ZA200100295B - 5-Thia-ω-substituted phenyl-prostaglandin E derivatives, process for producing the same and drugs containing the same as the active ingredient. - Google Patents
5-Thia-ω-substituted phenyl-prostaglandin E derivatives, process for producing the same and drugs containing the same as the active ingredient. Download PDFInfo
- Publication number
- ZA200100295B ZA200100295B ZA200100295A ZA200100295A ZA200100295B ZA 200100295 B ZA200100295 B ZA 200100295B ZA 200100295 A ZA200100295 A ZA 200100295A ZA 200100295 A ZA200100295 A ZA 200100295A ZA 200100295 B ZA200100295 B ZA 200100295B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- tetranor
- thiaprost
- dihydroxy
- alkyloxy
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims description 14
- 230000008569 process Effects 0.000 title claims description 7
- 239000004480 active ingredient Substances 0.000 title claims description 4
- 239000003814 drug Substances 0.000 title description 3
- 229940079593 drug Drugs 0.000 title description 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 86
- 150000001875 compounds Chemical class 0.000 claims description 57
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 26
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 13
- 150000002367 halogens Chemical class 0.000 claims description 13
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- 125000001424 substituent group Chemical group 0.000 claims description 8
- 229920000858 Cyclodextrin Polymers 0.000 claims description 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims description 6
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
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- 229910052783 alkali metal Inorganic materials 0.000 description 1
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- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20075298 | 1998-07-15 |
Publications (1)
Publication Number | Publication Date |
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ZA200100295B true ZA200100295B (en) | 2002-07-10 |
Family
ID=16429595
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200100295A ZA200100295B (en) | 1998-07-15 | 2001-01-10 | 5-Thia-ω-substituted phenyl-prostaglandin E derivatives, process for producing the same and drugs containing the same as the active ingredient. |
Country Status (21)
Country | Link |
---|---|
US (1) | US6462081B1 (no) |
EP (1) | EP1097922B1 (no) |
JP (1) | JP3174563B2 (no) |
KR (1) | KR100598660B1 (no) |
CN (1) | CN1173945C (no) |
AT (1) | ATE291013T1 (no) |
AU (1) | AU763668B2 (no) |
BR (1) | BR9912813B1 (no) |
CA (1) | CA2336952C (no) |
DE (1) | DE69924258T2 (no) |
DK (1) | DK1097922T3 (no) |
ES (1) | ES2239448T3 (no) |
HU (1) | HUP0204170A3 (no) |
NO (1) | NO327781B1 (no) |
NZ (1) | NZ509293A (no) |
PT (1) | PT1097922E (no) |
RU (1) | RU2220135C2 (no) |
TR (1) | TR200100623T2 (no) |
TW (1) | TWI249520B (no) |
WO (1) | WO2000003980A1 (no) |
ZA (1) | ZA200100295B (no) |
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JP4834224B2 (ja) | 1999-03-05 | 2011-12-14 | デューク ユニバーシティ | C16不飽和fp−選択的プロスタグランジン類縁体 |
CA2303060A1 (en) * | 1999-04-14 | 2000-10-14 | United States Gear Corporation | Towed vehicle brake controller |
WO2001024800A1 (fr) * | 1999-10-07 | 2001-04-12 | Ono Pharmaceutical Co., Ltd. | Remedes contre le dysfonctionnement de l'erection |
TWI247606B (en) * | 1999-11-24 | 2006-01-21 | Ono Pharmaceutical Co | Treating agent for osteopenic diseases |
AU2227401A (en) * | 2000-01-05 | 2001-07-16 | Ono Pharmaceutical Co. Ltd. | 5-thia-omega-(substituted phenyl)-prostaglandin e alcohols, process for preparing the alcohols and pharmaceutical preparations containing the same as the activeingredient |
