BR0113478A - Mecanismo especìfico para inibição de adesão de plaqueta a colágeno - Google Patents

Mecanismo especìfico para inibição de adesão de plaqueta a colágeno

Info

Publication number
BR0113478A
BR0113478A BR0113478-7A BR0113478A BR0113478A BR 0113478 A BR0113478 A BR 0113478A BR 0113478 A BR0113478 A BR 0113478A BR 0113478 A BR0113478 A BR 0113478A
Authority
BR
Brazil
Prior art keywords
inhibition
collagen
platelet adhesion
saratin
specific mechanism
Prior art date
Application number
BR0113478-7A
Other languages
English (en)
Inventor
Christopher Barnes
Matthias Frech
Uwe Hofmann
Johannes Gleitz
Wolfgang Strittmatter
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR0113478A publication Critical patent/BR0113478A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/0043—Catheters; Hollow probes characterised by structural features
    • A61M2025/0057—Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

"MECANISMO ESPECìFICO PARA INIBIçãO DE ADESãO DE PLAQUETA A COLáGENO". A invensão refere-se ao uso do polipeptídeo Saratin para a fabricação de um medicamento tendo a capacidade de diminuir significantemente adesão de plaquetas e acumulação de plaquetas após danos vasculares ou endarterectomia. A invenção ainda refere-se a um novo uso médico de Saratin como um inibidor de trombose e hiperplasia intimal, em que o dito polipeptídeo pode ser usado localmente como um agente tópico ou como um revestimento, ou de outro modo incorporado ou associado com dispositivos médicos.
BR0113478-7A 2000-08-25 2001-08-23 Mecanismo especìfico para inibição de adesão de plaqueta a colágeno BR0113478A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00118542 2000-08-25
PCT/EP2001/009746 WO2002015919A2 (en) 2000-08-25 2001-08-23 Saratin for inhibiting platelet adhesion to collagen

Publications (1)

Publication Number Publication Date
BR0113478A true BR0113478A (pt) 2003-07-15

Family

ID=8169664

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0113478-7A BR0113478A (pt) 2000-08-25 2001-08-23 Mecanismo especìfico para inibição de adesão de plaqueta a colágeno

Country Status (27)

Country Link
US (2) US6881722B2 (pt)
EP (1) EP1311284B1 (pt)
JP (1) JP4988131B2 (pt)
KR (1) KR100794277B1 (pt)
CN (1) CN1224421C (pt)
AR (1) AR030492A1 (pt)
AT (1) ATE285246T1 (pt)
AU (2) AU9550601A (pt)
BR (1) BR0113478A (pt)
CA (1) CA2419385C (pt)
CZ (1) CZ302353B6 (pt)
DE (1) DE60107962T2 (pt)
DK (1) DK1311284T3 (pt)
EC (1) ECSP034485A (pt)
ES (1) ES2234896T3 (pt)
HK (1) HK1059736A1 (pt)
HU (1) HU229367B1 (pt)
MX (1) MXPA03001604A (pt)
MY (1) MY128992A (pt)
NO (1) NO331326B1 (pt)
PT (1) PT1311284E (pt)
RU (1) RU2302880C2 (pt)
SI (1) SI1311284T1 (pt)
SK (1) SK287829B6 (pt)
UA (1) UA77402C2 (pt)
WO (1) WO2002015919A2 (pt)
ZA (1) ZA200302296B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000056885A1 (en) * 1999-03-18 2000-09-28 Merck Patent Gmbh Protein for blocking platelet adhesion
WO2004062551A2 (en) 2003-01-10 2004-07-29 Ablynx N.V. RECOMBINANT VHH SINGLE DOMAIN ANTIBODY FROM CAMELIDAE AGAINST VON WILLEBRAND FACTOR (vWF) OR AGAINST COLLAGEN
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
WO2007038749A2 (en) * 2005-09-28 2007-04-05 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20080069774A1 (en) * 2005-11-17 2008-03-20 Lance Liotta Proteomic antisense molecular shield and targeting
CN117229423B (zh) * 2023-11-10 2024-02-06 北京科技大学 一种用于结合胶原的多肽纳米材料及其制备方法和应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947401A (en) * 1971-10-05 1976-03-30 Union Optics Corporation Hydrogels of unsaturated ester copolymers
US5705355A (en) 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
IL86857A (en) * 1988-06-24 1994-04-12 Yissum Res Dev Co Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5304121A (en) * 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
GB9022040D0 (en) 1990-10-10 1990-11-21 Biopharm Ltd Platelet adhesion inhibitor
US5179082A (en) * 1990-11-13 1993-01-12 Merck & Co., Inc. Method for blocking platelet adhesion to collagen
DE4136513A1 (de) 1991-11-06 1993-05-13 Basf Ag Neues thrombininhibitorisches protein aus raubwanzen
AU680929B2 (en) * 1993-07-01 1997-08-14 Merck Patent Gmbh Inhibitor of collagen-stimulated platelet aggregation
DK1118325T4 (da) * 1993-07-29 2010-04-06 Us Health Anvendelse af paclitaxel og dets derivater ved fremstilling af et medikament til behandling af restenose
US5532287A (en) * 1994-05-04 1996-07-02 Ciba-Geigy Corporation Radiation cured drug release controlling membrane
US6246715B1 (en) * 1998-06-26 2001-06-12 Samsung Electronics Co., Ltd. Data transmitter and receiver of a DS-CDMA communication system
US5843172A (en) * 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
AU772460B2 (en) * 1998-10-16 2004-04-29 Immunex Corporation Inhibitors of platelet activation and recruitment
IT1304135B1 (it) * 1998-11-26 2001-03-07 Magneti Marelli Spa Metodo di controllo dell' iniezione e dell' accensione in un motoreendotermico ad iniezione diretta per accelerare il riscaldamento del
EP1382345A3 (en) * 1999-02-19 2004-01-28 Zymogenetics Inc Uses of inhibitors of hemostasis
WO2000056885A1 (en) 1999-03-18 2000-09-28 Merck Patent Gmbh Protein for blocking platelet adhesion

