ATE300316T1 - Radioaktive therapeutische liposomen - Google Patents

Radioaktive therapeutische liposomen

Info

Publication number
ATE300316T1
ATE300316T1 AT01910251T AT01910251T ATE300316T1 AT E300316 T1 ATE300316 T1 AT E300316T1 AT 01910251 T AT01910251 T AT 01910251T AT 01910251 T AT01910251 T AT 01910251T AT E300316 T1 ATE300316 T1 AT E300316T1
Authority
AT
Austria
Prior art keywords
liposomes
radioactive therapeutic
therapeutic liposomes
radioactive
ionophores
Prior art date
Application number
AT01910251T
Other languages
English (en)
Inventor
Roy H Larsen
Gjermund Henriksen
Original Assignee
Algeta As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Algeta As filed Critical Algeta As
Application granted granted Critical
Publication of ATE300316T1 publication Critical patent/ATE300316T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
    • A61K51/1072—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants the tumor cell being from the reproductive system, e.g. ovaria, uterus, testes or prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1217—Dispersions, suspensions, colloids, emulsions, e.g. perfluorinated emulsion, sols
    • A61K51/1234—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dispersion Chemistry (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AT01910251T 2000-02-21 2001-02-21 Radioaktive therapeutische liposomen ATE300316T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20000855A NO312708B1 (no) 2000-02-21 2000-02-21 Radioaktive liposomer til terapi
PCT/NO2001/000065 WO2001060417A2 (en) 2000-02-21 2001-02-21 Radioactive therapeutic liposomes

Publications (1)

Publication Number Publication Date
ATE300316T1 true ATE300316T1 (de) 2005-08-15

Family

ID=19910768

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01910251T ATE300316T1 (de) 2000-02-21 2001-02-21 Radioaktive therapeutische liposomen

Country Status (21)

Country Link
US (1) US6592843B2 (de)
EP (1) EP1257299B9 (de)
JP (1) JP4933712B2 (de)
KR (1) KR100822566B1 (de)
CN (1) CN100350981C (de)
AT (1) ATE300316T1 (de)
AU (2) AU3782701A (de)
BR (1) BR0108572A (de)
CA (1) CA2400994C (de)
CZ (1) CZ299032B6 (de)
DE (1) DE60112251T2 (de)
DK (1) DK1257299T3 (de)
EA (1) EA005624B1 (de)
ES (1) ES2247069T3 (de)
MX (1) MXPA02008110A (de)
NO (1) NO312708B1 (de)
NZ (1) NZ520848A (de)
PL (1) PL201398B1 (de)
UA (1) UA73160C2 (de)
WO (1) WO2001060417A2 (de)
ZA (1) ZA200206500B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
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NO310544B1 (no) * 1999-01-04 2001-07-23 Algeta As Opparbeidelse og anvendelse av radium-223 til fremstilling av preparat samt kit til behandling av kalsifisert vev for palliasjon, benkreft-terapi og/eller overflatebehandling av ben
NO314537B1 (no) * 1999-12-06 2003-04-07 Anticancer Therapeutic Inv Sa Reseptorbindende konjugater
US8029795B2 (en) * 1999-12-30 2011-10-04 Gwathmey, Inc. Targeted iron chelator delivery system
EP1289570B1 (de) * 2000-06-16 2008-09-10 Sloan-Kettering Institute For Cancer Research Liposomale einkapselung von alphastrahlern, und deren verwendung
US20040166060A1 (en) * 2000-06-16 2004-08-26 Sloan Kettering Institute For Cancer Research Liposomal encapsulation of alpha particle emittors and uses thereof
NO313180B1 (no) * 2000-07-04 2002-08-26 Anticancer Therapeutic Inv Sa Bensökende alfapartikkel emitterende radiofarmasöytika
US6869591B2 (en) * 2002-03-26 2005-03-22 Barnes-Jewish Hospital Paramagnetic particles that provide improved relaxivity
GB0213261D0 (en) * 2002-06-10 2002-07-17 Anticancer Therapeutic Inv Sa Method
GB0308731D0 (en) * 2003-04-15 2003-05-21 Anticancer Therapeutic Inv Sa Method of radiotherapy
NZ543044A (en) * 2003-04-15 2010-04-30 Algeta As Thorium-227 for use in radiotherapy of soft tissue disease
CN1849112B (zh) * 2003-09-09 2012-06-13 吉里德科学公司 治疗性脂质体
EA020542B1 (ru) * 2004-02-20 2014-12-30 Алгета Ас Альфа-излучающие частицы гидроксиапатита
US20070053845A1 (en) * 2004-03-02 2007-03-08 Shiladitya Sengupta Nanocell drug delivery system
CN101031287A (zh) * 2004-03-02 2007-09-05 麻省理工学院 纳米细胞药物递送系统
GB0423565D0 (en) * 2004-10-22 2004-11-24 Algeta As Formulation
WO2006099445A2 (en) * 2005-03-14 2006-09-21 Massachusetts Institute Of Technology Nanocells for diagnosis and treatment of diseases and disorders
US8709380B1 (en) * 2006-02-07 2014-04-29 Sirius Medicine, Llc Targeting agents for enhancing radiation therapy
US20070224115A1 (en) * 2006-03-22 2007-09-27 The Regents Of The University Of California Polymeric chelators for radionuclide delivery systems
CN101485629B (zh) * 2008-01-16 2013-01-23 沈阳药科大学 一种给药系统及其制备方法
US20100178245A1 (en) * 2009-01-13 2010-07-15 Arnsdorf Morton F Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites
US20100178244A1 (en) * 2009-01-13 2010-07-15 Arnsdorf Morton F Biocompatible Microbubbles to Deliver Radioactive Compounds to Tumors, Atherosclerotic Plaques, Joints and Other Targeted Sites
WO2010135714A2 (en) 2009-05-22 2010-11-25 The Methodist Hospital Research Institute Methods for modulating adipocyte expression using microrna compositions
EP2453927B1 (de) * 2009-07-17 2019-05-15 Technical University of Denmark Ladeverfahren für die zubereitung von radionuklid- und ioniophorhaltigen liposomen mit 2-hydroxychinolin (carbostyril) oder strukturverwandten 2-hydroxychinolinen als ionophor
JP2011111438A (ja) * 2009-11-30 2011-06-09 Akita Univ 有機金属錯体を有効成分として含有する抗がん剤
GB201002508D0 (en) 2010-02-12 2010-03-31 Algeta As Product
CA2821024A1 (en) 2010-12-14 2012-06-21 Technical University Of Denmark Entrapment of radionuclides in nanoparticle compositions
GB201105298D0 (en) * 2011-03-29 2011-05-11 Algeta Asa Pharmaceutical preparation
DE102011079031A1 (de) * 2011-07-12 2013-01-17 Algeta Asa Flüssigkeitsbehälter
GB201208309D0 (en) 2012-05-11 2012-06-27 Algeta As Complexes
EP2968150B1 (de) 2013-03-11 2020-08-19 Wayne State University Liposome enthaltend europium cryptanden und deren verwendung
US9433690B1 (en) 2015-02-26 2016-09-06 Sciencons AS Radiopharmaceutical solutions with advantageous properties
MX369632B (es) * 2015-02-26 2019-11-14 Sciencons AS Soluciones radiofarmaceuticas con propiedades ventajosas.
EP3061464B1 (de) * 2015-02-26 2017-10-25 Sciencons AS Radiopharmazeutische Lösungen mit vorteilhaften Eigenschaften
PL3111959T3 (pl) * 2015-07-03 2018-03-30 Oncoinvent As Radioterapeutyczne cząstki i zawiesiny
EP3432936A1 (de) 2016-03-24 2019-01-30 Bayer Pharma Aktiengesellschaft Radiopharmazeutische komplexe
AU2017277463A1 (en) 2016-06-10 2019-01-03 Bayer As Radio-pharmaceutical complexes
EP3474904A1 (de) * 2016-06-24 2019-05-01 Sciencons AS Herstellung von 212pb-markierten monoklonalen antikörpern
RU2763750C2 (ru) 2017-05-11 2022-01-10 Альфа Тау Медикал Лтд. Полимерные покрытия для брахитерапевтических устройств
WO2019193464A1 (en) 2018-04-02 2019-10-10 Alpha Tau Medical Ltd. Controlled release of radionuclides
AR119479A1 (es) 2019-07-25 2021-12-22 Bayer As Radiofármacos dirigidos para diagnóstico y tratamiento de cáncer
IL303002A (en) 2020-12-16 2023-07-01 Alpha Tau Medical Ltd Radiotherapy by diffuse alpha emitters with increased beta therapy