DE60120007T2 (de) | 2000-01-31 | 2006-11-16 | Pfizer Products Inc., Groton | Verwendung von Aktivatoren des Prostaglandinrezeptores 4 zur Behandlung von akuter oder chronischer Niereninsuffizienz |
US20020172693A1 (en) | 2000-03-31 | 2002-11-21 | Delong Michell Anthony | Compositions and methods for treating hair loss using non-naturally occurring prostaglandins |
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Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58198466A (ja) | 1982-05-12 | 1983-11-18 | Teijin Ltd | 5−チアプロスタグランジン類およびその製造法 |
JPH072711B2 (ja) | 1986-09-24 | 1995-01-18 | 帝人株式会社 | プロスタグランジンe▲下1▼誘導体の製造法 |
JPH03223244A (ja) * | 1989-02-20 | 1991-10-02 | Ono Pharmaceut Co Ltd | 5―ヘテロ―6―オキソ―pge誘導体、それらの製造方法およびそれらを含有する薬剤 |
EP0386901A1 (en) | 1989-02-20 | 1990-09-12 | Ono Pharmaceutical Co., Ltd. | Novel 5-hetero-6-oxo-PGE derivatives |
JP3579448B2 (ja) * | 1993-12-29 | 2004-10-20 | 大正製薬株式会社 | プロスタグランジン誘導体、その塩およびその使用 |
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1999
- 1999-07-09 TW TW088111637A patent/TWI249520B/zh not_active IP Right Cessation
- 1999-07-14 WO PCT/JP1999/003798 patent/WO2000003980A1/ja not_active Application Discontinuation
- 1999-07-14 BR BRPI9912813-6A patent/BR9912813B1/pt not_active IP Right Cessation
- 1999-07-14 NZ NZ509293A patent/NZ509293A/en not_active IP Right Cessation
- 1999-07-14 DE DE69924258T patent/DE69924258T2/de not_active Expired - Lifetime
- 1999-07-14 AU AU46518/99A patent/AU763668B2/en not_active Ceased
- 1999-07-14 DK DK99929831T patent/DK1097922T3/da active
- 1999-07-14 US US09/720,675 patent/US6462081B1/en not_active Expired - Fee Related
- 1999-07-14 JP JP2000560089A patent/JP3174563B2/ja not_active Expired - Fee Related
- 1999-07-14 CA CA002336952A patent/CA2336952C/en not_active Expired - Fee Related
- 1999-07-14 RU RU2001101470/04A patent/RU2220135C2/ru not_active IP Right Cessation
- 1999-07-14 AT AT99929831T patent/ATE291013T1/de active
- 1999-07-14 EP EP99929831A patent/EP1097922B1/en not_active Expired - Lifetime
- 1999-07-14 PT PT99929831T patent/PT1097922E/pt unknown
- 1999-07-14 HU HU0204170A patent/HUP0204170A3/hu unknown
- 1999-07-14 KR KR1020017000093A patent/KR100598660B1/ko not_active IP Right Cessation
- 1999-07-14 TR TR2001/00623T patent/TR200100623T2/xx unknown
- 1999-07-14 CN CNB998097039A patent/CN1173945C/zh not_active Expired - Fee Related
- 1999-07-14 ES ES99929831T patent/ES2239448T3/es not_active Expired - Lifetime
-
2001
- 2001-01-10 ZA ZA200100295A patent/ZA200100295B/en unknown
- 2001-01-12 NO NO20010213A patent/NO327781B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK1097922T3 (da) | 2005-05-30 |
ES2239448T3 (es) | 2005-09-16 |
HUP0204170A2 (hu) | 2003-04-28 |
BR9912813B1 (pt) | 2010-11-30 |
CA2336952C (en) | 2009-09-15 |
KR20010053386A (ko) | 2001-06-25 |
EP1097922B1 (en) | 2005-03-16 |
WO2000003980A1 (fr) | 2000-01-27 |
NO20010213L (no) | 2001-03-15 |
AU4651899A (en) | 2000-02-07 |
TR200100623T2 (tr) | 2001-06-21 |
ATE291013T1 (de) | 2005-04-15 |
EP1097922A4 (en) | 2003-02-12 |
DE69924258T2 (de) | 2006-01-26 |
AU763668B2 (en) | 2003-07-31 |
JP3174563B2 (ja) | 2001-06-11 |
NZ509293A (en) | 2003-05-30 |
BR9912813A (pt) | 2001-05-02 |
NO20010213D0 (no) | 2001-01-12 |
KR100598660B1 (ko) | 2006-07-13 |
US6462081B1 (en) | 2002-10-08 |
CN1312796A (zh) | 2001-09-12 |
EP1097922A1 (en) | 2001-05-09 |
CN1173945C (zh) | 2004-11-03 |
DE69924258D1 (de) | 2005-04-21 |
NO327781B1 (no) | 2009-09-21 |
CA2336952A1 (en) | 2000-01-27 |
TWI249520B (en) | 2006-02-21 |
PT1097922E (pt) | 2005-06-30 |
RU2220135C2 (ru) | 2003-12-27 |
HUP0204170A3 (en) | 2005-03-29 |
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