ZA200006758B - Substituted benzamides, their production and their use as cysteine protease inhibitors. - Google Patents
Substituted benzamides, their production and their use as cysteine protease inhibitors. Download PDFInfo
- Publication number
- ZA200006758B ZA200006758B ZA200006758A ZA200006758A ZA200006758B ZA 200006758 B ZA200006758 B ZA 200006758B ZA 200006758 A ZA200006758 A ZA 200006758A ZA 200006758 A ZA200006758 A ZA 200006758A ZA 200006758 B ZA200006758 B ZA 200006758B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- formula
- branched
- phenyl
- hydrogen
- Prior art date
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- 150000003936 benzamides Chemical class 0.000 title claims description 17
- 229940054066 benzamide antipsychotics Drugs 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title claims 2
- 239000002852 cysteine proteinase inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 claims description 33
- 239000001257 hydrogen Substances 0.000 claims description 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 31
- KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 claims description 26
- 150000001875 compounds Chemical class 0.000 claims description 22
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims description 21
- 150000002431 hydrogen Chemical class 0.000 claims description 17
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims description 16
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 16
- 125000000217 alkyl group Chemical group 0.000 claims description 15
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims description 15
- 239000003112 inhibitor Substances 0.000 claims description 14
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
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- 108010084457 Cathepsins Proteins 0.000 claims description 3
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- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 claims description 3
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims description 3
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 claims description 3
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- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 3
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- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 3
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- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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- A61P35/04—Antineoplastic agents specific for metastasis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19817461A DE19817461A1 (de) | 1998-04-20 | 1998-04-20 | Neue substituierte Benzamide, deren Herstellung und Anwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200006758B true ZA200006758B (en) | 2001-12-12 |
Family
ID=7865113
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200006758A ZA200006758B (en) | 1998-04-20 | 2000-11-20 | Substituted benzamides, their production and their use as cysteine protease inhibitors. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6436925B1 (de) |
| EP (1) | EP1073632A1 (de) |
| JP (1) | JP2002512220A (de) |
| KR (1) | KR20010042837A (de) |
| CN (1) | CN1306509A (de) |
| AU (1) | AU743245B2 (de) |
| BG (1) | BG104856A (de) |
| BR (1) | BR9909776A (de) |
| CA (1) | CA2328430A1 (de) |
| CZ (1) | CZ20003890A3 (de) |
| DE (1) | DE19817461A1 (de) |
| HR (1) | HRP20000777A2 (de) |
| HU (1) | HUP0101616A3 (de) |
| ID (1) | ID26305A (de) |
| IL (1) | IL138676A0 (de) |
| NO (1) | NO20005265D0 (de) |
| PL (1) | PL343466A1 (de) |
| SK (1) | SK14122000A3 (de) |
| TR (1) | TR200003069T2 (de) |
| WO (1) | WO1999054293A1 (de) |
| ZA (1) | ZA200006758B (de) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001002344A1 (fr) * | 1999-07-01 | 2001-01-11 | Taisho Pharmaceutical Co., Ltd. | Derives d'acide aminobenzoique |
| US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
| PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
| DE10114762A1 (de) * | 2001-03-26 | 2002-10-02 | Knoll Gmbh | Verwendung von Cysteinprotease-Inhibitoren |
| JP2005504040A (ja) * | 2001-08-03 | 2005-02-10 | スミスクライン ビーチャム コーポレーション | カテプシンＫ阻害剤としてのα−ケトアミド誘導体 |
| GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124932D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124941D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| US7282512B2 (en) | 2002-01-17 | 2007-10-16 | Smithkline Beecham Corporation | Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors |
