ZA200102764B - Biologically active implants. - Google Patents
Biologically active implants. Download PDFInfo
- Publication number
- ZA200102764B ZA200102764B ZA200102764A ZA200102764A ZA200102764B ZA 200102764 B ZA200102764 B ZA 200102764B ZA 200102764 A ZA200102764 A ZA 200102764A ZA 200102764 A ZA200102764 A ZA 200102764A ZA 200102764 B ZA200102764 B ZA 200102764B
- Authority
- ZA
- South Africa
- Prior art keywords
- implant
- coating
- polymer
- solvent
- varnish
- Prior art date
Links
- 239000007943 implant Substances 0.000 title claims abstract description 47
- 238000000576 coating method Methods 0.000 claims abstract description 31
- 239000011248 coating agent Substances 0.000 claims abstract description 30
- 239000003102 growth factor Substances 0.000 claims abstract description 15
- 239000006185 dispersion Substances 0.000 claims abstract description 14
- 230000003137 locomotive effect Effects 0.000 claims abstract description 8
- 229920002988 biodegradable polymer Polymers 0.000 claims abstract description 7
- 239000004621 biodegradable polymer Substances 0.000 claims abstract description 7
- 230000002138 osteoinductive effect Effects 0.000 claims abstract description 7
- 231100000915 pathological change Toxicity 0.000 claims abstract description 6
- 230000036285 pathological change Effects 0.000 claims abstract description 6
- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 239000003960 organic solvent Substances 0.000 claims abstract description 5
- 229920000747 poly(lactic acid) Polymers 0.000 claims abstract description 5
- 229920000642 polymer Polymers 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 13
- 239000002904 solvent Substances 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 7
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 claims description 4
- 150000007513 acids Chemical class 0.000 claims description 4
- 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 4
- 238000001704 evaporation Methods 0.000 claims description 4
- 230000008020 evaporation Effects 0.000 claims description 4
- 229920000151 polyglycol Polymers 0.000 claims description 4
- 239000010695 polyglycol Substances 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 108010010803 Gelatin Proteins 0.000 claims description 2
- 229920002472 Starch Polymers 0.000 claims description 2
- 239000001913 cellulose Substances 0.000 claims description 2
- 229920002678 cellulose Polymers 0.000 claims description 2
- 235000010980 cellulose Nutrition 0.000 claims description 2
- 229920000159 gelatin Polymers 0.000 claims description 2
- 235000019322 gelatine Nutrition 0.000 claims description 2
- 235000011852 gelatine desserts Nutrition 0.000 claims description 2
- 230000009477 glass transition Effects 0.000 claims description 2
- 108010033949 polytyrosine Proteins 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 239000008107 starch Substances 0.000 claims description 2
- 235000019698 starch Nutrition 0.000 claims description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 150000001261 hydroxy acids Chemical class 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 9
- 230000035876 healing Effects 0.000 abstract description 7
- 239000000463 material Substances 0.000 abstract description 5
- 239000000853 adhesive Substances 0.000 abstract description 2
- 230000001070 adhesive effect Effects 0.000 abstract description 2
- 206010017076 Fracture Diseases 0.000 description 10
- 208000010392 Bone Fractures Diseases 0.000 description 8
