ZA200300202B - 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-mehtyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. By cyclic acyl group. - Google Patents

9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-mehtyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. By cyclic acyl group.

Info

Publication number
ZA200300202B
ZA200300202B ZA200300202A ZA200300202A ZA200300202B ZA 200300202 B ZA200300202 B ZA 200300202B ZA 200300202 A ZA200300202 A ZA 200300202A ZA 200300202 A ZA200300202 A ZA 200300202A ZA 200300202 B ZA200300202 B ZA 200300202B
Authority
ZA
South Africa
Prior art keywords
alpha
mehtyl
androst
dienes
methoxycarbonyl
Prior art date
Application number
ZA200300202A
Other languages
English (en)
Inventor
Bernard Cuenoud
David Beattie
Keller Thomas Hugo
Pilgrim Gaynor Elizabeth
Sandham David Andrew
Watson Simon James
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA200300202B publication Critical patent/ZA200300202B/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
    • C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA200300202A 2000-06-28 2003-01-08 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-mehtyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. By cyclic acyl group. ZA200300202B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0015876.6A GB0015876D0 (en) 2000-06-28 2000-06-28 Organic compounds

Publications (1)

Publication Number Publication Date
ZA200300202B true ZA200300202B (en) 2003-12-31

Family

ID=9894607

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200300202A ZA200300202B (en) 2000-06-28 2003-01-08 9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-mehtyl-17-beta-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. By cyclic acyl group.

Country Status (30)

Country Link
US (1) US6921757B2 (de)
EP (1) EP1299409B1 (de)
JP (1) JP4065399B2 (de)
KR (1) KR100483865B1 (de)
CN (1) CN1214038C (de)
AR (1) AR030707A1 (de)
AT (1) ATE292639T1 (de)
AU (2) AU2001283891B2 (de)
BR (1) BR0112068A (de)
CA (1) CA2412541C (de)
CZ (1) CZ302513B6 (de)
DE (1) DE60109931T2 (de)
EC (1) ECSP014101A (de)
ES (1) ES2240499T3 (de)
GB (1) GB0015876D0 (de)
HK (1) HK1055974A1 (de)
HU (1) HUP0300783A3 (de)
IL (2) IL153703A0 (de)
MX (1) MXPA02012830A (de)
MY (1) MY129523A (de)
NO (1) NO324055B1 (de)
NZ (1) NZ523194A (de)
PE (1) PE20020179A1 (de)
PL (1) PL207722B1 (de)
PT (1) PT1299409E (de)
RU (1) RU2277100C2 (de)
SK (1) SK286690B6 (de)
TW (1) TWI232868B (de)
WO (1) WO2002000679A2 (de)
ZA (1) ZA200300202B (de)

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PL358428A1 (en) 2004-08-09
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HUP0300783A3 (en) 2010-01-28
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CN1439018A (zh) 2003-08-27
US6921757B2 (en) 2005-07-26
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