WO2020248295A1 - 一种植物软胶囊及其制备方法与用途 - Google Patents
一种植物软胶囊及其制备方法与用途 Download PDFInfo
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- WO2020248295A1 WO2020248295A1 PCT/CN2019/091929 CN2019091929W WO2020248295A1 WO 2020248295 A1 WO2020248295 A1 WO 2020248295A1 CN 2019091929 W CN2019091929 W CN 2019091929W WO 2020248295 A1 WO2020248295 A1 WO 2020248295A1
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- Prior art keywords
- soft capsule
- glue
- vegetable
- carrageenan
- rubber
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Definitions
- the invention belongs to the technical field of soft capsules, and specifically relates to a plant soft capsule and a preparation method and application thereof.
- Soft capsules are widely used in medical and pharmaceutical products and food fields.
- the rubber skins of commonly used soft capsule products use gelatin as the main raw material.
- Gelatin is mainly derived from the collagen in animal skin, bone, muscle membrane and other connective tissues.
- the most commonly used gelatin in industry is from pigs and cattle.
- industrial gelatin contains more heavy metal ions, it is extremely harmful; although gelatin is low in cost, it has cross-linking problems and easily makes soft capsules unstable. , Affecting the storage and transportation of soft capsule products.
- soft capsules with gelatin as the main ingredient do not meet the halal or vegetarian dietary habits and requirements. Based on the above reasons, the development of plant-based soft capsules is of great significance.
- hydroxypropyl starch is used as the main raw material and supplemented with gelling agents, softeners and film forming agents that can improve the properties of soft capsules.
- the starch-based rubber is prepared.
- the disadvantage is that compared with other gum raw materials, the rubber mainly made of hydroxypropyl starch is more brittle , The elasticity and toughness deviation of the rubber skin will be more likely to be broken into pellets; and one or more of calcium chloride, potassium chloride, potassium citrate plasma must be added in the preparation process.
- pullulan is used as the main raw material, and it is mixed with a variety of biological polysaccharides or seaweed polysaccharides. After several processes, the film is formed, and the pill is compressed by a rotating film soft capsule machine.
- the characteristic is that the prepared Soft capsule pills can reach a level similar to gelatin capsules in terms of transparency, elasticity and mechanical strength, and completely disintegrate within the relevant prescribed time; the disadvantage is that pullulan is expensive and expensive, and does not replace gelatin soft The possibility of capsules; and the drying time after the glue is formed into a film is long, and it needs to be dried at 60-70°C for 10-18h, which is low in production efficiency.
- CN 105434397 B in order to reduce the cost of pullulan in CN 102670563 A plan, hydroxypropyl starch and hydroxypropyl methylcellulose are used to replace part of pullulan.
- This patent can reduce part of the production cost and prepare soft
- the capsule rubber has low fragility and excellent disintegration performance, which is no different from gelatin soft capsules; moreover, the rubber composition does not need to be pre-spread and dried. After the prepared glue reaches a controlled viscosity, the glue can be directly combined with the pellet
- the glue feeding equipment of the machine is connected to directly press pellets to prepare soft capsules, which improves production efficiency.
- hydroxypropyl starch, hydroxypropyl methylcellulose and pullulan are indispensable, otherwise it will affect the friability and disintegration time limit of the soft capsule (see CN 105434397 B, page 9 of the specification) Examples 9-14 in Table 2); and the addition amount of hydroxypropyl starch, hydroxypropyl methylcellulose and pullulan must be strictly controlled. The addition amount of pullulan must meet certain conditions, and insufficient addition will cause Lead to the phenomenon of brittle crumbs. Therefore, although the patent uses hydroxypropyl starch and hydroxypropyl methylcellulose to replace part of pullulan to reduce part of the production cost, it still cannot fundamentally circumvent the use of pullulan. Reduce production costs; and the patent also uses calcium chloride, potassium chloride, potassium citrate plasma to achieve excellent film-forming properties to achieve a certain rubber toughness.
- CN 104721167 A a combination of ordinary starch and modified starch is used as the starch matrix, supplemented by plasticizers, gelling agents and deionized water to prepare soft starch capsules.
- the prepared soft capsules have high transparency, good toughness, and disintegration time limit. Shorten and other advantages.
- the preparation process used in the preparation process is a conventional preparation method, it is necessary to pre-spread and dry the film, and the drying time of the film is often longer.
