WO2021157549A1 - 肌質改善用外用組成物、化粧料組成物及び肌質改善方法 - Google Patents

肌質改善用外用組成物、化粧料組成物及び肌質改善方法 Download PDF

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Publication number
WO2021157549A1
WO2021157549A1 PCT/JP2021/003655 JP2021003655W WO2021157549A1 WO 2021157549 A1 WO2021157549 A1 WO 2021157549A1 JP 2021003655 W JP2021003655 W JP 2021003655W WO 2021157549 A1 WO2021157549 A1 WO 2021157549A1
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Prior art keywords
acid
glucan
cosmetic composition
skin quality
improving
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PCT/JP2021/003655
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English (en)
French (fr)
Japanese (ja)
Inventor
阿部　久美
誠治 小池
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株式会社Adeka
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Priority to JP2021575793A priority Critical patent/JPWO2021157549A1/ja
Publication of WO2021157549A1 publication Critical patent/WO2021157549A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin

Definitions

  • the present invention relates to an external composition for improving skin quality, a cosmetic composition, and a method for improving skin quality.
  • UV ultraviolet rays
  • ⁇ -glucan it has been reported that activation of Langerhans cells by ⁇ -glucan suppresses melanin synthesis from melanocytes (Patent Document 1). Further, it is known that the whiteness of the skin is increased by applying ⁇ -glucan to the pigmented skin after UV irradiation (Patent Document 2). Further, it is known that by applying ⁇ -glucan to the skin in which erythema is induced by UV irradiation, a sunlight burn healing effect is exhibited (Patent Documents 2 and 3).
  • an object of the present invention is an external composition for improving skin quality, a cosmetic composition, and a method for improving skin quality, which can be applied to the skin to improve skin that is hard to get sunburned and suppress redness due to inflammation caused by sunburn. Is to provide.
  • the present inventors have made various studies to solve the above-mentioned problems, and found that the above-mentioned problems can be solved by using ⁇ -1,3-1,6-glucan, that is, the skin that is hard to be sunburned can be improved in advance before sunburn.
  • ⁇ -1,3-1,6-glucan that is, the skin that is hard to be sunburned can be improved in advance before sunburn.
  • the present invention is an external composition for improving skin quality, which contains ⁇ -1,3-1,6-glucan.
  • the present invention is a cosmetic composition containing the above-mentioned external composition for improving skin quality, wherein the external composition for improving skin quality is ⁇ -1,3 with respect to the total amount of the cosmetic composition.
  • the present invention is a skin quality improving method including a step of applying the above cosmetic composition to the skin. Furthermore, the present invention is the use of an external composition for improving skin quality or a cosmetic composition containing ⁇ -1,3-1,6-glucan for improving skin quality.
  • the present invention by applying it to the skin, it is possible to improve the skin that is hard to get sunburned, and suppress redness due to inflammation caused by sunburn.
  • the skin quality is improved to a state in which redness due to inflammation is unlikely to occur. do.
  • symptoms such as inflammation caused by sunburn can be suppressed, and redness caused by inflammation caused by sunburn can be suppressed.
  • the production of melanin pigment caused by inflammation can be suppressed. In this way, the present invention can improve and maintain the condition of the skin which is hard to get sunburned.
  • the external composition for improving skin quality of the present invention contains ⁇ -1,3-1,6-glucan.
  • “improvement of skin quality” means to make the skin less inflamed or to maintain the state of the skin quality which is less likely to be inflamed by applying it to the skin.
  • making the skin less inflamed includes suppressing redness and the like, and specifically, suppressing redness and the like caused by sunburn.
  • “sunburn” means that the skin becomes reddish due to inflammation due to irradiation with ultraviolet rays.
  • Before sunburn means a state before the skin becomes reddish due to inflammation due to irradiation with ultraviolet rays.
  • “Sunburning” means a state in which redness due to inflammation occurs on the skin due to irradiation with ultraviolet rays.
  • “After sunburn” means a state after the skin becomes reddish due to inflammation due to irradiation with ultraviolet rays.
  • the external composition for improving skin quality of the present invention can improve the skin by applying it to any of the skin before, during, and after sunburn, but it is preferably applied to the skin in an untanned state. As a result, redness due to inflammation caused by sunburn can be effectively suppressed. Further, it is preferable that the skin quality improvement of the present invention is performed before the skin is sunburned. As a result, the skin quality is improved before sunburn, so that symptoms such as inflammation due to sunburn can be effectively suppressed.
  • the external composition for improving skin quality of the present invention is preferably applied to the skin in an untanned state, more preferably if the skin quality is improved before sunburn, when irradiated with ultraviolet rays. It may or may not be present. This is because even if the external composition for improving skin quality of the present invention is not applied to the skin at the time of ultraviolet irradiation, by applying it before sunburn, redness due to inflammation caused by sunburn can be effectively suppressed. be.
  • glucose is linked by ⁇ -1,3-glycosidic bond and ⁇ -1,6-glycosidic bond.
  • the main chain is a ⁇ -1,3-glycosidic bond and the ⁇ -1,6-glycosidic bond is branched, and (2) the main chain is a ⁇ -1,3-glycosidic bond. Those consisting of a bond and a ⁇ -1,6-glycosidic bond are known.
  • ⁇ -1,3-1,6-glucan used in the present invention those having a bond such as ⁇ -1,4-glycosidic bond may be used, but ⁇ -1,3-glycosidic bond is used.
  • the content of glucosidic bonds other than the bonds and ⁇ -1,6-glycosidic bonds must be 10 mol% or less with respect to the total of ⁇ -1,3-glycosidic bonds and ⁇ -1,6-glycosidic bonds.
  • any ⁇ -1,3-1,6-glucan can be used as ⁇ -1,3-1,6-glucan, but redness due to sunburn can be used. Since the inhibitory effect is good, ⁇ -1,3-1,6-glucan represented by the following general formula (1) is preferable:
  • R 1 represents a hydrogen atom or a group represented by the following formula (A), and one or more of a plurality of R 1 is the following formula (A).
