DE69323183T2 - Weitere indolderivate mit antiviraler wirkung - Google Patents

Weitere indolderivate mit antiviraler wirkung

Info

Publication number
DE69323183T2
DE69323183T2 DE69323183T DE69323183T DE69323183T2 DE 69323183 T2 DE69323183 T2 DE 69323183T2 DE 69323183 T DE69323183 T DE 69323183T DE 69323183 T DE69323183 T DE 69323183T DE 69323183 T2 DE69323183 T2 DE 69323183T2
Authority
DE
Germany
Prior art keywords
pct
derivatives
antiviral effect
sec
indolder derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69323183T
Other languages
English (en)
Other versions
DE69323183D1 (de
Inventor
Martin John Slater
George Stuart Cockerill
Edward Littler
Clive Leonard Yeates
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929206056A external-priority patent/GB9206056D0/en
Priority claimed from GB929206810A external-priority patent/GB9206810D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Application granted granted Critical
Publication of DE69323183D1 publication Critical patent/DE69323183D1/de
Publication of DE69323183T2 publication Critical patent/DE69323183T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
DE69323183T 1992-03-20 1993-03-19 Weitere indolderivate mit antiviraler wirkung Expired - Fee Related DE69323183T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929206056A GB9206056D0 (en) 1992-03-20 1992-03-20 Indole derivatives
GB929206810A GB9206810D0 (en) 1992-03-27 1992-03-27 Indole derivatives
PCT/GB1993/000571 WO1993018766A1 (en) 1992-03-20 1993-03-19 Further indole derivatives with antiviral activity

Publications (2)

Publication Number Publication Date
DE69323183D1 DE69323183D1 (de) 1999-03-04
DE69323183T2 true DE69323183T2 (de) 1999-05-27

Family

ID=26300559

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69323183T Expired - Fee Related DE69323183T2 (de) 1992-03-20 1993-03-19 Weitere indolderivate mit antiviraler wirkung

Country Status (9)

