JPS63198695A - レベカマイシン類似体 - Google Patents

レベカマイシン類似体

Info

Publication number
JPS63198695A
JPS63198695A JP62293854A JP29385487A JPS63198695A JP S63198695 A JPS63198695 A JP S63198695A JP 62293854 A JP62293854 A JP 62293854A JP 29385487 A JP29385487 A JP 29385487A JP S63198695 A JPS63198695 A JP S63198695A
Authority
JP
Japan
Prior art keywords
alkyl
formula
rebecamycin
alkoxy
alkoxycarbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62293854A
Other languages
English (en)
Japanese (ja)
Other versions
JPH05400B2 (https=
Inventor
タクシ　カネコ
ヘンリ　エス　ウォン
ジェイコブ　ジェイ　ウッツィグ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of JPS63198695A publication Critical patent/JPS63198695A/ja
Publication of JPH05400B2 publication Critical patent/JPH05400B2/ja
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Plant Substances (AREA)
JP62293854A 1986-11-21 1987-11-20 レベカマイシン類似体 Granted JPS63198695A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/933,428 US4785085A (en) 1986-11-21 1986-11-21 Rebeccamycin analogs
US933428 1992-08-21

Publications (2)

Publication Number Publication Date
JPS63198695A true JPS63198695A (ja) 1988-08-17
JPH05400B2 JPH05400B2 (https=) 1993-01-05

Family

ID=25463937

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62293854A Granted JPS63198695A (ja) 1986-11-21 1987-11-20 レベカマイシン類似体

Country Status (28)

Country Link
US (1) US4785085A (https=)
EP (1) EP0269025B1 (https=)
JP (1) JPS63198695A (https=)
KR (1) KR910000897B1 (https=)
CN (1) CN1019806B (https=)
AT (1) ATE84539T1 (https=)
AU (1) AU614068B2 (https=)
CA (1) CA1287349C (https=)
CS (1) CS265248B2 (https=)
CY (1) CY1701A (https=)
DE (1) DE3783577T2 (https=)
DK (1) DK165986C (https=)
EG (1) EG18409A (https=)
ES (1) ES2053510T3 (https=)
FI (1) FI86189C (https=)
GR (1) GR3006776T3 (https=)
HK (1) HK49093A (https=)
HU (1) HU201773B (https=)
IE (1) IE60595B1 (https=)
IL (1) IL84515A (https=)
MX (1) MX9202849A (https=)
MY (1) MY102722A (https=)
NO (1) NO167741C (https=)
NZ (1) NZ222544A (https=)
PT (1) PT86188B (https=)
SG (1) SG25193G (https=)
YU (1) YU46087B (https=)
ZA (1) ZA878714B (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
WO2005026185A1 (ja) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. 抗腫瘍性新規インドロピロロカルバゾール誘導体

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
CA2015996C (en) * 1989-05-05 2001-08-28 Hartmut Osswald Bis-(1h-indol-3-yl)-maleinimide derivatives and their use as pharmaceuticals
US5496809A (en) * 1989-05-10 1996-03-05 Bristol-Myers Squibb Co Stable solutions of rebeccamycin analog
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Rebeccamycin analogs, their production and pharmaceutical compositions containing them
JPH0725787B2 (ja) * 1990-03-06 1995-03-22 ブリストル−マイヤーズ スクイブ カンパニー 臭化物前駆物質物質供給によるレベカマイシン類似体
US5158938A (en) * 1990-03-06 1992-10-27 Bristol-Myers Squibb Company Rebeccamycin
US5344823A (en) * 1990-03-06 1994-09-06 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41219
US5478813A (en) * 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
EP0528030B1 (en) * 1990-05-11 1997-09-17 Banyu Pharmaceutical Co., Ltd. Antitumor be-13793c derivative
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5547976A (en) * 1992-03-20 1996-08-20 Burroughs Wellcome Co. Further indole derivatives with antiviral activity
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
PT657458E (pt) * 1993-12-07 2002-02-28 Lilly Co Eli Inibidores de proteina cinase c
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
EP0657411B1 (en) * 1993-12-07 1999-06-09 Eli Lilly And Company Synthesis of bisindolylmaleimides
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
CA2179650C (en) * 1993-12-23 2007-10-30 William Francis Heath, Jr. Bisindolemaleimides and their use as protein kinase c inhibitors
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
DE69531686T2 (de) * 1994-06-13 2004-07-15 Banyu Pharmaceutical Co., Ltd. Glycosyltransferase kodierendes gen und seine verwendung
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
EP0695755B1 (en) * 1994-08-04 1998-10-21 F. Hoffmann-La Roche AG Pyrrolocarbazole
US5919946A (en) * 1996-03-20 1999-07-06 Eli Lilly And Company Synthesis of indolylmaleimides
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
US6653290B2 (en) 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
RU2003131269A (ru) 2001-03-22 2005-05-10 Бристол-Маерс Сквибб Компани (Us) Производные индолопирролокарбазолов и сахаров, цитотоксические и селективные по отношению к топоизомеразе i
AU2002322720B2 (en) 2001-07-25 2008-11-13 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
CA2789262C (en) 2005-04-28 2016-10-04 Proteus Digital Health, Inc. Pharma-informatics system
EP2063905B1 (en) 2006-09-18 2014-07-30 Raptor Pharmaceutical Inc Treatment of liver disorders by administration of receptor-associated protein (rap)-conjugates
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
TR201908314T4 (tr) 2009-02-20 2019-06-21 2 Bbb Medicines B V Glutatyon bazlı ilaç dağıtım sistemi.
KR101909711B1 (ko) 2009-05-06 2018-12-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102125578B (zh) * 2010-11-24 2013-03-27 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102898489B (zh) * 2010-11-24 2014-04-02 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995030682A1 (en) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyprolocarbazole derivative
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
WO2005026185A1 (ja) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. 抗腫瘍性新規インドロピロロカルバゾール誘導体

