YU48416B - Novi derivati hidroksamske kiseline i n-hidroksikarbamida i postupci za njihovo dobijanje - Google Patents

Novi derivati hidroksamske kiseline i n-hidroksikarbamida i postupci za njihovo dobijanje

Info

Publication number
YU48416B
YU48416B YU186291A YU186291A YU48416B YU 48416 B YU48416 B YU 48416B YU 186291 A YU186291 A YU 186291A YU 186291 A YU186291 A YU 186291A YU 48416 B YU48416 B YU 48416B
Authority
YU
Yugoslavia
Prior art keywords
hydroxamic acid
derivatives
hydroxycarbamide
procedures
production
Prior art date
Application number
YU186291A
Other languages
English (en)
Other versions
YU186291A (sh
Inventor
Ikeda
Kawai
Mano
Okumura
Stevens
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=18158900&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU48416(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU186291A publication Critical patent/YU186291A/sh
Publication of YU48416B publication Critical patent/YU48416B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/64—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups singly-bound to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/59—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/46—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms
    • C07C323/47—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having at least one of the nitrogen atoms, not being part of nitro or nitroso groups, further bound to other hetero atoms to oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

NOVI DERIVATI HIDROKSAMSKE KISELINE I N-HIDROKSIKARBAMIDA I POSTUPCI ZA NJIHOVO DOBIJANJE, sto n predstavlja O ili 1, m je O do 3, p je 1 do 6, q je 1 ili 2, R1 je vodonik, C1 do C4 alkil, C2 do C4 alkenil, alkiltioalkil, alkoksialkil ili NR2R3 gde R2 i R3 su svaki, nezavisno, vodonik, C1 do C4 alkil, hidroksi, aril, ili supstituisan aril gde je supstituent, odnosno supstituenti odabrani iz grupe koju sacinjavaju halo, nitro, cijano, C1 do C12 alkil, C1 do C12 alkoksi, C1 do C12 halosupstituisani alkil, C1 do C12 hidroksisupstituisani alkil, C1 do C12 alkoksikarbonil, aminokarbonil, C1 do C12 alkilaminokarbonil, C1 do C12 dialkilaminokarbonil i C1 do C12 alkilsulfonil; pod uslovom sto R2 i R3 nisu oba hidroksi; R4 je vodonik, farmaceutski prihvatljiv katjon, aroil, ili C1 do C6 alkoil; A je C1 do C6 alkilen ili C2 do C6 alkenilen; B je svaki, nezavisno, halo, nitro, cijano, -SH, -OH, C1-C6 halosupstituisani alkil, C1 do C6 alkil, C2 do C6 alkenil, C1 do C6 alkoksi, C1 do C6 tioalkil, C1 do C12 aminokarbonil, C1 do C6 alkilaminokarbonil, C1 do C6 dialkilaminokarbonil, C2 do C12 alkoksialkil; AR je svako, nezavisno, fenil, naftil, piridil, hinolil, tienil, furil ili fenoksifenil ili njihovi supstituisani derivati; gde supstituent odnosno supstituenti su odabrani iz grupe koju sacinjavaju hidroksi, halo, nitro, cijano, C1 - C12 alkil, C1 - C12 alkoksi, C1 -C12 halosupstituisani alkil, C1 - C12 hidroksisupstituisani alkil, C1 - C12 alkilamino, C1 - C12 dialkilamino, C1 - C12 alkoksikarbonil, aminokarbonil, C1 do C12 alkilaminokarbonil, C1 do C12 dialkilaminokarbonil i C1 do C12 alkilsulfonil; B, Ar i vezujuca grupa A mogu biti vezani za bilo koji raspoloziv polozaj u prstenu; Ar i B uzeti zajedno sa atomima ugljenika za koji su vezani mogu obrazovati prsten i tackasta linija u hemijskoj formuli predstavlja opciono prostu ili dvogubu vezu. - Prijava sadrzi jos 1 nezavisan i 10 zavisnih zahteva.
YU186291A 1990-11-27 1991-11-26 Novi derivati hidroksamske kiseline i n-hidroksikarbamida i postupci za njihovo dobijanje YU48416B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2323814A JP3007138B2 (ja) 1990-11-27 1990-11-27 新規なヒドロキサム酸とｎ―ヒドロキシ尿素誘導体およびそれらの組成物

Publications (2)

Publication Number Publication Date
YU186291A YU186291A (sh) 1994-01-20
YU48416B true YU48416B (sh) 1998-07-10

Family

ID=18158900

Family Applications (1)

Application Number Title Priority Date Filing Date
YU186291A YU48416B (sh) 1990-11-27 1991-11-26 Novi derivati hidroksamske kiseline i n-hidroksikarbamida i postupci za njihovo dobijanje

Country Status (32)

