RU2302880C2 - Новый специфический механизм ингибирования адгезии тромбоцитов к коллагену - Google Patents

Новый специфический механизм ингибирования адгезии тромбоцитов к коллагену Download PDF

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Publication number
RU2302880C2
RU2302880C2 RU2003107919/15A RU2003107919A RU2302880C2 RU 2302880 C2 RU2302880 C2 RU 2302880C2 RU 2003107919/15 A RU2003107919/15 A RU 2003107919/15A RU 2003107919 A RU2003107919 A RU 2003107919A RU 2302880 C2 RU2302880 C2 RU 2302880C2
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RU
Russia
Prior art keywords
saratin
collagen
platelet
catheter
endarterectomy
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RU2003107919/15A
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English (en)
Russian (ru)
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RU2003107919A (ru
Inventor
БАРНЕС Кристофер (DE)
БАРНЕС Кристофер
ФРЕХ Маттиас (DE)
ФРЕХ Маттиас
ХОФМАНН Уве (DE)
Хофманн Уве
ГЛАЙТЦ Иоганнес (DE)
ГЛАЙТЦ Иоганнес
ШТРИТТМАТТЕР Вольфганг (DE)
Штриттматтер Вольфганг
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Мерк Патент Гмбх
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Publication of RU2003107919A publication Critical patent/RU2003107919A/ru
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1767Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00Catheters; Hollow probes
    • A61M25/0043Catheters; Hollow probes characterised by structural features
    • A61M2025/0057Catheters delivering medicament other than through a conventional lumen, e.g. porous walls or hydrogel coatings

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
RU2003107919/15A 2000-08-25 2001-08-23 Новый специфический механизм ингибирования адгезии тромбоцитов к коллагену RU2302880C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00118542 2000-08-25
EP00118542.0 2000-08-25

Publications (2)

Publication Number Publication Date
RU2003107919A RU2003107919A (ru) 2004-09-10
RU2302880C2 true RU2302880C2 (ru) 2007-07-20

Family

ID=8169664

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003107919/15A RU2302880C2 (ru) 2000-08-25 2001-08-23 Новый специфический механизм ингибирования адгезии тромбоцитов к коллагену

Country Status (26)

Country Link
US (2) US6881722B2 (OSRAM)
EP (1) EP1311284B1 (OSRAM)
JP (1) JP4988131B2 (OSRAM)
KR (1) KR100794277B1 (OSRAM)
CN (1) CN1224421C (OSRAM)
AR (1) AR030492A1 (OSRAM)
AT (1) ATE285246T1 (OSRAM)
AU (2) AU9550601A (OSRAM)
BR (1) BR0113478A (OSRAM)
CA (1) CA2419385C (OSRAM)
CZ (1) CZ302353B6 (OSRAM)
DE (1) DE60107962T2 (OSRAM)
DK (1) DK1311284T3 (OSRAM)
EC (1) ECSP034485A (OSRAM)
ES (1) ES2234896T3 (OSRAM)
HU (1) HU229367B1 (OSRAM)
MX (1) MXPA03001604A (OSRAM)
MY (1) MY128992A (OSRAM)
NO (1) NO331326B1 (OSRAM)
PT (1) PT1311284E (OSRAM)
RU (1) RU2302880C2 (OSRAM)
SI (1) SI1311284T1 (OSRAM)
SK (1) SK287829B6 (OSRAM)
UA (1) UA77402C2 (OSRAM)
WO (1) WO2002015919A2 (OSRAM)
ZA (1) ZA200302296B (OSRAM)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4805461B2 (ja) * 1999-03-18 2011-11-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 血小板接着の阻止用タンパク質
MXPA05006043A (es) 2003-01-10 2006-01-30 Ablynx Nv Polipeptidos terapeuticos, homologos de los mismos, fragmentos de los mismos y para uso al modular la agregacion mediada de plaquetas.
US7691839B2 (en) 2005-09-28 2010-04-06 Biovascular, Inc. Methods and compositions for blocking platelet and cell adhesion, cell migration and inflammation
US20110034396A1 (en) * 2005-09-28 2011-02-10 Biovascular, Inc. Methods and compositions for inhibiting cell migration and treatment of inflammatory conditions
US20080069774A1 (en) * 2005-11-17 2008-03-20 Lance Liotta Proteomic antisense molecular shield and targeting
EP3846867B1 (en) * 2018-09-06 2025-02-19 Biomodics APS A medical tubular device
CN117229423B (zh) * 2023-11-10 2024-02-06 北京科技大学 一种用于结合胶原的多肽纳米材料及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879135A (en) * 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
WO1992007005A1 (en) * 1990-10-10 1992-04-30 Merck Patent Gmbh Platelet adhesion inhibitor
WO1998008552A1 (en) * 1995-08-22 1998-03-05 Medtronic, Inc. Method for making improved heparinized biomaterials
RU2128705C1 (ru) * 1991-09-05 1999-04-10 Шеринг Аг Протеин, ингибирующий вызываемую коллагеном агрегацию тромбоцитов млекопитающих, рекомбинантный протеин, ингибирующий вызываемую коллагеном агрегацию тромбоцитов, фрагмент днк, кодирующий рекомбинантный протеин, вектор экспрессии (варианты), штамм культивируемых животных клеток внк - продуцент рекомбинантного протеина (варианты), способ получения рекомбинантного протеина, фармацевтическая композиция