- the vegetable soft capsules reported in the prior art have the disadvantages of high raw material cost, long rubber drying time during the preparation process, low production efficiency, poor encapsulation, and the need to add additional metal ions to ensure film formation; they cannot simultaneously solve the plant soft capsules
- the two key factors of medium cost and quality cannot achieve the level of industrialization of vegetable soft capsules to replace gelatin soft capsules.
- the purpose of the present invention is to solve the problems of low cost and high quality in the existing plant soft capsule technology, and to provide a plant soft capsule with industrial applications and a preparation method thereof;
- the present invention controls the weight average molecular weight of carrageenan, and
- a vegetable soft capsule with excellent performance is prepared from starch, plasticizer and water;
- the vegetable soft capsule of the present invention has a lower production cost than the vegetable soft capsule in the prior art, and the product quality meets the requirements of the gelatin soft capsule;
- USP United States Pharmacopoeia
- the present invention provides a vegetable soft capsule, comprising carrageenan, starch, plasticizer and water, and the carrageenan has a weight average molecular weight Mw of 1.20 ⁇ 10 6 to 2.00 ⁇ 10 6 .
- the weight-average molecular weight Mw of conventional carrageenan is 2.0 ⁇ 10 5 or more.
- the glue prepared by using the carrageenan with the defined weight-average molecular weight range of the present invention as a gelling agent has excellent fluidity and film-forming properties, and it can eliminate metal ion additives such as calcium chloride, potassium chloride or lemon Under the premise of potassium acid potassium), it can be prepared to meet the requirements of soft capsule film formation and rubber toughness, and the rupture time is significantly shortened to meet the requirements of USP standards.
- the vegetable soft capsule includes 3-20 parts by weight of carrageenan, 10-50 parts by weight of starch, 10-35 parts by weight of plasticizer, and 30-70 parts by weight of water;
- carrageenan 3-20 parts by weight of carrageenan, 10-50 parts by weight of starch, 10-35 parts by weight of plasticizer, and 30-70 parts by weight of water;
- those skilled in the art can adjust the proportion of the vegetable soft capsule of the present invention according to the performance of the product in combination with known techniques.
- the carrageenan is any combination of one or more of K-type (Kappa), I-type (Iota) and L-type (Lambda); more preferably, it is I-type (Iota) or I-type (Iota). ) And K-type (Kappa) combination.
- the glue made from L-type carrageenan had poor film-forming properties, while the glue made from pure K-type carrageenan had better film-forming properties, but its viscosity was poor.
- pure type I or type I+K carrageenan the glue produced is easy to spread into a film, has moderate viscosity, good rubber toughness, and is not easy to break.
- the produced capsules have low oil leakage and high production efficiency.
- the plasticizer is one or any combination of two or more of glycerol, sorbitol, xylitol, and polyethylene glycol, and more preferably glycerol;
- the starch is modified starch, and the modified starch is oxidized starch, acid starch, hydroxypropyl starch, oxidized hydroxypropyl starch, and a combination of one or more of two or more in any weight ratio, more preferably hydroxy Propyl starch or oxidized hydroxypropyl starch;
- the vegetable soft capsule also includes pigments, sunscreens or fragrances
- the pigments are natural pigments and synthetic pigments
- the natural pigments are brown (caramel color), blue (phyco blue), or purple-red (Purple potato red) or orange (annatto)
- synthetic pigments are one or more of carmine, lemon yellow, sunset yellow, indigo, etc.
- Natural pigments are more green and safer than synthetic pigments, but due to the high temperature of the production process of vegetable soft capsules, natural pigments are easily faded at high temperatures.
- the present invention tested the effect of various pigments on the performance of the glue, and found that when the caramel color was added in a higher proportion, the glue was extremely viscous, but the glue had poor performance and could not be flattened into a film.
- purple sweet potato red can meet the production needs, the natural pigment is easily faded under high temperature. Although red iron oxide does not fade under high temperature, the glue performance is poor. After many screenings, we found that annatto and algae blue pigments do not affect the performance of the glue, and can be colorless under high temperature for a certain period of time, which is extremely important for our rich product variety.
- the present invention studies different types of color retention agents, and finally screens meglumine as color retention agent. The prepared soft capsules will not fade even when placed at high temperature for a long time. Have practical industrial application prospects.
- the present invention provides a method for preparing a vegetable soft capsule, which includes the following steps:
- a certain hardness means that the hardness is between 50 and 70N.
- the heating temperature in step 1) is 80-90°C; the heat preservation time is 20-120 min;
- the thickness of the rubber in step 2) is less than 1.0mm, and more preferably 0.30mm to 0.60mm; currently in the industry, the thickness of the soft capsule rubber is increased (0.70mm to 0.90mm) and the speed of the pellet mill (1.5rpm) is sacrificed
- the present invention can control the rubber thickness to be 0.30mm to 0.60mm on the basis of achieving high rotation speed and low oil leakage rate.
