ZA200302438B - A thiazolidinedione derivatives and its use as antidiabetic. - Google Patents
A thiazolidinedione derivatives and its use as antidiabetic. Download PDFInfo
- Publication number
- ZA200302438B ZA200302438B ZA200302438A ZA200302438A ZA200302438B ZA 200302438 B ZA200302438 B ZA 200302438B ZA 200302438 A ZA200302438 A ZA 200302438A ZA 200302438 A ZA200302438 A ZA 200302438A ZA 200302438 B ZA200302438 B ZA 200302438B
- Authority
- ZA
- South Africa
- Prior art keywords
- potassium salt
- amino
- dione
- methyl
- pyridyl
- Prior art date
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- 239000003472 antidiabetic agent Substances 0.000 title claims description 13
- 150000001467 thiazolidinediones Chemical class 0.000 title description 3
- 230000003178 anti-diabetic effect Effects 0.000 title description 2
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims description 72
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- 150000003839 salts Chemical class 0.000 claims description 15
- YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims description 14
- -1 3-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione potassium salt Chemical compound 0.000 claims description 13
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 13
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- ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims description 10
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- ZGRMKPSQTQQYNY-UHFFFAOYSA-N 3-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CN1C(=O)CSC1=O ZGRMKPSQTQQYNY-UHFFFAOYSA-N 0.000 claims 2
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Communicable Diseases (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0023970.7A GB0023970D0 (en) | 2000-09-29 | 2000-09-29 | Novel pharmaceutical |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200302438B true ZA200302438B (en) | 2004-04-28 |
Family
ID=9900427
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200302438A ZA200302438B (en) | 2000-09-29 | 2003-03-28 | A thiazolidinedione derivatives and its use as antidiabetic. |
Country Status (34)
| Country | Link |
|---|---|
| US (1) | US20040038968A1 (ko) |
| EP (2) | EP1325000B1 (ko) |
| JP (1) | JP2004509960A (ko) |
| KR (2) | KR100822135B1 (ko) |
| CN (2) | CN101961333A (ko) |
| AP (1) | AP1841A (ko) |
| AT (1) | ATE368038T1 (ko) |
| AU (2) | AU9203401A (ko) |
| BG (1) | BG107678A (ko) |
| BR (1) | BR0114364A (ko) |
| CA (1) | CA2423978A1 (ko) |
| CY (1) | CY1107767T1 (ko) |
| CZ (1) | CZ2003849A3 (ko) |
| DE (1) | DE60129576T2 (ko) |
| DK (1) | DK1325000T3 (ko) |
| DZ (1) | DZ3481A1 (ko) |
| EA (1) | EA005110B1 (ko) |
| EC (1) | ECSP034529A (ko) |
| ES (1) | ES2290169T3 (ko) |
| GB (1) | GB0023970D0 (ko) |
| HK (1) | HK1058192A1 (ko) |
| HU (1) | HUP0301199A3 (ko) |
| IL (2) | IL155140A0 (ko) |
| MA (1) | MA25913A1 (ko) |
| MX (1) | MXPA03002867A (ko) |
| NO (2) | NO324970B1 (ko) |
| NZ (1) | NZ524932A (ko) |
| OA (1) | OA12400A (ko) |
| PL (1) | PL361157A1 (ko) |
| PT (1) | PT1325000E (ko) |
| SK (1) | SK3792003A3 (ko) |
| UA (1) | UA76121C2 (ko) |
| WO (1) | WO2002026736A1 (ko) |
| ZA (1) | ZA200302438B (ko) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU225919B1 (en) * | 1999-12-18 | 2007-12-28 | Richter Gedeon Nyrt | Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates |
| HUP0800755A2 (en) | 2008-12-11 | 2010-09-28 | Richter Gedeon Nyrt | Crystalline forms of rosiglitazone |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0842925A1 (en) * | 1987-09-04 | 1998-05-20 | Beecham Group Plc | Substituted thiazolidinedione derivatives |