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US3947401A (en) * 1971-10-05 1976-03-30 Union Optics Corporation Hydrogels of unsaturated ester copolymers
US5705355A (en) 1984-03-27 1998-01-06 Transgene, S.A. Hirudin, pharmaceutical compositions comprising it and their use
US4898734A (en) * 1988-02-29 1990-02-06 Massachusetts Institute Of Technology Polymer composite for controlled release or membrane formation
IL86857A (en) * 1988-06-24 1994-04-12 Yissum Res Dev Co Platelet-aggregating inhibitory agents from leech saliva and pharmaceutical preparations containing the same
US5304121A (en) * 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
CA2052486A1 (en) * 1990-10-09 1992-04-10 Thomas M. Connolly Protein for inhibiting collagen-stimulated platelet aggregation
US5179082A (en) * 1990-11-13 1993-01-12 Merck & Co., Inc. Method for blocking platelet adhesion to collagen
DE4136513A1 (de) 1991-11-06 1993-05-13 Basf Ag Neues thrombininhibitorisches protein aus raubwanzen
JP3742429B2 (ja) 1993-07-01 2006-02-01 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング コラーゲン刺激血小板凝集の阻害剤
ES2255477T5 (es) * 1993-07-29 2010-04-08 The United States Of America, Represented By The Secretary, Department Of Health And Human Services Uso de paclitaxel y sus derivados en la fabricacion de un medicamento para el tratamiento de reestenosis.
US5532287A (en) * 1994-05-04 1996-07-02 Ciba-Geigy Corporation Radiation cured drug release controlling membrane
US6246715B1 (en) * 1998-06-26 2001-06-12 Samsung Electronics Co., Ltd. Data transmitter and receiver of a DS-CDMA communication system
US5843172A (en) * 1997-04-15 1998-12-01 Advanced Cardiovascular Systems, Inc. Porous medicated stent
WO2000023094A2 (en) * 1998-10-16 2000-04-27 Immunex Corporation Methods of inhibiting platelet activation and recruitment
IT1304135B1 (it) * 1998-11-26 2001-03-07 Magneti Marelli Spa Metodo di controllo dell' iniezione e dell' accensione in un motoreendotermico ad iniezione diretta per accelerare il riscaldamento del
JP2002537270A (ja) * 1999-02-19 2002-11-05 ザイモジェネティクス,インコーポレイティド 止血及び免疫機能における使用のためのインヒビター
JP4805461B2 (ja) 1999-03-18 2011-11-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 血小板接着の阻止用タンパク質

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4879135A (en) * 1984-07-23 1989-11-07 University Of Medicine And Dentistry Of New Jersey Drug bonded prosthesis and process for producing same
WO1992007005A1 (en) * 1990-10-10 1992-04-30 Merck Patent Gmbh Platelet adhesion inhibitor
RU2128705C1 (ru) * 1991-09-05 1999-04-10 Шеринг Аг Протеин, ингибирующий вызываемую коллагеном агрегацию тромбоцитов млекопитающих, рекомбинантный протеин, ингибирующий вызываемую коллагеном агрегацию тромбоцитов, фрагмент днк, кодирующий рекомбинантный протеин, вектор экспрессии (варианты), штамм культивируемых животных клеток внк - продуцент рекомбинантного протеина (варианты), способ получения рекомбинантного протеина, фармацевтическая композиция
WO1998008552A1 (en) * 1995-08-22 1998-03-05 Medtronic, Inc. Method for making improved heparinized biomaterials

Also Published As

Publication number Publication date
AR030492A1 (es) 2003-08-20
NO20030841L (no) 2003-02-24
HUP0303747A3 (en) 2006-01-30
HU229367B1 (en) 2013-11-28
UA77402C2 (en) 2006-12-15
CZ302353B6 (cs) 2011-03-30
ES2234896T3 (es) 2005-07-01
US20030190342A1 (en) 2003-10-09
CN1224421C (zh) 2005-10-26
CA2419385A1 (en) 2002-02-28
ATE285246T1 (de) 2005-01-15
WO2002015919A3 (en) 2002-05-30
US6881722B2 (en) 2005-04-19
HK1059736A1 (en) 2004-07-16
ZA200302296B (en) 2004-06-30
KR20030034141A (ko) 2003-05-01
ECSP034485A (es) 2003-03-31
AU9550601A (en) 2002-03-04
AU2001295506B2 (en) 2007-02-15
CN1449291A (zh) 2003-10-15
JP4988131B2 (ja) 2012-08-01
DE60107962T2 (de) 2005-12-15
MY128992A (en) 2007-03-30
MXPA03001604A (es) 2003-06-04
KR100794277B1 (ko) 2008-01-11
NO331326B1 (no) 2011-11-28
NO20030841D0 (no) 2003-02-24
HUP0303747A2 (hu) 2004-03-01
EP1311284A2 (en) 2003-05-21
EP1311284B1 (en) 2004-12-22
CA2419385C (en) 2011-05-10
PT1311284E (pt) 2005-05-31
BR0113478A (pt) 2003-07-15
DK1311284T3 (da) 2005-04-18
US20050143305A1 (en) 2005-06-30
WO2002015919A2 (en) 2002-02-28
CZ2003720A3 (cs) 2003-06-18
SK3132003A3 (en) 2003-08-05
SI1311284T1 (OSRAM) 2005-08-31
SK287829B6 (sk) 2011-11-04
PL359246A1 (en) 2004-08-23
US7459438B2 (en) 2008-12-02
DE60107962D1 (de) 2005-01-27
JP2004506690A (ja) 2004-03-04

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20150824