Also Published As

Publication number Publication date
YU208687A (en) 1988-10-31
AU8114887A (en) 1988-05-26
KR910000897B1 (ko) 1991-02-12
DK612987D0 (da) 1987-11-20
PT86188B (pt) 1990-11-07
FI86189C (fi) 1992-07-27
IE873152L (en) 1988-05-21
CN87107928A (zh) 1988-08-10
ES2053510T3 (es) 1994-08-01
PT86188A (en) 1987-12-01
FI875091A7 (fi) 1988-05-22
YU46087B (sh) 1992-12-21
IL84515A (en) 1991-11-21
CA1287349C (en) 1991-08-06
IE60595B1 (en) 1994-07-27
CS265248B2 (en) 1989-10-13
CY1701A (en) 1994-01-14
SG25193G (en) 1993-05-21
NO167741B (no) 1991-08-26
NO874857L (no) 1988-05-24
EP0269025A2 (en) 1988-06-01
DE3783577D1 (de) 1993-02-25
MX9202849A (es) 1992-06-30
HUT45543A (en) 1988-07-28
FI86189B (fi) 1992-04-15
NO874857D0 (no) 1987-11-20
ATE84539T1 (de) 1993-01-15
DK165986C (da) 1993-07-19
NO167741C (no) 1991-12-04
EP0269025A3 (en) 1990-08-29
ZA878714B (https=) 1988-05-20
FI875091A0 (fi) 1987-11-18
KR880006246A (ko) 1988-07-22
DK612987A (da) 1988-05-22
MY102722A (en) 1992-09-30
AU614068B2 (en) 1991-08-22
HK49093A (en) 1993-05-27
US4785085A (en) 1988-11-15
EG18409A (en) 1993-02-28
DK165986B (da) 1993-02-22
GR3006776T3 (https=) 1993-06-30
HU201773B (en) 1990-12-28
JPH05400B2 (https=) 1993-01-05
NZ222544A (en) 1990-11-27
DE3783577T2 (de) 1993-05-19
EP0269025B1 (en) 1993-01-13
IL84515A0 (en) 1988-04-29
CN1019806B (zh) 1992-12-30
CS824987A2 (en) 1989-01-12

Similar Documents

Publication Publication Date Title
JPS63198695A (ja) レベカマイシン類似体
US4808613A (en) Rebeccamycin derivative containing pharmaceutical composition
KR100312445B1 (ko) 트리플루오로메틸피롤로인돌카르복실산 에스테르 유도체의 제조방법
NZ245203A (en) 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
JPS5936999B2 (ja) ２′，３′−保護５′−デオキシ−５−フルオロシチジン及び−ウリジン
US3868373A (en) 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines
US4639454A (en) Phenylquinazolinecarboxylic acids and derivatives as cancer chemotherapeutic agents
WO1991018003A1 (fr) Derive antitumoral de be-13793c
EP0683788B1 (en) 3'-aziridino-anthracycline derivatives
US20080113927A1 (en) Indolopyrrolocarbazole derivatives and anti-tumor agent
JPH08509740A (ja) カンプトテシンの水溶性誘導体
NZ205669A (en) Anthracycline glycosides,intermediates,and pharmaceutical compositions
EP0378706B1 (en) 5-substituted uridine derivatives and intermediates for their preparation
US3691199A (en) 2-hydroxy-indole-3-dithiocarboxylates
EP0601520A1 (en) Trifluorothymidine derivatives, process for producing the same and anti-cancer agent containing the same
JP2655003B2 (ja) ５―置換ウリジン誘導体及びその製造中間体
US20060189800A1 (en) Indolopyrrolocabazole derivative and antitumor agent
JPH0631303B2 (ja) 新規な６位置換アルドヘキソピラノ−ス誘導体
GB2287463A (en) Bis-anthracycline derivatives
JPS6399071A (ja) マイトマイシン誘導体
JPS6270376A (ja) ジスルフイド化合物及び抗腫瘍剤