ZA200206500B - Radioactive therapeutic liposomes. - Google Patents
Radioactive therapeutic liposomes. Download PDFInfo
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- ZA200206500B ZA200206500B ZA200206500A ZA200206500A ZA200206500B ZA 200206500 B ZA200206500 B ZA 200206500B ZA 200206500 A ZA200206500 A ZA 200206500A ZA 200206500 A ZA200206500 A ZA 200206500A ZA 200206500 B ZA200206500 B ZA 200206500B
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- ZA
- South Africa
- Prior art keywords
- liposomes
- antibodies
- folate
- conjugator system
- receptor
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- BHYOQNUELFTYRT-DPAQBDIFSA-N cholesterol sulfate Chemical compound C1C=C2C[C@@H](OS(O)(=O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 BHYOQNUELFTYRT-DPAQBDIFSA-N 0.000 description 1
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- 230000001419 dependent effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
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- 230000002255 enzymatic effect Effects 0.000 description 1
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- 102000015694 estrogen receptors Human genes 0.000 description 1
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- 239000012458 free base Substances 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
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- 229910052732 germanium Inorganic materials 0.000 description 1
- GNPVGFCGXDBREM-UHFFFAOYSA-N germanium atom Chemical compound [Ge] GNPVGFCGXDBREM-UHFFFAOYSA-N 0.000 description 1
- 229930004094 glycosylphosphatidylinositol Natural products 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 229910052738 indium Inorganic materials 0.000 description 1
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- 238000007917 intracranial administration Methods 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
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- 229920000515 polycarbonate Polymers 0.000 description 1
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 238000011002 quantification Methods 0.000 description 1
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- 229910052702 rhenium Inorganic materials 0.000 description 1
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- 230000007017 scission Effects 0.000 description 1
- JZNWSCPGTDBMEW-YFKPBYRVSA-N sn-glycero-3-phosphoethanolamine Chemical compound NCCO[P@@](O)(=O)OC[C@@H](O)CO JZNWSCPGTDBMEW-YFKPBYRVSA-N 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 229910052712 strontium Inorganic materials 0.000 description 1
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- 230000002459 sustained effect Effects 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 229940056501 technetium 99m Drugs 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
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- 239000002691 unilamellar liposome Substances 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
- A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
- A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
- A61K51/1234—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Reproductive Health (AREA)
- Organic Chemistry (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO20000855A NO312708B1 (no) | 2000-02-21 | 2000-02-21 | Radioaktive liposomer til terapi |
Publications (1)
Publication Number | Publication Date |
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ZA200206500B true ZA200206500B (en) | 2003-08-14 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ZA200206500A ZA200206500B (en) | 2000-02-21 | 2002-08-14 | Radioactive therapeutic liposomes. |
Country Status (21)
Country | Link |
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US (1) | US6592843B2 (ru) |
EP (1) | EP1257299B9 (ru) |
JP (1) | JP4933712B2 (ru) |
KR (1) | KR100822566B1 (ru) |
CN (1) | CN100350981C (ru) |