- 239000013543 active substance Substances 0.000 description 4
- 239000011888 foil Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 210000003041 ligament Anatomy 0.000 description 3
- 102000018386 EGF Family of Proteins Human genes 0.000 description 2
- 108010066486 EGF Family of Proteins Proteins 0.000 description 2
- 102000018233 Fibroblast Growth Factor Human genes 0.000 description 2
- 108050007372 Fibroblast Growth Factor Proteins 0.000 description 2
- 102000013275 Somatomedins Human genes 0.000 description 2
- 102000009618 Transforming Growth Factors Human genes 0.000 description 2
- 108010009583 Transforming Growth Factors Proteins 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical compound C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 1
- 208000025978 Athletic injury Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- -1 PEG 1000 carbonates Chemical class 0.000 description 1
- 229920002538 Polyethylene Glycol 20000 Polymers 0.000 description 1
- 206010041738 Sports injury Diseases 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 238000005299 abrasion Methods 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000001680 brushing effect Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 150000001875 compounds Chemical group 0.000 description 1
- 238000007428 craniotomy Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000000921 morphogenic effect Effects 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 229920002523 polyethylene Glycol 1000 Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002787 reinforcement Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polymers & Plastics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843251 | 1998-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200102764B true ZA200102764B (en) | 2004-02-04 |
Family
ID=7881711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200102764A ZA200102764B (en) | 1998-09-11 | 2001-04-04 | Biologically active implants. |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US6998134B2 (ja) |
| EP (1) | EP1112095B1 (ja) |
| JP (2) | JP4854114B2 (ja) |
| AT (1) | ATE228021T1 (ja) |
| AU (1) | AU5862199A (ja) |
| CA (1) | CA2350638C (ja) |
| DE (1) | DE59903490D1 (ja) |
| DK (1) | DK1112095T3 (ja) |
| ES (1) | ES2187195T3 (ja) |
| PT (1) | PT1112095E (ja) |
| SI (1) | SI1112095T1 (ja) |
| WO (1) | WO2000015273A1 (ja) |
| ZA (1) | ZA200102764B (ja) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE59903490D1 (de) * | 1998-09-11 | 2003-01-02 | Schmidmaier Gerhard | Biologisch aktive implantate |
| US7592017B2 (en) | 2000-03-10 | 2009-09-22 | Mast Biosurgery Ag | Resorbable thin membranes |
| CH694935A5 (de) * | 2000-07-26 | 2005-09-30 | Straumann Holding Ag | Oberflaechenmodifizierte Implantate. |
| DE10059986C2 (de) * | 2000-11-30 | 2003-02-13 | Martin Wiemann | Verfahren zur nicht-kovalenten Immobilisierung hitzeresistenter Biomoleküle auf Implantatmaterialien |
| US8048444B2 (en) | 2002-07-31 | 2011-11-01 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
| US7767222B2 (en) | 2002-07-31 | 2010-08-03 | Mast Biosurgery Ag | Apparatus and method for preventing adhesions between an implant and surrounding tissues |
| DE10237572A1 (de) * | 2002-08-13 | 2004-02-26 | Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin | Stent mit polymerer Beschichtung |
| DE10241572B4 (de) * | 2002-09-07 | 2007-02-08 | Werner Scholz | Stütz- oder Halteteil zum Einbringen in ein Knochenteil |
