BR9909776A - Benzamida, uso das benzamidas, e, preparação de medicamento para uso oral, parenteral ou intraperitoneal - Google Patents
Benzamida, uso das benzamidas, e, preparação de medicamento para uso oral, parenteral ou intraperitonealInfo
- Publication number
- BR9909776A BR9909776A BR9909776-1A BR9909776A BR9909776A BR 9909776 A BR9909776 A BR 9909776A BR 9909776 A BR9909776 A BR 9909776A BR 9909776 A BR9909776 A BR 9909776A
- Authority
- BR
- Brazil
- Prior art keywords
- benzamides
- benzamide
- parenteral
- oral
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/77—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/78—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Vascular Medicine (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Abstract
"BENZAMIDA, USO DAS BENZAMIDAS, E, PREPARAçãO DE MEDICAMENTO PARA USO ORAL, PARENTERAL OU INTRAPERITONEAL" A invenção diz respeito às benzamidas da fórmula geral (I) e suas formas tautoméricas, assim como as possíveis formas enanciomérica e diastereomérica, às suas formas E e Z e aos possíveis sais fisiologicamente compatíveis, onde as variáveis R¹, R², R³, A e B têm os significados dados na reivindicação 1. A invenção também diz respeito aos usos como seus inibidores de cisteína proteases.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19817461A DE19817461A1 (de) | 1998-04-20 | 1998-04-20 | Neue substituierte Benzamide, deren Herstellung und Anwendung |
PCT/EP1999/002617 WO1999054293A1 (de) | 1998-04-20 | 1999-04-19 | Substituierte benzamide, deren herstellung und anwendung als inhibitoren von cystein-proteasen |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9909776A true BR9909776A (pt) | 2000-12-19 |
Family
ID=7865113
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9909776-1A BR9909776A (pt) | 1998-04-20 | 1999-04-19 | Benzamida, uso das benzamidas, e, preparação de medicamento para uso oral, parenteral ou intraperitoneal |
Country Status (21)
Country | Link |
---|---|
US (1) | US6436925B1 (pt) |
EP (1) | EP1073632A1 (pt) |
JP (1) | JP2002512220A (pt) |
KR (1) | KR20010042837A (pt) |
CN (1) | CN1306509A (pt) |
AU (1) | AU743245B2 (pt) |
BG (1) | BG104856A (pt) |
BR (1) | BR9909776A (pt) |
CA (1) | CA2328430A1 (pt) |
CZ (1) | CZ20003890A3 (pt) |
DE (1) | DE19817461A1 (pt) |
HR (1) | HRP20000777A2 (pt) |
HU (1) | HUP0101616A3 (pt) |
ID (1) | ID26305A (pt) |
IL (1) | IL138676A0 (pt) |
NO (1) | NO20005265L (pt) |
PL (1) | PL343466A1 (pt) |
SK (1) | SK14122000A3 (pt) |
TR (1) | TR200003069T2 (pt) |
WO (1) | WO1999054293A1 (pt) |
ZA (1) | ZA200006758B (pt) |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001002344A1 (fr) * | 1999-07-01 | 2001-01-11 | Taisho Pharmaceutical Co., Ltd. | Derives d'acide aminobenzoique |
US6846813B2 (en) * | 2000-06-30 | 2005-01-25 | Pharmacia & Upjohn Company | Compounds to treat alzheimer's disease |
PE20020506A1 (es) * | 2000-08-22 | 2002-07-09 | Glaxo Group Ltd | Derivados de pirazol fusionados como inhibidores de la proteina cinasa |
DE10114762A1 (de) * | 2001-03-26 | 2002-10-02 | Knoll Gmbh | Verwendung von Cysteinprotease-Inhibitoren |
US20050107616A1 (en) * | 2001-08-03 | 2005-05-19 | David Gene Barrett | Alpha-ketoamide derivatives as cathepsin k inhibitors |
GB0124939D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124933D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124934D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124931D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124938D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124936D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124932D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
GB0124941D0 (en) * | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