- the plant soft capsule process of the present invention can reduce the thickness of the rubber skin to half of the normal level or even lower, while ensuring the hardness of the capsule and a very low oil leakage rate (less than 1%), which is extremely important for controlling the cost of soft capsules Meaning.
- the temperature of heating the plastic box of the blasting machine is 80-95°C; the heating temperature of the drum is 20-40°C.
- the drum of the pellet mill in the industry is refrigerated, and the purpose of refrigeration is to cool the gelatin glue liquid as soon as possible; although the purpose of cooling and shaping can be achieved as soon as possible by refrigeration, the vegetable glue liquid of the present invention has a higher moisture content, and the refrigeration method It is difficult to dry to form a rubber with good toughness, resulting in a small amount of content and a high oil leakage rate.
- the invention heats the drum, and the vegetable rubber after the heated drum can be quickly dried, has good toughness and viscosity, saves the drying time in the early stage, ensures the rubber quality, thereby increases the machine speed and ensures the production efficiency.
- the present invention provides a use of vegetable soft capsules, which are filled with active ingredients as content for preparing medicines, functional foods or dietary nutritional supplements.
- the medicine, functional food or dietary nutritional supplement is Danqi soft capsule, linseed oil vegetable soft capsule, vitamin E vegetable soft capsule, evening primrose oil vegetable soft capsule, biotin vegetable soft capsule, lutein vegetable soft capsule Capsules, coenzyme Q10 vegetable soft capsules, vitamin K2 vegetable soft capsules, phospholipid vegetable soft capsules, conjugated linoleic acid vegetable soft capsules, coconut oil vegetable soft capsules, multivitamin and mineral vegetable soft capsules, DHA algae oil vegetable soft capsules, Fish oil vegetable soft capsule.
- the content of the linseed oil is linseed oil, a linseed oil vegetable soft capsule made of carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components.
- the linseed oil contains a high content of ⁇ -linolenic acid , ⁇ -linolenic acid has the effects of anti-tumor, anti-thrombosis, lowering blood fat, nourishing brain cells, and regulating autonomic nerves.
- the vitamin E vegetable soft capsule is a vitamin E vegetable soft capsule made of vitamin E and soybean oil as the content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components.
- Vitamin E is a fat-soluble vitamin
- the hydrolyzate is tocopherol, which is one of the most important antioxidants.
- the evening primrose oil vegetable soft capsule is an evening primrose oil vegetable soft capsule made with evening primrose oil as the content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components. Oil can prevent cardiovascular disease, premenstrual syndrome, and menopausal syndrome.
- the biotin vegetable soft capsule is a biotin vegetable soft capsule made with biotin, rice bran oil, phospholipids, and beeswax as the content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components.
- Biotin is A nutrient necessary to maintain the human body's natural growth, development and normal human body function and health. It not only prevents hair loss and the top of the head from seeing light, but also prevents juvenile gray hair that is common in modern people.
- the vitamin D3 vegetable soft capsule is a vitamin D3 vegetable soft capsule made of vitamin D3 and rice bran oil with carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components. Vitamin D3 can promote the body's calcium , Phosphorus absorption, so that plasma calcium and plasma phosphorus levels reach saturation, promote growth and bone calcification, and promote healthy teeth.
- the lutein vegetable soft capsule is a lutein vegetable soft capsule made with lutein, rice bran oil, beeswax, and phospholipids as the content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components.
- Natural lutein is an excellent antioxidant, which can resist free radicals causing cell and organ damage in the human body, thereby preventing cardiovascular sclerosis, coronary heart disease and tumor diseases caused by body aging.
- the coenzyme Q10 vegetable soft capsule is made of coenzyme Q10, rice bran oil, beeswax, and phospholipid as the content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components. It can provide power to the heart. It also has excellent anti-oxidation and free radical scavenging functions. It can prevent lipid peroxidation of blood vessel walls and prevent atherosclerosis without any side effects.
- the vitamin K2 vegetable soft capsule is a vitamin K2 vegetable soft capsule made of vitamin K2, rice bran oil and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber ingredients.
- Vitamin K2 is a fat-soluble Vitamin, a derivative of the naphthoquinone group with phylloquinone biological activity, is one of the indispensable and important vitamins in the human body, and can treat and prevent osteoporosis.
