PT2034830E - Anticorpos anti-vla-1 para o tratamento de acidentes vasculares cerebrais - Google Patents

Anticorpos anti-vla-1 para o tratamento de acidentes vasculares cerebrais Download PDF

Info

Publication number
PT2034830E
PT2034830E PT77841088T PT07784108T PT2034830E PT 2034830 E PT2034830 E PT 2034830E PT 77841088 T PT77841088 T PT 77841088T PT 07784108 T PT07784108 T PT 07784108T PT 2034830 E PT2034830 E PT 2034830E
Authority
PT
Portugal
Prior art keywords
vla
antibody
treating stroke
stroke
treating
Prior art date
Application number
PT77841088T
Other languages
English (en)
Inventor
Jane K Relton
Humphrey Gardner
Original Assignee
Biogen Idec Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc
Publication of PT2034830E publication Critical patent/PT2034830E/pt

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/49Urokinase; Tissue plasminogen activator
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • C07K16/2842Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2871Cerebrovascular disorders, e.g. stroke, cerebral infarct, cerebral haemorrhage, transient ischemic event
PT77841088T 2006-05-25 2007-05-24 Anticorpos anti-vla-1 para o tratamento de acidentes vasculares cerebrais PT2034830E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80914906P 2006-05-25 2006-05-25

Publications (1)

Publication Number Publication Date
PT2034830E true PT2034830E (pt) 2014-10-14

Family

ID=38778998

Family Applications (1)

Application Number Title Priority Date Filing Date
PT77841088T PT2034830E (pt) 2006-05-25 2007-05-24 Anticorpos anti-vla-1 para o tratamento de acidentes vasculares cerebrais

Country Status (14)

Country Link
US (3) US10119979B2 (pt)
EP (2) EP2034830B1 (pt)
JP (5) JP5496658B2 (pt)
CN (2) CN105381459A (pt)
AU (1) AU2007267579B2 (pt)
BR (1) BRPI0712607A8 (pt)
CA (1) CA2652815C (pt)
DK (1) DK2034830T3 (pt)
ES (2) ES2509878T3 (pt)
HK (1) HK1207576A1 (pt)
MX (1) MX2008014793A (pt)
PL (1) PL2034830T3 (pt)
PT (1) PT2034830E (pt)
WO (1) WO2007140249A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1488806T3 (en) 1999-06-01 2016-02-08 Biogen Ma Inc Blocking monoclonal antibody to VLA-1 and its use in the treatment of vascular disorders
CZ303450B6 (cs) 2001-04-13 2012-09-19 Biogen Idec Ma Inc. Protilátky k VLA-1, kompozice je obsahující a nukleové kyseliny, které je kódují, zpusob stanovení hladiny VLA-1 a použití pri lécení imunologického onemocnení
ES2509878T3 (es) 2006-05-25 2014-10-20 Biogen Idec Ma Inc. Anticuerpo anti-VLA-1 para tratar accidente cerebrovascular
NZ591294A (en) * 2008-08-20 2012-10-26 Anthrogenesis Corp Treatment of stroke using isolated placental cells
DK3466977T3 (en) 2010-04-16 2022-04-11 Biogen Ma Inc Anti-vla-4-antistoffer
KR101950561B1 (ko) * 2011-10-17 2019-02-20 에프. 호프만-라 로슈 아게 트로포닌 및 bnp 토대의 뇌졸중의 위험 환자 및 원인 진단
ES2732243T3 (es) 2012-02-16 2019-11-21 Santarus Inc Composiciones farmacéuticas de anticuerpos ANTI-VLA1 (CD49A)
TWI511724B (zh) * 2012-06-01 2015-12-11 Univ Nat Cheng Kung 治療出血性腦中風及顱內蜘蛛膜下腔出血所導致之腦損傷之醫藥組成物
AR095398A1 (es) * 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida
AR095399A1 (es) 2013-03-13 2015-10-14 Genentech Inc Formulaciones con oxidación reducida, método
WO2015003156A1 (en) * 2013-07-05 2015-01-08 Biogen Idec Ma Inc. Compositions and methods for treatment of stroke
US9119832B2 (en) 2014-02-05 2015-09-01 The Regents Of The University Of California Methods of treating mild brain injury
US20150302155A1 (en) * 2014-04-16 2015-10-22 Xerox Corporation Methods and systems for predicting health condition of human subject
MA49645A (fr) 2017-07-20 2021-03-31 Univ Virginia Patent Foundation Procédés de traitement ou de prévention d'un trouble neurologique du système immunitaire
US20220119532A1 (en) * 2019-01-14 2022-04-21 University Of Virginia Patent Foundation Use of integrin inhibitors for treatment or prevention of a neurological immunity disorder and/or nervous system injury
JP7477446B2 (ja) 2020-12-28 2024-05-01 古河産機システムズ株式会社 横型回転機械のシャフトアセンブリ用の治具
WO2023205124A2 (en) * 2022-04-20 2023-10-26 The Regents Of The University Of California Glycosylation inhibitors as therapeutics for stroke