JP2005515254A (ja) * | 2002-01-17 | 2005-05-26 | スミスクライン ビーチャム コーポレーション | カテプシンk阻害剤として有用なシクロアルキルケトアミド誘導体 |
PT1474395E (pt) * | 2002-02-12 | 2008-01-02 | Smithkline Beecham Corp | Derivados de nicotinamida úteis como inibidores de p38 |
GB0217757D0 (en) | 2002-07-31 | 2002-09-11 | Glaxo Group Ltd | Novel compounds |
CA2505098A1 (en) | 2002-11-12 | 2004-05-27 | Merck & Co., Inc. | Phenylcarboxamide beta-secretase inhibitors for the treatment of alzheimer's disease |
GB0228410D0 (en) | 2002-12-05 | 2003-01-08 | Glaxo Group Ltd | Novel Compounds |
GB0308201D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308186D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0308185D0 (en) * | 2003-04-09 | 2003-05-14 | Smithkline Beecham Corp | Novel compounds |
GB0318814D0 (en) * | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
EP1700850B1 (en) * | 2003-12-22 | 2015-07-15 | Ajinomoto Co., Inc. | Phenylalanine derivative |
GB0402143D0 (en) * | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
US20080051416A1 (en) * | 2004-10-05 | 2008-02-28 | Smithkline Beecham Corporation | Novel Compounds |
GB0512429D0 (en) * | 2005-06-17 | 2005-07-27 | Smithkline Beecham Corp | Novel compound |
WO2008080969A1 (en) | 2006-12-29 | 2008-07-10 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
TWI453019B (zh) | 2007-12-28 | 2014-09-21 | Abbvie Deutschland | 甲醯胺化合物 |
US20100222396A1 (en) * | 2009-01-30 | 2010-09-02 | Novartis Ag | 4-aryl-butane-1,3-diamides |
TWI519530B (zh) | 2009-02-20 | 2016-02-01 | 艾伯維德國有限及兩合公司 | 羰醯胺化合物及其作為鈣蛋白酶(calpain)抑制劑之用途 |
SG11201406345XA (en) | 2012-04-03 | 2014-11-27 | Abbvie Deutschland | Carboxamide compounds and their use as calpain inhibitors v |
AU2015279047B2 (en) | 2014-06-27 | 2020-01-02 | Nogra Pharma Limited | Aryl receptor modulators and methods of making and using the same |
EP3426674A4 (en) | 2016-03-09 | 2019-08-14 | Blade Therapeutics, Inc. | CYCLIC KETO AMID COMPOUNDS AS CALPAIN MODULATORS AND METHOD FOR THE PRODUCTION AND USE THEREOF |
WO2018009417A1 (en) | 2016-07-05 | 2018-01-11 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
WO2018064119A1 (en) | 2016-09-28 | 2018-04-05 | Blade Therapeutics, Inc. | Calpain modulators and therapeutic uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11503417A (ja) * | 1995-03-24 | 1999-03-26 | アリス・ファーマシューティカル・コーポレイション | 可逆的プロテアーゼインヒビター |
WO1998008802A1 (en) * | 1996-08-28 | 1998-03-05 | Smithkline Beecham Corporation | Inhibitors of cysteine protease |
TR199901305T2 (xx) * | 1996-12-11 | 1999-08-23 | Basf Aktiengesellschaft | Calpain-�nleyicileri olarak ketonbenzamidler |
-
1998
- 1998-04-20 DE DE19817461A patent/DE19817461A1/de not_active Withdrawn
-
1999
- 1999-04-19 HU HU0101616A patent/HUP0101616A3/hu unknown
- 1999-04-19 AU AU38186/99A patent/AU743245B2/en not_active Ceased
- 1999-04-19 IL IL13867699A patent/IL138676A0/xx unknown
- 1999-04-19 PL PL99343466A patent/PL343466A1/xx not_active Application Discontinuation
- 1999-04-19 CZ CZ20003890A patent/CZ20003890A3/cs unknown
- 1999-04-19 ID IDW20002113A patent/ID26305A/id unknown
- 1999-04-19 SK SK1412-2000A patent/SK14122000A3/sk unknown
- 1999-04-19 WO PCT/EP1999/002617 patent/WO1999054293A1/de not_active Application Discontinuation
- 1999-04-19 EP EP99920704A patent/EP1073632A1/de not_active Withdrawn
- 1999-04-19 CA CA002328430A patent/CA2328430A1/en not_active Abandoned
- 1999-04-19 US US09/647,673 patent/US6436925B1/en not_active Expired - Fee Related
- 1999-04-19 TR TR2000/03069T patent/TR200003069T2/xx unknown
- 1999-04-19 JP JP2000544634A patent/JP2002512220A/ja active Pending
- 1999-04-19 KR KR1020007011601A patent/KR20010042837A/ko not_active Application Discontinuation
- 1999-04-19 CN CN99807638A patent/CN1306509A/zh active Pending
- 1999-04-19 BR BR9909776-1A patent/BR9909776A/pt not_active IP Right Cessation
