ZA200104864B - Phenylphenanthridines with PDE-IV inhibiting activity. - Google Patents
Phenylphenanthridines with PDE-IV inhibiting activity. Download PDFInfo
- Publication number
- ZA200104864B ZA200104864B ZA200104864A ZA200104864A ZA200104864B ZA 200104864 B ZA200104864 B ZA 200104864B ZA 200104864 A ZA200104864 A ZA 200104864A ZA 200104864 A ZA200104864 A ZA 200104864A ZA 200104864 B ZA200104864 B ZA 200104864B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- phenyl
- aryl
- Prior art date
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- 230000002401 inhibitory effect Effects 0.000 title description 3
- SKHUPKIELOSDON-UHFFFAOYSA-N 1-phenylphenanthridine Chemical class C1=CC=CC=C1C1=CC=CC2=NC=C(C=CC=C3)C3=C12 SKHUPKIELOSDON-UHFFFAOYSA-N 0.000 title 1
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- 230000003287 optical effect Effects 0.000 claims description 100
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 84
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 41
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- BIVMWDQSMDXTCT-RYUDHWBXSA-N (1s,2s)-2-(3,4-dimethoxyphenyl)cyclohexan-1-amine Chemical compound C1=C(OC)C(OC)=CC=C1[C@H]1[C@@H](N)CCCC1 BIVMWDQSMDXTCT-RYUDHWBXSA-N 0.000 claims description 6
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- Epidemiology (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100694 | 1999-01-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200104864B true ZA200104864B (en) | 2003-04-15 |
Family
ID=8237351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200104864A ZA200104864B (en) | 1999-01-15 | 2001-06-14 | Phenylphenanthridines with PDE-IV inhibiting activity. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US6476025B1 (xx) |
| EP (2) | EP1650193A3 (xx) |
| JP (1) | JP4653314B2 (xx) |
| KR (1) | KR100720906B1 (xx) |
| CN (1) | CN1152864C (xx) |
| AT (1) | ATE312081T1 (xx) |
| AU (1) | AU774868B2 (xx) |
| BG (1) | BG65126B1 (xx) |
| BR (1) | BR0007527B1 (xx) |
| CA (1) | CA2359440C (xx) |
| CY (1) | CY1106436T1 (xx) |
| CZ (1) | CZ300366B6 (xx) |
| DE (1) | DE60024581T2 (xx) |
| DK (1) | DK1147089T3 (xx) |
| EA (1) | EA003780B1 (xx) |
| EE (1) | EE05105B1 (xx) |
| ES (1) | ES2254132T3 (xx) |
| HK (1) | HK1040997B (xx) |
| HR (1) | HRP20010578A2 (xx) |
| HU (1) | HU227624B1 (xx) |
| ID (1) | ID29070A (xx) |
| IL (2) | IL144026A0 (xx) |
| NO (1) | NO320182B1 (xx) |
| NZ (1) | NZ512872A (xx) |
| PL (1) | PL205670B1 (xx) |
| RS (1) | RS50297B (xx) |
| SI (1) | SI1147089T1 (xx) |
| SK (1) | SK286946B6 (xx) |
| TR (2) | TR200501553T2 (xx) |
| UA (1) | UA69436C2 (xx) |
| WO (1) | WO2000042020A1 (xx) |
| ZA (1) | ZA200104864B (xx) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002006238A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines |
| CA2495597A1 (en) * | 2002-08-17 | 2004-03-04 | Altana Pharma Ag | Novel phenanthridines |
| WO2004019945A1 (en) | 2002-08-29 | 2004-03-11 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| WO2004019944A1 (en) | 2002-08-29 | 2004-03-11 | Altana Pharma Ag | 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| US6894061B2 (en) | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
| CA2533636A1 (en) * | 2003-07-31 | 2005-02-10 | Altana Pharma Ag | Novel 6-phenylphenanthridines |
| EP1658270A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenantridines |
| JP2007504201A (ja) * | 2003-09-05 | 2007-03-01 | アルタナ ファルマ アクチエンゲゼルシャフト | 真性糖尿病の治療のためのｐｄｅ４阻害剤の使用 |
| WO2005077906A1 (en) | 2004-02-18 | 2005-08-25 | Altana Pharma Ag | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (pde) 4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| PL2589599T4 (pl) | 2004-03-03 | 2015-06-30 | Takeda Gmbh | Nowe hydroksy-6-heteroarylofenantrydyny i ich zastosowanie jako inhibitorów PDE4 |