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634665A (en) 1980-02-25 1987-01-06 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5179017A (en) 1980-02-25 1993-01-12 The Trustees Of Columbia University In The City Of New York Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4475196A (en) 1981-03-06 1984-10-02 Zor Clair G Instrument for locating faults in aircraft passenger reading light and attendant call control system
US4447233A (en) 1981-04-10 1984-05-08 Parker-Hannifin Corporation Medication infusion pump
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4447224A (en) 1982-09-20 1984-05-08 Infusaid Corporation Variable flow implantable infusion apparatus
US4487603A (en) 1982-11-26 1984-12-11 Cordis Corporation Implantable microinfusion pump system
US4486194A (en) 1983-06-08 1984-12-04 James Ferrara Therapeutic device for administering medicaments through the skin
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
WO1987000201A1 (en) 1985-07-05 1987-01-15 Whitehead Institute For Biomedical Research Epithelial cells expressing foreign genetic material
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5116742A (en) 1986-12-03 1992-05-26 University Patents, Inc. RNA ribozyme restriction endoribonucleases and methods
US4987071A (en) 1986-12-03 1991-01-22 University Patents, Inc. RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
EP0307434B2 (en) 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
WO1989002468A1 (en) 1987-09-11 1989-03-23 Whitehead Institute For Biomedical Research Transduced fibroblasts and uses therefor
EP0391960B1 (en) 1987-12-11 1994-08-17 Whitehead Institute For Biomedical Research Genetic modification of endothelial cells
WO1989007136A2 (en) 1988-02-05 1989-08-10 Whitehead Institute For Biomedical Research Modified hepatocytes and uses therefor
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5530101A (en) * 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5859205A (en) * 1989-12-21 1999-01-12 Celltech Limited Humanised antibodies
WO1991010737A1 (en) * 1990-01-11 1991-07-25 Molecular Affinities Corporation Production of antibodies using gene libraries
US6075181A (en) 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US6150584A (en) * 1990-01-12 2000-11-21 Abgenix, Inc. Human antibodies derived from immunized xenomice
US5789650A (en) * 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5391481A (en) 1990-08-31 1995-02-21 The Trustees Of Columbia University Antibody which is directed against and inhibits collagen binding to a VLA-1 epitope and uses thereof
CA2095153C (en) 1990-10-31 2007-01-09 Lori F. Rafield Genetic modification of endothelial cells
DE69230142T2 (de) * 1991-05-15 2000-03-09 Cambridge Antibody Tech Verfahren zur herstellung von spezifischen bindungspaargliedern
JP4124480B2 (ja) * 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
ES2136092T3 (es) * 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
ES2102009T5 (es) 1992-01-13 2004-12-16 Biogen Inc Tratamiento para el asma.
US5733743A (en) * 1992-03-24 1998-03-31 Cambridge Antibody Technology Limited Methods for producing members of specific binding pairs
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US6307026B1 (en) * 1992-12-10 2001-10-23 Celltech Limited Humanized antibodies directed against A33 antigen
JPH08507680A (ja) * 1993-01-12 1996-08-20 バイオジェン インコーポレイテッド 組換え抗vla4抗体分子
EP0682529B2 (en) 1993-02-09 2005-12-28 Biogen Idec MA, Inc. Antibody for the treatment of insulin dependent diabetes