Country Link
US (1) US6291520B1 (sh)
EP (1) EP0559743B1 (sh)
JP (1) JP3007138B2 (sh)
KR (1) KR100192722B1 (sh)
CN (1) CN1029230C (sh)
AT (1) ATE119520T1 (sh)
AU (1) AU653763B2 (sh)
BR (1) BR9107124A (sh)
CA (1) CA2094137C (sh)
CZ (1) CZ281345B6 (sh)
DE (2) DE69108048T2 (sh)
DK (1) DK0559743T3 (sh)
EG (1) EG20001A (sh)
ES (1) ES2069410T3 (sh)
FI (1) FI932390A0 (sh)
GR (1) GR3015879T3 (sh)
HU (1) HU221975B1 (sh)
IE (1) IE64963B1 (sh)
IL (1) IL100100A (sh)
MX (1) MX9102209A (sh)
MY (1) MY107341A (sh)
NO (1) NO179582C (sh)
NZ (1) NZ240737A (sh)
PL (1) PL167584B1 (sh)
PT (1) PT99597B (sh)
RU (1) RU2104267C1 (sh)
SK (1) SK282645B6 (sh)
TW (1) TW262461B (sh)
UA (1) UA39166C2 (sh)
WO (1) WO1992009566A1 (sh)
YU (1) YU48416B (sh)
ZA (1) ZA919317B (sh)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU660277B2 (en) * 1990-03-27 1995-06-22 Smithkline Beecham Corporation 5-lipoxygenase inhibitors
US5639782A (en) * 1992-03-04 1997-06-17 Center For Innovative Technology Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors
JPH05294921A (ja) * 1992-04-17 1993-11-09 Pfizer Pharmaceut Co Ltd 新規なフェニル置換シクロアルキル尿素誘導体および組成物
US5326787A (en) * 1992-05-12 1994-07-05 Abbott Laboratories Cycloalkyl N-hydroxy derivatives having lipoxygenase inhibitory activity
US5434151A (en) * 1992-08-24 1995-07-18 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5463083A (en) * 1992-07-13 1995-10-31 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
CA2140034A1 (en) 1992-07-13 1994-01-20 Xiong Cai 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders
US5648486A (en) * 1992-07-13 1997-07-15 Cytomed, Inc. Compounds and methods for the treatment of inflammatory and immune disorders
US5358938A (en) * 1992-07-13 1994-10-25 Cytomed, Inc. Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase
US5552419A (en) * 1993-01-06 1996-09-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5506242A (en) * 1993-01-06 1996-04-09 Ciba-Geigy Corporation Arylsufonamido-substituted hydroxamic acids
US5455258A (en) * 1993-01-06 1995-10-03 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamic acids
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
WO1994018158A1 (en) * 1993-02-15 1994-08-18 Pfizer Inc. Spiroalkylhydroxyureas for use as lipoxygenase inhibitors
DE69411003T2 (de) * 1993-04-07 1998-10-08 Pfizer Inc., New York, N.Y. Cycloalkylhydroxyharnstoffe und ihre verwendung als lipoxy-genase-inhibitoren
DE69421183T2 (de) * 1993-07-20 2000-01-20 Pfizer Inc., New York Heteroaryl-cyloalkenyl-hydroxy-harnstoeffe
TW448144B (en) * 1993-08-19 2001-08-01 Pfizer Phenoxyphenyl cyclopentenyl hydroxyureas
AU1120795A (en) * 1993-12-22 1995-07-10 Pfizer Inc. Phenylthiophenyl cycloalkenyl hydroxyureas as lipoxygenase inhibitors
US5750565A (en) * 1995-05-25 1998-05-12 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5792776A (en) * 1994-06-27 1998-08-11 Cytomed, Inc., Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
US5703093A (en) * 1995-05-31 1997-12-30 Cytomed, Inc. Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders
ATE184272T1 (de) * 1994-11-10 1999-09-15 Pfizer Aryloxycycloalkenyl- und aryloxyiminocycloalkenyl-hydroxyharnstoffe mit 5-lipoxygenase inhibierender wirkung
CN1059669C (zh) * 1994-11-10 2000-12-20 辉瑞大药厂 芳氧基环烯基－和芳氧基亚氨基环烯基羟基脲类化合物
WO1996016054A1 (en) * 1994-11-18 1996-05-30 Pfizer Pharmaceuticals Inc. Cycloalkenyl-n-hydroxyureas
JP3322885B2 (ja) * 1995-02-02 2002-09-09 日研化学株式会社 Ｎ−ヒドロキシウレア誘導体
CA2176854A1 (en) * 1995-06-07 1996-12-08 Daniel J. Keavy N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics
US6828460B2 (en) 1999-03-22 2004-12-07 Pfizer Inc. Resorcinol derivatives
EP1418173A1 (en) * 1999-03-26 2004-05-12 Ucb, S.A. N-(3-butyn-1-yl) N-hydroxyurea
US6521619B2 (en) 2000-06-29 2003-02-18 Icos Corporation Aryl phenylcyclopropyl sulfide derivatives and their use as cell adhesion inhibiting anti-inflammatory and immune suppressive agents
US20040029893A1 (en) * 2002-07-23 2004-02-12 Lane Edward M. Method of treatment of non-invasive mucositis
US20070078116A1 (en) * 2003-08-20 2007-04-05 Fairfield Clinical Trials, Llc Method of treatment of otitis externa
US20050159369A1 (en) * 2003-08-20 2005-07-21 Qtm Llc Method of treatment of otitis externa
US20050043251A1 (en) * 2003-08-20 2005-02-24 Fairfield Clinical Trials, Llc Method of treatment of otitis externa
KR100786479B1 (ko) 2006-09-22 2007-12-17 삼성에스디아이 주식회사 평판표시장치 및 이를 이용한 휴대용 표시기기
MX2009012685A (es) 2007-05-31 2009-12-14 Sepracor Inc Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.
ES2475737T3 (es) * 2009-10-16 2014-07-11 Syngenta Participations Ag Nuevos microbiocidas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU201300B (en) 1985-03-16 1990-10-28 Wellcome Found Process for production of derivatives of aryl and medical compositions containing them as active substance
DE3888574T2 (de) 1987-04-24 1994-06-30 Abbott Lab Harnstoff-Derivate mit lipoxygenasehemmender Wirkung.
GB8830427D0 (en) 1988-12-30 1989-03-01 Fujisawa Pharmaceutical Co New hydroxylamine derivatives,a process for the preparation thereof and pharmaceutical composition comprising the same
US5120752A (en) 1989-12-28 1992-06-09 Abbott Laboratories Cyclopropyl derivative lipoxygenase inhibitors
GB9025514D0 (en) 1990-11-23 1991-01-09 Wellcome Found Anti-inflammatory compounds
DE4124345A1 (de) * 1991-07-23 1993-01-28 Gruenenthal Gmbh Substituierte 3,4-dihydronaphthaline, diese verbindungen enthaltende arzneimittel und verfahren zur herstellung dieser verbindungen und arzneimittel
US5187192A (en) 1992-03-13 1993-02-16 Abbott Laboratories Cyclobutyl derivatives having lipoxygenase inhibitory activity