| US7704520B1 (en) | 2002-09-10 | 2010-04-27 | Mast Biosurgery Ag | Methods of promoting enhanced healing of tissues after cardiac surgery |
| CA2564605A1 (en) * | 2004-05-12 | 2005-12-01 | Massachusetts Institute Of Technology | Manufacturing process, such as three-dimensional printing, including solvent vapor filming and the like |
| US7887587B2 (en) * | 2004-06-04 | 2011-02-15 | Synthes Usa, Llc | Soft tissue spacer |
| DE102005002703C5 (de) | 2005-01-19 | 2013-07-04 | Heraeus Kulzer Gmbh | Antibiotische Beschichtung von Implantaten sowie Verfahren zur antibiotischen Beschichtung |
| WO2007130648A2 (en) * | 2006-05-05 | 2007-11-15 | Ceramatec, Inc. | Fully or partially bioresorbable orthopedic implant |
| WO2008003320A2 (en) * | 2006-07-05 | 2008-01-10 | Region Midtjylland | Three-dimensional cell scaffolds |
| JP2010503509A (ja) * | 2006-09-22 | 2010-02-04 | ユー アンド アイ コーポレーション | 生体分解性金属を含むインプラントおよびその製造方法 |
| EP1913960A1 (en) * | 2006-10-19 | 2008-04-23 | Albert Schömig | Coated implant |
| EP1916006A1 (en) * | 2006-10-19 | 2008-04-30 | Albert Schömig | Implant coated with a wax or a resin |
| DE102006052552A1 (de) | 2006-11-06 | 2008-05-08 | Auriga Medical Products Gmbh | Beschichtetes Zahnimplantat |
| US8597673B2 (en) * | 2006-12-13 | 2013-12-03 | Advanced Cardiovascular Systems, Inc. | Coating of fast absorption or dissolution |
| US8048857B2 (en) | 2006-12-19 | 2011-11-01 | Warsaw Orthopedic, Inc. | Flowable carrier compositions and methods of use |
| US8133553B2 (en) | 2007-06-18 | 2012-03-13 | Zimmer, Inc. | Process for forming a ceramic layer |
| US8309521B2 (en) | 2007-06-19 | 2012-11-13 | Zimmer, Inc. | Spacer with a coating thereon for use with an implant device |
| US20110230973A1 (en) * | 2007-10-10 | 2011-09-22 | Zimmer, Inc. | Method for bonding a tantalum structure to a cobalt-alloy substrate |
| US8608049B2 (en) * | 2007-10-10 | 2013-12-17 | Zimmer, Inc. | Method for bonding a tantalum structure to a cobalt-alloy substrate |
| US20090187256A1 (en) * | 2008-01-21 | 2009-07-23 | Zimmer, Inc. | Method for forming an integral porous region in a cast implant |
| US20090192609A1 (en) * | 2008-01-29 | 2009-07-30 | Zimmer, Inc. | Implant device for use in an implant system |
| US20090198286A1 (en) * | 2008-02-05 | 2009-08-06 | Zimmer, Inc. | Bone fracture fixation system |
| US9616153B2 (en) | 2008-04-17 | 2017-04-11 | Warsaw Orthopedic, Inc. | Rigid bone graft substitute |
| US20090263507A1 (en) * | 2008-04-18 | 2009-10-22 | Warsaw Orthopedic, Inc. | Biological markers and response to treatment for pain, inflammation, neuronal or vascular injury and methods of use |
| US10022164B2 (en) * | 2008-06-11 | 2018-07-17 | Eventions, Llc | Orthopedic fastener device |
| GB0818933D0 (en) | 2008-10-16 | 2008-11-19 | Depuy Int Ltd | An implantable medical device |
| CH700138B1 (it) * | 2008-12-19 | 2012-12-14 | Ind Biomediche Insubri S A | Matrice per impianto osseo e procedimento di preparazione della stessa. |
| US20100215716A1 (en) * | 2009-02-23 | 2010-08-26 | Biomet Manufacturing Corp. | Compositions and methods for coating orthopedic implants |
| US20100247600A1 (en) * | 2009-03-24 | 2010-09-30 | Warsaw Orthopedic, Inc. | Therapeutic drug eluting implant cover and method of making the same |
| US20100249783A1 (en) * | 2009-03-24 | 2010-09-30 | Warsaw Orthopedic, Inc. | Drug-eluting implant cover |
| JP2012521800A (ja) | 2009-03-24 | 2012-09-20 | スタビリッツ オルトペディクス， エルエルシー | 生体再吸収性材料層を有する整形外科固定デバイス |
