuerdo con un régimen de tratamiento en el cual una serie de composiciones del por lo menos un compuesto estrogénico que liberan una cantidad diaria que se incrementa progresivamente se administra a lo largo de un período de por lo menos aproximadamente 1 mes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US70766205P | 2005-08-12 | 2005-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR056453A1 true AR056453A1 (es) | 2007-10-10 |
Family
ID=37758140
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP060103508A AR056453A1 (es) | 2005-08-12 | 2006-08-10 | Composiciones con estrogeno y metodos terapeuticos para su uso |
Country Status (13)
Country | Link |
---|---|
US (1) | US20070036848A1 (es) |
EP (1) | EP1912623A2 (es) |
JP (1) | JP2009504667A (es) |
KR (1) | KR20080033400A (es) |
CN (1) | CN101351188A (es) |
AR (1) | AR056453A1 (es) |
AU (1) | AU2006280002A1 (es) |
BR (1) | BRPI0614625A2 (es) |
CA (1) | CA2617106A1 (es) |
IL (1) | IL189364A0 (es) |
MX (1) | MX2008001687A (es) |
PE (1) | PE20070329A1 (es) |
WO (1) | WO2007021805A2 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101232869B (zh) * | 2005-06-16 | 2016-03-02 | 沃纳奇尔科特有限责任公司 | 局部给药的凝胶组合物 |
EP1904028A1 (en) * | 2005-06-16 | 2008-04-02 | Warner Chilcott Company Inc. | Estrogen compositions for vaginal administration |
CN101249070B (zh) * | 2008-04-02 | 2010-07-21 | 郑州大学 | 2-甲氧基雌二醇静脉纳米乳剂 |
ES2344673B1 (es) * | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
ES2344675B1 (es) | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
US10568891B2 (en) * | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
CN103394127A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有中西医药的阴道模具材料 |
CN103394132A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种制备阴道模具的材料 |
CN103394129A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种制备模具的材料 |
CN103394128A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有川芎的模具材料 |
CN103445892A (zh) * | 2013-08-02 | 2013-12-18 | 苏州市马尔泰新材料有限公司 | 一种含有甲酯树脂和雌酚的阴道模具 |
CN103405810A (zh) * | 2013-08-02 | 2013-11-27 | 苏州市马尔泰新材料有限公司 | 一种含有甲基丙烯酸甲酯树脂的阴道模具 |
CN103393488A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有雌三醇的阴道模具 |
CN103405294A (zh) * | 2013-08-02 | 2013-11-27 | 苏州市马尔泰新材料有限公司 | 一种含有雌酚的阴道模具 |
CN103431930A (zh) * | 2013-08-02 | 2013-12-11 | 苏州市马尔泰新材料有限公司 | 一种含有甲酯树脂的阴道模具 |
CN103393489A (zh) * | 2013-08-02 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有雌二醇的阴道模具 |
CN103357074A (zh) * | 2013-08-02 | 2013-10-23 | 苏州市马尔泰新材料有限公司 | 一种缓释型制备模具的材料 |
CN103394130A (zh) * | 2013-08-13 | 2013-11-20 | 苏州市马尔泰新材料有限公司 | 一种含有雌酚和川芎的模具材料 |
RU2713888C2 (ru) * | 2013-10-10 | 2020-02-10 | Терапьютиксмд, Инк. | Фармацевтические составы и способы на основе эстрадиола для интравагинального введения |
WO2015138668A1 (en) * | 2014-03-12 | 2015-09-17 | Warner Chilcott Company, Llc | Low-dose estradiol cream |
WO2017000080A1 (zh) * | 2015-06-30 | 2017-01-05 | 上海交通大学 | Estrone在制备抗卵巢癌和/或乳腺癌产品中的应用 |
SG11201809440PA (en) * | 2016-05-02 | 2018-11-29 | T & A Pharma Pty Ltd | Compositions for the treatment of chronic vulval and perineal pain and symptoms and conditions associated therewith |
SE1750680A1 (en) * | 2017-05-30 | 2018-12-01 | Peptonic Medical Ab | Composition for treating or preventing climacteric disorders |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4436738A (en) * | 1982-03-15 | 1984-03-13 | Mead Johnson & Company | Stabilized estradiol cream composition |