US6111598A (en) * 1993-11-12 2000-08-29 Peveo, Inc. System and method for producing and displaying spectrally-multiplexed images of three-dimensional imagery for use in flicker-free stereoscopic viewing thereof
US5827690A (en) * 1993-12-20 1998-10-27 Genzyme Transgenics Corporatiion Transgenic production of antibodies in milk
EP1759709B1 (en) 1994-01-25 2013-02-27 Elan Pharmaceuticals Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
US5840299A (en) 1994-01-25 1998-11-24 Athena Neurosciences, Inc. Humanized antibodies against leukocyte adhesion molecule VLA-4
WO1995028961A1 (fr) * 1994-04-26 1995-11-02 Kanebo, Ltd. Medicament pour polyarthrite rhumatoide
JPH08131185A (ja) 1994-11-14 1996-05-28 Sumitomo Electric Ind Ltd マウスvla−1分子に対するモノクローナル抗体
JPH08160972A (ja) * 1994-12-01 1996-06-21 Sega Enterp Ltd エフェクト制御方法、制御装置およびこれを利用したカラオケ装置
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
GB9516399D0 (en) 1995-08-10 1995-10-11 Camelot Superabsorbents Ltd Process for the production of water-absorbing compositions
ES2176484T3 (es) * 1995-08-18 2002-12-01 Morphosys Ag Bancos de proteinas/(poli)peptidos.
EP0843961B1 (en) 1995-08-29 2007-01-24 Kirin Beer Kabushiki Kaisha Chimeric animal and method for constructing the same
DE19534177A1 (de) * 1995-09-15 1997-03-20 Merck Patent Gmbh Cyclische Adhäsionsinhibitoren
GB9519667D0 (en) 1995-09-27 1995-11-29 Univ Manchester Pharmaceutical composition
DE19541844C1 (de) * 1995-11-09 1997-07-24 Gsf Forschungszentrum Umwelt Verfahren zur Herstellung von menschlichen Antikörpern und deren Verwendung
US20030143204A1 (en) 2001-07-27 2003-07-31 Lewis David L. Inhibition of RNA function by delivery of inhibitors to animal cells
JP4404968B2 (ja) * 1996-04-23 2010-01-27 中外製薬株式会社 Il−8結合阻害物質を有効成分として含有する脳卒中及び脳浮腫の予防または治療剤
AU2405297A (en) 1996-04-23 1997-11-12 Chugai Seiyaku Kabushiki Kaisha Cerebral stroke/cerebral edema preventive or remedy containing il-8 binding inhibitor as active ingredient
CA2261130A1 (en) 1996-08-16 1998-02-19 Eric T. Whalley Methods to treat cerebral ischemic injury and other neuronal diseases
US6127524A (en) * 1996-10-18 2000-10-03 Dade Behring Inc. Binding molecules and computer-based methods of increasing the binding affinity thereof
EP2305027B1 (en) * 1996-12-03 2014-07-02 Amgen Fremont Inc. Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom
DK0999853T3 (da) 1997-06-13 2003-04-22 Genentech Inc Stabiliseret antostofformulering
SI1079843T1 (sl) 1998-05-22 2007-10-31 Bpys Town Nat Res Hospital Uporaba inhibitorjev receptorja alfa1beta1-integrina in inhibitorjev TGF-beta1 pri zdravljenju ledvične bolezni
DE19831710A1 (de) 1998-07-15 2000-01-20 Merck Patent Gmbh Diacylhydrazinderivate
JP2003513005A (ja) 1998-10-06 2003-04-08 バイオジェン インコーポレイテッド α1β1インテグリンI−ドメインの結晶およびそれらの使用
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
EE05662B1 (et) * 1999-04-22 2013-06-17 Biogen, Inc. Fibroosi ravimise kompositsioon, mis kasutab integriin alfa-4 subhiku antagonisti ja selle kompositsiooni kasutamine
DK1488806T3 (en) * 1999-06-01 2016-02-08 Biogen Ma Inc Blocking monoclonal antibody to VLA-1 and its use in the treatment of vascular disorders
JP2003502094A (ja) 1999-06-17 2003-01-21 デジンガー カイ 侵害を最小限にした組織採取のための外科用ゾンデ
US20060115473A1 (en) * 2000-12-14 2006-06-01 Biogen Idec Ma Inc., A Massachusetts Corporation Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists
EP1242118B1 (en) * 1999-12-16 2009-11-11 Biogen Idec MA Inc. Methods of treating central nervous system ischemic or hemorrhagic injury using anti alpha4 integrin antagonists
