ZA200200425B - Opthalmic composition. - Google Patents
Opthalmic composition. Download PDFInfo
- Publication number
- ZA200200425B ZA200200425B ZA200200425A ZA200200425A ZA200200425B ZA 200200425 B ZA200200425 B ZA 200200425B ZA 200200425 A ZA200200425 A ZA 200200425A ZA 200200425 A ZA200200425 A ZA 200200425A ZA 200200425 B ZA200200425 B ZA 200200425B
- Authority
- ZA
- South Africa
- Prior art keywords
- composition
- glycerol
- ketotifen
- concentration
- water
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims description 35
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 36
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 24
- 229960003630 ketotifen fumarate Drugs 0.000 claims description 13
- YNQQEYBLVYAWNX-WLHGVMLRSA-N ketotifen fumarate Chemical group OC(=O)\C=C\C(O)=O.C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 YNQQEYBLVYAWNX-WLHGVMLRSA-N 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 239000003755 preservative agent Substances 0.000 claims description 8
- 230000002335 preservative effect Effects 0.000 claims description 8
- ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical class C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 claims description 7
- 229960000686 benzalkonium chloride Drugs 0.000 claims description 7
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical group [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 claims description 7
- 239000012929 tonicity agent Substances 0.000 claims description 5
- 239000008215 water for injection Substances 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims description 3
- 239000002585 base Substances 0.000 claims description 3
- 239000013543 active substance Substances 0.000 description 3
- 206010010744 Conjunctivitis allergic Diseases 0.000 description 2
- 239000004480 active ingredient Substances 0.000 description 2
- 208000002205 allergic conjunctivitis Diseases 0.000 description 2
- 208000024998 atopic conjunctivitis Diseases 0.000 description 2
- 239000006196 drop Substances 0.000 description 2
- 239000003889 eye drop Substances 0.000 description 2
- 229940012356 eye drops Drugs 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000010894 electron beam technology Methods 0.000 description 1
- 229940117927 ethylene oxide Drugs 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 229960004958 ketotifen Drugs 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001932 seasonal effect Effects 0.000 description 1
- 229940037001 sodium edetate Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99114508 | 1999-07-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200200425B true ZA200200425B (en) | 2002-10-30 |
Family
ID=8238654
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200200425A ZA200200425B (en) | 1999-07-23 | 2002-01-17 | Opthalmic composition. |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US6777429B1 (cs) |
| EP (1) | EP1198223A2 (cs) |
| JP (1) | JP2003505419A (cs) |
| KR (1) | KR20020012261A (cs) |
| CN (1) | CN1358086A (cs) |
| BR (2) | BRPI0017528B8 (cs) |
| CA (1) | CA2377024A1 (cs) |
| CZ (1) | CZ300614B6 (cs) |