AT (1) | ATE300316T1 (ru) |
AU (2) | AU2001237827B2 (ru) |
BR (1) | BR0108572A (ru) |
CA (1) | CA2400994C (ru) |
CZ (1) | CZ299032B6 (ru) |
DE (1) | DE60112251T2 (ru) |
DK (1) | DK1257299T3 (ru) |
EA (1) | EA005624B1 (ru) |
ES (1) | ES2247069T3 (ru) |
MX (1) | MXPA02008110A (ru) |
NO (1) | NO312708B1 (ru) |
NZ (1) | NZ520848A (ru) |
PL (1) | PL201398B1 (ru) |
UA (1) | UA73160C2 (ru) |
WO (1) | WO2001060417A2 (ru) |
ZA (1) | ZA200206500B (ru) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
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NO310544B1 (no) * | 1999-01-04 | 2001-07-23 | Algeta As | Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben |
NO314537B1 (no) * | 1999-12-06 | 2003-04-07 | Anticancer Therapeutic Inv Sa | Reseptorbindende konjugater |
US8029795B2 (en) * | 1999-12-30 | 2011-10-04 | Gwathmey, Inc. | Targeted iron chelator delivery system |
CA2411826A1 (en) * | 2000-06-16 | 2001-12-27 | Sloan-Kettering Institute For Cancer Research | Liposomal encapsulation of chelated actinium-225 and uses thereof |
US20040166060A1 (en) * | 2000-06-16 | 2004-08-26 | Sloan Kettering Institute For Cancer Research | Liposomal encapsulation of alpha particle emittors and uses thereof |
NO313180B1 (no) * | 2000-07-04 | 2002-08-26 | Anticancer Therapeutic Inv Sa | Bensökende alfapartikkel emitterende radiofarmasöytika |
US6869591B2 (en) * | 2002-03-26 | 2005-03-22 | Barnes-Jewish Hospital | Paramagnetic particles that provide improved relaxivity |
GB0213261D0 (en) * | 2002-06-10 | 2002-07-17 | Anticancer Therapeutic Inv Sa | Method |
GB0308731D0 (en) * | 2003-04-15 | 2003-05-21 | Anticancer Therapeutic Inv Sa | Method of radiotherapy |
AU2004229218B2 (en) * | 2003-04-15 | 2009-05-07 | Algeta As | Thorium-227 for use in radiotherapy of soft tissue disease |
CN102293746A (zh) * | 2003-09-09 | 2011-12-28 | 吉里德科学公司 | 治疗性脂质体 |
WO2005079867A2 (en) * | 2004-02-20 | 2005-09-01 | Algeta As | Alpha-emitting hydroxyapatite particles |
US20070053845A1 (en) * | 2004-03-02 | 2007-03-08 | Shiladitya Sengupta | Nanocell drug delivery system |
JP2007526322A (ja) * | 2004-03-02 | 2007-09-13 | マサチューセッツ インスティテュート オブ テクノロジー | ナノセル薬物送達系 |
GB0423565D0 (en) * | 2004-10-22 | 2004-11-24 | Algeta As | Formulation |
US20070065359A1 (en) * | 2005-03-14 | 2007-03-22 | Shiladitya Sengupta | Nanocells for diagnosis and treatment of diseases and disorders |
US8709380B1 (en) * | 2006-02-07 | 2014-04-29 | Sirius Medicine, Llc | Targeting agents for enhancing radiation therapy |
US20070224115A1 (en) * | 2006-03-22 | 2007-09-27 | The Regents Of The University Of California | Polymeric chelators for radionuclide delivery systems |
CN101485629B (zh) * | 2008-01-16 | 2013-01-23 | 沈阳药科大学 | 一种给药系统及其制备方法 |
US20100178245A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
US20100178244A1 (en) * | 2009-01-13 | 2010-07-15 | Arnsdorf Morton F | Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites |
WO2010135714A2 (en) | 2009-05-22 | 2010-11-25 | The Methodist Hospital Research Institute | Methods for modulating adipocyte expression using microrna compositions |
IN2012DN01449A (ru) * | 2009-07-17 | 2015-06-05 | Univ Denmark Tech Dtu | |
JP2011111438A (ja) * | 2009-11-30 | 2011-06-09 | Akita Univ | 有機金属錯体を有効成分として含有する抗がん剤 |
GB201002508D0 (en) | 2010-02-12 | 2010-03-31 | Algeta As | Product |
KR20140092226A (ko) | 2010-12-14 | 2014-07-23 | 테크니칼 유니버시티 오브 덴마크 | 나노입자 조성물에서 방사성 핵종의 포집 |
GB201105298D0 (en) * | 2011-03-29 | 2011-05-11 | Algeta Asa | Pharmaceutical preparation |
DE102011079031A1 (de) * | 2011-07-12 | 2013-01-17 | Algeta Asa | Flüssigkeitsbehälter |
GB201208309D0 (en) | 2012-05-11 | 2012-06-27 | Algeta As | Complexes |
WO2014164712A1 (en) | 2013-03-11 | 2014-10-09 | Wayne State University | Formation and uses of europium |
US9433690B1 (en) | 2015-02-26 | 2016-09-06 | Sciencons AS | Radiopharmaceutical solutions with advantageous properties |