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
IE58659B1 (en) * 1984-10-22 1993-11-03 Vestar Inc Use of a micellular particle composition encapsulating a chemotherapeutic agent for intravenous targeting to tumors
CA1314209C (en) * 1987-11-04 1993-03-09 Gary Fujii Composition and method for use for liposome encapsulated compounds for neutron capture tumor therapy
US5527528A (en) * 1989-10-20 1996-06-18 Sequus Pharmaceuticals, Inc. Solid-tumor treatment method
ATE210464T1 (de) * 1992-06-09 2001-12-15 Neorx Corp BIOTIN-DOTA KONJUGATE UND DEREN VERWENDUNG IN ßPRETARGETINGß VERFAHREN
GB9420390D0 (en) * 1994-10-10 1994-11-23 Nycomed Salutar Inc Liposomal agents
CA2333125C (en) * 1998-05-26 2009-12-15 Sloan-Kettering Institute For Cancer Research Alpha emitting constructs and uses thereof

Also Published As

Publication number Publication date
JP4933712B2 (ja) 2012-05-16
CZ20023164A3 (cs) 2003-04-16
CN100350981C (zh) 2007-11-28
JP2003522808A (ja) 2003-07-29
PL358541A1 (en) 2004-08-09
WO2001060417A2 (en) 2001-08-23
DE60112251D1 (de) 2005-09-01
AU2001237827B2 (en) 2007-11-22
ES2247069T3 (es) 2006-03-01
KR20020092963A (ko) 2002-12-12
NO312708B1 (no) 2002-06-24
ZA200206500B (en) 2003-08-14
KR100822566B1 (ko) 2008-04-16
US20010048914A1 (en) 2001-12-06
DK1257299T3 (da) 2005-11-21
UA73160C2 (uk) 2005-06-15
NO20000855D0 (no) 2000-02-21
EA200200793A1 (ru) 2003-02-27
MXPA02008110A (es) 2003-12-11
EA005624B1 (ru) 2005-04-28
CN1404402A (zh) 2003-03-19
NO20000855L (no) 2001-08-22
BR0108572A (pt) 2002-11-19
CA2400994A1 (en) 2001-08-23
AU3782701A (en) 2001-08-27
CZ299032B6 (cs) 2008-04-09
PL201398B1 (pl) 2009-04-30
CA2400994C (en) 2009-07-07
NZ520848A (en) 2005-02-25
EP1257299B9 (de) 2005-11-30
EP1257299A2 (de) 2002-11-20
DE60112251T2 (de) 2006-03-30
US6592843B2 (en) 2003-07-15
WO2001060417A3 (en) 2002-02-07
EP1257299B1 (de) 2005-07-27
AU2001237827B8 (en) 2001-08-27

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