| EE (1) | EE05439B1 (cs) |
| HK (1) | HK1046631A1 (cs) |
| HU (1) | HU230738B1 (cs) |
| IL (1) | IL146973A0 (cs) |
| MX (1) | MXPA02000849A (cs) |
| NO (1) | NO331228B1 (cs) |
| NZ (1) | NZ516108A (cs) |
| PL (1) | PL202496B1 (cs) |
| RU (1) | RU2248789C2 (cs) |
| UA (1) | UA74788C2 (cs) |
| WO (1) | WO2001007049A2 (cs) |
| ZA (1) | ZA200200425B (cs) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR034372A1 (es) * | 2001-06-08 | 2004-02-18 | Novartis Ag | Composiciones farmaceuticas |
| AU2002345015A1 (en) * | 2001-06-08 | 2002-12-23 | Novartis Pharma Gmbh | Ophthalmic once-a-day composition |
| AR034371A1 (es) * | 2001-06-08 | 2004-02-18 | Novartis Ag | Composiciones farmaceuticas |
| WO2004064817A1 (ja) * | 2003-01-22 | 2004-08-05 | Nichiban Co., Ltd. | 眼疾患治療用経皮吸収型製剤、その使用、及び眼疾患治療薬の眼の局所組織への移行方法 |
| US20060089384A1 (en) * | 2004-10-25 | 2006-04-27 | Minno George E | Ophthalmic compositions and methods of using the same |
| CN101087607B (zh) * | 2004-10-25 | 2010-07-28 | 博士伦公司 | 眼用组合物及使用其的方法 |
| US20070208058A1 (en) * | 2004-10-25 | 2007-09-06 | Bryant Roy W | Stable Pharmaceutical Compositions and Methods of Making and Using Same |
| US20070048389A1 (en) * | 2005-08-26 | 2007-03-01 | Fu-Pao Tsao | Stabilized and preserved ketotifen ophthalmic compositions |
| US20070077302A1 (en) * | 2005-09-30 | 2007-04-05 | Azaam Alli | Methods for stabilizing ophthalmic compositions |
| EP3753548A1 (en) | 2006-06-16 | 2020-12-23 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| US8445437B2 (en) * | 2006-07-27 | 2013-05-21 | The Brigham And Women's Hospital, Inc. | Treatment and prevention of cardiovascular disease using mast cell stabilizers |
| CN101541303A (zh) | 2006-09-29 | 2009-09-23 | 庄臣及庄臣视力保护公司 | 用于治疗眼变态反应性的方法和眼科装置 |
| US20100166804A1 (en) * | 2007-05-23 | 2010-07-01 | Dennis Penn | Methods |
| CN101808642B (zh) * | 2007-09-28 | 2012-05-02 | 布里格海姆妇女医院公司 | 肥大细胞稳定剂治疗肥胖症 |
| WO2009142772A2 (en) | 2008-05-23 | 2009-11-26 | Mastcell Pharmaceuticals, Inc. | Methods and treatment for allergies and inflammation associated with gastrointestinal diseases |
| EP2408302A4 (en) * | 2009-03-17 | 2012-08-15 | Aciex Therapeutics Inc | OPHTALMIC FORMULATIONS OF KTOTICENE AND METHODS OF USE |
| RU2549472C1 (ru) * | 2013-12-26 | 2015-04-27 | Илья Александрович Марков | Фармацевтическая композиция в форме капель для профилактики и лечения аллергических заболеваний глаз |
| CN114712497B (zh) | 2015-12-03 | 2024-03-22 | 雷杰纳荣制药公司 | 抗vegf剂在制备用于治疗新生血管性年龄相关性黄斑变性患者的药物中的用途 |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| CN111450051B (zh) * | 2020-04-21 | 2022-03-18 | 武汉贝参药业股份有限公司 | 一种富马酸酮替芬口服溶液的制备方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62277323A (ja) | 1986-02-19 | 1987-12-02 | Sankyo Co Ltd | フマル酸ケトチフエン含有点眼液の製法 |
| RU2003350C1 (ru) * | 1991-03-01 | 1993-11-30 | Институт иммунологии | Способ лечени глюкокортикостероидзависимых атопических заболеваний |
| RU2007117C1 (ru) * | 1992-03-20 | 1994-02-15 | Юлия Михайловна Залесская | Способ индивидуального подбора веществ для коррекции нарушений в организме |
