YU46087B - Postupak za dobijanje analoga rebekamicina - Google Patents

Postupak za dobijanje analoga rebekamicina

Info

Publication number
YU46087B
YU46087B YU208687A YU208687A YU46087B YU 46087 B YU46087 B YU 46087B YU 208687 A YU208687 A YU 208687A YU 208687 A YU208687 A YU 208687A YU 46087 B YU46087 B YU 46087B
Authority
YU
Yugoslavia
Prior art keywords
group
alkyl
rebecamycin
alkoxycarbonyl
mono
Prior art date
Application number
YU208687A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU208687A (en
Inventor
T. Kaneko
H.S. Wong
J.J. Utzig
Original Assignee
Bristol-Myers Company New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Company New York filed Critical Bristol-Myers Company New York
Publication of YU208687A publication Critical patent/YU208687A/xx
Publication of YU46087B publication Critical patent/YU46087B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
YU208687A 1986-11-21 1987-11-18 Postupak za dobijanje analoga rebekamicina YU46087B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/933,428 US4785085A (en) 1986-11-21 1986-11-21 Rebeccamycin analogs

Publications (2)

Publication Number Publication Date
YU208687A YU208687A (en) 1988-10-31
YU46087B true YU46087B (sh) 1992-12-21

Family

ID=25463937

Family Applications (1)

Application Number Title Priority Date Filing Date
YU208687A YU46087B (sh) 1986-11-21 1987-11-18 Postupak za dobijanje analoga rebekamicina

Country Status (28)

Country Link
US (1) US4785085A (https=)
EP (1) EP0269025B1 (https=)
JP (1) JPS63198695A (https=)
KR (1) KR910000897B1 (https=)
CN (1) CN1019806B (https=)
AT (1) ATE84539T1 (https=)
AU (1) AU614068B2 (https=)
CA (1) CA1287349C (https=)
CS (1) CS265248B2 (https=)
CY (1) CY1701A (https=)
DE (1) DE3783577T2 (https=)
DK (1) DK165986C (https=)
EG (1) EG18409A (https=)
ES (1) ES2053510T3 (https=)
FI (1) FI86189C (https=)
GR (1) GR3006776T3 (https=)
HK (1) HK49093A (https=)
HU (1) HU201773B (https=)
IE (1) IE60595B1 (https=)
IL (1) IL84515A (https=)
MX (1) MX9202849A (https=)
MY (1) MY102722A (https=)
NO (1) NO167741C (https=)
NZ (1) NZ222544A (https=)
PT (1) PT86188B (https=)
SG (1) SG25193G (https=)
YU (1) YU46087B (https=)
ZA (1) ZA878714B (https=)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
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JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5496809A (en) * 1989-05-10 1996-03-05 Bristol-Myers Squibb Co Stable solutions of rebeccamycin analog
US5344823A (en) * 1990-03-06 1994-09-06 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41219
CA2037596C (en) * 1990-03-06 1995-07-18 Kin Sing Lam Rebeccamycin analog by bromide precursor feeding
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
US5158938A (en) * 1990-03-06 1992-10-27 Bristol-Myers Squibb Company Rebeccamycin
US5478813A (en) * 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
JP3064416B2 (ja) * 1990-05-11 2000-07-12 萬有製薬株式会社 抗腫瘍性物質ｂｅ―１３７９３ｃ誘導体
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5547976A (en) * 1992-03-20 1996-08-20 Burroughs Wellcome Co. Further indole derivatives with antiviral activity
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
DK0657411T3 (da) * 1993-12-07 1999-11-15 Lilly Co Eli Forbedret syntese af bisindolylmaleimider
NO308798B1 (no) * 1993-12-07 2000-10-30 Lilly Co Eli Proteinkinase-C-hemmere, anvendelse av samme for fremstilling av farmasøytika samt farmasøytisk formulering omfattende samme
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
ES2236702T3 (es) * 1993-12-23 2005-07-16 Eli Lilly And Company Inhibidores de la proteina quinasa c.
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
EP0769555B1 (en) * 1994-06-13 2003-09-03 Banyu Pharmaceutical Co., Ltd. Gene coding for glycosyltransferase and use thereof
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
DK0695755T3 (da) * 1994-08-04 1999-06-28 Hoffmann La Roche Pyrrolocarbazoler
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
EP0888339A4 (en) * 1996-03-20 2001-02-28 Lilly Co Eli SYNTHESIS OF INDOLYLMALEINIMIDES
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) * 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
KR20030085035A (ko) 2001-03-22 2003-11-01 브리스톨-마이어스스퀴브컴파니 토포아이소머라아제 ｉ 선택성 세포독성인돌로피롤로카바졸 당 유도체
JP4202250B2 (ja) 2001-07-25 2008-12-24 バイオマリン ファーマシューティカル インコーポレイテッド 血液脳関門輸送を調節するための組成物および方法
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
EP1666485A1 (en) * 2003-09-16 2006-06-07 Banyu Pharmaceutical Co., Ltd. Novel indolopyrrolocarbazole derivative with antitumor activity
EP2671507A3 (en) 2005-04-28 2014-02-19 Proteus Digital Health, Inc. Pharma-informatics system
MX2009002893A (es) 2006-09-18 2009-07-10 Raptor Pharmaceutical Inc Tratamiento de trastornos hepaticos mediante la administracion de conjugados de la proteina asociada al receptor (rap).
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
CA2752373C (en) 2009-02-20 2017-10-10 To-Bbb Holding B.V. Glutathione-based drug delivery system
IL255113B (en) 2009-05-06 2022-09-01 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102125578B (zh) * 2010-11-24 2013-03-27 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102898489B (zh) * 2010-11-24 2014-04-02 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１