  • a represents a number having a mass average molecular weight of ⁇ -1,3-1,6-glucan represented by the general formula (1) of 3,000 to 5,000,000. Both ends of ⁇ -1,3-1,6-glucan represented by the general formula (1) are hydroxyl groups, and * represents a bond.
  • preferably 16 or more are hydrogen atoms, and more preferably 20 or more are hydrogen atoms.
  • R 1 represents a hydrogen atom or a group represented by the following formula (A), and one or more of a plurality of R 1 is the following formula.
  • a (a) it is preferable more than 20 among a plurality of R 1 is a hydrogen atom.
  • the mass average molecular weight of ⁇ -1,3-1,6-glucan represented by the general formula (1) is preferably 5,000 to 3,000,000, more preferably 7,000 to 1,000,000. Most preferably 10,000 to 500,000.
  • the mass average molecular weight of ⁇ -1,3-1,6-glucan is the pullulan equivalent when gel permeation chromatography (also referred to as GPC) analysis is performed using water as a solvent.
  • Mass average molecular weight may also be referred to as a "weight average molecular weight”.
  • the method for measuring the mass average molecular weight is not particularly limited, but as an example, a calibration curve (holding time on the x-axis) using a differential refractometer using several types of pullruns having a known molecular weight Create a molecular weight on the y-axis).
  • a calibration curve holding time on the x-axis
  • a differential refractometer using several types of pullruns having a known molecular weight Create a molecular weight on the y-axis.
  • pullulan and ⁇ -1,3-1,6-glucan have different molecular sizes even if they have the same molecular weight (same number of glucose units) due to the difference in structure, so only relative values can be obtained by gel permeation chromatography, which is a molecular sieve.
  • the correction include a method of measuring the concentration of a sample and measuring and calculating three points of differential pressure viscosity, differential refractometer, and light scattering. Specifically, first, a pullulan standard solution having a known concentration, viscosity, and refractive index is used to determine the device constant k.
  • the original body whose concentration of ⁇ -1,3-1,6-glucan was measured by the phenol-sulfuric acid method is precisely measured, and an aqueous solution having a known concentration is prepared and used as a sample. Then, the molecular weight is calculated from the values measured by the differential pressure viscosity detector, the differential refractometer detector, and the light scattering detector.
  • the ratio of the unit in which R 1 is the formula (A) to the unit in which R 1 is a hydrogen atom is preferably 0.2 to 1 from the viewpoint of suppressing redness due to inflammation. , 0.5 to 0.95, more preferably 0.6 to 0.9.
  • the unit unit and R 1 R 1 is a hydrogen atom is an expression (A), may be bonded in a random form, it is attached to the block-shaped good.
  • the ratio of the unit in which R 1 is the formula (A) to the unit in which R 1 is a hydrogen atom is obtained by the following method. First, after methylating the free hydroxyl group of ⁇ -1,3-1,6-glucan, ⁇ -1,3-1,6-glucan is acid-hydrolyzed to a monosaccharide to acetylate the hydroxyl group generated by the decomposition. .. In the obtained glucose derivative, the hydroxyl group that contributed to the bond is acetylated, and the hydroxyl group that does not contribute to the bond is methylated. Various glucose derivatives are quantified by gas chromatography (GC) or the like. do.
  • GC gas chromatography
  • ⁇ -1,3-1,6-glucan is analyzed in detail using 13C-NMR or the like to calculate the ratio of one branch to two glucose residues and one branch to three glucose residues. From these calculated values, the ratio of the above units can be obtained.
  • ⁇ -1,3-1,6-glucan represented by the general formula (1) is a known method, for example, yeast, lactic acid bacterium, natto bacterium, acetic acid bacterium, aspergillus, algae such as chlorella and spirulina, filamentous fungus and the like. It can be obtained by extracting from the cell wall or product of yeast. Among them, ⁇ -1,3-1,6-glucan, which has a high moisturizing effect on the skin, can be extracted from black yeast (Aureobasidium pullulans). The method for extracting ⁇ -1,3-1,6-glucan is not particularly limited, and a known method may be used.
  • the deposit number FERM BP-8391 can be used in the present invention.
  • the details of the deposit number FERM BP-8391 are explained in International Publication No. 2004/001053 (WO2004 / 001053), and the deposit number is deposited at the Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology. .. The details that identify the deposit are described below.
  • the extracted ⁇ -1,3-1,6-glucan is concentrated, it is not particularly limited as long as it is a method for removing water or powdering.
  • spray drying, freeze drying, vacuum drying, heat drying, precipitation recovery with a solvent and the like can be mentioned, and these can be appropriately combined.
  • the external composition for improving skin quality of the present invention can be used for pharmaceuticals, quasi-drugs, cosmetics and the like.
  • An additive or the like necessary for the external composition for improving skin quality of the present invention can be blended to obtain a product, and an appropriate amount of the external composition for improving skin quality of the present invention is added as a raw material ( ⁇ -1) of the product. , 3-1,6-Glucan premix composition).
  • the external composition for improving skin quality of the present invention is, for example, ⁇ -1,3-1,6-
  • the solid content of glucan is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, further preferably 0.1% by mass or more, and 0.5% by mass or more. It is even more preferably contained, and most preferably 0.7% by mass or more.
  • the upper limit of ⁇ -1,3-1,6-glucan is not particularly limited as long as the effects of the present invention can be obtained, but from the viewpoint of high fluidity and good handleability, the total amount of the external composition is used.
  • the above ⁇ -1,3-1,6-glucan is preferably contained in an amount of 20% by mass or less, more preferably 10% by mass or less, and 5.0% by mass or less as a solid content. Is even more preferable, and the content is even more preferably 3.0% by mass or less, and most preferably 2.0% by mass or less.
  • the concentration of the ⁇ -1,3-1,6-glucan is 2% by mass. In the above case, it may not be completely dissolved and precipitation may easily occur. In this case, by adding 50 to 90% by mass of a polyhydric alcohol having 2 to 6 carbon atoms to the external composition for improving skin quality, it becomes easy to use as the external composition.