| DE69327878T2 (de) * | 1993-04-16 | 2000-06-15 | Wakamoto Pharmaceutical Co., Ltd. | Unter wärmeeinwirkung reversibel gelierende medizinische zusammensetzung auf wasserbasis |
| JPH07324034A (ja) * | 1994-05-30 | 1995-12-12 | Toa Yakuhin Kk | フマル酸ケトチフェン含有の点眼剤 |
| JPH11189533A (ja) * | 1997-12-25 | 1999-07-13 | Taisho Pharmaceut Co Ltd | 点眼薬 |
| EP0938896A1 (en) | 1998-01-15 | 1999-09-01 | Novartis AG | Autoclavable pharmaceutical compositions containing a chelating agent |
-
2000
- 2000-07-19 US US09/619,349 patent/US6777429B1/en not_active Expired - Lifetime
- 2000-07-21 CZ CZ20020243A patent/CZ300614B6/cs not_active IP Right Cessation
- 2000-07-21 CN CN00809538A patent/CN1358086A/zh active Pending
- 2000-07-21 CA CA002377024A patent/CA2377024A1/en not_active Abandoned
- 2000-07-21 BR BRPI0017528A patent/BRPI0017528B8/pt not_active IP Right Cessation
- 2000-07-21 EE EEP200200040A patent/EE05439B1/xx unknown
- 2000-07-21 HK HK02107011.8A patent/HK1046631A1/zh unknown
- 2000-07-21 UA UA2002010531A patent/UA74788C2/uk unknown
- 2000-07-21 RU RU2002103315/15A patent/RU2248789C2/ru active
- 2000-07-21 IL IL14697300A patent/IL146973A0/xx unknown
- 2000-07-21 EP EP00953080A patent/EP1198223A2/en not_active Withdrawn
- 2000-07-21 PL PL352382A patent/PL202496B1/pl unknown
- 2000-07-21 WO PCT/EP2000/007030 patent/WO2001007049A2/en not_active Ceased
- 2000-07-21 NZ NZ516108A patent/NZ516108A/en not_active IP Right Cessation
- 2000-07-21 MX MXPA02000849A patent/MXPA02000849A/es active IP Right Grant
- 2000-07-21 JP JP2001511933A patent/JP2003505419A/ja active Pending
- 2000-07-21 KR KR1020017015745A patent/KR20020012261A/ko not_active Ceased
- 2000-07-21 BR BR0012696-9A patent/BR0012696A/pt not_active Application Discontinuation
- 2000-07-21 HU HU0202243A patent/HU230738B1/hu unknown
-
2002
- 2002-01-17 ZA ZA200200425A patent/ZA200200425B/en unknown
- 2002-01-21 NO NO20020319A patent/NO331228B1/no not_active IP Right Cessation
- 2002-04-29 US US10/134,795 patent/US6774137B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2377024A1 (en) | 2001-02-01 |
| EE200200040A (et) | 2003-04-15 |
| BRPI0017528A2 (pt) | 2010-01-19 |
| HUP0202243A3 (en) | 2006-03-28 |
| UA74788C2 (en) | 2006-02-15 |
| BR0012696A (pt) | 2002-04-09 |
| JP2003505419A (ja) | 2003-02-12 |
| BRPI0017528B8 (pt) | 2021-05-25 |
| IL146973A0 (en) | 2002-08-14 |
| CZ300614B6 (cs) | 2009-07-01 |
| HK1046631A1 (zh) | 2003-01-24 |
| KR20020012261A (ko) | 2002-02-15 |
| EP1198223A2 (en) | 2002-04-24 |
| CN1358086A (zh) | 2002-07-10 |
| US6774137B2 (en) | 2004-08-10 |
| HU230738B1 (hu) | 2018-01-29 |
| NO331228B1 (no) | 2011-11-07 |
| MXPA02000849A (es) | 2002-07-30 |
| PL202496B1 (pl) | 2009-06-30 |
| NO20020319L (no) | 2002-01-21 |
| WO2001007049A3 (en) | 2001-03-29 |
| RU2248789C2 (ru) | 2005-03-27 |
| CZ2002243A3 (cs) | 2002-04-17 |
| HUP0202243A2 (hu) | 2002-12-28 |
| PL352382A1 (en) | 2003-08-25 |
| US20020183359A1 (en) | 2002-12-05 |
| NZ516108A (en) | 2004-04-30 |
| WO2001007049A2 (en) | 2001-02-01 |
| US6777429B1 (en) | 2004-08-17 |
| EE05439B1 (et) | 2011-08-15 |
| BRPI0017528B1 (pt) | 2017-06-13 |
| NO20020319D0 (no) | 2002-01-21 |
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