ZA200304067B - Condensed purine derivatives as A1 adenosine receptor antagonists. - Google Patents
Condensed purine derivatives as A1 adenosine receptor antagonists. Download PDFInfo
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- ZA200304067B ZA200304067B ZA200304067A ZA200304067A ZA200304067B ZA 200304067 B ZA200304067 B ZA 200304067B ZA 200304067 A ZA200304067 A ZA 200304067A ZA 200304067 A ZA200304067 A ZA 200304067A ZA 200304067 B ZA200304067 B ZA 200304067B
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- South Africa
- Prior art keywords
- group
- alkyl
- substituted
- amino
- compound
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
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| US25065800P | 2000-12-01 | 2000-12-01 |
Publications (1)
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| ZA200304067B true ZA200304067B (en) | 2005-05-30 |
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Country Status (33)
| Country | Link |
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| EP (1) | EP1347981B1 (zh) |
| JP (2) | JP2004514723A (zh) |
| KR (1) | KR20040011439A (zh) |
| CN (1) | CN100497340C (zh) |
| AR (1) | AR035400A1 (zh) |
| AT (1) | ATE394402T1 (zh) |
| AU (2) | AU2002219977B2 (zh) |
| BG (1) | BG107849A (zh) |
| BR (1) | BR0115833A (zh) |
| CA (1) | CA2430508C (zh) |
| CZ (1) | CZ20031513A3 (zh) |
| DE (1) | DE60133931D1 (zh) |
| EA (1) | EA009814B1 (zh) |
| EE (1) | EE200300260A (zh) |
| ES (1) | ES2305139T3 (zh) |
| GE (1) | GEP20094697B (zh) |
| HK (1) | HK1059927A1 (zh) |
| HU (1) | HUP0400530A3 (zh) |
| IL (1) | IL156046A0 (zh) |
| IS (1) | IS6821A (zh) |
| MX (1) | MXPA03004857A (zh) |
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| NO (1) | NO20032483L (zh) |
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| PL (1) | PL362642A1 (zh) |
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| UA (1) | UA75625C2 (zh) |
| WO (1) | WO2002044182A1 (zh) |
| YU (1) | YU42903A (zh) |
| ZA (2) | ZA200304067B (zh) |
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| AU2223501A (en) * | 1999-12-24 | 2001-07-09 | Kyowa Hakko Kogyo Co. Ltd. | Fused purine derivatives |
| YU42903A (sh) * | 2000-12-01 | 2006-05-25 | Biogen Inc. | Kondenzovani derivati purina kao antagonisti a1 receptora adenozina |
| US7202252B2 (en) * | 2003-02-19 | 2007-04-10 | Endacea, Inc. | A1 adenosine receptor antagonists |
| US20040229901A1 (en) * | 2003-02-24 | 2004-11-18 | Lauren Otsuki | Method of treatment of disease using an adenosine A1 receptor antagonist |
| NZ543109A (en) | 2003-04-25 | 2008-06-30 | Novacardia Inc | Method of improved diuresis in individuals with impaired renal function |
| EP1637532A1 (en) * | 2003-04-25 | 2006-03-22 | Kyowa Hakko Kogyo Co., Ltd. | Fused pyrimidine derivative |
| CA2528385C (en) * | 2003-06-06 | 2011-03-15 | Endacea, Inc. | A1 adenosine receptor antogonists |
| CA2601032A1 (en) * | 2005-03-11 | 2006-09-21 | Aderis Pharmaceuticals, Inc. | Substituted 9-alkyladenines and the use thereof |
| US7795427B2 (en) * | 2006-02-14 | 2010-09-14 | New York University | Methods for inhibiting osteoclast differentiation, formation, or function and for increasing bone mass |
| WO2007117549A2 (en) * | 2006-04-06 | 2007-10-18 | Novacardia, Inc. | Co-administration of adenosine a1 receptor antagonists and anticonvulsants |
| WO2007137030A2 (en) | 2006-05-19 | 2007-11-29 | Abbott Laboratories | Cns active fused bicycloheterocycle substituted azabicyclic alkane derivatives |
| CN101466383A (zh) * | 2006-06-16 | 2009-06-24 | 美国诺华卡迪亚公司 | 包含低频率投与aa1ra的肾功能延长改善 |
| CA2656002A1 (en) | 2006-06-23 | 2007-12-27 | Incyte Corporation | Purinone derivatives as hm74a agonists |
| CA2656039A1 (en) | 2006-06-23 | 2007-12-27 | Incyte Corporation | Purinone derivatives as hm74a agonists |
| US20080242684A1 (en) * | 2007-03-29 | 2008-10-02 | Howard Dittrich | Methods of administration of adenosine a1 receptor antagonists |
| US20090197900A1 (en) * | 2007-03-29 | 2009-08-06 | Howard Dittrich | Methods of treating heart failure and renal dysfunction in individuals with an adenosine a1 receptor antagonist |
| WO2011063268A2 (en) * | 2009-11-19 | 2011-05-26 | Biogen Idec Ma Inc | Novel synthetic methods |
| US20130109645A1 (en) | 2010-03-31 | 2013-05-02 | The united States of America,as represented by Secretary,Dept.,of Health and Human Services | Adenosine receptor agonists for the treatment and prevention of vascular or joint capsule calcification disorders |
| CA3087655A1 (en) | 2018-01-04 | 2019-07-11 | Impetis Biosciences Ltd. | Tricyclic compounds, compositions and medicinal applications thereof |
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|---|---|---|---|---|
| JPH06102662B2 (ja) * | 1989-09-01 | 1994-12-14 | 協和醗酵工業株式会社 | キサンチン誘導体 |
| CA2028235C (en) | 1989-10-20 | 1997-01-21 | Fumio Suzuki | Condensed purine derivatives |
| CA2418125C (en) | 1991-09-23 | 2007-12-04 | Florida State University | Beta-lactams useful in the preparation of substituted isoserine esters |
| WO1998015555A1 (fr) * | 1996-10-07 | 1998-04-16 | Kyowa Hakko Kogyo Co., Ltd. | Derives de purine fondue |
| EP1014995A4 (en) * | 1997-06-18 | 2005-02-16 | Aderis Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR PREVENTING RESTENOSES CONSECUTIVE TO REVASCULARIZATION INTERVENTIONS |
| US6489331B1 (en) * | 1998-07-02 | 2002-12-03 | Kyowa Hakko Kogyo Co., Ltd. | Remedies for diabetes |
| AU2223501A (en) * | 1999-12-24 | 2001-07-09 | Kyowa Hakko Kogyo Co. Ltd. | Fused purine derivatives |
| YU42903A (sh) * | 2000-12-01 | 2006-05-25 | Biogen Inc. | Kondenzovani derivati purina kao antagonisti a1 receptora adenozina |
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- 2001-11-30 KR KR10-2003-7007322A patent/KR20040011439A/ko active IP Right Grant
- 2001-11-30 EE EEP200300260A patent/EE200300260A/xx unknown
- 2001-11-30 DE DE60133931T patent/DE60133931D1/de not_active Expired - Lifetime
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- 2001-11-30 TR TR2003/00766T patent/TR200300766T2/xx unknown
- 2001-11-30 UA UA2003066041A patent/UA75625C2/uk unknown
- 2001-11-30 HU HU0400530A patent/HUP0400530A3/hu unknown
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2003
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2004
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- 2004-10-28 ZA ZA200408755A patent/ZA200408755B/xx unknown
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2009
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