  • polyvalent alcohol having 2 to 6 carbon atoms examples include ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, propylene glycol, dipropylene glycol, 1,3-propanediol, 1,2-butanediol, and 1, , 3-Butanediol, 1,4-Butanediol, 2,3-Butanediol, 2-Methyl-1,2-Propanediol, 2-Methyl-1,3-Propanediol, 1,2-Pentanediol, 1, , 3-Pentanediol, 1,4-Pentanediol, 1,5-Pentanediol, 2,3-Pentanediol, 2,4-Pentanediol, 2-Methyl-1,2-Butanediol, 2-Methyl-2 , 3-butanediol, 2-methyl-1,4-butanedio
  • dihydric alcohol or trihydric alcohol is preferable because ⁇ -1,3-1,6-glucan has excellent dispersion stability, and propylene glycol, dipropylene glycol, and 1,3-butane are preferable. Diol and glycerin are more preferable, and 1,3-butanediol is even more preferable.
  • the composition for external use of the present invention is excellent in the dispersion stability of ⁇ -1,3-1,6-glucan.
  • the amount is preferably 5 to 27% by mass.
  • the external composition for improving skin quality of the present invention is preferably blended with a cosmetic composition.
  • the external composition for improving skin quality of the present invention includes various compounding ingredients that can be usually used in cosmetics depending on the purpose of use, such as various surfactants, various enzymes, chemicals, antibacterial agents (preservatives), and isotonicization. Agents, buffers, stabilizers, chelating agents, solubilizing agents, pH adjusters, fragrances and the like can be blended as appropriate in a range of normal usage amounts.
  • the same antibacterial agent (preservative) as that contained in the cosmetic composition described later can be used in the same manner, but the effect of the present invention is exhibited.
  • ether derivative systems such as phenoxyethanol and ethylhexyl glycerin are preferable.
  • the antibacterial agent can be used in the same blending amount as in the cosmetic composition.
  • the cosmetic composition of the present invention may be in any form such as an aqueous solution containing substantially no oil, a gel-like cosmetic, an emulsified cosmetic, or a solid content dispersed therein.
  • an emulsified cosmetic it can be provided in the form of either an oil-in-water type or a water-in-oil emulsion, but is like the oil-in-water type or the water-in-oil type, that is, continuous. It is preferably an aqueous cosmetic whose phase is an aqueous phase.
  • the cosmetic composition of the present invention contains the above-mentioned external composition for improving skin quality, and is contained in the cosmetic composition (cosmetic composition) from the viewpoint of satisfactorily exerting the effect of improving the skin that is hard to get sunburned.
  • ⁇ -1,3-1,6-glucan preferably 0.0001 to 1% by mass, more preferably 0.0005 to 1% by mass, still more preferably 0.001 to 1% by mass. %, More preferably 0.005 to 0.5% by mass, even more preferably 0.005 to 0.2% by mass, even more preferably 0.005 to 0.1% by mass, most preferably 0.005 to 0.005 to It is contained so as to be 0.01% by mass.
  • the cosmetic composition contains 0.0001% by mass or more of ⁇ -1,3-1,6-glucan as an active ingredient, for example, in terms of solid content. Is preferable. From the viewpoint of ease of adjustment of the cosmetic composition and prevention of change in usability, ⁇ -1,3-1,6-glucan as an active ingredient, for example, in solid content, is contained in the cosmetic composition. It is preferably contained in an amount of 1% by mass or less.
  • the cosmetic composition of the present invention can contain any component that can be usually used in cosmetics, in addition to the above-mentioned external composition for improving skin quality.
  • surfactants for example, surfactants, chelating agents, low molecular weight polyhydric alcohols, plant-derived extracts, animal-derived extracts, microbial-derived extracts, microbial cultures, zinc compounds, thickeners, oils, pigments, pigments, antibacterial agents (preservatives). ), Moisturizers, pH adjusters, antioxidants, UV absorbers, moisturizing ingredients, enzymes, fragrances and the like.
  • Cultures with microorganisms include whole cultures containing microorganisms and cultures, supernatants, microorganisms, or whole cultures, lyophilized supernatants or microorganisms, concentrates or extracts.
  • surfactant examples include anionic surfactants, nonionic surfactants, cationic surfactants and amphoteric surfactants.
  • anionic surfactant examples include higher fatty acid salt, higher alcohol sulfate ester salt, sulfated olefin salt, higher alkyl sulfonate, ⁇ -olefin sulfonate, sulfated fatty acid salt, sulfonated fatty acid salt, and phosphoric acid ester.
  • Salts fatty acid ester sulfates, glyceride sulfates, fatty acid ester sulfonates, ⁇ -sulfo fatty acid methyl ester salts, polyoxyalkylene alkyl ether sulfates, polyoxyalkylene alkylphenyl ether sulfates, polyoxy Alkylene alkyl ether carboxylate, acylated peptide, fatty acid alkanolamide or sulfate ester salt of its alkylene oxide adduct, sulfosuccinate, alkylbenzene sulfonate, alkylnaphthalene sulfonate, alkylbenzoimidazole sulfonate, polyoxyalkylene Sulfosuccinate, salt of N-acyl-N-methyltaurine, N-acylglutamic acid or its salt, acyloxyethane sulfonate, alkoxyethane sulf
  • nonionic surfactant examples include polyoxyalkylene alkyl ether, polyoxyalkylene alkenyl ether, and polyoxyethylene polyoxypropylene alkyl ether (the addition form of ethylene oxide and propylene oxide may be random or block. ), Polyethylene glycol propylene oxide adduct, Polyethylene glycol ethylene oxide adduct, Glycerin fatty acid ester or ethylene oxide adduct thereof, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, alkylpolyglucoside, fatty acid monoethanolamide or ethylene oxide addition thereof.