- the phospholipid vegetable soft capsule is a phospholipid vegetable soft capsule made of carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components. Phospholipids can decompose high blood fat and high cholesterol. Sweeping blood vessels, so that blood vessels circulate smoothly, is recognized as "vascular scavenger".
- the conjugated linoleic acid vegetable soft capsule is a conjugated linoleic acid vegetable soft capsule made with conjugated linoleic acid as the content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components.
- Conjugated linoleic acid has many important physiological functions such as anti-tumor, anti-oxidation, anti-atherosclerosis, improving immunity, increasing bone density, and preventing and treating diabetes; it can also reduce animal and human cholesterol, triglycerides and low-density lipids. Protein cholesterol can also reduce animal and human fat and increase muscle.
- the coconut oil vegetable soft capsule is a coconut oil vegetable soft capsule made of coconut oil as the content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber ingredients.
- coconut oil is the only medium-chain Fats composed of fatty acids can increase the efficiency of metabolism.
- the multi-vitamin-mineral plant soft capsule is mainly composed of vitamins such as vitamin A, vitamin B 2 , vitamin B 6 , vitamin B 12 , vitamin C, vitamin D 3 , and vitamin E, and minerals such as calcium, iron, zinc, and selenium.
- the active ingredients are made of soybean oil, phospholipids, and beeswax to make the content, and a multi-vitamin mineral soft capsule made of carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber ingredients to supplement the various needs of the human body. Vitamins and minerals.
- the DHA algae oil vegetable soft capsule is a DHA algae oil vegetable soft capsule made with DHA algae oil as its content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components.
- DHA is the growth and development of nervous system cells.
- One of the main elements for maintenance is the important constituent fatty acids of the brain and retina.
- the content in the human cerebral cortex is as high as 20%, and it accounts for the largest proportion in the retina of the eye, accounting for about 50%. It is essential for the development of infant intelligence and vision.
- the fish oil vegetable soft capsule is a fish oil vegetable soft capsule made of fish oil as its content and carrageenan, hydroxypropyl starch, glycerin, and water as the main rubber components.
- Fish oil is a kind of oil extracted from fatty fish. Rich in omega-3 polyunsaturated fatty acids (DHA and EPA), it has health benefits such as anti-inflammatory and blood lipid regulation.
- the present invention surprisingly discovered when developing vegetable soft capsules that when the molecular weight of carrageenan is limited to a certain range, the glue composed of hydroxypropyl starch, plasticizer and water has good film-forming properties. Compared with the prior art, the present invention The invention has the following beneficial effects:
- the plant soft capsules of the present invention have simple raw materials. Under the premise of controlling the molecular weight of carrageenan, only starch, plasticizer and water need to be added, without adding expensive pullulan, which greatly reduces the cost of plant soft capsules. Cost of production;
- the vegetable soft capsule prepared by the present invention can achieve excellent film-forming properties, stronger rubber toughness, and cracking Time is greatly shortened;
- the present invention can achieve high rolling speed and low oil leakage rate of vegetable soft capsules on the basis of controlling the thickness of the rubber skin to be 0.30mm ⁇ 0.60mm; there is no need to sacrifice production efficiency and Increase rubber thickness to ensure low oil leakage rate;
- the thickness of the vegetable soft capsule rubber prepared by the present invention is much lower than half of the normal level or even lower, while ensuring the hardness of the capsule and extremely low oil leakage rate, which is extremely significant for controlling the cost of the soft capsule;
- the pure starch rubber has a high oil leakage rate due to insufficient toughness, and has a large limitation on the machine speed, which is only 1.5 rpm.
- the invention can be produced at a machine speed of 1.5 rpm-5.0 rpm, which is completely comparable to gelatin; and greatly saves the drying time after the capsule is formed, and solves the coexistence problem of many plant soft capsules-the drying time is too long;
- the rupture time of vegetable soft capsules is about 30 minutes; the present invention can reduce the rupture time of soft capsules by removing the soluble salt film-forming agent and reducing the thickness of the rubber. 15 minutes, in line with USP standards;
- Mn stands for number average molecular weight
- Mw stands for weight average molecular weight
- Mz stands for average molecular weight
- Mw/Mn stands for polydispersity index
- the horizontal axis represents the logarithm of the molecular weight; the vertical axis represents a point on the curve.
- the vertical axis value is a value related to the content of sample molecules at each molecular weight.
- the equipment involved in the examples the glue tank TRRJ-10, from Wenzhou Tianrui Pharmaceutical Machinery Co., Ltd.; the automatic soft capsule machine BCM-GB6, from BOCHANG CO, L, td; the SLX-A hardness tester: from At Wenzhou Shandu Instrument Co., Ltd.