Also Published As

Publication number Publication date
RU2104267C1 (ru) 1998-02-10
SK282645B6 (sk) 2002-10-08
ES2069410T3 (es) 1995-05-01
CA2094137C (en) 2002-07-09
NZ240737A (en) 1994-07-26
DE9190171U1 (de) 1993-08-12
PT99597A (pt) 1992-10-30
NO179582B (no) 1996-07-29
PL167584B1 (pl) 1995-09-30
UA39166C2 (uk) 2001-06-15
HU221975B1 (hu) 2003-03-28
JP3007138B2 (ja) 2000-02-07
HU9301550D0 (en) 1993-09-28
EP0559743A1 (en) 1993-09-15
FI932390A (fi) 1993-05-26
ATE119520T1 (de) 1995-03-15
YU186291A (sh) 1994-01-20
JPH04193857A (ja) 1992-07-13
DK0559743T3 (da) 1995-07-03
NO931921L (no) 1993-05-26
CZ99093A3 (en) 1994-07-13
NO179582C (no) 1996-11-06
DE69108048T2 (de) 1995-07-06
US6291520B1 (en) 2001-09-18
FI932390A0 (fi) 1993-05-26
MY107341A (en) 1995-11-30
CA2094137A1 (en) 1992-05-28
IL100100A0 (en) 1992-08-18
MX9102209A (es) 1992-06-01
WO1992009566A1 (en) 1992-06-11
CN1061775A (zh) 1992-06-10
HUT67436A (en) 1995-04-28
GR3015879T3 (en) 1995-07-31
IL100100A (en) 1998-03-10
CZ281345B6 (cs) 1996-08-14
TW262461B (sh) 1995-11-11
AU653763B2 (en) 1994-10-13
IE64963B1 (en) 1995-09-20
CN1029230C (zh) 1995-07-05
EG20001A (en) 1997-03-27
NO931921D0 (no) 1993-05-26
ZA919317B (en) 1993-05-26
IE914101A1 (en) 1992-06-03
BR9107124A (pt) 1993-11-09
EP0559743B1 (en) 1995-03-08
PT99597B (pt) 2000-08-31
AU9053591A (en) 1992-06-25
SK54793A3 (en) 1993-10-06
KR100192722B1 (ko) 1999-06-15
DE69108048D1 (de) 1995-04-13

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