YU74901A - Upotreba antagonista subjedinica alfa-4 integrina za pripremanje farmaceutskog preparata za tretiranje fibroze - Google Patents

Upotreba antagonista subjedinica alfa-4 integrina za pripremanje farmaceutskog preparata za tretiranje fibroze

Info

Publication number
YU74901A
YU74901A YU74901A YUP74901A YU74901A YU 74901 A YU74901 A YU 74901A YU 74901 A YU74901 A YU 74901A YU P74901 A YUP74901 A YU P74901A YU 74901 A YU74901 A YU 74901A
Authority
YU
Yugoslavia
Prior art keywords
fibrosis
treatment
subunit
antagonist
integrin alpha
Prior art date
Application number
YU74901A
Other languages
English (en)
Inventor
Philip Gotwals
Roy R. Lobb
Original Assignee
Biogen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Inc. filed Critical Biogen Inc.
Publication of YU74901A publication Critical patent/YU74901A/sh
Publication of RS50086B publication Critical patent/RS50086B/sr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Pronalazak se odnosi na upotrebu antagonista subjedinice alfa-4 integrina za pripremanje farmaceutskog preparata za tretiranje fibrozisa kod humanog i životinjskog subjekta.
YUP-749/01A 1999-04-22 2000-04-21 Upotreba antagonista subjedinica alfa-4 integrina za pripremanje farmaceutskog preparata za tretiranje fibroze RS50086B (sr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13084799P 1999-04-22 1999-04-22
US13721499P 1999-06-01 1999-06-01

Publications (2)

Publication Number Publication Date
YU74901A true YU74901A (sh) 2004-07-15
RS50086B RS50086B (sr) 2009-01-22

Family

ID=26828876

Country Status (31)

Country Link
US (3) US6652856B2 (sh)
EP (1) EP1173201B1 (sh)
JP (3) JP5483515B2 (sh)
KR (3) KR100746522B1 (sh)
CN (3) CN1332714C (sh)
AT (1) ATE298249T1 (sh)
AU (1) AU783054B2 (sh)
BG (2) BG65578B1 (sh)
BR (1) BR0010669A (sh)
CA (1) CA2370814C (sh)
CY (1) CY1106046T1 (sh)
CZ (1) CZ301636B6 (sh)
DE (1) DE60020955T2 (sh)
DK (1) DK1173201T3 (sh)
EA (1) EA006681B1 (sh)
EE (1) EE05662B1 (sh)
ES (1) ES2243259T3 (sh)
GE (1) GEP20063844B (sh)
HK (2) HK1041452B (sh)
HU (1) HU226383B1 (sh)
IL (5) IL145898A0 (sh)
IS (1) IS2259B (sh)
MX (1) MXPA01010612A (sh)
NO (1) NO330221B1 (sh)
NZ (2) NZ541431A (sh)
PL (1) PL198975B1 (sh)
PT (1) PT1173201E (sh)
RS (2) RS50086B (sh)
SK (1) SK287328B6 (sh)
TR (1) TR200200027T2 (sh)
WO (1) WO2000064474A1 (sh)

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BR0011250A (pt) * 1999-06-01 2002-03-05 Biogen Inc Anticorpo monoclonal de bloqueio a vla-1 e seu uso para o tratamento de distúrbios inflamatórios
AU780358B2 (en) * 1999-06-08 2005-03-17 Lorantis Limited Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway
WO2001070210A2 (en) * 2000-03-17 2001-09-27 Avocet Polymer Technologies, Inc. Methods for improving size and appearance of a wound
AU2002225878A1 (en) * 2000-11-02 2002-05-15 Smith Kline Beecham Corporation Receptor antagonist-lipid conjugates and delivery vehicles containing same
AU2002258778C1 (en) 2001-04-13 2008-12-04 Biogen Ma Inc. Antibodies to VLA-1
US20030154499A1 (en) * 2001-06-08 2003-08-14 Monika Wasel-Nielen Mouse unable to express functional alpha-4 integrin protein, and methods for assaying compounds or agents for alpha-4 integrin protein antagonist activity and a genetic marker for evaluating efficacy of modulators of signaling activity of a VLA-4 receptor
WO2005007110A2 (en) * 2003-07-11 2005-01-27 Pro-Pharmaceuticals, Inc. Compositions and methods for hydrophobic drug delivery
US20050053664A1 (en) * 2003-09-08 2005-03-10 Eliezer Zomer Co-administration of a polysaccharide with a chemotherapeutic agent for the treatment of cancer
EP3412686A1 (en) * 2003-10-17 2018-12-12 AlJamal-Naylor, Rehab Tissue repair by modulation of beta-1 integrin biological function
EP1718146A2 (en) * 2004-02-13 2006-11-08 Pro-Pharmaceuticals, Inc. Compositions and methods used to treat acne and candida
WO2006017417A2 (en) * 2004-08-02 2006-02-16 Pro-Pharmaceuticals, Inc. Compositions and methods for the enhancement of chemotherapy with microbial cytotoxins
WO2006124269A2 (en) * 2005-05-16 2006-11-23 Amgen Fremont Inc. Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
WO2008011216A2 (en) 2006-05-16 2008-01-24 Pro-Pharmaceuticals, Inc. Galactose-pronged polysaccharides in a formulation for antifibrotic therapies
PT2034830E (pt) * 2006-05-25 2014-10-14 Biogen Idec Inc Anticorpos anti-vla-1 para o tratamento de acidentes vasculares cerebrais
ES2402334T3 (es) 2007-08-02 2013-04-30 Gilead Biologics, Inc Procedimientos y composiciones para el tratamiento y el diagnóstico de la fibrosis
AU2013221635B2 (en) 2012-02-16 2017-12-07 Santarus, Inc. Anti-VLA1 (CD49a) antibody pharmaceutical compositions
EP2832368B1 (en) * 2012-03-28 2021-11-10 Hiroshima University Fibrosis suppression by inhibiting integrin alpha8beta1 function
WO2014130648A1 (en) 2013-02-20 2014-08-28 Galectin Therapeutics, Inc. Method for treatment of pulmonary fibrosis