| EP1474395B1 (de) | 2002-02-12 | 2007-10-17 | Smithkline Beecham Corporation | Nicotinamide und deren verwendung als p38 inhibitoren |
| GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
| EP1562897B1 (de) | 2002-11-12 | 2009-09-16 | Merck & Co., Inc. | Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer |
| GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
| GB0308185D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308201D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0308186D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
| GB0318814D0 (en) * | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| EP2615087A3 (de) * | 2003-12-22 | 2013-08-07 | Ajinomoto Co., Inc. | Phenylalaninderivate |
| GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
| GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
| EP2439205B1 (de) | 2006-12-29 | 2015-03-11 | AbbVie Deutschland GmbH & Co KG | Carboxamidverbindungen und ihre Verwendung als Calpain-Hemmer |
| TWI453019B (zh) | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
| UY32404A (es) * | 2009-01-30 | 2010-08-31 | Novartis Ag | 4-aril-butan-1,3-diamidas |
| TWI519530B (zh) * | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶（ｃａｌｐａｉｎ）抑制劑之用途 |
| JP2015512427A (ja) | 2012-04-03 | 2015-04-27 | アッヴィ・ドイチュラント・ゲー・エム・ベー・ハー・ウント・コー・カー・ゲー | カルボキサミド化合物およびそれのカルパイン阻害薬ｖとしての使用 |
| CN106536520B (zh) | 2014-06-27 | 2020-08-14 | 诺格拉制药有限公司 | 芳基受体调制剂及其制备和使用方法 |
| WO2017156071A1 (en) | 2016-03-09 | 2017-09-14 | Blade Therapeutics, Inc. | Cyclic keto-amide compounds as calpain modulators and methods of production and use thereof |
| EP3481835A4 (de) | 2016-07-05 | 2020-02-26 | Blade Therapeutics, Inc. | Calpain-modulatoren und therapeutische verwendungen davon |
| CN110023304A (zh) | 2016-09-28 | 2019-07-16 | 布莱德治疗公司 | 钙蛋白酶调节剂及其治疗用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ305626A (en) * | 1995-03-24 | 2000-01-28 | Axys Pharm Inc | Reversible protease inhibitors |
| EP0923535A4 (de) | 1996-08-28 | 2001-01-10 | Smithkline Beecham Corp | Inhibitoren der cystein-protease |
| RU2190599C2 (ru) * | 1996-12-11 | 2002-10-10 | Басф Акциенгезельшафт | Новые кетобензамиды |
-
1998
- 1998-04-20 DE DE19817461A patent/DE19817461A1/de not_active Withdrawn
-
1999
- 1999-04-19 ID IDW20002113A patent/ID26305A/id unknown
- 1999-04-19 HU HU0101616A patent/HUP0101616A3/hu unknown
- 1999-04-19 SK SK1412-2000A patent/SK14122000A3/sk unknown
- 1999-04-19 IL IL13867699A patent/IL138676A0/xx unknown
- 1999-04-19 WO PCT/EP1999/002617 patent/WO1999054293A1/de not_active Application Discontinuation
- 1999-04-19 EP EP99920704A patent/EP1073632A1/de not_active Withdrawn
- 1999-04-19 PL PL99343466A patent/PL343466A1/xx not_active Application Discontinuation
- 1999-04-19 CN CN99807638A patent/CN1306509A/zh active Pending
- 1999-04-19 US US09/647,673 patent/US6436925B1/en not_active Expired - Fee Related
- 1999-04-19 CZ CZ20003890A patent/CZ20003890A3/cs unknown
- 1999-04-19 BR BR9909776-1A patent/BR9909776A/pt not_active IP Right Cessation
- 1999-04-19 KR KR1020007011601A patent/KR20010042837A/ko not_active Application Discontinuation
- 1999-04-19 JP JP2000544634A patent/JP2002512220A/ja active Pending
- 1999-04-19 TR TR2000/03069T patent/TR200003069T2/xx unknown
- 1999-04-19 AU AU38186/99A patent/AU743245B2/en not_active Ceased
- 1999-04-19 CA CA002328430A patent/CA2328430A1/en not_active Abandoned
-
2000
- 2000-10-13 BG BG104856A patent/BG104856A/xx unknown
- 2000-10-19 NO NO20005265A patent/NO20005265D0/no not_active Application Discontinuation
- 2000-11-15 HR HR20000777A patent/HRP20000777A2/hr not_active Application Discontinuation
- 2000-11-20 ZA ZA200006758A patent/ZA200006758B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3818699A (en) | 1999-11-08 |
| US6436925B1 (en) | 2002-08-20 |
| DE19817461A1 (de) | 1999-10-21 |
| HUP0101616A3 (en) | 2002-10-28 |
| CN1306509A (zh) | 2001-08-01 |
| EP1073632A1 (de) | 2001-02-07 |
| TR200003069T2 (tr) | 2009-01-21 |
| CA2328430A1 (en) | 1999-10-28 |
| SK14122000A3 (sk) | 2001-05-10 |
| BG104856A (en) | 2001-05-31 |
| PL343466A1 (en) | 2001-08-13 |
| IL138676A0 (en) | 2001-10-31 |
| KR20010042837A (ko) | 2001-05-25 |
| ID26305A (id) | 2000-12-14 |
| JP2002512220A (ja) | 2002-04-23 |
| NO20005265L (no) | 2000-10-19 |
| HRP20000777A2 (en) | 2001-06-30 |
| CZ20003890A3 (cs) | 2001-11-14 |
| BR9909776A (pt) | 2000-12-19 |
| WO1999054293A1 (de) | 1999-10-28 |
| NO20005265D0 (no) | 2000-10-19 |
| HUP0101616A1 (hu) | 2001-09-28 |
| AU743245B2 (en) | 2002-01-24 |
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