ZA200206484B - Improved paste formulations. - Google Patents
Improved paste formulations. Download PDFInfo
- Publication number
- ZA200206484B ZA200206484B ZA200206484A ZA200206484A ZA200206484B ZA 200206484 B ZA200206484 B ZA 200206484B ZA 200206484 A ZA200206484 A ZA 200206484A ZA 200206484 A ZA200206484 A ZA 200206484A ZA 200206484 B ZA200206484 B ZA 200206484B
- Authority
- ZA
- South Africa
- Prior art keywords
- formulation according
- paste formulation
- paste
- therapeutic agent
- host
- Prior art date
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- 239000000203 mixture Substances 0.000 title claims description 127
- 238000009472 formulation Methods 0.000 title claims description 101
- 150000001875 compounds Chemical class 0.000 claims description 74
- 239000003814 drug Substances 0.000 claims description 51
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 45
- 229940124597 therapeutic agent Drugs 0.000 claims description 42
- 239000004034 viscosity adjusting agent Substances 0.000 claims description 42
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 claims description 40
- 229910021485 fumed silica Inorganic materials 0.000 claims description 35
- -1 polyethvlene Polymers 0.000 claims description 33
- 238000000034 method Methods 0.000 claims description 31
- 239000002253 acid Substances 0.000 claims description 21
- 239000005660 Abamectin Substances 0.000 claims description 20
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical group O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 20
- 229940111134 coxibs Drugs 0.000 claims description 20
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims description 20
- 239000001087 glyceryl triacetate Substances 0.000 claims description 20
- 235000013773 glyceryl triacetate Nutrition 0.000 claims description 20
- 229960002622 triacetin Drugs 0.000 claims description 20
- 229920002556 Polyethylene Glycol 300 Polymers 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 16
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 15
- 239000003086 colorant Substances 0.000 claims description 15
- 239000002250 absorbent Substances 0.000 claims description 14
- 230000002745 absorbent Effects 0.000 claims description 14
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical group [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 claims description 13
- 239000001095 magnesium carbonate Substances 0.000 claims description 13
- 229910000021 magnesium carbonate Inorganic materials 0.000 claims description 13
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- RRZXIRBKKLTSOM-XPNPUAGNSA-N avermectin B1a Chemical group C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 RRZXIRBKKLTSOM-XPNPUAGNSA-N 0.000 claims description 10
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- 239000003755 preservative agent Substances 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 claims description 8
- 241000283690 Bos taurus Species 0.000 claims description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 8
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- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 claims description 7
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- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 claims description 6
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 6
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 6
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
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- 229960003276 erythromycin Drugs 0.000 claims description 5
- 150000008048 phenylpyrazoles Chemical class 0.000 claims description 5
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- 229940126409 proton pump inhibitor Drugs 0.000 claims description 5
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- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 claims description 4
- ZOCSXAVNDGMNBV-UHFFFAOYSA-N 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile Chemical compound NC1=C(S(=O)C(F)(F)F)C(C#N)=NN1C1=C(Cl)C=C(C(F)(F)F)C=C1Cl ZOCSXAVNDGMNBV-UHFFFAOYSA-N 0.000 claims description 4
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- OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 claims description 4
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- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 3
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 3
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-
2000
- 2000-02-16 US US09/504,741 patent/US6787342B2/en not_active Expired - Lifetime
-
2001
- 2001-02-05 BR BRPI0108449-6 patent/BRPI0108449B8/pt not_active IP Right Cessation
- 2001-02-05 EP EP06005716A patent/EP1688149B9/en not_active Expired - Lifetime
- 2001-02-05 PT PT06005716T patent/PT1688149E/pt unknown
- 2001-02-05 AU AU3373801A patent/AU3373801A/xx active Pending
- 2001-02-05 PL PL356429A patent/PL203304B1/pl not_active IP Right Cessation
- 2001-02-05 ES ES01905731T patent/ES2266157T3/es not_active Expired - Lifetime
- 2001-02-05 DE DE60120122T patent/DE60120122T2/de not_active Expired - Lifetime
- 2001-02-05 AT AT01905731T patent/ATE327769T1/de active
- 2001-02-05 AT AT06005716T patent/ATE430583T1/de active
- 2001-02-05 ES ES06005716T patent/ES2326426T3/es not_active Expired - Lifetime
- 2001-02-05 DK DK06005716T patent/DK1688149T3/da active
- 2001-02-05 JP JP2001559505A patent/JP2003522805A/ja active Pending
- 2001-02-05 AU AU2001233738A patent/AU2001233738B2/en not_active Expired
- 2001-02-05 CA CA002400317A patent/CA2400317C/en not_active Expired - Lifetime
- 2001-02-05 WO PCT/EP2001/001155 patent/WO2001060409A1/en active IP Right Grant
- 2001-02-05 NZ NZ520707A patent/NZ520707A/en not_active IP Right Cessation
- 2001-02-05 DE DE60138660T patent/DE60138660D1/de not_active Expired - Lifetime
- 2001-02-05 PT PT01905731T patent/PT1263467E/pt unknown
- 2001-02-05 RU RU2002124584/15A patent/RU2304962C2/ru active
- 2001-02-05 EP EP01905731A patent/EP1263467B1/en not_active Expired - Lifetime
- 2001-02-05 DK DK01905731T patent/DK1263467T3/da active
- 2001-02-05 CZ CZ2002-2772A patent/CZ304469B6/cs not_active IP Right Cessation
- 2001-02-05 NZ NZ532434A patent/NZ532434A/en not_active IP Right Cessation
- 2001-02-14 AR ARP010100646A patent/AR029655A1/es not_active Application Discontinuation
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2002
- 2002-08-14 ZA ZA200206484A patent/ZA200206484B/en unknown
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2006
- 2006-06-26 CY CY20061100864T patent/CY1105626T1/el unknown
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2007
- 2007-05-29 RU RU2007120070/15A patent/RU2452468C2/ru active
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2009
- 2009-07-23 CY CY20091100792T patent/CY1109286T1/el unknown
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