| US20070191414A1 (en) * | 2004-03-09 | 2007-08-16 | Altana Pharma Ag | Novel isoamido-substituted hydroxy-6-phenylphenanthridines |
| CA2558532A1 (en) * | 2004-03-10 | 2005-09-15 | Altana Pharma Ag | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| US20070185149A1 (en) * | 2004-03-10 | 2007-08-09 | Altana Pharma Ag | Novel amido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibtors |
| EP1725533A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel thio containing hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| WO2006027345A2 (en) * | 2004-09-08 | 2006-03-16 | Altana Pharma Ag | Novel 3-thia-10-aza-phenanthrene derivatives |
| US7411093B2 (en) * | 2004-12-20 | 2008-08-12 | Hoffman-La Roche Inc. | Aminocycloalkanes as DPP-IV inhibitors |
| US7718668B2 (en) | 2005-03-02 | 2010-05-18 | Nycomed Gmbh | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives |
| US8017633B2 (en) | 2005-03-08 | 2011-09-13 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
| CA2599368A1 (en) * | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
| MX2010003155A (es) | 2007-10-04 | 2010-04-01 | Hoffmann La Roche | Derivados de ciclopropil aril amida y uso de los mismos. |
| TWI622578B (zh) | 2011-12-21 | 2018-05-01 | 諾維拉治療公司 | Ｂ型肝炎抗病毒劑 |
| BR112015004192B1 (pt) | 2012-08-28 | 2021-02-09 | Janssen Sciences Ireland Uc | sulfamoíl-arilamidas, composição farmacêutica que os compreende e uso das mesmas no tratamento da hepatite b |
| WO2014131847A1 (en) | 2013-02-28 | 2014-09-04 | Janssen R&D Ireland | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| BR112015025052A2 (pt) | 2013-04-03 | 2021-07-06 | Janssen Sciences Ireland Uc | derivados de n-fenil-carboxamida e o seu uso como medicamentos para o tratamento da hepatite b |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| EA035500B1 (ru) | 2013-05-17 | 2020-06-25 | Янссен Сайенсиз Айрлэнд Юси | Производные сульфамоилтиофенамида и их применение в качестве медикаментов для лечения гепатита b |
| EP3357906B1 (en) | 2013-07-25 | 2019-12-04 | Janssen Sciences Ireland Unlimited Company | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| WO2015120178A1 (en) | 2014-02-05 | 2015-08-13 | Novira Therapeutics, Inc. | Combination therapy for treatment of hbv infections |
| CN105980378B (zh) | 2014-02-06 | 2019-09-27 | 爱尔兰詹森科学公司 | 氨磺酰基吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
| CN107847762A (zh) | 2015-03-19 | 2018-03-27 | 诺维拉治疗公司 | 氮杂环辛烷和氮杂环壬烷衍生物以及治疗乙型肝炎感染的方法 |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| EP3356328A1 (en) | 2015-09-29 | 2018-08-08 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis b antiviral agent |
| SG11201808949SA (en) | 2016-04-15 | 2018-11-29 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
| AU2019235522A1 (en) | 2018-03-14 | 2020-09-03 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| MA55020A (fr) | 2019-02-22 | 2021-12-29 | Janssen Sciences Ireland Unlimited Co | Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b |
| AR119732A1 (es) | 2019-05-06 | 2022-01-05 | Janssen Sciences Ireland Unlimited Co | Derivados de amida útiles en el tratamiento de la infección por vhb o de enfermedades inducidas por vhb |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899494A (en) * | 1970-05-13 | 1975-08-12 | Sandoz Ltd | Substituted 6-phenyl benzo-naphthyridines |
| US6191138B1 (en) * | 1996-01-31 | 2001-02-20 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| JP4141501B2 (ja) * | 1996-03-26 | 2008-08-27 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の６位置換フェナントリジン |