Also Published As

Publication number Publication date
DK612987A (da) 1988-05-22
JPS63198695A (ja) 1988-08-17
AU614068B2 (en) 1991-08-22
SG25193G (en) 1993-05-21
FI875091A0 (fi) 1987-11-18
ATE84539T1 (de) 1993-01-15
CS265248B2 (en) 1989-10-13
NO874857L (no) 1988-05-24
EP0269025A3 (en) 1990-08-29
HU201773B (en) 1990-12-28
ZA878714B (https=) 1988-05-20
FI86189B (fi) 1992-04-15
MY102722A (en) 1992-09-30
NZ222544A (en) 1990-11-27
DK165986B (da) 1993-02-22
KR880006246A (ko) 1988-07-22
FI86189C (fi) 1992-07-27
EG18409A (en) 1993-02-28
HK49093A (en) 1993-05-27
NO167741C (no) 1991-12-04
ES2053510T3 (es) 1994-08-01
CN87107928A (zh) 1988-08-10
CA1287349C (en) 1991-08-06
EP0269025B1 (en) 1993-01-13
DK165986C (da) 1993-07-19
NO874857D0 (no) 1987-11-20
DK612987D0 (da) 1987-11-20
AU8114887A (en) 1988-05-26
DE3783577T2 (de) 1993-05-19
CS824987A2 (en) 1989-01-12
IE873152L (en) 1988-05-21
IE60595B1 (en) 1994-07-27
US4785085A (en) 1988-11-15
KR910000897B1 (ko) 1991-02-12
DE3783577D1 (de) 1993-02-25
FI875091A7 (fi) 1988-05-22
NO167741B (no) 1991-08-26
GR3006776T3 (https=) 1993-06-30
IL84515A0 (en) 1988-04-29
IL84515A (en) 1991-11-21
PT86188A (en) 1987-12-01
YU208687A (en) 1988-10-31
EP0269025A2 (en) 1988-06-01
CN1019806B (zh) 1992-12-30
MX9202849A (es) 1992-06-30
CY1701A (en) 1994-01-14
PT86188B (pt) 1990-11-07
HUT45543A (en) 1988-07-28
JPH05400B2 (https=) 1993-01-05

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