NO320182B1 - Fenylfenantridiner med PDE-IV inhiberende aktivitet, legemidler omfattende dem samt anvendelse av forbindelsene. - Google Patents
Fenylfenantridiner med PDE-IV inhiberende aktivitet, legemidler omfattende dem samt anvendelse av forbindelsene. Download PDFInfo
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- NO320182B1 NO320182B1 NO20013341A NO20013341A NO320182B1 NO 320182 B1 NO320182 B1 NO 320182B1 NO 20013341 A NO20013341 A NO 20013341A NO 20013341 A NO20013341 A NO 20013341A NO 320182 B1 NO320182 B1 NO 320182B1
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- hydrogen
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- methoxy
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- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
- C07D221/12—Phenanthridines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
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- Public Health (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99100694 | 1999-01-15 | ||
| PCT/EP2000/000172 WO2000042020A1 (en) | 1999-01-15 | 2000-01-12 | Phenylphenanthridines with pde-iv inhibiting activity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20013341D0 NO20013341D0 (no) | 2001-07-05 |
| NO20013341L NO20013341L (no) | 2001-09-17 |
| NO320182B1 true NO320182B1 (no) | 2005-11-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20013341A NO320182B1 (no) | 1999-01-15 | 2001-07-05 | Fenylfenantridiner med PDE-IV inhiberende aktivitet, legemidler omfattende dem samt anvendelse av forbindelsene. |
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| EP (2) | EP1147089B1 (xx) |
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| CN (1) | CN1152864C (xx) |
| AT (1) | ATE312081T1 (xx) |
| AU (1) | AU774868B2 (xx) |
| BG (1) | BG65126B1 (xx) |
| BR (1) | BR0007527B1 (xx) |
| CA (1) | CA2359440C (xx) |
| CY (1) | CY1106436T1 (xx) |
| CZ (1) | CZ300366B6 (xx) |
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| DK (1) | DK1147089T3 (xx) |
| EA (1) | EA003780B1 (xx) |
| EE (1) | EE05105B1 (xx) |
| ES (1) | ES2254132T3 (xx) |
| HK (1) | HK1040997B (xx) |
| HR (1) | HRP20010578A2 (xx) |
| HU (1) | HU227624B1 (xx) |
| ID (1) | ID29070A (xx) |
| IL (2) | IL144026A0 (xx) |
| NO (1) | NO320182B1 (xx) |
| NZ (1) | NZ512872A (xx) |
| PL (1) | PL205670B1 (xx) |
| RS (1) | RS50297B (xx) |
| SI (1) | SI1147089T1 (xx) |
| SK (1) | SK286946B6 (xx) |
| TR (2) | TR200101938T2 (xx) |
| UA (1) | UA69436C2 (xx) |
| WO (1) | WO2000042020A1 (xx) |
| ZA (1) | ZA200104864B (xx) |
Families Citing this family (40)
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| WO2002006238A1 (en) * | 2000-07-14 | 2002-01-24 | Altana Pharma Ag | Cycloalkyl - or cycloalkylmethyl-substituted 6-phenylphenanthridines |
| AU2003253408A1 (en) * | 2002-08-17 | 2004-03-11 | Nycomed Gmbh | Novel phenanthridines |
| EP1539164B1 (en) | 2002-08-29 | 2006-12-20 | ALTANA Pharma AG | 2-hydroxy-6-phenylphenanthridines as pde-4 inhibitors |
| DE60311662T2 (de) * | 2002-08-29 | 2007-10-25 | Altana Pharma Ag | 3-hydroxy-6-phenylphenanthridine als pde-4 inhibitoren |
| US6894061B2 (en) | 2002-12-04 | 2005-05-17 | Wyeth | Substituted dihydrophenanthridinesulfonamides |
| US20060189641A1 (en) * | 2003-07-31 | 2006-08-24 | Beate Schmidt | Novel 6-phenlyphenanthridines |
| EP1658270A1 (en) * | 2003-07-31 | 2006-05-24 | ALTANA Pharma AG | Novel 6-phenylphenantridines |
| US7776893B2 (en) | 2003-09-05 | 2010-08-17 | Nycomed Gmbh | Use of PDE4 inhibitors for the treatment of diabetes mellitus |