US4551148A (en) * | 1982-09-07 | 1985-11-05 | Kv Pharmaceutical Company | Vaginal delivery systems and their methods of preparation and use |
US5266329A (en) * | 1985-10-31 | 1993-11-30 | Kv Pharmaceutical Company | Vaginal delivery system |
FR2739559B1 (fr) * | 1995-10-05 | 1997-11-28 | Innothera Lab Sa | Gel pour hormonotherapie locale de la secheresse vaginale |
FR2739558B1 (fr) * | 1995-10-05 | 1997-11-28 | Innothera Lab Sa | Forme galenique unitaire pour hormonotherapie locale de la secheresse vaginale |
US20040234606A1 (en) * | 1997-09-12 | 2004-11-25 | Levine Howard L. | Localized vaginal delivery without detrimental blood levels |
US5877216A (en) * | 1997-10-28 | 1999-03-02 | Vivus, Incorporated | Treatment of female sexual dysfunction |
US7018992B2 (en) * | 2000-12-15 | 2006-03-28 | Novo Nordisk A/S | Hormone composition |
US6899890B2 (en) * | 2002-03-20 | 2005-05-31 | Kv Pharmaceutical Company | Bioadhesive drug delivery system |
ES2237298B1 (es) * | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
WO2005027807A1 (en) * | 2003-09-19 | 2005-03-31 | Drugtech Corporation | Pharmaceutical delivery system |
GB0405406D0 (en) * | 2004-03-10 | 2004-04-21 | Edko Pazarlama Tanitim Ltd Sti | Anti-vaginitis compositions |
US20060040904A1 (en) * | 2004-08-17 | 2006-02-23 | Ahmed Salah U | Vaginal cream compositions, kits thereof and methods of using thereof |
US20060183724A1 (en) * | 2005-02-03 | 2006-08-17 | Diliberti Charles E | Compositions of unconjugated estrogens and methods for their use |
WO2006127057A1 (en) * | 2005-05-24 | 2006-11-30 | Lyle Corporate Drvelopment, Inc. | Non-systematic vaginal administration of estrogen and an androgen for the treatment of sexual dysfunction |
-
2006
- 2006-08-10 WO PCT/US2006/031153 patent/WO2007021805A2/en active Application Filing
- 2006-08-10 JP JP2008526186A patent/JP2009504667A/ja active Pending
- 2006-08-10 CA CA002617106A patent/CA2617106A1/en not_active Abandoned
- 2006-08-10 US US11/502,253 patent/US20070036848A1/en not_active Abandoned
- 2006-08-10 KR KR1020087003460A patent/KR20080033400A/ko not_active Application Discontinuation
- 2006-08-10 CN CNA2006800286924A patent/CN101351188A/zh active Pending
- 2006-08-10 EP EP06801104A patent/EP1912623A2/en not_active Withdrawn
- 2006-08-10 AR ARP060103508A patent/AR056453A1/es unknown
- 2006-08-10 BR BRPI0614625-2A patent/BRPI0614625A2/pt not_active Application Discontinuation
- 2006-08-10 MX MX2008001687A patent/MX2008001687A/es not_active Application Discontinuation
- 2006-08-10 PE PE2006000972A patent/PE20070329A1/es not_active Application Discontinuation
- 2006-08-10 AU AU2006280002A patent/AU2006280002A1/en not_active Abandoned
-
2008
- 2008-02-07 IL IL189364A patent/IL189364A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN101351188A (zh) | 2009-01-21 |
AU2006280002A1 (en) | 2007-02-22 |
EP1912623A2 (en) | 2008-04-23 |
WO2007021805A3 (en) | 2007-08-09 |
US20070036848A1 (en) | 2007-02-15 |
MX2008001687A (es) | 2008-02-19 |
BRPI0614625A2 (pt) | 2011-04-12 |
WO2007021805A2 (en) | 2007-02-22 |
IL189364A0 (en) | 2008-06-05 |
PE20070329A1 (es) | 2007-03-29 |
JP2009504667A (ja) | 2009-02-05 |
KR20080033400A (ko) | 2008-04-16 |
CA2617106A1 (en) | 2007-02-22 |
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Legal Events
Date | Code | Title | Description |
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FB | Suspension of granting procedure |