ZA200109227B - Expression and export of Interferon-alpha proteins as Fc fusion proteins. - Google Patents
Expression and export of Interferon-alpha proteins as Fc fusion proteins. Download PDFInfo
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- ZA200109227B ZA200109227B ZA200109227A ZA200109227A ZA200109227B ZA 200109227 B ZA200109227 B ZA 200109227B ZA 200109227 A ZA200109227 A ZA 200109227A ZA 200109227 A ZA200109227 A ZA 200109227A ZA 200109227 B ZA200109227 B ZA 200109227B
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/56—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13489599P | 1999-05-19 | 1999-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200109227B true ZA200109227B (en) | 2003-02-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200109227A ZA200109227B (en) | 1999-05-19 | 2001-11-08 | Expression and export of Interferon-alpha proteins as Fc fusion proteins. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20020081664A1 (ja) |
| EP (1) | EP1187852B1 (ja) |
| JP (1) | JP2003530070A (ja) |
| KR (1) | KR20020018197A (ja) |
| CN (1) | CN1361793A (ja) |
| AT (1) | ATE369384T1 (ja) |
| AU (1) | AU777963B2 (ja) |
| BR (1) | BR0010725A (ja) |
| CA (1) | CA2372400C (ja) |
| CZ (1) | CZ20014123A3 (ja) |
| DE (1) | DE60035871T2 (ja) |
| DK (1) | DK1187852T3 (ja) |
| ES (1) | ES2291205T3 (ja) |
| HK (1) | HK1046694A1 (ja) |
| HU (1) | HUP0201474A3 (ja) |
| MX (1) | MXPA01011845A (ja) |
| NO (1) | NO20015587L (ja) |
| PL (1) | PL352332A1 (ja) |
| PT (1) | PT1187852E (ja) |
| RU (1) | RU2262510C9 (ja) |
| WO (1) | WO2000069913A1 (ja) |
| ZA (1) | ZA200109227B (ja) |
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|---|---|---|---|---|
| DE69824039T2 (de) * | 1997-12-08 | 2005-08-18 | Lexigen Pharmaceuticals Corp., Lexington | Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung |
| US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
| WO1999052562A2 (en) * | 1998-04-15 | 1999-10-21 | Lexigen Pharmaceuticals Corp. | Enhancement of antibody-cytokine fusion protein mediated immune responses by co-administration with angiogenesis inhibitor |
| JP2003530070A (ja) * | 1999-05-19 | 2003-10-14 | レキシジェン ファーマシューティカルズ コーポレイション | Ｆｃ融合タンパク質としてのインターフェロン−αタンパク質の発現および搬出 |
| SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
| US6617135B1 (en) * | 1999-08-09 | 2003-09-09 | Emd Lexigen Research Center Corp. | Multiple cytokine protein complexes |
| US20050202538A1 (en) * | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
| WO2001058957A2 (en) * | 2000-02-11 | 2001-08-16 | Lexigen Pharmaceuticals Corp. | Enhancing the circulating half-life of antibody-based fusion proteins |
| CA2405557C (en) | 2000-04-12 | 2013-09-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| MXPA02012734A (es) * | 2000-06-29 | 2003-04-25 | Merck Patent Gmbh | Mejoramiento de las respuestas inmunes mediadas por la proteina de fusion anticuerpo-citocina, mediante tratamiento combinado con agentes mejoradores de la captacion de inmunocitocina. |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| MXPA03008031A (es) * | 2001-03-07 | 2003-12-04 | Merck Patent Gmbh | Tecnologia de expresion para proteinas que contienen porcion de anticuerpo isotipo hibrida. |
| US6992174B2 (en) | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
| US20030065148A1 (en) * | 2001-05-02 | 2003-04-03 | Villarete Lorelie H. | Method for expression of human interferon alpha 1 in Pichia pastoris |
| CN100503639C (zh) * | 2001-05-03 | 2009-06-24 | 默克专利有限公司 | 重组肿瘤特异性抗体及其应用 |
| WO2003048334A2 (en) * | 2001-12-04 | 2003-06-12 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
| EP2261250B1 (en) | 2001-12-21 | 2015-07-01 | Human Genome Sciences, Inc. | GCSF-Albumin fusion proteins |
| NZ540043A (en) * | 2002-11-18 | 2007-11-30 | Maxygen Inc | Isolated or recombinant Interferon-alpha polypeptides and conjugates |
| US7314613B2 (en) | 2002-11-18 | 2008-01-01 | Maxygen, Inc. | Interferon-alpha polypeptides and conjugates |
| ATE471946T1 (de) * | 2002-12-17 | 2010-07-15 | Merck Patent Gmbh | Humanisierter antikörper (h14.18) des maus antikörpers 14.18, der gd2 bindet und seine fusion mit il-2 |
| WO2004074486A2 (en) * | 2003-02-18 | 2004-09-02 | Merck Patent Gmbh | Fusion proteins of interferon alpha muteins with improved properties |
| US20040180054A1 (en) * | 2003-03-13 | 2004-09-16 | Hanmi Pharm. Co., Ltd. | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