| US9078712B2 (en) * | 2009-04-15 | 2015-07-14 | Warsaw Orthopedic, Inc. | Preformed drug-eluting device to be affixed to an anterior spinal plate |
| US9414864B2 (en) | 2009-04-15 | 2016-08-16 | Warsaw Orthopedic, Inc. | Anterior spinal plate with preformed drug-eluting device affixed thereto |
| US8333791B2 (en) * | 2009-04-24 | 2012-12-18 | Warsaw Orthopedic, Inc. | Medical implant with tie configured to deliver a therapeutic substance |
| US20100274295A1 (en) * | 2009-04-24 | 2010-10-28 | Warsaw Orthopedic, Inc. | Medical implant configured to deliver a therapeutic substance |
| DE102009024616A1 (de) * | 2009-06-08 | 2010-12-23 | Telos Gmbh | Sterilisierbare Implantatbeschichtung und Verfahren zu deren Herstellung |
| RU2012148716A (ru) | 2010-04-16 | 2014-05-27 | Новартис Аг | Способы и композиции для улучшения оссеоинтеграции имплантата |
| HUE051021T2 (hu) | 2011-09-07 | 2021-01-28 | Sinai School Medicine | Ceramidáz és sejtek differenciálódása |
| US9775853B2 (en) | 2013-03-15 | 2017-10-03 | Biomet Manufacturing, Llc. | Hemostatic compositions and methods |
| US9763911B2 (en) * | 2013-12-12 | 2017-09-19 | Mayo Foundation For Medical Education And Research | Prostacyclin compositions for regulation of fracture repair and bone formation |
| CN112996546A (zh) * | 2018-10-18 | 2021-06-18 | 南丹麦大区 | 用于医学植入物的涂布组合物 |
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-
1999
- 1999-09-10 DE DE59903490T patent/DE59903490D1/de not_active Expired - Lifetime
- 1999-09-10 WO PCT/EP1999/006708 patent/WO2000015273A1/de active IP Right Grant
- 1999-09-10 AT AT99946158T patent/ATE228021T1/de active
- 1999-09-10 EP EP99946158A patent/EP1112095B1/de not_active Expired - Lifetime
- 1999-09-10 JP JP2000569857A patent/JP4854114B2/ja not_active Expired - Lifetime
- 1999-09-10 CA CA002350638A patent/CA2350638C/en not_active Expired - Lifetime
- 1999-09-10 AU AU58621/99A patent/AU5862199A/en not_active Abandoned
- 1999-09-10 SI SI9930182T patent/SI1112095T1/xx unknown
- 1999-09-10 PT PT99946158T patent/PT1112095E/pt unknown
- 1999-09-10 DK DK99946158T patent/DK1112095T3/da active
- 1999-09-10 ES ES99946158T patent/ES2187195T3/es not_active Expired - Lifetime
-
2001
- 2001-03-09 US US09/801,752 patent/US6998134B2/en not_active Expired - Lifetime
- 2001-04-04 ZA ZA200102764A patent/ZA200102764B/en unknown
-
2005
- 2005-10-18 US US11/254,200 patent/US8114427B2/en not_active Expired - Fee Related
-
2009
- 2009-05-29 US US12/474,756 patent/US20090317538A1/en not_active Abandoned
-
2011
- 2011-08-05 JP JP2011171961A patent/JP5726014B2/ja not_active Expired - Lifetime
-
2016
- 2016-04-06 US US15/091,812 patent/US10646622B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4854114B2 (ja) | 2012-01-18 |
| JP2011235175A (ja) | 2011-11-24 |
| US20010031274A1 (en) | 2001-10-18 |
| US8114427B2 (en) | 2012-02-14 |
| US20160220740A1 (en) | 2016-08-04 |
| CA2350638A1 (en) | 2000-03-23 |
| SI1112095T1 (en) | 2003-04-30 |
| ATE228021T1 (de) | 2002-12-15 |
| CA2350638C (en) | 2009-11-24 |
| DK1112095T3 (da) | 2003-03-17 |
| US20090317538A1 (en) | 2009-12-24 |
| DE59903490D1 (de) | 2003-01-02 |
| EP1112095B1 (de) | 2002-11-20 |
| US20060039947A1 (en) | 2006-02-23 |
| JP2002524208A (ja) | 2002-08-06 |
| ES2187195T3 (es) | 2003-05-16 |
| AU5862199A (en) | 2000-04-03 |
| PT1112095E (pt) | 2003-04-30 |
| WO2000015273A1 (de) | 2000-03-23 |
| US6998134B2 (en) | 2006-02-14 |
| US10646622B2 (en) | 2020-05-12 |
| JP5726014B2 (ja) | 2015-05-27 |
| EP1112095A1 (de) | 2001-07-04 |
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