  • fatty acid-N-methylmonoethanolamide or ethylene oxide adduct thereof fatty acid diethanolamide or ethylene oxide adduct thereof, sucrose fatty acid ester, alkyl (poly) glycerin ether, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, fatty acid Examples thereof include methyl ester ethoxylate and N-long chain alkyldimethylamine oxide.
  • Examples of the cationic surfactant include an alkyl (alkenyl) trimethylammonium salt, a dialkyl (alkenyl) dimethylammonium salt, an alkyl (alkenyl) quaternary ammonium salt, and a mono or dialkyl (alkenyl) containing an ether group or an ester group or an amide group.
  • Quaternary ammonium salt alkyl (alkenyl) pyridinium salt, alkyl (alkenyl) dimethylbenzylammonium salt, alkyl (alkenyl) isoquinolinium salt, dialkyl (alkenyl) morpholinium salt, polyoxyethylene alkyl (alkenyl) amine, alkyl (alkenyl) amine Examples thereof include salts, polyamine fatty acid derivatives, amyl alcohol fatty acid derivatives, benzalconium chloride, and benzethonium chloride.
  • amphoteric surfactants include carboxybetaine, sulfobetaine, phosphobetaine, amide amino acids, and imidazolinium betaine-based surfactants.
  • the above-mentioned surfactant may be blended with one or more of the above-mentioned one or more.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.01 to 80% by mass with respect to the total amount of the cosmetic composition. More preferably, it is 05 to 60% by mass.
  • the chelating agent examples include an aminopolycarboxylic acid chelating agent, an aromatic or aliphatic carboxylic acid chelating agent, an amino acid chelating agent, an ether polycarboxylic acid chelating agent, a phosphonic acid chelating agent, and a phosphoric acid chelating agent.
  • examples thereof include hydroxycarboxylic acid chelating agents, high molecular weight electrolyte (including oligomeric electrolyte) chelating agents, dimethylglioxime, ascorbic acid, thioglycolic acid, phytic acid, glyoxylic acid, and glyoxal acid.
  • Each of these chelating agents may be in the form of a free acid or in the form of a salt such as a sodium salt, a potassium salt or an ammonium salt. In addition, they may be in the form of their hydrolyzable ester derivatives.
  • aminopolycarboxylic acid-based chelating agent examples include ethylenediaminetetraacetic acid, ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, and N- (2).
  • ethylenediaminetetraacetic acid ethylenediaminediacetic acid, cyclohexanediaminetetraacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, diethylenetriaminepentaacetic acid, and N- (2).
  • aromatic or aliphatic carboxylic acid-based chelating agents include oxalic acid, malonic acid, succinic acid, glutaric acid, adipic acid, pimelic acid, sebacic acid, azelaic acid, itaconic acid, aconitic acid, pyruvate, and salicylic acid.
  • examples thereof include acetylsalicylic acid, hydroxybenzoic acid, aminobenzoic acid (including anthranylic acid), phthalic acid, fumaric acid, trimellitic acid, gallic acid, hexahydrophthalic acid and salts thereof, methyl esters and ethyl esters.
  • amino acid-based chelating agents include glycine, serine, alanine, lysine, cystine, cysteine, ethionine, tyrosine, methionine and salts and derivatives thereof.
  • phosphonic acid-based chelating agent include iminodimethylphosphonic acid, alkyldiphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof.
  • phosphoric acid-based chelating agent include orthophosphoric acid, pyrophosphoric acid, triphosphoric acid and polyphosphoric acid.
  • Examples of the hydroxycarboxylic acid-based chelating agent include malic acid, citric acid, glycolic acid, gluconic acid, heptonic acid, tartaric acid, lactic acid and salts thereof.
  • Examples of the polymer electrolyte (including oligomeric electrolyte) chelating agent include an acrylic acid polymer, a maleic anhydride polymer, an ⁇ -hydroxyacrylic acid polymer, an itaconic acid polymer, and two types of constituent monomers of these polymers. Examples thereof include a copolymer composed of the above and an epoxy succinic acid polymer.
  • ethylenediaminetetraacetic acid ethylenediaminediacetic acid, nitrilotriacetic acid, iminodiacetic acid, N- (2-hydroxyethyl) iminodiacetic acid, aspartate diacetic acid, and succinic acid are highly safe and have a large chelating effect.
  • Acids, salicylic acid, oxalic acid, lactic acid, fumaric acid, citric acid, tartrate, 1-hydroxyethane-1,1-diphosphonic acid and salts thereof are preferred.
  • the chelating agent may be a mixture of one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.01 to 30% by mass with respect to the total amount of the cosmetic composition. More preferably, it is 05 to 20% by mass.
  • the low molecular weight polyhydric alcohol is a polyhydric alcohol having a molecular weight of 50 to 1000 and a molecular weight of 50 to 500 from the viewpoint of exerting the effect of the present invention.
  • ethylene glycol diethylene glycol, triethylene glycol, tetraethylene glycol, etc.