WO2001073444A2 (en) 2000-03-28 2001-10-04 Cambridge University Technical Services Limited Receptor/peptide crystal structure for identification of inhibitors
US8288322B2 (en) * 2000-04-17 2012-10-16 Dyax Corp. Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries
AU2001257331A1 (en) 2000-04-28 2001-11-12 Sangamo Biosciences, Inc. Methods for designing exogenous regulatory molecules
DE10028402A1 (de) 2000-06-13 2001-12-20 Merck Patent Gmbh Pyridin-2-yl-aminoalkycarbonylglycyl-beta-alanin und Derivate
US7153944B2 (en) 2000-07-31 2006-12-26 The General Hospital Corporation High affinity integrin polypeptides and uses thereof
CZ303450B6 (cs) * 2001-04-13 2012-09-19 Biogen Idec Ma Inc. Protilátky k VLA-1, kompozice je obsahující a nukleové kyseliny, které je kódují, zpusob stanovení hladiny VLA-1 a použití pri lécení imunologického onemocnení
EP1572902B1 (en) 2002-02-01 2014-06-11 Life Technologies Corporation HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
WO2003068262A1 (en) * 2002-02-14 2003-08-21 Biogen, Inc. Alpha1beta1 antagonists for treatment of atherosclerosis
WO2003093430A2 (en) 2002-05-03 2003-11-13 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for use in preparing sirnas
AU2003248982B2 (en) * 2002-08-01 2009-12-10 Immunomedics, Inc. Alpha-fetoprotein immu31 antibodies and fusion proteins and methods of use thereof
ATE435303T1 (de) 2002-08-12 2009-07-15 New England Biolabs Inc Verfahren und zusammensetzungen in verbindung mit gen-silencing
US20040208870A1 (en) 2003-01-30 2004-10-21 Medimmune, Inc. Stabilized high concentration anti-integrin alphanubeta3 antibody formulations
WO2005019200A2 (en) * 2003-08-14 2005-03-03 Icos Corporation Aryl piperidine derivatives as vla-1 integrin antagonists and uses thereof
WO2005019177A1 (en) * 2003-08-14 2005-03-03 Icos Corporation Aminopiperidine amide derivatives as vla-1 integrin antagonists and uses thereof
JP2008513477A (ja) * 2004-09-16 2008-05-01 バイロゲノミックス インコーポレイテッド 虚血の治療方法
US7285530B2 (en) * 2004-10-21 2007-10-23 Viron Therapeutics, Inc. Use of SERP-1 as an antiplatelet agent
WO2006124269A2 (en) * 2005-05-16 2006-11-23 Amgen Fremont Inc. Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
WO2006133286A2 (en) 2005-06-07 2006-12-14 Tel Hashomer Medical Research Infrastructure And Services Ltd. Treatment of tnf antagonist-resistant inflammatory disorders and related methods
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
MY149159A (en) * 2005-11-15 2013-07-31 Hoffmann La Roche Method for treating joint damage
US20080118496A1 (en) * 2006-04-10 2008-05-22 Medich John R Uses and compositions for treatment of juvenile rheumatoid arthritis
JO3324B1 (ar) 2006-04-21 2019-03-13 Amgen Inc مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية
ES2509878T3 (es) 2006-05-25 2014-10-20 Biogen Idec Ma Inc. Anticuerpo anti-VLA-1 para tratar accidente cerebrovascular
JP4951596B2 (ja) * 2008-07-31 2012-06-13 株式会社日立製作所 冷却システム及び電子装置
AR076640A1 (es) 2009-03-06 2011-06-29 Genentech Inc Formulacion con anticuerpo. metodo para estabilizar anticuerpo. articulo de manufactura
ES2765657T3 (es) 2009-12-21 2020-06-10 Hoffmann La Roche Formulación farmacéutica de bevacizumab
EP2670438A4 (en) 2011-02-03 2015-05-20 Santarus Inc SELECTION AND TREATMENT OF PATIENTS
US9018035B2 (en) 2012-01-11 2015-04-28 Panasonic Intellectual Property Management Co., Ltd. Pressed-contact type semiconductor device and method for manufacturing the same
WO2015003156A1 (en) * 2013-07-05 2015-01-08 Biogen Idec Ma Inc. Compositions and methods for treatment of stroke