Country Link
US (1) US5547976A (de)
EP (1) EP0630242B1 (de)
JP (1) JPH07504674A (de)
AT (1) ATE175873T1 (de)
AU (1) AU685389B2 (de)
CA (1) CA2130836A1 (de)
DE (1) DE69323183T2 (de)
ES (1) ES2125976T3 (de)
WO (1) WO1993018766A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4217964A1 (de) * 1992-05-30 1993-12-02 Goedecke Ag Indolocarbazol-Imide und deren Verwendung
DE4243321A1 (de) * 1992-12-21 1994-06-23 Goedecke Ag Aminosäurederivate von Heterocyclen als PKC-Inhibitoren
GB9319297D0 (en) * 1993-09-17 1993-11-03 Wellcome Found Indole derivatives
CA2144940A1 (en) * 1994-03-18 1995-09-19 Chikara Murakata Therapeutic agent for thrombocytopenia and indolocarbazole derivatives
GB9416467D0 (en) * 1994-08-13 1994-10-05 Wellcome Found Compounds for use in medicine
FR2725371B1 (fr) * 1994-10-05 1997-08-29 Techni Pharma Nouveau procede de fabrication de suppositoires
US5808060A (en) * 1995-12-11 1998-09-15 Cephalon, Inc. Fused isoindolones
US5932618A (en) * 1996-11-04 1999-08-03 Signal Pharmaceuticals, Inc. Anti-viral agents and methods relating to the use thereof
EP1801591B1 (de) 1997-08-04 2016-12-28 Advanced Life Science Institute, Inc. Verfahren für den Nachweis oder die Messung von Viren
US6281356B1 (en) * 1999-12-22 2001-08-28 Hoffmann-La Roche Inc. Substituted pyrroles
ES2189597B2 (es) * 2000-07-18 2004-06-16 Fundacion Universitaria San Pablo-Ceu Derivados de 12,13-dihidro-5h-indolo(2,3-a)pirrolo(3,4-c)carbazol-5,7(6h)-diona como agentes antineoplasicos.
TWI335221B (en) 2001-09-27 2011-01-01 Alcon Inc Inhibtors of glycogen synthase kinase-3 (gsk-3) for treating glaucoma
DE10161940A1 (de) * 2001-12-17 2003-07-03 Nad Ag N-Carbacyclus-monosubstitutierte Indolocarbazole als Proteinkinase-inhibitoren
ES2292123T3 (es) * 2004-04-26 2008-03-01 Pfizer Inc. Inhibidores de la enzima integrasa de vih.
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
ITMI20091432A1 (it) * 2009-08-06 2011-02-07 Isagro Ricerca Srl Derivati dell'n-idrossimaleimmide ad elevata attivita' fungicida e relativo uso
EP3119768B1 (de) 2014-03-16 2019-07-31 Hadasit Medical Research Services And Development Ltd. 3,4-bromo oder -sulfonat-substituierte 1h-pyrrole-2,5-dion-derivate als type iii deiodinase (dio3) inhibitoren zur behandlung von depressionen und krebs
EP3741375A1 (de) 2014-07-17 2020-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Verfahren zur behandlung von erkrankungen in zusammenhang mit neuromuskulären verbindungen
WO2016207366A1 (en) 2015-06-26 2016-12-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of viral infections
CN106478643B (zh) * 2016-09-07 2018-07-10 河南师范大学 吲哚[2,3-a]吡咯[3,4-c]咔唑-5,7-二酮-6-芳腙类化合物及其制备方法和在抗癌药物中的应用
CN106432250B (zh) * 2016-09-07 2018-07-10 河南师范大学 具有抗癌活性的吲哚[2,3-a]吡咯[3,4-c]咔唑-5,7-二酮-6-缩氨基硫脲类化合物及其制备方法和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4487925A (en) * 1983-01-28 1984-12-11 Bristol-Myers Company Rebeccamycin and process for its preparation
US4567143A (en) * 1984-09-04 1986-01-28 Bristol-Myers Company Process for preparing 4'-deschlororebeccamycin
US4524145A (en) * 1984-09-04 1985-06-18 Bristol-Myers Company 4'-Deschlororebeccamycin pharmaceutical composition and method of use
US4743594A (en) * 1984-09-17 1988-05-10 Schering Corporation Antibiotic, antitumor compounds and their use
US4785085A (en) * 1986-11-21 1988-11-15 Bristol-Myers Company Rebeccamycin analogs
DE3803620A1 (de) * 1988-02-06 1989-08-17 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und diese enthaltende arzneimittel
DE3835842A1 (de) * 1988-10-21 1990-04-26 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung als arzneimittel
JP3010675B2 (ja) * 1989-03-23 2000-02-21 萬有製薬株式会社 抗腫瘍性物質ｂｅ―１３７９３ｃ
US5496809A (en) * 1989-05-10 1996-03-05 Bristol-Myers Squibb Co Stable solutions of rebeccamycin analog
DE3924538A1 (de) * 1989-07-25 1991-01-31 Goedecke Ag Indolocarbazol und dessen verwendung
DE3935066A1 (de) * 1989-10-20 1991-04-25 Lohmann Rudolf Lomapharm Verfahren zur isolierung von violacein und seine verwendung zur prophylaxe und therapie von viruserkrankungen
WO1991009034A1 (en) * 1989-12-14 1991-06-27 Schering Corporation Indolocarbazoles from saccharothrix aerocolonigenes subsp. copiosa subsp. nov. scc 1951 atcc 53856
DE3942296A1 (de) * 1989-12-21 1991-06-27 Goedecke Ag Indolocarbazol-derivate, verfahren zu deren herstellung und deren verwendung
IL97233A (en) * 1990-03-06 1995-03-30 Bristol Myers Squibb Co Analogs of rabamycin, their manufacture and pharmaceutical preparations containing them
JPH0725787B2 (ja) * 1990-03-06 1995-03-22 ブリストル−マイヤーズ スクイブ カンパニー 臭化物前駆物質物質供給によるレベカマイシン類似体
WO1991018003A1 (en) * 1990-05-11 1991-11-28 Banyu Pharmaceutical Co., Ltd. Antitumor be-13793c derivative

Also Published As

Publication number Publication date
AU3761493A (en) 1993-10-21
EP0630242B1 (de) 1999-01-20
JPH07504674A (ja) 1995-05-25
WO1993018766A1 (en) 1993-09-30
AU685389B2 (en) 1998-01-22
DE69323183D1 (de) 1999-03-04
CA2130836A1 (en) 1993-09-30
US5547976A (en) 1996-08-20
ATE175873T1 (de) 1999-02-15
ES2125976T3 (es) 1999-03-16
EP0630242A1 (de) 1994-12-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee