ZA878714B - - Google Patents

Info

Publication number
ZA878714B
ZA878714B ZA878714A ZA878714A ZA878714B ZA 878714 B ZA878714 B ZA 878714B ZA 878714 A ZA878714 A ZA 878714A ZA 878714 A ZA878714 A ZA 878714A ZA 878714 B ZA878714 B ZA 878714B
Authority
ZA
South Africa
Prior art keywords
alkyl
rebeccamycin
alkoxycarbonyl
carboxyl
mono
Prior art date
Application number
ZA878714A
Other languages
English (en)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of ZA878714B publication Critical patent/ZA878714B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/044—Pyrrole radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
ZA878714A 1986-11-21 1987-11-20 ZA878714B (xx)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/933,428 US4785085A (en) 1986-11-21 1986-11-21 Rebeccamycin analogs

Publications (1)

Publication Number Publication Date
ZA878714B true ZA878714B (xx) 1988-05-20

Family

ID=25463937

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA878714A ZA878714B (xx) 1986-11-21 1987-11-20

Country Status (28)

Country Link
US (1) US4785085A (xx)
EP (1) EP0269025B1 (xx)
JP (1) JPS63198695A (xx)
KR (1) KR910000897B1 (xx)
CN (1) CN1019806B (xx)
AT (1) ATE84539T1 (xx)
AU (1) AU614068B2 (xx)
CA (1) CA1287349C (xx)
CS (1) CS265248B2 (xx)
CY (1) CY1701A (xx)
DE (1) DE3783577T2 (xx)
DK (1) DK165986C (xx)
EG (1) EG18409A (xx)
ES (1) ES2053510T3 (xx)
FI (1) FI86189C (xx)
GR (1) GR3006776T3 (xx)
HK (1) HK49093A (xx)
HU (1) HU201773B (xx)
IE (1) IE60595B1 (xx)
IL (1) IL84515A (xx)
MX (1) MX9202849A (xx)
MY (1) MY102722A (xx)
NO (1) NO167741C (xx)
NZ (1) NZ222544A (xx)
PT (1) PT86188B (xx)
SG (1) SG25193G (xx)
YU (1) YU46087B (xx)
ZA (1) ZA878714B (xx)

Families Citing this family (51)