-
2000
- 2000-10-13 BG BG104856A patent/BG104856A/xx unknown
- 2000-10-19 NO NO20005265A patent/NO20005265L/no not_active Application Discontinuation
- 2000-11-15 HR HR20000777A patent/HRP20000777A2/hr not_active Application Discontinuation
- 2000-11-20 ZA ZA200006758A patent/ZA200006758B/en unknown
Also Published As
Publication number | Publication date |
---|---|
TR200003069T2 (tr) | 2009-01-21 |
ID26305A (id) | 2000-12-14 |
CZ20003890A3 (cs) | 2001-11-14 |
NO20005265D0 (no) | 2000-10-19 |
BG104856A (en) | 2001-05-31 |
EP1073632A1 (de) | 2001-02-07 |
CN1306509A (zh) | 2001-08-01 |
HUP0101616A1 (hu) | 2001-09-28 |
CA2328430A1 (en) | 1999-10-28 |
DE19817461A1 (de) | 1999-10-21 |
JP2002512220A (ja) | 2002-04-23 |
KR20010042837A (ko) | 2001-05-25 |
PL343466A1 (en) | 2001-08-13 |
AU743245B2 (en) | 2002-01-24 |
US6436925B1 (en) | 2002-08-20 |
NO20005265L (no) | 2000-10-19 |
IL138676A0 (en) | 2001-10-31 |
AU3818699A (en) | 1999-11-08 |
HUP0101616A3 (en) | 2002-10-28 |
ZA200006758B (en) | 2001-12-12 |
HRP20000777A2 (en) | 2001-06-30 |
WO1999054293A1 (de) | 1999-10-28 |
SK14122000A3 (sk) | 2001-05-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9909776A (pt) | Benzamida, uso das benzamidas, e, preparação de medicamento para uso oral, parenteral ou intraperitoneal | |
BR9909773A (pt) | Amida heterociclicamente substituìda, uso da mesma, e, preparação farmacêutica para uso oral, parenteral e intraperitoneal | |
BR0116063A (pt) | Inibidores de sulfonamida heterocìclica da produção de beta amilóide e seus usos | |
BRPI0014076B8 (pt) | benzamidas e inibidores correlatos do fator xa | |
BR9814956A (pt) | Inibidores de benzotiazol da tirosina cinase de proteìna | |
BR9713363A (pt) | Epotilonas c, d, e e f, preparação e composições | |
SE0001899D0 (sv) | New compounds | |
PT1295890E (pt) | Novos derivados de pirazina ou os seus sais, composicoes farmaceuticas que os contem, e compostos intermedios utilizados na sua producao | |
BR0212141A (pt) | Inibidores de protease de cisteìna com estrutura 2-ciano-4-amino-pirimidina e atividade inibidora de catepsina k para o tratamento de inflamações e outras doenças | |
BR9916307A (pt) | Derivados quinolina | |
BR0109272A (pt) | Agentes conjugados terapêuticos de ácido poliglutâmico, métodos para suas preparações e usos | |
BR0111457A (pt) | Derivados de acilfeniluréia, processos para a sua preparação e sua aplicação como medicamentos | |
NO20024005D0 (no) | Pteridinforbindelser for behandling av psoriasis | |
ATE231872T1 (de) | Thiazolopyrimidinderivate | |
NO914217L (no) | Sakkarinderivater nyttige som proteolytiske enzyminhibitorer og fremstilling derav | |
DK0675717T3 (da) | Anvendelse af 2-amino-6-n-propyl-amino-4,5,6,7-tetrahydrobenzothiazol (pramipexol) som lægemiddel med antidepressiv virknin | |
IT1216686B (it) | Formulazioni farmaceutiche acquose di piroxicam e procedimento per laloro preparazione. | |
ES2126211T3 (es) | Agentes antitromboticos. | |
BR0011700A (pt) | Dinitrilas de ácido arilmalÈnico substituìdo como intermediários para a preparação de herbicidas | |
BR0211995A (pt) | Preparados de combinação de derivados de propanolamina substituìdos por arila com outras substâncias ativas e sua aplicação | |
IS5851A (is) | Ný lyf til inntöku 5-HT4 gerandefna eða mótlyfja | |
BR9916887A (pt) | Uso de derivados de pirimidina | |
BR0212031A (pt) | Preparados de combinação de derivados de 1,1-dióxido de 1-4-benzotiepina com outras substâncias ativas e seu emprego | |
BR9809763A (pt) | Combinações de substâncias ativas fungicidas | |
BR0113581A (pt) | Derivados de aril-piperazinas e seu uso como psicofármacos |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 5O,6O, 7O E 8O ANUIDADES |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1911 DE 21/08/2007. |