  • 1,2-Cyclopentanediol 1,3-cyclopentanediol, 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, 1,2-cycloheptanediol, 2,3-norbornane Glycol, 2,5-norbornandiol, 2,7-norbornandiol, 1,2-cyclooctanediol, 1,4-cyclooctanediol, 1,2-cyclodecanediol, 5-cyclooctene-1,2-diol , 1,5-decalindiol, limonene glycol, 1,2-terpenediol, 4,4'-bicyclohexanediol, 1,2-cyclododecanediol and other alicyclic diols;
  • Glycerin 1,2,3-butanetriol, 1,2,4-butanetriol, 2-methyl-1,2,3-propanetriol, 1,2,3-pentanetriol, 1,2,4-pentanetriol , 1,3,5-pentantriol, 2,3,4-pentantriol, 2-methyl-2,3,4-butanetriol, trimethylolethane, 2,3,4-hexanetriol, 2-ethyl-1 , 2,3-Butantriol, Trimethylol Propane, 4-propyl-3,4,5-Heptanetriol, 2,4-Dimethyl-2,3,4-Pentantriol, Triethanolamine, Triisopropanolamine, etc. 3 Triol;
  • Ellisritol pentaerythritol, 1,2,3,4-pentatetrol, 2,3,4,5-hexatetrol, 1,2,4,5-pentantetrol, 1,3,4,5-hexane Tetrol, diglycerin, sorbitan, N, N, N', N'-tetrax (2-hydroxypropyl) ethylenediamine, N, N, N', N'-tetrax (hydroxyethyl) ethylenediamine and other tetrahydric alcohols;
  • Pentahydric alcohols such as adonitol, arabitol, xylitol and triglycerin; hexahydric alcohols such as dipentaerythritol, sorbitol, mannitol, iditol, inositol, darsitol, tarose and allose;
  • N-substituted diethanolamines such as N-methyldiethanolamine, N-ethyldiethanolamine, N-propyldiethanolamine, N-isopropyldiethanolamine, N-butyldiethanolamine, N-cyclohexyldiethanolamine, N- (2-ethylhexyl) diethanolamine; N-methyldiisopropanolamine, N-ethyldiisopropanolamine, N-propyldiisopropanolamine, N-isopropyldiisopropanolamine, N-butyldiisopropanolamine, N-cyclohexyldiisopropanolamine, N- (2-ethylhexyl) di N-substituted diisopropanolamines such as isopropanolamine;
  • Glycol 1,2-pentanediol, 3-methyl-1,3 butanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 2-ethyl-1,3-hexanediol , 1,2-Nonandiol, 2-butyl-2-ethyl-1,3-propanediol, 1,2-decanediol, 1,10-decanediol, glycerin, triethanolamine, triisopropanolamine, erythritol, di Glycerin, sorbitane, N, N, N', N'-tetrakis (2-hydroxypropyl) ethylenediamine, N, N, N', N'-tetrakis (hydroxyethyl) ethylenediamine, sorbitol, 1-methylglyceryl ether, 1- Ethyl glyceryl ether
  • the small molecule polyhydric alcohol may contain one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.01 to 90% by mass with respect to the total amount of the cosmetic composition. More preferably, it is 05 to 70% by mass.
  • the cosmetic composition is an aqueous cosmetic such as a lotion or an oil-in-water emulsified cosmetic
  • the blending amount of the low molecule polyhydric alcohol is 0.1 to 50 with respect to the total amount of the cosmetic composition. It is preferably by mass%, more preferably 1 to 20% by mass.
  • the plant-derived extract is the whole plant, algae, or fungus, or a specific part such as flowers, leaves, stems, fruits, bark, roots, seeds, and resin, as it is, or by squeezing, drying, crushing, or fermenting. It is obtained by extracting with a solvent at room temperature or heating, and is soluble in water, ethanol, propylene glycol or fats and oils. Alternatively, the extract may be diluted, concentrated, or dried. Further, the essential oil may be obtained by using a steam distillation method, an extraction method, a chromatography method or the like.
  • the extraction solvent for the plant-derived extract from the viewpoint of exerting the effect of the present invention, those usually used for extracting natural components, for example, water; alcohols such as methanol, ethanol, propanol and butanol; ethylene glycol and propylene.
  • Polyhydric alcohols such as glycol, butylene glycol and glycerin; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; ethers such as tetrahydrofuran, diethyl ether and polyethylene glycol; halogenated carbides such as dichloroethane and chloroform Hydrogens; aliphatic hydrocarbons such as petroleum ether, n-hexane and cyclohexane; aromatic hydrocarbons such as toluene; pyridines; sodium chloride solution and the like, especially water, ethanol, propylene glycol and butylene glycol. preferable.
  • Plants that can be used as plant-derived extracts include, for example, arch choke, almond, eye, Eisenhardia polystakia, eyebright, Aonoryu zetsuran, Aomoji, Acacia consina, Acacia senegal, Acacia senegal gum, Acacia declins, Akatsumexa, etc.
  • Examples include lichens and hyphae such as Ebernia full fracea, Oakmoss, Usnia barbata, Cynomorium cocci, Kabaanatake, Shiitake, Ningyotake, Himematsutake, Fuyumusinatsukusatake, Kabaanatake, Choreimaitake, and winter worm summer grass.
  • lichens and hyphae such as Ebernia full fracea, Oakmoss, Usnia barbata, Cynomorium cocci, Kabaanatake, Shiitake, Ningyotake, Himematsutake, Fuyumusinatsukusatake, Kabaanatake, Choreimaitake, and winter worm summer grass.
  • the plant-derived extract may contain one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.0001 to 5% by mass with respect to the total amount of the cosmetic composition. More preferably, it is 001 to 1% by mass.
  • animal-derived extracts include cow placenta extract, cow apical ligament (elastin) extract, cow blood (hematin) extract, cow / pig stomach (mucopolysaccharide) extract, cow / pig skin / fish (collagen).
  • animal-derived extracts include cow placenta extract, cow apical ligament (elastin) extract, cow blood (hematin) extract, cow / pig stomach (mucopolysaccharide) extract, cow / pig skin / fish (collagen).
  • examples include extract, chicken crown extract, bee royal milk (royal jelly), silk (fibroin, sericin) extract, milk (whey, sugar protein, lactoferrin) extract, crab shell (chitin, chitosan) extract, ceramide, squalene and the like.
  • the animal-derived extract may contain one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, 0.0001 to 5% by mass is preferable with respect to the total amount of the cosmetic composition, and 0.001. ⁇ 1% by mass is more preferable.
  • the microbial-derived extract examples include bacterial metabolites, bacterial extract extracts, metabolites such as mold and mushrooms, actinomycete metabolites, extracts such as mold and mushrooms, actinomycete extract, natto fungus metabolites, and natto extract.
  • the microorganism-derived extract may contain, for example, lipopolysaccharide (LPS).
  • the above-mentioned one or more kinds of microbial-derived extracts may be blended.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, 0.0001 to 5% by mass is preferable with respect to the total amount of the cosmetic composition, and 0.001. ⁇ 1% by mass is more preferable.
  • Examples of zinc compounds include zinc acetate, zinc laurate, zinc myristate, zinc palmitate, zinc ricinoleate, zinc undesylene, zinc aspartate, zinc acetylmethionine, zinc gluconate, zinc citrate, and polypyrrolidone carboxylic acid.
  • Organic acid zinc salts such as zinc and zinc picolinate; zinc sulfonates such as zinc p-phenol sulfonate, zinc phosphate esters such as zinc ascorbyl phosphate, sodium cetyl phosphate, and DNA zinc; zinc complexes such as zinc pyrithione.
  • Zinc-bearing zeolite such as (silver / zinc / ammonium) zeolite, silicic acid (ammonium / silver / zinc / aluminum); aluminum hydroxide such as aluminum oxide / zinc, aluminum oxide / zinc / cerium, aluminum oxide / zinc / iron Bake products such as: Zinc sulfate, Zinc sulfide, Zinc chloride, Zinc bromide, Zinc nitrate, Zinc ammonium chloride, Zinc aluminum sulfate, Zinc potassium sulfate, Zinc iodide, Basic zinc carbonate and other inorganic zinc salts; / Carbonate) (Mg / Al / Zinc), zinc oxide and the like.
  • silicic acid ammonium / silver / zinc / aluminum
  • aluminum hydroxide such as aluminum oxide / zinc, aluminum oxide / zinc / cerium, aluminum oxide / zinc / iron Bake products such as: Zinc sulfate, Zinc sul
  • the solubility in 100 g of water at 20 ° C. is preferably 5 g or more, and the solubility is more preferably 10 g or more.
  • zinc compounds include zinc sulfate, zinc chloride, zinc gluconate, zinc bromide, zinc nitrate, zinc ammonium chloride, zinc aluminum sulfate, potassium zinc sulfate, zinc iodide and the like.
  • the zinc compound may contain one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.001 to 10% by mass with respect to the total amount of the cosmetic composition. 01 to 3% by mass is more preferable.
  • thickener examples include dimethyldiallylammonium chloride / acrylamide copolymer, acrylamide / acrylic acid / dimethyldiallylammonium chloride copolymer, cellulose or a derivative thereof, keratin and collagen or a derivative thereof, calcium alginate, purulan, agar.
  • Gelatin tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, arabic rubber, crystalline cellulose, arabinogalactan, karaya gum, tragacanth gum, alginic acid, albumin, casein, curdlan, ⁇ -1,3 Examples thereof include ⁇ -glucan other than -1,6-glucan, ⁇ -glucan derivative, gellan gum, dextran, ⁇ -glucose and ⁇ -glucose derivative, glucomannan, galactomannan, arabinoxylan, cellulose derivative, dextrin and dextrin derivative.
  • the thickener may be one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.01 to 20% by mass with respect to the total amount of the cosmetic composition. More preferably, it is 05 to 10% by mass.
  • oil agent examples include volatile and non-volatile oil agents, solvents and resins usually used in cosmetic compositions, which may be liquids, pastes or solids at room temperature, but liquids having excellent handling are preferable.
  • oil agent examples include higher alcohols such as cetyl alcohol, isostearyl alcohol, lauryl alcohol, hexadecyl alcohol, and octyldodecanol; lauric acid, undecylene acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, 12 -Higher fatty acids such as hydroxystearic acid, oleic acid, linoleic acid, linolenic acid, arachidonic acid, eicosapentaenoic acid, docosahexaenoic acid, isostearic acid, 12-hydroxystearic acid, lanolin fatty acid; myristyl myristate, hexyl laurate,
  • the oil agent may be a mixture of one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.1 to 90% by mass with respect to the total amount of the cosmetic composition. More preferably, it is 5 to 70% by mass.
  • pigments such as Red No. 201, Yellow No. 4, Blue No. 1, Black No. 401, and rake pigments such as Yellow No. 4 Al Lake and Yellow No. 203 Ba Lake.
  • the pigment examples include white pigments such as titanium oxide, extender pigments such as silica, talc, mica, sericite and kaolin, and pearl pigments such as mica titanium.
  • the shape of these pigments is not particularly limited.
  • These pigments have conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, and polyacrylic.
  • the surface may be treated in advance by acid treatment, metal soap treatment, amino acid treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment or the like. Moreover, you may use these as an ultraviolet scattering agent.
  • the pigment and / or the pigment may be blended with one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.1 to 90% by mass with respect to the total amount of the cosmetic composition. More preferably, it is 5 to 70% by mass.
  • antibacterial agent examples include paraben antibacterial agents such as methylparaben and ethylparaben; imidazole antibacterial agents such as thiabendazole and methylpriventol 2-benzimidazolylcarbamate; trichlorocarbanilide, cloflucarban and the like.
  • Ethylene glycol diethylene glycol, triethylene glycol, butylene glycol, propylene glycol, dipropylene glycol, pentylene glycol, caprylyl glycol and other glucol antibacterial agents, sodium benzoate, potassium benzoate, calcium benzoate and other benzoic acids
  • Antibacterial agents and the like can be mentioned.
  • an ether derivative type antibacterial agent, a glycol type antibacterial agent and the like are preferably used from the viewpoint of exerting the effect of the present invention.
  • the antibacterial agent may be one or more of the above, but when these antibacterial agents are used in combination, it should be used carefully in consideration of irritation to the human body.
  • the blending amount thereof is preferably 0.01 to 10% by mass, more preferably 0.03 to 6% by mass, and 0.03 to 3% by mass with respect to the total amount of the cosmetic composition. % Is more preferable.
  • pH adjuster examples include potassium carbonate, sodium hydrogen carbonate, ammonium hydrogen carbonate, ascorbic acid, hydrochloric acid, gluconic acid, acetic acid, lactic acid, phosphoric acid, sulfuric acid, citric acid, anionic surfactants and the like. These pH adjusters may be the same as or different from the acid-base used in the preparation of the cationic surfactant consisting of the tertiary amine and the amidamine described above.