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JPH07113027B2 (ja) * 1987-12-24 1995-12-06 協和醗酵工業株式会社 Ｋ−２５２誘導体
US5438050A (en) * 1988-02-06 1995-08-01 Godecke Aktiengesellschaft Indolocarbazole derivatives, processes for their preparation and compositions containing them
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
US5015578A (en) * 1989-03-23 1991-05-14 Bristol-Myers Squibb Company BMY-41950 antitumor antibiotic
PT93947B (pt) * 1989-05-05 1996-11-29 Goedecke Ag Processo para a preparacao de novos derivados de maleinimidas e de composicoes farmaceuticas que os contem
US5496809A (en) * 1989-05-10 1996-03-05 Bristol-Myers Squibb Co Stable solutions of rebeccamycin analog
EP0445736A1 (en) * 1990-03-06 1991-09-11 Bristol-Myers Squibb Company Rebeccamycin analog and pharmaceutical composition containing it
US5344823A (en) * 1990-03-06 1994-09-06 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41219
US5158938A (en) * 1990-03-06 1992-10-27 Bristol-Myers Squibb Company Rebeccamycin
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them
WO1991018003A1 (en) * 1990-05-11 1991-11-28 Banyu Pharmaceutical Co., Ltd. Antitumor be-13793c derivative
US5478813A (en) * 1990-05-11 1995-12-26 Banyu Pharmaceutical Co., Ltd. Antitumor substance BE-13793C derivatives
NZ245203A (en) * 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5591842A (en) * 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5437996A (en) * 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5589365A (en) * 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
DE69323183T2 (de) * 1992-03-20 1999-05-27 Wellcome Found Weitere indolderivate mit antiviraler wirkung
JP3603322B2 (ja) * 1992-12-14 2004-12-22 萬有製薬株式会社 インドロピロロカルバゾール誘導体の製造法
ES2134910T3 (es) * 1993-12-07 1999-10-16 Lilly Co Eli Sintesis de bisindolilmaleimidas.
US5624949A (en) * 1993-12-07 1997-04-29 Eli Lilly And Company Protein kinase C inhibitors
US5723456A (en) * 1993-12-07 1998-03-03 Eli Lilly & Company Therapeutic treatment for cardiovascular diseases
US5541347A (en) * 1993-12-07 1996-07-30 Eli Lilly And Company Synthesis of bisindolylmaleimides
JP3581731B2 (ja) * 1993-12-07 2004-10-27 イーライ・リリー・アンド・カンパニー プロテインキナーゼｃ阻害物質
US5843935A (en) * 1993-12-07 1998-12-01 Eli Lilly And Company Protein kinase C inhibitors
US5545636A (en) * 1993-12-23 1996-08-13 Eli Lilly And Company Protein kinase C inhibitors
CA2179650C (en) * 1993-12-23 2007-10-30 William Francis Heath, Jr. Bisindolemaleimides and their use as protein kinase c inhibitors
WO1995030682A1 (fr) * 1994-05-09 1995-11-16 Banyu Pharmaceutical Co., Ltd. Derive d'indolopyrolocarbazole antitumoral
US5804564A (en) * 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5861293A (en) * 1994-06-13 1999-01-19 Banyu Pharmaceutical Co., Ltd. Gene encoding glycosyltransferase and its uses
US5491242A (en) * 1994-06-22 1996-02-13 Eli Lilly And Company Protein kinase C inhibitors
US5481003A (en) * 1994-06-22 1996-01-02 Eli Lilly And Company Protein kinase C inhibitors
ATE172463T1 (de) * 1994-08-04 1998-11-15 Hoffmann La Roche Pyrrolocarbazol
WO1997009339A1 (fr) * 1995-09-05 1997-03-13 Banyu Pharmaceutical Co., Ltd. Derives antitumoraux d'indolopyrrolocarbazole
AU2217797A (en) * 1996-03-20 1997-10-10 Eli Lilly And Company Synthesis of indolylmaleimides
US5859261A (en) * 1997-03-20 1999-01-12 Eli Lilly And Company Synthesis of indolylmaleimides
US6677450B2 (en) 2000-10-06 2004-01-13 Bristol-Myers Squibb Company Topoisomerase inhibitors
US6653290B2 (en) * 2000-10-06 2003-11-25 Bristol-Myers Squibb Company Tumor proliferation inhibitors
US6610727B2 (en) 2000-10-06 2003-08-26 Bristol-Myers Squibb Company Anhydro sugar derivatives of indolocarbazoles
SK12022003A3 (sk) 2001-03-22 2004-05-04 Bristol-Myers Squibb Company Na topoizomerázu I selektívne cytotoxické cukrové deriváty indolpyrolkarbazolov
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
CA2393720C (en) * 2002-07-12 2010-09-14 Eli Lilly And Company Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride
AU2004272457A1 (en) * 2003-09-16 2005-03-24 Banyu Pharmaceutical Co., Ltd. Novel indolopyrrolocarbazole derivative with antitumor activity
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
KR20090071598A (ko) 2006-09-18 2009-07-01 랩터 파마슈티컬 인코포레이티드 수용체 결합 단백질(ｒａｐ)-접합체 투여에 의한 간 질환의 치료
ES2326459B1 (es) 2008-04-08 2010-05-28 Universidad De Oviedo Indolocarbazoles glicosilados, su procedimiento de obtencion y sus usos.
EP2398500B1 (en) 2009-02-20 2019-03-13 2-BBB Medicines B.V. Glutathione-based drug delivery system
MY163048A (en) 2009-05-06 2017-08-15 Laboratory Skin Care Inc Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates
CN102898489B (zh) * 2010-11-24 2014-04-02 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法
CN102125578B (zh) * 2010-11-24 2013-03-27 河南师范大学 具有抗癌活性的蝴蝶霉素类似物及合成方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4552842A (en) * 1983-01-28 1985-11-12 Bristol-Myers Company Process for producing rebeccamycin
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
JPS62220196A (ja) * 1986-03-20 1987-09-28 Kyowa Hakko Kogyo Co Ltd 新規物質ｕｃｎ―０１

Also Published As

Publication number Publication date
DE3783577D1 (de) 1993-02-25
EG18409A (en) 1993-02-28
CA1287349C (en) 1991-08-06
FI86189C (fi) 1992-07-27
IE60595B1 (en) 1994-07-27
PT86188A (en) 1987-12-01
IL84515A (en) 1991-11-21
EP0269025A3 (en) 1990-08-29
DK612987A (da) 1988-05-22
EP0269025A2 (en) 1988-06-01
YU46087B (sh) 1992-12-21
CS824987A2 (en) 1989-01-12
MX9202849A (es) 1992-06-30
FI875091A (fi) 1988-05-22
HU201773B (en) 1990-12-28
NO874857L (no) 1988-05-24
DE3783577T2 (de) 1993-05-19
DK165986C (da) 1993-07-19
PT86188B (pt) 1990-11-07
ATE84539T1 (de) 1993-01-15
DK612987D0 (da) 1987-11-20
ES2053510T3 (es) 1994-08-01
HUT45543A (en) 1988-07-28
AU8114887A (en) 1988-05-26
SG25193G (en) 1993-05-21
CN87107928A (zh) 1988-08-10
IL84515A0 (en) 1988-04-29
DK165986B (da) 1993-02-22
NO874857D0 (no) 1987-11-20
US4785085A (en) 1988-11-15
EP0269025B1 (en) 1993-01-13
YU208687A (en) 1988-10-31
KR880006246A (ko) 1988-07-22
FI875091A0 (fi) 1987-11-18
HK49093A (en) 1993-05-27
MY102722A (en) 1992-09-30
JPH05400B2 (xx) 1993-01-05
KR910000897B1 (ko) 1991-02-12
IE873152L (en) 1988-05-21
JPS63198695A (ja) 1988-08-17
NO167741B (no) 1991-08-26
NO167741C (no) 1991-12-04
CN1019806B (zh) 1992-12-30
CS265248B2 (en) 1989-10-13
AU614068B2 (en) 1991-08-22
NZ222544A (en) 1990-11-27
FI86189B (fi) 1992-04-15
GR3006776T3 (xx) 1993-06-30
CY1701A (en) 1994-01-14

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