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Also Published As

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US20050281818A1 (en) 2005-12-22
HUP0201015A3 (en) 2004-12-28
US20020182213A1 (en) 2002-12-05
EA006681B1 (ru) 2006-02-24
IL206830A (en) 2013-06-27
GEP20063844B (en) 2006-06-12
CN1596979A (zh) 2005-03-23
SK287328B6 (sk) 2010-07-07
US20040037827A1 (en) 2004-02-26
BG66149B1 (bg) 2011-08-31
CN1356911A (zh) 2002-07-03
CZ301636B6 (cs) 2010-05-12
IL206830A0 (en) 2010-12-30
JP2002542300A (ja) 2002-12-10
BG106118A (en) 2002-05-31
RS20080471A (en) 2010-12-31
BR0010669A (pt) 2002-02-19
CZ20013754A3 (cs) 2002-07-17
HK1041452A1 (en) 2002-07-12
CN1332714C (zh) 2007-08-22
HUP0201015A2 (hu) 2002-07-29
KR100746522B1 (ko) 2007-08-07
WO2000064474A8 (en) 2001-04-05
RS50086B (sr) 2009-01-22
IL182908A0 (en) 2007-08-19
JP2014065747A (ja) 2014-04-17
PT1173201E (pt) 2005-08-31
EE200100549A (et) 2002-12-16
EP1173201A1 (en) 2002-01-23
US6652856B2 (en) 2003-11-25
HU226383B1 (hu) 2008-10-28
PL198975B1 (pl) 2008-08-29
BG65578B1 (bg) 2009-01-30
JP5483515B2 (ja) 2014-05-07
IL145898A (en) 2007-07-24
NO20015122L (no) 2001-12-21
HK1076379A1 (en) 2006-01-20
MXPA01010612A (es) 2003-09-04
KR100837715B1 (ko) 2008-06-13
CY1106046T1 (el) 2011-04-06
CN100360183C (zh) 2008-01-09
PL351916A1 (en) 2003-06-30
AU783054B2 (en) 2005-09-22
IL145898A0 (en) 2002-07-25
DE60020955T2 (de) 2006-05-11
IS6105A (is) 2001-10-11
AU4480000A (en) 2000-11-10
NO330221B1 (no) 2011-03-07
IL182908A (en) 2010-11-30
CA2370814C (en) 2010-07-06
KR20070050979A (ko) 2007-05-16
IL206829A (en) 2013-06-27
IL206829A0 (en) 2010-12-30
SK15202001A3 (sk) 2002-09-10
CN1679935A (zh) 2005-10-12
NO20015122D0 (no) 2001-10-19
HK1041452B (zh) 2005-10-14
ES2243259T3 (es) 2005-12-01
CN1191860C (zh) 2005-03-09
WO2000064474A1 (en) 2000-11-02
DK1173201T3 (da) 2005-09-12
EP1173201B1 (en) 2005-06-22
JP2007182453A (ja) 2007-07-19
EE05662B1 (et) 2013-06-17
KR20020000221A (ko) 2002-01-05
ATE298249T1 (de) 2005-07-15
BG110115A (en) 2008-12-30
NZ541431A (en) 2008-01-31
TR200200027T2 (tr) 2002-07-22
IS2259B (is) 2007-06-15
EA200101116A1 (ru) 2002-04-25
NZ515053A (en) 2004-02-27
KR20070102760A (ko) 2007-10-19
CA2370814A1 (en) 2000-11-02
DE60020955D1 (de) 2005-07-28

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