ZA200302296B - Saratine for inhibiting platelet adhesion to collagen. - Google Patents

Saratine for inhibiting platelet adhesion to collagen. Download PDF

Info

Publication number
ZA200302296B
ZA200302296B ZA200302296A ZA200302296A ZA200302296B ZA 200302296 B ZA200302296 B ZA 200302296B ZA 200302296 A ZA200302296 A ZA 200302296A ZA 200302296 A ZA200302296 A ZA 200302296A ZA 200302296 B ZA200302296 B ZA 200302296B
Authority
ZA
South Africa
Prior art keywords
saratin
substance
composition
platelet
collagen
Prior art date
Application number
ZA200302296A
Other languages
English (en)
Inventor
Christopher Barnes
Matthias Frech
Uwe Hofmann
Johannes Gleitz
Wolfgang Strittmatter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of ZA200302296B publication Critical patent/ZA200302296B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M2025/0057Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
ZA200302296A 2000-08-25 2003-03-24 Saratine for inhibiting platelet adhesion to collagen. ZA200302296B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP00118542 2000-08-25

Publications (1)

Publication Number Publication Date
ZA200302296B true ZA200302296B (en) 2004-06-30

Family

ID=8169664

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200302296A ZA200302296B (en) 2000-08-25 2003-03-24 Saratine for inhibiting platelet adhesion to collagen.

Country Status (26)

Country Link
US (2) US6881722B2 (OSRAM)
EP (1) EP1311284B1 (OSRAM)
JP (1) JP4988131B2 (OSRAM)
KR (1) KR100794277B1 (OSRAM)
CN (1) CN1224421C (OSRAM)
AR (1) AR030492A1 (OSRAM)
AT (1) ATE285246T1 (OSRAM)
AU (2) AU9550601A (OSRAM)
BR (1) BR0113478A (OSRAM)
CA (1) CA2419385C (OSRAM)
CZ (1) CZ302353B6 (OSRAM)
DE (1) DE60107962T2 (OSRAM)
DK (1) DK1311284T3 (OSRAM)
EC (1) ECSP034485A (OSRAM)
ES (1) ES2234896T3 (OSRAM)
HU (1) HU229367B1 (OSRAM)
MX (1) MXPA03001604A (OSRAM)
MY (1) MY128992A (OSRAM)
NO (1) NO331326B1 (OSRAM)
PT (1) PT1311284E (OSRAM)
RU (1) RU2302880C2 (OSRAM)
SI (1) SI1311284T1 (OSRAM)
SK (1) SK287829B6 (OSRAM)
UA (1) UA77402C2 (OSRAM)
WO (1) WO2002015919A2 (OSRAM)
ZA (1) ZA200302296B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4805461B2 (ja) * 1999-03-18 2011-11-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 血小板接着の阻止用タンパク質
MXPA05006043A (es) 2003-01-10 2006-01-30 Ablynx Nv Polipeptidos terapeuticos, homologos de los mismos, fragmentos de los mismos y para uso al modular la agregacion mediada de plaquetas.
US7691839B2 (en) 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US20080069774A1 (en) * 2005-11-17 2008-03-20 Lance Liotta Proteomic antisense molecular shield and targeting
EP3846867B1 (en) * 2018-09-06 2025-02-19 Biomodics APS A medical tubular device
CN117229423B (zh) * 2023-11-10 2024-02-06 北京科技大学 一种用于结合胶原的多肽纳米材料及其制备方法和应用

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947401A (en) * 1971-10-05 1976-03-30 Union Optics Corporation Hydrogels of unsaturated ester copolymers
US5705355A (en) 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
US4879135A (en) * 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
IL86857A (en) * 1988-06-24 1994-04-12 Yissum Res Dev Co Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5304121A (en) * 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
US5179082A (en) * 1990-11-13 1993-01-12 Merck & Co., Inc. Method for blocking platelet adhesion to collagen
ATE169674T1 (de) * 1991-09-05 1998-08-15 Schering Ag Hemmstoff der kollagen-induzierten plättchenaggregation
DE4136513A1 (de) 1991-11-06 1993-05-13 Basf Ag Neues thrombininhibitorisches protein aus raubwanzen
JP3742429B2 (ja) 1993-07-01 2006-02-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング コラーゲン刺激血小板凝集の阻害剤
ES2255477T5 (es) * 1993-07-29 2010-04-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Uso de paclitaxel y sus derivados en la fabricacion de un medicamento para el tratamiento de reestenosis.
US5532287A (en) * 1994-05-04 1996-07-02 Ciba-Geigy Corporation Radiation cured drug release controlling membrane
US5767108A (en) * 1995-08-22 1998-06-16 Medtronic, Inc. Method for making improved heparinized biomaterials
US6246715B1 (en) * 1998-06-26 2001-06-12 Samsung Electronics Co., Ltd. Data transmitter and receiver of a DS-CDMA communication system
US5843172A (en) * 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
WO2000023094A2 (en) * 1998-10-16 2000-04-27 Immunex Corporation Methods of inhibiting platelet activation and recruitment
IT1304135B1 (it) * 1998-11-26 2001-03-07 Magneti Marelli Spa Metodo di controllo dell' iniezione e dell' accensione in un motoreendotermico ad iniezione diretta per accelerare il riscaldamento del
JP2002537270A (ja) * 1999-02-19 2002-11-05 ザイモジェネティクス,インコーポレイティド 止血及び免疫機能における使用のためのインヒビター
JP4805461B2 (ja) 1999-03-18 2011-11-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 血小板接着の阻止用タンパク質