| AU2005212857B2 (en) * | 2004-02-18 | 2011-04-28 | Takeda Gmbh | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors |
| AR049419A1 (es) * | 2004-03-03 | 2006-08-02 | Altana Pharma Ag | Hidroxi-6-fenilfenantridinas sustituidas con heterociclilo |
| ES2427256T3 (es) | 2004-03-03 | 2013-10-30 | Takeda Gmbh | Nuevas hidroxi-6-heteroaril-fenantridinas y su uso como agentes inhibidores de la PDE4 |
| WO2005084104A2 (en) * | 2004-03-09 | 2005-09-15 | Altana Pharma Ag | Novel isoamido-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| EP1725532A1 (en) * | 2004-03-10 | 2006-11-29 | Altana Pharma AG | Novel difluoroethoxy-substituted hydroxy-6-phenylphenanthridines and their use as pde4 inhibitors |
| KR20060130697A (ko) * | 2004-03-10 | 2006-12-19 | 알타나 파마 아게 | 신규한 아미도-치환 히드록시-6-페닐페난트리딘 및 ｐｄｅ4억제제로서의 이의 용도 |
| JP2007527900A (ja) * | 2004-03-10 | 2007-10-04 | アルタナ ファルマ アクチエンゲゼルシャフト | チオ含有の新規のヒドロキシ−６−フェニルフェナントリジン及びｐｄｅ４インヒビターとしてのそれらの使用 |
| CA2579000C (en) | 2004-09-08 | 2013-02-05 | Altana Pharma Ag | Novel 3-thia-10-aza-phenanthrene derivatives |
| US7411093B2 (en) * | 2004-12-20 | 2008-08-12 | Hoffman-La Roche Inc. | Aminocycloalkanes as DPP-IV inhibitors |
| NZ560268A (en) | 2005-03-02 | 2010-12-24 | Nycomed Gmbh | Novel salts of 6-heterocyclyl substituted hexahydrophenanthridine derivatives |
| US8017633B2 (en) | 2005-03-08 | 2011-09-13 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
| AU2006221957A1 (en) * | 2005-03-09 | 2006-09-14 | Nycomed Gmbh | Amido-substituted 6-phenylphenanthridines |
| JP5362729B2 (ja) | 2007-10-04 | 2013-12-11 | エフ．ホフマン−ラ ロシュ アーゲー | シクロプロピルアリールアミド誘導体及びその使用 |
| EA037918B1 (ru) | 2011-12-21 | 2021-06-07 | Новира Терапьютикс, Инк. | Противовирусные агенты против гепатита в |
| CR20200276A (es) | 2012-08-28 | 2021-01-27 | Janssen Sciences Ireland Uc | Sulfamoilarilamidas y su uso como medicamentos para el tratamientos de la hepatitis b (divisional exp. 2015-0059) |
| HUE034820T2 (en) | 2013-02-28 | 2018-02-28 | Janssen Sciences Ireland Uc | Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B |
| HUE033542T2 (en) | 2013-04-03 | 2017-12-28 | Janssen Sciences Ireland Uc | Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B |
| CN105960400B (zh) | 2013-05-17 | 2019-05-31 | 爱尔兰詹森科学公司 | 氨磺酰基噻吩酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
| JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
| WO2015011281A1 (en) | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| UA117261C2 (uk) | 2013-10-23 | 2018-07-10 | ЯНССЕН САЙЄНСЕЗ АЙРЛЕНД ЮСі | Похідні карбоксаміду та їх застосування як медикаментів для лікування гепатиту b |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| AU2015214096B2 (en) | 2014-02-05 | 2021-02-11 | Novira Therapeutics, Inc. | Combination therapy for treatment of HBV infections |
| AU2015214961B2 (en) | 2014-02-06 | 2018-08-30 | Janssen Sciences Ireland Uc | Sulphamoylpyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| EP3271019A1 (en) | 2015-03-19 | 2018-01-24 | Novira Therapeutics Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| JP6845231B2 (ja) | 2015-09-29 | 2021-03-17 | ノヴィラ・セラピューティクス・インコーポレイテッド | Ｂ型肝炎抗ウイルス薬の結晶形態 |
| SG11201808949SA (en) | 2016-04-15 | 2018-11-29 | Novira Therapeutics Inc | Combinations and methods comprising a capsid assembly inhibitor |
| AU2019235522A1 (en) | 2018-03-14 | 2020-09-03 | Janssen Sciences Ireland Unlimited Company | Capsid assembly modulator dosing regimen |
| US11096931B2 (en) | 2019-02-22 | 2021-08-24 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