| US20050176108A1 (en) * | 2003-03-13 | 2005-08-11 | Young-Min Kim | Physiologically active polypeptide conjugate having prolonged in vivo half-life |
| CA2522690A1 (en) * | 2003-05-06 | 2004-11-25 | Syntonix Pharmaceuticals, Inc. | Inhibition of drug binding to serum albumin |
| ATE497783T1 (de) | 2003-05-06 | 2011-02-15 | Syntonix Pharmaceuticals Inc | Gerinnungsfaktor vii-fc chimäre proteine zur behandlung von hämostatischen krankheiten |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| US7348004B2 (en) * | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| US20050069521A1 (en) * | 2003-08-28 | 2005-03-31 | Emd Lexigen Research Center Corp. | Enhancing the circulating half-life of interleukin-2 proteins |
| US8383132B2 (en) * | 2003-10-16 | 2013-02-26 | The Regents Of The University Of California | Immunostimulatory recombinant intracellular pathogen immunogenic compositions and methods of use |
| WO2005047327A2 (en) | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | NEONATAL Fc RECEPTOR (FcRn)-BINDING POLYPEPTIDE VARIANTS, DIMERIC Fc BINDING PROTEINS AND METHODS RELATED THERETO |
| JP4870569B2 (ja) | 2003-11-13 | 2012-02-08 | ハンミ ホールディングス カンパニー リミテッド | 免疫グロブリン断片を用いた蛋白質結合体およびその製造方法 |
| US8110665B2 (en) | 2003-11-13 | 2012-02-07 | Hanmi Holdings Co., Ltd. | Pharmaceutical composition comprising an immunoglobulin FC region as a carrier |
| JP2008502317A (ja) | 2003-12-30 | 2008-01-31 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | Ｉｌ−７融合タンパク質 |
| WO2005063808A1 (en) * | 2003-12-31 | 2005-07-14 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
| AU2005203962C1 (en) | 2004-01-05 | 2012-11-08 | Antisoma Research Limited | Interleukin-12 targeted to oncofoetal fibronectin |
| AU2005206277B2 (en) * | 2004-01-22 | 2011-06-23 | Merck Patent Gmbh | Anti-cancer antibodies with reduced complement fixation |
| JP4896745B2 (ja) | 2004-02-02 | 2012-03-14 | アンブレツクス・インコーポレイテツド | 修飾されたヒトインターフェロンポリペプチドおよびこれらの使用 |
| AU2008201682B2 (en) * | 2004-02-02 | 2011-02-24 | Ambrx, Inc. | Modified human interferon polypeptides and their uses |
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- 2000-05-19 CN CN00810671A patent/CN1361793A/zh active Pending
- 2000-05-19 KR KR1020017014691A patent/KR20020018197A/ko not_active Application Discontinuation
- 2000-05-19 PT PT00932622T patent/PT1187852E/pt unknown
- 2000-05-19 WO PCT/US2000/013827 patent/WO2000069913A1/en active IP Right Grant
- 2000-05-19 CZ CZ20014123A patent/CZ20014123A3/cs unknown
- 2000-05-19 EP EP00932622A patent/EP1187852B1/en not_active Expired - Lifetime
- 2000-05-19 AU AU50318/00A patent/AU777963B2/en not_active Expired
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- 2000-05-19 BR BR0010725-5A patent/BR0010725A/pt not_active IP Right Cessation
- 2000-05-19 CA CA2372400A patent/CA2372400C/en not_active Expired - Lifetime
- 2000-05-19 DK DK00932622T patent/DK1187852T3/da active
- 2000-05-19 ES ES00932622T patent/ES2291205T3/es not_active Expired - Lifetime
- 2000-05-19 RU RU2001130984/13A patent/RU2262510C9/ru not_active IP Right Cessation
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- 2001-11-08 ZA ZA200109227A patent/ZA200109227B/en unknown
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2002
- 2002-11-14 HK HK02108255.1A patent/HK1046694A1/zh unknown
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| DK1187852T3 (da) | 2007-11-26 |
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| ATE369384T1 (de) | 2007-08-15 |
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| WO2000069913A1 (en) | 2000-11-23 |
| MXPA01011845A (es) | 2002-06-21 |
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| BR0010725A (pt) | 2002-02-19 |
| JP2003530070A (ja) | 2003-10-14 |
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| DE60035871D1 (de) | 2007-09-20 |
| KR20020018197A (ko) | 2002-03-07 |
| NO20015587D0 (no) | 2001-11-15 |
| EP1187852A1 (en) | 2002-03-20 |
| CA2372400A1 (en) | 2000-11-23 |
| HK1046694A1 (zh) | 2003-01-24 |
| RU2262510C2 (ru) | 2005-10-20 |
| PT1187852E (pt) | 2007-11-14 |
| AU5031800A (en) | 2000-12-05 |
| HUP0201474A3 (en) | 2002-11-28 |
| ES2291205T3 (es) | 2008-03-01 |
| RU2262510C9 (ru) | 2006-04-20 |
| EP1187852B1 (en) | 2007-08-08 |
| CA2372400C (en) | 2010-04-27 |
| CZ20014123A3 (cs) | 2002-06-12 |
| DE60035871T2 (de) | 2008-06-05 |
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