  • the pH adjuster may contain one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.001 to 10% by mass with respect to the total amount of the cosmetic composition. 01 to 5% by mass is more preferable.
  • the pH adjuster varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, the cosmetic composition is preferably pH 3.0 to 13.0, more preferably pH 4.0 to. It is preferable to add the mixture so as to have 12.0, more preferably pH 5.0 to 10.0, and most preferably pH 6.0 to 7.0.
  • antioxidant examples include tocopherol, butylhydroxyanisole, dibutylhydroxytoluene, phytic acid and the like.
  • the antioxidant one or more of the above may be blended.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.001 to 10% by mass with respect to the total amount of the cosmetic composition. 01 to 5% by mass is more preferable.
  • Examples of the ultraviolet absorber include salicylic acid-based agents such as homomentyl salicylate, octyl salicylate, and triethanolamine salicylate; paraaminobenzoic acid, ethyldihydroxypropyl paraaminobenzoic acid, glyceryl paraaminobenzoic acid, octyldimethylparaaminobenzoic acid, and paradimethylaminobenzoic acid.
  • salicylic acid-based agents such as homomentyl salicylate, octyl salicylate, and triethanolamine salicylate
  • paraaminobenzoic acid ethyldihydroxypropyl paraaminobenzoic acid
  • glyceryl paraaminobenzoic acid octyldimethylparaaminobenzoic acid
  • paradimethylaminobenzoic acid paradimethylaminobenzoic acid.
  • PABAs such as amyl, 2-ethylhexyl paradimethylaminobenzoate; 4- (2- ⁇ -glucopyranosyloxy) propoxy-2-hydroxybenzophenone, dihydroxydimethoxybenzophenone, sodium dihydroxydimethoxybenzophenone disulfonate, 2-hydroxy -4-methoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its trihydrate, sodium hydroxymethoxybenzophenone sulfonate, 2-hydroxy-4-methoxybenzophenone-5-sulfate, 2,2'-dihydroxy-4-methoxybenzophenone, 2 , 4-Dihydroxybenzophenone, 2,2'4,4'-tetrahydroxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2-hydroxy-4-N-octoxybenzophenone and other benzophenones; 2-Ethylhexyl paramethoxycinerate (also known
  • the ultraviolet absorber may be a mixture of one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.01 to 10% by mass with respect to the total amount of the cosmetic composition. 1 to 1% by mass is more preferable.
  • the moisturizing component examples include mucopolysaccharides such as deoxyribonucleic acid, hyaluronic acid and its sodium salt, potassium salt, and derivatives, chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane, polyoxyethylene methyl glucoside, and poly.
  • mucopolysaccharides such as deoxyribonucleic acid, hyaluronic acid and its sodium salt, potassium salt, and derivatives, chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membrane, polyoxyethylene methyl glucoside, and poly.
  • mucopolysaccharides such as deoxyribonucleic acid, hyaluronic acid and its sodium salt, potassium salt, and derivatives, chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyze
  • the moisturizing ingredient may be one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.001 to 30% by mass with respect to the total amount of the cosmetic composition. 01 to 20% by mass is more preferable.
  • enzymes include acylcoenzyme A desaturase, aminopeptidase, amyloglucosidase, oxidoreductase, catalase, glucose oxidase, superoxide dismutase, soybean peroxidase, dextran-immobilized protease, transglutaminase, hyaluronidase, protease, hesperidinase, lactoperoxidase, lipase. And so on.
  • the enzyme may contain one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.001 to 10% by mass with respect to the total amount of the cosmetic composition. 01 to 5% by mass is more preferable.
  • the fragrance is blended to add aroma and scent to the cosmetic composition or to mask an unpleasant odor. It is not particularly limited as long as it is a fragrance generally blended in a cosmetic composition, and flowers, seeds, leaves, roots, etc. of various plants including various extracts exemplified in the above-mentioned physiologically active ingredients and the like. Fragrances extracted from, fragrances extracted from seaweeds, fragrances extracted from animal parts or secretions (eg, jako, musk), artificially synthesized fragrances (eg, menthol, musk, acetate, vanilla) Is exemplified.
  • the fragrance may be a mixture of one or more of the above.
  • the blending amount is not particularly limited and varies depending on the type of cosmetic composition, but from the viewpoint of exerting the effect of the present invention, it is generally preferably 0.001 to 10% by mass with respect to the total amount of the cosmetic composition. 01 to 3% by mass is more preferable.
  • cosmetic composition of the present invention include, for example, scalp care cosmetics; creams (hand creams, body creams), lotions (body lotions, sunscreen lotions, etc.), lotions, emulsions (sunscreens, etc.). Emulsion, etc.), beauty liquid, beauty liquid used for face mask, beauty liquid used for sheet-shaped processed products (for example, sheets with fine needles), packs, shaving lotions, after-shave lotions, after-sun lotions
  • Skin care cosmetics such as; cleaning cosmetics such as washing pigments, makeup removers, and body shampoos; makeup cosmetics such as foundations, makeup bases, and lip creams; bathing agents, etc., among others, body lotions, body creams, etc.
  • Sunscreen lotions, lotions, emulsions (such as sunscreen emulsions) and beauty essences are particularly preferred.
  • the cosmetic composition of the present invention can be produced according to a conventional method, and it is preferable that the external composition is contained in the aqueous phase.
  • the method of using the cosmetic composition of the present invention can be adjusted according to the condition, age, gender, etc. of the skin to be used, and for example, the following method may be used. That is, several times a day (for example, about 1 to 5 times, preferably 1 to 3 times), an appropriate amount (for example, about 0.02 mg to 20 mg is preferably applied in a section of, for example, 6 cm ⁇ 10 cm). It can be applied to the skin of the whole body including the face and limbs.
  • the application period is not particularly limited, but from the viewpoint of the skin turnover cycle and the efficient exertion of the effects of the present invention, for example, about 1 to 110 days is preferable, about 15 to 80 days is more preferable, and about 25 to 25 to 60 days is more preferred.