| US11491148B2 (en) | 2019-05-06 | 2022-11-08 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3899494A (en) * | 1970-05-13 | 1975-08-12 | Sandoz Ltd | Substituted 6-phenyl benzo-naphthyridines |
| ES2194180T3 (es) * | 1996-01-31 | 2003-11-16 | Altana Pharma Ag | Nuevas fenantridinas. |
| JP4141501B2 (ja) * | 1996-03-26 | 2008-08-27 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規の６位置換フェナントリジン |
| US6127378A (en) | 1996-03-26 | 2000-10-03 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Phenanthridines substituted in the 6 position |
| PT937074E (pt) | 1996-11-11 | 2003-07-31 | Altana Pharma Ag | Benzonaftiridinas como terapeutica bronquica |
| ES2206909T3 (es) | 1997-03-07 | 2004-05-16 | Altana Pharma Ag | Derivados de tetrazol. |
| JP2002502403A (ja) | 1997-06-03 | 2002-01-22 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | ベンゾナフチリジン |
| JP2001510825A (ja) * | 1997-07-25 | 2001-08-07 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 新規テトラゾール誘導体 |
| DE69809754T2 (de) * | 1997-07-25 | 2003-09-18 | Altana Pharma Ag | Substituierte 6-phenylphenanthridine |
| DE60025327T2 (de) * | 1999-01-15 | 2006-08-24 | Altana Pharma Ag | 6-arylphenanthridine mit pde-iv hemmender wirkung |
| ES2242594T3 (es) * | 1999-01-15 | 2005-11-16 | Altana Pharma Ag | N-oxidos de fenantridinas con una acitvidad inhidora de pde-iv. |
| DK1147103T3 (da) * | 1999-01-15 | 2005-08-29 | Altana Pharma Ag | Phenanthridin-N-oxider med PDE-IV-inhiberende aktivitet |
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2000
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- 2000-01-12 CA CA002359440A patent/CA2359440C/en not_active Expired - Fee Related
- 2000-01-12 CN CNB008027951A patent/CN1152864C/zh not_active Expired - Fee Related
- 2000-01-12 PL PL348925A patent/PL205670B1/pl unknown
- 2000-01-12 WO PCT/EP2000/000172 patent/WO2000042020A1/en not_active Application Discontinuation
- 2000-01-12 US US09/889,144 patent/US6476025B1/en not_active Expired - Lifetime
- 2000-01-12 AT AT00901534T patent/ATE312081T1/de active
- 2000-01-12 DE DE60024581T patent/DE60024581T2/de not_active Expired - Lifetime
- 2000-01-12 TR TR2001/01938T patent/TR200101938T2/xx unknown
- 2000-01-12 NZ NZ512872A patent/NZ512872A/en not_active IP Right Cessation
- 2000-01-12 RS YUP-487/01A patent/RS50297B/sr unknown
- 2000-01-12 EP EP00901534A patent/EP1147089B1/en not_active Expired - Lifetime
- 2000-01-12 SK SK980-2001A patent/SK286946B6/sk not_active IP Right Cessation
- 2000-01-12 SI SI200030806T patent/SI1147089T1/sl unknown
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- 2000-01-12 EA EA200100731A patent/EA003780B1/ru not_active IP Right Cessation
- 2000-01-12 CZ CZ20012248A patent/CZ300366B6/cs not_active IP Right Cessation
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- 2000-01-12 EP EP05108689A patent/EP1650193A3/en not_active Withdrawn
- 2000-01-12 TR TR2005/01553T patent/TR200501553T2/xx unknown
- 2000-01-12 KR KR1020017008670A patent/KR100720906B1/ko not_active IP Right Cessation
- 2000-01-12 DK DK00901534T patent/DK1147089T3/da active
- 2000-12-01 UA UA2001085778A patent/UA69436C2/uk unknown
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2001
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- 2001-06-14 ZA ZA200104864A patent/ZA200104864B/en unknown
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2002
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2006
- 2006-02-14 CY CY20061100209T patent/CY1106436T1/el unknown
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