Also Published As

Publication number Publication date
AR030492A1 (es) 2003-08-20
NO20030841L (no) 2003-02-24
HUP0303747A3 (en) 2006-01-30
HU229367B1 (en) 2013-11-28
UA77402C2 (en) 2006-12-15
CZ302353B6 (cs) 2011-03-30
ES2234896T3 (es) 2005-07-01
US20030190342A1 (en) 2003-10-09
CN1224421C (zh) 2005-10-26
CA2419385A1 (en) 2002-02-28
ATE285246T1 (de) 2005-01-15
WO2002015919A3 (en) 2002-05-30
US6881722B2 (en) 2005-04-19
HK1059736A1 (en) 2004-07-16
KR20030034141A (ko) 2003-05-01
ECSP034485A (es) 2003-03-31
AU9550601A (en) 2002-03-04
AU2001295506B2 (en) 2007-02-15
CN1449291A (zh) 2003-10-15
JP4988131B2 (ja) 2012-08-01
RU2302880C2 (ru) 2007-07-20
DE60107962T2 (de) 2005-12-15
MY128992A (en) 2007-03-30
MXPA03001604A (es) 2003-06-04
KR100794277B1 (ko) 2008-01-11
NO331326B1 (no) 2011-11-28
NO20030841D0 (no) 2003-02-24
HUP0303747A2 (hu) 2004-03-01
EP1311284A2 (en) 2003-05-21
EP1311284B1 (en) 2004-12-22
CA2419385C (en) 2011-05-10
PT1311284E (pt) 2005-05-31
BR0113478A (pt) 2003-07-15
DK1311284T3 (da) 2005-04-18
US20050143305A1 (en) 2005-06-30
WO2002015919A2 (en) 2002-02-28
CZ2003720A3 (cs) 2003-06-18
SK3132003A3 (en) 2003-08-05
SI1311284T1 (OSRAM) 2005-08-31
SK287829B6 (sk) 2011-11-04
PL359246A1 (en) 2004-08-23
US7459438B2 (en) 2008-12-02
DE60107962D1 (de) 2005-01-27
JP2004506690A (ja) 2004-03-04

Similar Documents

Publication Publication Date Title
Van Belle et al. Accelerated endothelialization by local delivery of recombinant human vascular endothelial growth factor reduces in-stent intimal formation
US20060062768A1 (en) Biocompatible hydrogel compositions
US5914316A (en) Method of inhibiting intimal hyperplasia
JP2003501151A (ja) 動脈再狭窄治療用装置および化合物
Chesebro et al. Importance of antithrombin therapy during coronary angioplasty
AU2001295506B2 (en) Saratin for inhibiting platelet adhesion to collagen
Miyawaki et al. The effect of low-molecular-weight heparin in the survival of a rabbit congested skin flap
AU2001295506A1 (en) Saratin for inhibiting platelet adhesion to collagen
Zhou et al. Effect of anti-tumor necrosis factor-α polyclonal antibody on restenosis after balloon angioplasty in a rabbit atherosclerotic model
Pemberton et al. Characterization of microvascular vasoconstriction following ischemia/reperfusion in skeletal muscle using videomicroscopy
Lin et al. Carotid stenting using heparin-coated balloon-expandable stent reduces intimal hyperplasia in a baboon model
US5824644A (en) Method of attenuating arterial stenosis
Cohen et al. Phlegmasia cerulea dolens and its association with hypercoagulable states
PL203469B1 (pl) Zastosowanie polipeptydowej Saratyny do wytwarzania leku
US9375518B2 (en) Surface protection of exposed biological tissues
US9217042B2 (en) Method of reducing MACE in diabetic patients subsequent to stent placement
HK1059736B (en) A new specific mechanism for inhibiting platelet adhesion to collagen
Cerqueira et al. Effect of diclofenac sodium on the healing process of end-to-end anastomosis in carotid arteries of rabbits
Baumbach et al. Porous balloon delivery of low molecular weight heparin in the dog coronary artery
Delaere et al. Side-Effects of Rinsing Fluids on the Rat Femoral Artery: A histological and electron microscopic study
Ewing et al. Small Animal Models to Study Restenosis and Effects of (Local) Drug Therapy
Rapp Inhibition of neointimal smooth muscle accumulation after angioplasty by an antibody to PDGF: Ferns GAA, Raines EW, Sprugel KH, Motant AS, Reidy MA, Ross R. Science 1991; 253: 1129–1132