| EA001551B1 (ru) | 1996-11-11 | 2001-04-23 | Бык Гюльден Ломберг Хемише Фабрик Гмбх | Бензонафтиридины в качестве бронхиальных терапевтических средств |
| AU6825898A (en) | 1997-03-07 | 1998-09-29 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazoles |
| ES2193539T3 (es) | 1997-06-03 | 2003-11-01 | Altana Pharma Ag | Benzonaftiridinas. |
| ES2189235T3 (es) * | 1997-07-25 | 2003-07-01 | Altana Pharma Ag | 6-fenilfenantridinas sustituidas. |
| CA2297923A1 (en) * | 1997-07-25 | 1999-02-04 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazole-substituted 6-phenyl-pheanathridines as pde inhibitors |
| ATE295352T1 (de) * | 1999-01-15 | 2005-05-15 | Altana Pharma Ag | Phenanthridine-n-oxide mit pde-iv hemmender wirkung |
| PT1147103E (pt) * | 1999-01-15 | 2005-08-31 | Altana Pharma Ag | Fenantridina-n-oxidos com actividade inibitoria de pde-iv |
| ES2255483T3 (es) * | 1999-01-15 | 2006-07-01 | Altana Pharma Ag | 6-arilfenantridinas con actividad inhibidora de pde-iv. |
-
2000
- 2000-01-12 DE DE60024581T patent/DE60024581T2/de not_active Expired - Lifetime
- 2000-01-12 US US09/889,144 patent/US6476025B1/en not_active Expired - Lifetime
- 2000-01-12 AT AT00901534T patent/ATE312081T1/de active
- 2000-01-12 SK SK980-2001A patent/SK286946B6/sk not_active IP Right Cessation
- 2000-01-12 TR TR2005/01553T patent/TR200501553T2/xx unknown
- 2000-01-12 IL IL14402600A patent/IL144026A0/xx active IP Right Grant
- 2000-01-12 WO PCT/EP2000/000172 patent/WO2000042020A1/en not_active Application Discontinuation
- 2000-01-12 CN CNB008027951A patent/CN1152864C/zh not_active Expired - Fee Related
- 2000-01-12 ES ES00901534T patent/ES2254132T3/es not_active Expired - Lifetime
- 2000-01-12 ID IDW00200101411A patent/ID29070A/id unknown
- 2000-01-12 RS YUP-487/01A patent/RS50297B/sr unknown
- 2000-01-12 HU HU0105001A patent/HU227624B1/hu not_active IP Right Cessation
- 2000-01-12 EA EA200100731A patent/EA003780B1/ru not_active IP Right Cessation
- 2000-01-12 DK DK00901534T patent/DK1147089T3/da active
- 2000-01-12 BR BRPI0007527-2A patent/BR0007527B1/pt not_active IP Right Cessation
- 2000-01-12 TR TR2001/01938T patent/TR200101938T2/xx unknown
- 2000-01-12 NZ NZ512872A patent/NZ512872A/en not_active IP Right Cessation
- 2000-01-12 KR KR1020017008670A patent/KR100720906B1/ko not_active IP Right Cessation
- 2000-01-12 EE EEP200100350A patent/EE05105B1/xx not_active IP Right Cessation
- 2000-01-12 CA CA002359440A patent/CA2359440C/en not_active Expired - Fee Related
- 2000-01-12 PL PL348925A patent/PL205670B1/pl unknown
- 2000-01-12 CZ CZ20012248A patent/CZ300366B6/cs not_active IP Right Cessation
- 2000-01-12 EP EP05108689A patent/EP1650193A3/en not_active Withdrawn
- 2000-01-12 SI SI200030806T patent/SI1147089T1/sl unknown
- 2000-01-12 AU AU22896/00A patent/AU774868B2/en not_active Ceased
- 2000-01-12 JP JP2000593588A patent/JP4653314B2/ja not_active Expired - Fee Related
- 2000-01-12 EP EP00901534A patent/EP1147089B1/en not_active Expired - Lifetime
- 2000-12-01 UA UA2001085778A patent/UA69436C2/uk unknown
-
2001
- 2001-06-04 BG BG105561A patent/BG65126B1/bg unknown
- 2001-06-14 ZA ZA200104864A patent/ZA200104864B/en unknown
- 2001-06-27 IL IL144026A patent/IL144026A/en not_active IP Right Cessation
- 2001-07-05 NO NO20013341A patent/NO320182B1/no not_active IP Right Cessation
- 2001-08-02 HR HR20010578A patent/HRP20010578A2/hr not_active Application Discontinuation
-
2002
- 2002-04-10 HK HK02102714.9A patent/HK1040997B/zh not_active IP Right Cessation
-
2006
- 2006-02-14 CY CY20061100209T patent/CY1106436T1/el unknown
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