ZA200300868B - Particulate compositions of eletriptan showing a sigmoidal pattern of controlled release. - Google Patents
Particulate compositions of eletriptan showing a sigmoidal pattern of controlled release. Download PDFInfo
- Publication number
- ZA200300868B ZA200300868B ZA200300868A ZA200300868A ZA200300868B ZA 200300868 B ZA200300868 B ZA 200300868B ZA 200300868 A ZA200300868 A ZA 200300868A ZA 200300868 A ZA200300868 A ZA 200300868A ZA 200300868 B ZA200300868 B ZA 200300868B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- eletriptan
- pharmaceutically acceptable
- core
- drug
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 115
- 229960002472 eletriptan Drugs 0.000 title claims description 76
- OTLDLQZJRFYOJR-LJQANCHMSA-N eletriptan Chemical group CN1CCC[C@@H]1CC1=CN=C2[C]1C=C(CCS(=O)(=O)C=1C=CC=CC=1)C=C2 OTLDLQZJRFYOJR-LJQANCHMSA-N 0.000 title claims description 75
- 238000013270 controlled release Methods 0.000 title claims description 15
- 239000003814 drug Substances 0.000 claims description 91
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- 238000000576 coating method Methods 0.000 claims description 43
- 238000009472 formulation Methods 0.000 claims description 41
- 150000003839 salts Chemical class 0.000 claims description 40
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
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- TTWJBBZEZQICBI-UHFFFAOYSA-N metoclopramide Chemical compound CCN(CC)CCNC(=O)C1=CC(Cl)=C(N)C=C1OC TTWJBBZEZQICBI-UHFFFAOYSA-N 0.000 description 1
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- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
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- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
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- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
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- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Electroluminescent Light Sources (AREA)
- Luminescent Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0018968.8A GB0018968D0 (en) | 2000-08-02 | 2000-08-02 | Particulate composition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200300868B true ZA200300868B (en) | 2004-04-16 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200300868A ZA200300868B (en) | 2000-08-02 | 2003-01-31 | Particulate compositions of eletriptan showing a sigmoidal pattern of controlled release. |
Country Status (38)
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| US (1) | US20020034545A1 (cs) |
| EP (1) | EP1365748B1 (cs) |
| JP (1) | JP2004505034A (cs) |
| KR (1) | KR20030024820A (cs) |
| CN (1) | CN1630511A (cs) |
| AP (1) | AP2001002233A0 (cs) |
| AR (1) | AR030099A1 (cs) |
| AT (1) | ATE308978T1 (cs) |
| AU (1) | AU2001270932A1 (cs) |
| BG (1) | BG107361A (cs) |
| BR (1) | BR0112839A (cs) |
| CA (1) | CA2417887C (cs) |
| CZ (1) | CZ2003241A3 (cs) |
| DE (1) | DE60114887T2 (cs) |
| EA (1) | EA200300110A1 (cs) |
| EC (1) | ECSP034451A (cs) |
| EE (1) | EE200300051A (cs) |
| ES (1) | ES2250429T3 (cs) |
| GB (1) | GB0018968D0 (cs) |
| GT (1) | GT200100149A (cs) |
| HR (1) | HRP20030036A2 (cs) |
| HU (1) | HUP0301453A2 (cs) |
| IL (1) | IL153494A0 (cs) |
| IS (1) | IS6649A (cs) |
| MA (1) | MA26934A1 (cs) |
| MX (1) | MXPA03000999A (cs) |
| NO (1) | NO20030498L (cs) |
| NZ (1) | NZ522976A (cs) |
| OA (1) | OA12348A (cs) |
| PA (1) | PA8523101A1 (cs) |
| PE (1) | PE20020385A1 (cs) |
| PL (1) | PL359847A1 (cs) |
| SK (1) | SK1082003A3 (cs) |
| SV (1) | SV2002000574A (cs) |
| TN (1) | TNSN01115A1 (cs) |
| UY (1) | UY26861A1 (cs) |
| WO (1) | WO2002009675A1 (cs) |
| ZA (1) | ZA200300868B (cs) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040022853A1 (en) * | 2001-04-26 | 2004-02-05 | Control Delivery Systems, Inc. | Polymer-based, sustained release drug delivery system |
| EP1572107A1 (en) * | 2002-12-16 | 2005-09-14 | CHX Technologies Inc. | Temporary, pharmacologically-inactive dental coating for the "in situ" protection of dental therapeutic agents from saliva and abrasion from chewing |
| JP2006522790A (ja) * | 2003-04-11 | 2006-10-05 | ファイザー・インク | エレトリプタンと重炭酸ナトリウムを含む医薬組み合わせ物 |
| GB2407498B (en) * | 2003-10-30 | 2008-06-11 | Cipla Ltd | Oral formulations for 5-HT receptor agonists with reduced degradation of active ingredient |
| WO2005120456A2 (en) * | 2004-06-09 | 2005-12-22 | Pfizer Limited | Formulation of eletriptan |
| WO2006013431A1 (en) * | 2004-07-29 | 2006-02-09 | Pfizer Limited | Stable controlled-release pharmaceutical formulation of eletriptan |
| US20080107727A1 (en) * | 2005-01-31 | 2008-05-08 | Katashi Nakashima | Multiple Unit Oral Sustained Release Preparation and Production Method Thereof |