| US5521201A (en) * | 1987-09-04 | 1996-05-28 | Beecham Group P.L.C. | Method for treatment of atherosclerosis |
| GB9124513D0 (en) * | 1991-11-19 | 1992-01-08 | Smithkline Beecham Plc | Novel process |
| GB9308487D0 (en) * | 1993-04-23 | 1993-06-09 | Smithkline Beecham Plc | Novel compounds |
| GB9712866D0 (en) * | 1997-06-18 | 1997-08-20 | Smithkline Beecham Plc | Novel method of treatment |
| GB9723295D0 (en) * | 1997-11-04 | 1998-01-07 | Smithkline Beecham Plc | Novel process |
| CN1183130C (zh) * | 1999-09-24 | 2005-01-05 | 中国人民解放军军事医学科学院毒物药物研究所 | 噻唑烷类衍生物及其医药用途 |
| HU225919B1 (en) * | 1999-12-18 | 2007-12-28 | Richter Gedeon Nyrt | Thiazolidine-derivatives, process for their preparation pharmaceutical and intermediates |
-
2000
- 2000-09-29 GB GBGB0023970.7A patent/GB0023970D0/en not_active Ceased
-
2001
- 2001-09-28 PT PT01972254T patent/PT1325000E/pt unknown
- 2001-09-28 DE DE60129576T patent/DE60129576T2/de not_active Expired - Lifetime
- 2001-09-28 MX MXPA03002867A patent/MXPA03002867A/es active IP Right Grant
- 2001-09-28 CZ CZ2003849A patent/CZ2003849A3/cs unknown
- 2001-09-28 CN CN2010100046806A patent/CN101961333A/zh active Pending
- 2001-09-28 CN CN01816563XA patent/CN1620453B/zh not_active Expired - Fee Related
- 2001-09-28 KR KR1020037004496A patent/KR100822135B1/ko not_active IP Right Cessation
- 2001-09-28 KR KR1020077018614A patent/KR20070089258A/ko not_active Application Discontinuation
- 2001-09-28 EP EP01972254A patent/EP1325000B1/en not_active Revoked
- 2001-09-28 EA EA200300423A patent/EA005110B1/ru not_active IP Right Cessation
- 2001-09-28 CA CA002423978A patent/CA2423978A1/en not_active Abandoned
- 2001-09-28 NZ NZ524932A patent/NZ524932A/en unknown
- 2001-09-28 EP EP07105370A patent/EP1795531A1/en not_active Withdrawn
- 2001-09-28 DK DK01972254T patent/DK1325000T3/da active
- 2001-09-28 BR BR0114364-6A patent/BR0114364A/pt not_active Application Discontinuation
- 2001-09-28 SK SK379-2003A patent/SK3792003A3/sk not_active Application Discontinuation
- 2001-09-28 AU AU9203401A patent/AU9203401A/xx active Pending
- 2001-09-28 OA OA1200300091A patent/OA12400A/en unknown
- 2001-09-28 US US10/381,497 patent/US20040038968A1/en not_active Abandoned
- 2001-09-28 WO PCT/GB2001/004346 patent/WO2002026736A1/en active IP Right Grant
- 2001-09-28 PL PL36115701A patent/PL361157A1/xx not_active Application Discontinuation
- 2001-09-28 AT AT01972254T patent/ATE368038T1/de active
- 2001-09-28 DZ DZ013481A patent/DZ3481A1/fr active
- 2001-09-28 JP JP2002531120A patent/JP2004509960A/ja active Pending
- 2001-09-28 HU HU0301199A patent/HUP0301199A3/hu unknown
- 2001-09-28 IL IL15514001A patent/IL155140A0/xx unknown
- 2001-09-28 UA UA2003032736A patent/UA76121C2/uk unknown
- 2001-09-28 AP APAP/P/2003/002766A patent/AP1841A/en active
- 2001-09-28 AU AU2001292034A patent/AU2001292034B2/en not_active Ceased
- 2001-09-28 ES ES01972254T patent/ES2290169T3/es not_active Expired - Lifetime
-
2003
- 2003-03-26 BG BG107678A patent/BG107678A/bg unknown
- 2003-03-27 IL IL155140A patent/IL155140A/en not_active IP Right Cessation
- 2003-03-28 ZA ZA200302438A patent/ZA200302438B/en unknown
- 2003-03-28 EC EC2003004529A patent/ECSP034529A/es unknown
- 2003-03-28 MA MA27077A patent/MA25913A1/fr unknown
- 2003-03-28 NO NO20031434A patent/NO324970B1/no not_active IP Right Cessation
- 2003-12-23 HK HK03109359A patent/HK1058192A1/xx not_active IP Right Cessation
-
2007
- 2007-10-16 CY CY20071101336T patent/CY1107767T1/el unknown
- 2007-10-31 NO NO20075507A patent/NO20075507L/no unknown
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