Also Published As

Publication number Publication date
EP2034830A4 (en) 2010-12-29
US20100233159A1 (en) 2010-09-16
JP2017222719A (ja) 2017-12-21
EP2839843B1 (en) 2018-06-20
WO2007140249A1 (en) 2007-12-06
CN101494978A (zh) 2009-07-29
ES2685802T3 (es) 2018-10-11
JP6445997B2 (ja) 2018-12-26
MX2008014793A (es) 2008-12-02
DK2034830T3 (da) 2014-10-27
ES2509878T3 (es) 2014-10-20
EP2034830B1 (en) 2014-09-03
AU2007267579B2 (en) 2013-05-30
CN105381459A (zh) 2016-03-09
JP5970027B2 (ja) 2016-08-17
EP2839843A1 (en) 2015-02-25
BRPI0712607A2 (pt) 2012-08-14
JP5496658B2 (ja) 2014-05-21
PL2034830T3 (pl) 2015-04-30
HK1207576A1 (en) 2016-02-05
JP2014196348A (ja) 2014-10-16
US10119979B2 (en) 2018-11-06
US20210018519A1 (en) 2021-01-21
JP2013082732A (ja) 2013-05-09
JP2009538346A (ja) 2009-11-05
US20190101546A1 (en) 2019-04-04
CA2652815C (en) 2015-12-15
CA2652815A1 (en) 2007-12-06
JP2016138147A (ja) 2016-08-04
BRPI0712607A8 (pt) 2019-06-04
EP2034830A1 (en) 2009-03-18
AU2007267579A1 (en) 2007-12-06
JP5801281B2 (ja) 2015-10-28

Similar Documents

Publication Publication Date Title
PL2034830T3 (pl) Przeciwciało anty-VLA-1 do leczenia udaru
EP2006379A4 (en) HIGHLY FUNCTIONAL BISPECIFIC ANTIBODY
AP2009004853A0 (en) Improved reciprocating devices
IL197914A (en) Antibodies to ereg for cancer treatment
GB0615662D0 (en) Antibody
ZA200904022B (en) Monoclonal antibodies against ANGPTL3
EP2076614A4 (en) SYNTHETIC ANTIBODIES
HK1146728A1 (en) Modified antibody constant region
IL194113A (en) Combinations of stroke treatment materials
IL197487A0 (en) Improved immunoassay methods
PL2011869T3 (pl) Nowe przeciwciało anty-CD98
HK1136970A1 (en) Penta-specific antibody
EP1942281A4 (en) CYLINDER DEVICE
EP2138576A4 (en) ANTI-CLAUDIN-4 ANTIBODY
EP2172483A4 (en) ANTI-MUC17 ANTIBODY
EP1860120A4 (en) PROCESS FOR AN IMPROVED ANTIBODY
IL205073A0 (en) Anti-bst2 antibody
IL194993A0 (en) Warfarin dosage prediction
EP2029172A4 (en) ANTI-C35 ANTIBODIES FOR THE TREATMENT OF CANCER
HK1119755A1 (en) Brake cylinder
EP2015785A4 (en) ANTIGEN AGRM2
PT2444812E (pt) Métodos de imunoensaio melhorados
GB0606276D0 (en) Antibodies
GB0607376D0 (en) Antibodies
TWM291932U (en) Forming structure for crank