| DK1915137T3 (da) | 2005-08-10 | 2013-11-04 | Add Advanced Drug Delivery Technologies Ltd | Oralt præparat med kontrolleret frisætning |
| US20070134322A1 (en) * | 2005-12-14 | 2007-06-14 | Forest Laboratories, Inc. | Modified and pulsatile release pharmaceutical formulations of escitalopram |
| DE602007012236D1 (de) | 2006-04-26 | 2011-03-10 | Supernus Pharmaceuticals Inc | Oxcarbazepin-zubereitungen für kontrollierte freisetzung mit sigmoidalem freisetzungsprofil |
| US20080226715A1 (en) * | 2007-03-16 | 2008-09-18 | Albert Cha | Therapeutic compositions and methods |
| CA2694440A1 (en) | 2007-07-25 | 2009-01-29 | Biolex Therapeutics, Inc. | Controlled release interferon drug products and treatment of hcv infection using same |
| KR20120110098A (ko) | 2009-11-16 | 2012-10-09 | 에보니크 룀 게엠베하 | 고형 (메트)아크릴레이트 공중합체를 분산제에 의해 분산된 형태로 전환시키는 방법 |
| KR20170054446A (ko) * | 2014-09-09 | 2017-05-17 | 찰스톤 래보라토리즈, 인크. | 약학적 조성물 |
| GB201716716D0 (en) * | 2017-10-12 | 2017-11-29 | Univ Of Hertfordshire Higher Education Corporation | Method for coating particles |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2624732B1 (fr) * | 1987-12-21 | 1991-02-15 | Synthelabo | Formulation pharmaceutique a liberation prolongee |
| US5411745A (en) * | 1994-05-25 | 1995-05-02 | Euro-Celtique, S.A. | Powder-layered morphine sulfate formulations |
| GB9417310D0 (en) * | 1994-08-27 | 1994-10-19 | Pfizer Ltd | Therapeutic agents |
| GB9825988D0 (en) * | 1998-11-27 | 1999-01-20 | Pfizer Ltd | Indole derivatives |
| GB9922963D0 (en) * | 1999-09-28 | 1999-12-01 | Pfizer Ltd | Polymorphic salt |
| FR2795962B1 (fr) * | 1999-07-08 | 2003-05-09 | Prographarm Laboratoires | Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif |
| US20020044962A1 (en) * | 2000-06-06 | 2002-04-18 | Cherukuri S. Rao | Encapsulation products for controlled or extended release |
-
2000
- 2000-08-02 GB GBGB0018968.8A patent/GB0018968D0/en not_active Ceased
-
2001
- 2001-07-18 WO PCT/IB2001/001279 patent/WO2002009675A1/en active IP Right Grant
- 2001-07-18 EP EP01949819A patent/EP1365748B1/en not_active Expired - Lifetime
- 2001-07-18 DE DE60114887T patent/DE60114887T2/de not_active Expired - Lifetime
- 2001-07-18 CA CA002417887A patent/CA2417887C/en not_active Expired - Fee Related
- 2001-07-18 SK SK108-2003A patent/SK1082003A3/sk not_active Application Discontinuation
- 2001-07-18 EA EA200300110A patent/EA200300110A1/ru unknown
- 2001-07-18 HU HU0301453A patent/HUP0301453A2/hu unknown
- 2001-07-18 AT AT01949819T patent/ATE308978T1/de not_active IP Right Cessation
- 2001-07-18 CZ CZ2003241A patent/CZ2003241A3/cs unknown
- 2001-07-18 ES ES01949819T patent/ES2250429T3/es not_active Expired - Lifetime
- 2001-07-18 EE EEP200300051A patent/EE200300051A/xx unknown
- 2001-07-18 IL IL15349401A patent/IL153494A0/xx unknown
- 2001-07-18 KR KR10-2003-7001402A patent/KR20030024820A/ko not_active Application Discontinuation
- 2001-07-18 PL PL35984701A patent/PL359847A1/xx not_active Application Discontinuation
- 2001-07-18 BR BR0112839-6A patent/BR0112839A/pt not_active Application Discontinuation
- 2001-07-18 AU AU2001270932A patent/AU2001270932A1/en not_active Abandoned
- 2001-07-18 NZ NZ522976A patent/NZ522976A/en unknown
- 2001-07-18 JP JP2002515228A patent/JP2004505034A/ja active Pending
- 2001-07-18 AP APAP/P/2001/002233A patent/AP2001002233A0/en unknown
- 2001-07-18 CN CNA018134041A patent/CN1630511A/zh active Pending
- 2001-07-18 MX MXPA03000999A patent/MXPA03000999A/es active IP Right Grant
- 2001-07-18 OA OA1200300020A patent/OA12348A/en unknown
- 2001-07-25 PA PA20018523101A patent/PA8523101A1/es unknown
- 2001-07-25 GT GT200100149A patent/GT200100149A/es unknown
- 2001-07-25 US US09/912,774 patent/US20020034545A1/en not_active Abandoned
- 2001-07-30 UY UY26861A patent/UY26861A1/es not_active Application Discontinuation
- 2001-07-30 SV SV2001000574A patent/SV2002000574A/es not_active Application Discontinuation
- 2001-08-01 TN TNTNSN01115A patent/TNSN01115A1/fr unknown
- 2001-08-01 PE PE2001000770A patent/PE20020385A1/es not_active Application Discontinuation
- 2001-08-01 AR ARP010103668A patent/AR030099A1/es unknown
-
2002
- 2002-12-05 IS IS6649A patent/IS6649A/is unknown
- 2002-12-06 BG BG107361A patent/BG107361A/bg unknown
-
2003
- 2003-01-21 HR HR20030036A patent/HRP20030036A2/hr not_active Application Discontinuation
- 2003-01-23 MA MA27009A patent/MA26934A1/fr unknown
- 2003-01-24 EC EC2003004451A patent/ECSP034451A/es unknown
- 2003-01-31 ZA ZA200300868A patent/ZA200300868B/en unknown
- 2003-01-31 NO NO20030498A patent/NO20030498L/no unknown
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