NO3061464T3 (ru) * | 2015-02-26 | 2018-03-24 | ||
MX369632B (es) * | 2015-02-26 | 2019-11-14 | Sciencons AS | Soluciones radiofarmaceuticas con propiedades ventajosas. |
PT3111959T (pt) * | 2015-07-03 | 2017-12-14 | Oncoinvent As | Partículas e suspensões radioterapêuticas |
EP3432936A1 (en) | 2016-03-24 | 2019-01-30 | Bayer Pharma Aktiengesellschaft | Radio-pharmaceutical complexes |
CA3026900A1 (en) | 2016-06-10 | 2017-12-14 | Bayer Pharma Aktiengesellschaft | Radio-pharmaceutical complexes |
US11306038B2 (en) * | 2016-06-24 | 2022-04-19 | Sciencons AS | Preparation of 212Pb labeled monoclonal antibodies |
RU2763750C2 (ru) | 2017-05-11 | 2022-01-10 | Альфа Тау Медикал Лтд. | Полимерные покрытия для брахитерапевтических устройств |
JP2021519126A (ja) | 2018-04-02 | 2021-08-10 | アルファ タウ メディカル リミテッド | 放射性核種の管理された放出 |
TW202116733A (zh) | 2019-07-25 | 2021-05-01 | 挪威商拜耳公司 | 用於癌症診斷及治療之靶向放射性藥品 |
IL303002A (en) | 2020-12-16 | 2023-07-01 | Alpha Tau Medical Ltd | Radiotherapy by diffuse alpha emitters with increased beta therapy |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4310506A (en) * | 1979-02-22 | 1982-01-12 | California Institute Of Technology | Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species |
DK482685D0 (da) * | 1984-10-22 | 1985-10-21 | Hope Nat Medical Center | Fremgangsmaade til tilfoersel af micellulaere partikler, der indkapslerbilleddannende og kemoterapeutiske midler, til tumorer i et legeme |
WO1989004176A1 (en) * | 1987-11-04 | 1989-05-18 | Vestar, Inc. | Composition and method of use for liposome encapsulated compounds for neutron capture tumor therapy |
US5527528A (en) * | 1989-10-20 | 1996-06-18 | Sequus Pharmaceuticals, Inc. | Solid-tumor treatment method |
EP1138334A3 (en) * | 1992-06-09 | 2002-04-03 | Neorx Corporation | Pretargeting methods and compounds |
GB9420390D0 (en) * | 1994-10-10 | 1994-11-23 | Nycomed Salutar Inc | Liposomal agents |
ES2299256T3 (es) * | 1998-05-26 | 2008-05-16 | Sloan-Kettering Institute For Cancer Research | Constructos que emiten particulas alfa y sus usos. |
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2000
- 2000-02-21 NO NO20000855A patent/NO312708B1/no not_active IP Right Cessation
-
2001
- 2001-02-21 AU AU2001237827A patent/AU2001237827B2/en not_active Ceased
- 2001-02-21 CZ CZ20023164A patent/CZ299032B6/cs not_active IP Right Cessation
- 2001-02-21 CN CNB018053726A patent/CN100350981C/zh not_active Expired - Fee Related
- 2001-02-21 DE DE60112251T patent/DE60112251T2/de not_active Expired - Lifetime
- 2001-02-21 AT AT01910251T patent/ATE300316T1/de active
- 2001-02-21 JP JP2001559512A patent/JP4933712B2/ja not_active Expired - Fee Related
- 2001-02-21 UA UA2002086850A patent/UA73160C2/ru unknown
- 2001-02-21 KR KR1020027010848A patent/KR100822566B1/ko not_active IP Right Cessation
- 2001-02-21 EP EP01910251A patent/EP1257299B9/en not_active Expired - Lifetime
- 2001-02-21 CA CA002400994A patent/CA2400994C/en not_active Expired - Fee Related
- 2001-02-21 PL PL358541A patent/PL201398B1/pl unknown
- 2001-02-21 MX MXPA02008110A patent/MXPA02008110A/es active IP Right Grant
- 2001-02-21 NZ NZ520848A patent/NZ520848A/en not_active IP Right Cessation
- 2001-02-21 EA EA200200793A patent/EA005624B1/ru not_active IP Right Cessation
- 2001-02-21 WO PCT/NO2001/000065 patent/WO2001060417A2/en active IP Right Grant
- 2001-02-21 BR BR0108572-7A patent/BR0108572A/pt not_active IP Right Cessation
- 2001-02-21 ES ES01910251T patent/ES2247069T3/es not_active Expired - Lifetime
- 2001-02-21 US US09/790,260 patent/US6592843B2/en not_active Expired - Lifetime
- 2001-02-21 DK DK01910251T patent/DK1257299T3/da active
- 2001-02-21 AU AU3782701A patent/AU3782701A/xx active Pending
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2002
- 2002-08-14 ZA ZA200206500A patent/ZA200206500B/en unknown
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