  • the cosmetic composition of the present invention can improve the skin quality to prevent sunburn, and has the effect of suppressing redness due to inflammation caused by sunburn.
  • the target of use is not limited, but it exerts a good effect of improving the skin to a state in which it is difficult to get sunburn, especially for people with skin that is easily sunburned. In addition, even for people with skin that is difficult to get sunburned, the ease of getting sunburned can be suppressed and the state of being hard to get sunburned can be maintained.
  • the skin quality improving method of the present invention includes a step of applying the cosmetic composition of the present invention to the skin.
  • the skin that is hard to get sunburned can be improved or the state can be maintained, so that redness due to inflammation caused by sunburn can be suppressed.
  • the application environment such as temperature of the cosmetic composition of the present invention is not particularly limited.
  • the cosmetic composition of the present invention before the skin is sunburned.
  • the skin is exposed to ultraviolet rays of 2.0 mJ / cm 2 or more for 1 minute or more.
  • it is preferred to coating before being irradiated it is more preferably performed before 5.0mJ / cm 2 or more ultraviolet rays are irradiated over 1 minute, 10.0 mJ / cm 2 or more ultraviolet rays are irradiated over 1 minute
  • the external composition for improving skin quality of the present invention may or may not be applied to the skin at the time of ultraviolet irradiation.
  • the cosmetic composition of the present invention can exert a skin quality improving effect even when applied to sunburned skin.
  • Examples 1 to 4 (preparation of samples A to D)> Black yeast (deposit number FERM BP-8391) was cultured in potato dextrose agar slope medium to prepare a preserved strain, inoculated into a 500 ml Erlenmeyer flask containing 100 ml of YM liquid medium (manufactured by Diffco), and at 28 ° C. Pre-cultured for 3 days. This culture broth was transferred to a 30-liter fermenter containing 15 liters of Czapeak's medium (manufactured by Diffco) and cultured at 28 ° C. for 3 days. The culture solution was sterilized by heating at 90 ° C. for 30 minutes, and then the cells were removed by centrifugation to obtain a culture supernatant ( ⁇ -1,3-1,6-glucan 1% by mass).
  • This culture supernatant was diluted to 0.8% with water and used as Sample A (Example 1) ( ⁇ -1,3-1,6-glucan contained in Sample A was 0.008% by mass). ). Further, the culture supernatant was diluted to 80% with water and used as Sample B (Example 2) ( ⁇ -1,3-1,6-glucan contained in Sample B was 0.8% by mass). ). Further, the culture supernatant was used as Sample C (Example 3). Further, phenoxyethanol and ethylhexyl glycerin were added as antibacterial agents to the culture supernatant, and water was further added to dilute the culture supernatant to 80%, which was used as Sample D (Example 4) (Sample D).
  • ⁇ -1,3-1,6-glucan contained in is 0.8% by mass, phenoxyethanol is 0.5% by mass, and ethylhexylglycerin is 0.3% by mass).
  • the samples A to D correspond to the external composition for improving skin quality of the present invention.
  • the ⁇ -1,3-1,6-glucan contained in the samples A, B, C, and D has a mass average molecular weight of 300 in the ⁇ -1,3-1,6-glucan represented by the general formula (1).
  • the ratio of the unit whose R 1 is the formula (A) to the unit whose R 1 is a hydrogen atom was 0.85.
  • the method for measuring the mass average molecular weight and the method for calculating the unit ratio are shown below.
  • methylation analysis was performed according to a conventional method. That is, the sample was dissolved in distilled water at a concentration of 1 mg / ml, three times the amount of ethanol was added to precipitate ⁇ -1,3-1,6-glucan, the supernatant was removed, and then the sample was reconstituted in distilled water. It was dissolved. This operation was repeated 3 times to prepare a purified sample from which components other than ⁇ -1,3-1,6-glucan were removed. 2 ml of DMSO was added to 1 mg of the lyophilized purified sample to dissolve it, and 0.5 ml of carbanion reagent was added.
  • ⁇ Evaluation example 1 (examination of skin quality improvement)> A Multiport Solar UV Simulator Model 601 (Solar Light Co. Inc.) was used as a light source, and the irradiation intensity was measured using a multifunctional measurement system model PMA2100 (Solar Light Co. Inc.), and the minimum amount of erythema (MED: Minimal) was measured. Erythema Dose) was measured.
  • samples A and B were applied to another site inside the upper left arm of each subject twice a day, 2 ml each in the morning and evening, for 4 weeks.
  • pullulan manufactured by Hayashibara Co., Ltd., 90% by mass
  • Pullulan was diluted with water to 0.008% by weight and used.
  • the inside of the upper right arm where nothing was applied was used as the control.
  • the same irradiation was performed on the inside of the left and right upper arms of the subject again, and the MED was determined 24 hours after the irradiation.
  • the case where no coating was applied was evaluated as Comparative Example 1
  • the case where pullulan was applied was evaluated as Comparative Example 2.
  • Table 1 shows the changes in MED ( ⁇ MED) before and 4 weeks after the start of application of the subject.
  • the numerical values in Table 1 are the average values of MED measurements of 9 subjects.
  • ⁇ Evaluation example 2 (examination of skin quality improvement in low MED group)>
  • four subjects having a MED of 1.25 or less were classified into a low MED group (a group prone to sunburn) by MED before the start of application, and data analysis was performed.
  • Table 2 shows changes in MED before the start of application and 4 weeks after application in the low MED group.
  • the numerical values in Table 2 are the average values of the MED measurements of the subjects.
  • the p value indicates a significant difference (paired t-test) from before the start of coating. The smaller the p-value, the more significant it was, and in particular, the p-value less than 0.05 was considered to be statistically significant.
  • the MED value after 4 weeks of application was higher than that before the start of application as compared with the application sites of the cosmetic compositions of Comparative Examples 3 and 4. rice field. That is, at the application site of the cosmetic composition of Examples 5 to 8, it was observed that erythema due to sunburn was less likely to occur.

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