ZA200406467B - N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as DDP-IV inhibitors. - Google Patents

N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as DDP-IV inhibitors. Download PDF

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ZA200406467B
ZA200406467B ZA200406467A ZA200406467A ZA200406467B ZA 200406467 B ZA200406467 B ZA 200406467B ZA 200406467 A ZA200406467 A ZA 200406467A ZA 200406467 A ZA200406467 A ZA 200406467A ZA 200406467 B ZA200406467 B ZA 200406467B
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compounds
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ZA200406467A
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Peter Aranyi
Imre Bata
Eva Boronkay
Kanai Karoly Susan Edit
Lajos T Nagy
Marton Varga
Laszlo Blazs
Sandor Batori
Philippe Bovy
Zoltan Kapui
Tibor Szabo
Katalin Urban-Szabo
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Sanofi Aventis
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof

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ZA200406467A 2002-03-06 2004-08-13 N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as DDP-IV inhibitors. ZA200406467B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0200849A HUP0200849A2 (hu) 2002-03-06 2002-03-06 N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra

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ZA200406467B true ZA200406467B (en) 2005-06-22

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ZA200406467A ZA200406467B (en) 2002-03-06 2004-08-13 N-aminoacetyl-pyrrolidine-2-carbonitriles and their use as DDP-IV inhibitors.

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US (3) US7348327B2 (enExample)
EP (1) EP1487807B1 (enExample)
JP (1) JP4559737B2 (enExample)
KR (1) KR100977898B1 (enExample)
CN (2) CN1990486A (enExample)
AR (1) AR038868A1 (enExample)
AT (1) ATE443054T1 (enExample)
AU (1) AU2003209514B2 (enExample)
BR (1) BR0307960A (enExample)
CA (1) CA2475312C (enExample)
DE (1) DE60329282D1 (enExample)
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EC (1) ECSP045274A (enExample)
HR (1) HRP20040910A2 (enExample)
HU (1) HUP0200849A2 (enExample)
IL (2) IL163286A (enExample)
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MA (1) MA27105A1 (enExample)
MX (1) MXPA04008613A (enExample)
NO (1) NO20044221L (enExample)
NZ (1) NZ535662A (enExample)
PL (1) PL371099A1 (enExample)
RS (1) RS79004A (enExample)
TN (1) TNSN04141A1 (enExample)
TW (1) TWI250978B (enExample)
UA (1) UA78291C2 (enExample)
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HUP0202001A2 (hu) * 2002-06-14 2005-08-29 Sanofi-Aventis DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
TW200401635A (en) * 2002-07-23 2004-02-01 Yamanouchi Pharma Co Ltd 2-Cyano-4-fluoropyrrolidine derivative or salt thereof
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20040242566A1 (en) 2003-03-25 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
JP4806628B2 (ja) 2003-05-05 2011-11-02 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤
WO2004103993A1 (en) 2003-05-14 2004-12-02 Syrrx, Inc. Dipeptidyl peptidase inhibitors
AU2004265341A1 (en) 2003-08-13 2005-02-24 Takeda Pharmaceutical Company Limited 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
HU227684B1 (en) 2003-08-29 2011-11-28 Sanofi Aventis Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors
WO2005049027A2 (en) 2003-11-03 2005-06-02 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
KR20120008093A (ko) * 2003-11-17 2012-01-25 노파르티스 아게 디펩티딜 펩티다제 ⅳ 억제제의 용도
RU2385723C2 (ru) * 2003-11-17 2010-04-10 Новартис Аг Применение ингибиторов дипептидилпептидазы iv
PT3738585T (pt) 2004-01-20 2023-01-30 Novartis Ag Formulação e processo de compressão direta
EP1712547B1 (en) 2004-02-05 2011-12-14 Kyorin Pharmaceutical Co., Ltd. Bicycloester derivative
JP4996926B2 (ja) 2004-02-05 2012-08-08 プロビオドルグ エージー グルタミニルシクラーゼの新規の阻害剤
FR2870538B1 (fr) * 2004-05-19 2006-07-14 Servier Lab Nouveaux derives de pyrrolidines et de thiazolidines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP4959569B2 (ja) 2004-10-12 2012-06-27 グレンマーク・ファーマシューティカルズ・エスエー 新規なジペプチジルペプチダーゼｉｖ阻害剤、それらを含む医薬品組成物、およびそれらを調製するためのプロセス
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
DOP2006000008A (es) * 2005-01-10 2006-08-31 Arena Pharm Inc Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
JP2008024592A (ja) * 2005-01-28 2008-02-07 Taisho Pharmaceut Co Ltd シアノピロリジン誘導体含有固形製剤用組成物、それを含有する固形製剤及びその製造方法
BRPI0608469A2 (pt) 2005-04-22 2010-01-05 Alantos Pharmaceuticals Holding Inc inibidores de dipeptidil peptidase-iv
CA2617715A1 (en) * 2005-08-11 2007-02-15 F. Hoffmann-La Roche Ag Pharmaceutical composition comprising a dpp-iv inhibitor
PL1942898T5 (pl) 2005-09-14 2014-10-31 Takeda Pharmaceuticals Co Inhibitory peptydazy dipeptydylowej do leczenia cukrzycy
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