Also Published As

Publication number Publication date
US20050143305A1 (en) 2005-06-30
ECSP034485A (es) 2003-03-31
ES2234896T3 (es) 2005-07-01
HK1059736A1 (en) 2004-07-16
JP2004506690A (ja) 2004-03-04
SK287829B6 (sk) 2011-11-04
HUP0303747A3 (en) 2006-01-30
SK3132003A3 (en) 2003-08-05
US6881722B2 (en) 2005-04-19
WO2002015919A3 (en) 2002-05-30
US20030190342A1 (en) 2003-10-09
MXPA03001604A (es) 2003-06-04
DE60107962T2 (de) 2005-12-15
NO20030841D0 (no) 2003-02-24
CN1224421C (zh) 2005-10-26
NO20030841L (no) 2003-02-24
NO331326B1 (no) 2011-11-28
CA2419385C (en) 2011-05-10
HU229367B1 (en) 2013-11-28
AU2001295506B2 (en) 2007-02-15
EP1311284B1 (en) 2004-12-22
CZ2003720A3 (cs) 2003-06-18
AU9550601A (en) 2002-03-04
ATE285246T1 (de) 2005-01-15
DE60107962D1 (de) 2005-01-27
DK1311284T3 (da) 2005-04-18
HUP0303747A2 (hu) 2004-03-01
RU2302880C2 (ru) 2007-07-20
WO2002015919A2 (en) 2002-02-28
SI1311284T1 (pt) 2005-08-31
JP4988131B2 (ja) 2012-08-01
PL359246A1 (en) 2004-08-23
KR20030034141A (ko) 2003-05-01
US7459438B2 (en) 2008-12-02
PT1311284E (pt) 2005-05-31
UA77402C2 (en) 2006-12-15
CZ302353B6 (cs) 2011-03-30
CN1449291A (zh) 2003-10-15
CA2419385A1 (en) 2002-02-28
MY128992A (en) 2007-03-30
KR100794277B1 (ko) 2008-01-11
EP1311284A2 (en) 2003-05-21
AR030492A1 (es) 2003-08-20
ZA200302296B (en) 2004-06-30

Similar Documents

Publication Publication Date Title
BR0304168A (pt) Curativo hemostático para ferimentos contendo polissacarìdeo modificado por aldeìdo e agentes hemostáticos
BR0215397A (pt) Pensos cirúrgicos revestidos
BR0110838A (pt) Agente de emplastro
ES2149775T3 (es) Composicion para el tratamiento de tejidos que comprende fibrina o fibrinogeno y un polimero biodegradable y biocompatible.
TR200401545T4 (tr) NOSS inhibitörü ilaçların amalatı için ikame imidazo [1,2-a]piridin-,-pirimidin- ve-pirazin-3-amin-türevlerinin kullanımı
AR006484A1 (es) Composición farmacéutica con efecto anestésico, uso de esta composición para la fabricación de medicamentos, y proceso para la fabricación de esta composición .
AR002254A1 (es) Formulacion antitrombotica y procedimiento para su manufactura
PT1019111E (pt) Revestimento que liberta um agente bioactivo
ES2192860T3 (es) Uso de una composicion que comprende heparina como agente de revestimiento superficial no trombogenico para prevenir la trombosis arterial.
PA8506101A1 (es) Uso de un compuesto acat para fabricar una composicion farmaceutica
BR0116087A (pt) Fio dental e fita dental revestidos com hemostato e método de feitura dos mesmos
BR0110506A (pt) Uso de inibidores de il-18 para o tratamento e/ou prevenção da aterosclerose
BR0108753A (pt) Corpos sólidos
DE50109226D1 (de) Dermales therapeutisches system enthaltend nichtsteroidale antiphlogistika mit selektiver cox-2-hemmung
BR9810520A (pt) Inibidor do fator xa isolado ou em combinação com um anti-agregador plaquetário, contra a trambose arterial
BR0015225A (pt) Tratamento de enfisema utilizando antagonistas retinóides seletivos para rar
BR0112212A (pt) Uma combinação de inibidores de fbpase e agentes antidiabéticos úteis para o tratamento de diabetes
ES2180649T3 (es) Agente antiadherente.
BR0113478A (pt) Mecanismo especìfico para inibição de adesão de plaqueta a colágeno
BR9807523A (pt) Quinoxalinas em combinação tripla com inibidores da protease e inibidores de transcriptase reversa como medicamentos para o tratamento de aids.
BR0315455A (pt) Composição farmacêutica para o tratamento de manifestações dolorosas e inflamatórios e utilização combinada do tenatoprazol e de pelo menos um antiinflamatório
SE9600216D0 (sv) Styrning av läkningsprocesser
PT866870E (pt) Proteinas de fusao factor tecidual-dominio de kunitz como inibidores do factor viia
RS51534B (en) NEW COMPOUND OF SINUSOID IF CURRENT INHIBITORS AND CALCIUM INHIBITOR AND PHARMACEUTICAL MIXTURE CONTAINED BY IT
YU39598A (sh) Upotreba duloksetina i njegova farmaceutska smeša

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: INDEFIRO O PEDIDO DE ACORDO COM O(S) ARTIGO(S) 8O, 11, 25 DA LPI

B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.