- Rubber seam rate the ratio of rubber seam thickness to rubber thickness
- Oil leakage rate the percentage of oil leaking soft capsules in all soft capsules
- Content loading refers to the maximum loading of the mold
- Rupture time Refer to the Rupture Test in USP ⁇ 2040>
- Hardness The hardness of the soft capsule after drying, which measures the drying effect of the soft capsule.
- the weight-average molecular weight of type I is 1.2 ⁇ 10 6
- the weight-average molecular weight of type K is 2.0 ⁇ 10 6
- the weight-average molecular weight of type L is 1.8 ⁇ 10 6
- type I+K refers to the use of Type I and Type K carrageenan are used as raw materials
- the weight ratio of Type I: Type K can be in the range of 9.9:0.1 to 7.0:3.0 based on the weight ratio, which is 8:1 in this embodiment.
- the glue made from L-type carrageenan had no gel properties and could not be flattened into a film.
- the glue made from pure K-type carrageenan had better film-forming properties, but poor viscosity. Only pure type I or type I+K carrageenan can make the glue liquid that is easy to spread into a film, with moderate viscosity, good rubber toughness, not easy to break, the produced capsules have low oil leakage rate and high production efficiency.
- Drum temperature 15°C 20°C 30°C 40°C 50°C Rubber joint rate 50% 60% 70% 70% 40% Contents loading 600mg 800mg 850mg 850mg 700 Oil leakage rate 20% less than 1% less than 1% less than 1% 40%
- Plasticizers have a greater impact on the toughness of the rubber.
- the toughness of the rubber determines the filling range of the capsule. The better the toughness, the larger the filling.
- the capsule can be filled with 850mg.
- the same mold uses sorbitol, xylitol or As a plasticizer, polyethylene glycol has insufficient rubber toughness and low capsule capacity.
- Xylitol and polyethylene glycol have a high oil leakage rate as plasticizers. Therefore, glycerin is the first choice as a rubber plasticizer.
- starch Oxidized starch Acid starch Hydroxypropyl starch Oxidized hydroxypropyl starch Rubber joint rate 10% 20% 70% 70% Contents loading 300mg 500mg 850mg 900mg Oil leakage rate 80% 60% less than 1% less than 1%
- Starch has a great influence on the viscosity of the rubber.
- the viscosity of the rubber is too low, the seam thickness is insufficient, the oil leakage rate is high, and the rubber is too viscous, and it is easy to stick to the surface of the drum, which affects the production efficiency. Therefore, we screened oxidized starch, acidic starch, hydroxypropyl starch, and oxidized hydroxypropyl starch for experiments.
- We found that the rubbers made from oxidized starch and acid starch were not sufficiently viscous, and the capsules made were easy to leak oil.
- Starch and oxidized hydroxypropyl starch have good viscosity and meet the production requirements, so we prefer hydroxypropyl starch or oxidized hydroxypropyl starch.
- the present invention can prepare a rubber skin with a thickness of 0.30 mm to 0.60 mm under the premise of meeting the above performance indicators.
- the thickness of the rubber skin can be 0.30 mm to 0.60 mm.
- the rubber thickness is thick, the oil leakage rate of the capsule is low, but the rupture time is too long and the rubber cost is too high.
- the preferred rubber thickness is 0.30mm to 0.60mm.
- the oil leakage rate is considered.
- the machine speed is relatively low.
- the low-speed production efficiency is low, and the plant soft capsule production process of the present invention can achieve a similar rubber seam rate at a machine speed of 1.5 to 5.0 rpm, and the oil leakage rate is less than 1%, which has extremely high production efficiency. .
- Purple sweet potato red (also known as purple sweet potato red pigment) in Table 9 is a natural red pigment extracted from the roots, stems and leaves of purple sweet potato, and its structure contains multiple phenolic hydroxyl groups.
- Existing technology Food Processing, 2016 Vol. 41, Issue 2, Pages 38-41, Study on the Stability of Purple Sweet Potato Red Pigment
- the most stable ones are Al3 + , Ca2 + , Sn2 + , but the addition of metal ions in the system of the present invention has a greater impact on the rupture time of the soft capsule, and the article shows that the type of metal ions may accelerate the color fade It’s counterproductive, so the reference is of little significance.
- the present invention has studied different types of food additives as color protectants of purple sweet potato red, and found that meglumine can effectively solve the problem of purple sweet potato fading
- the method for preparing soft capsules with color-preserving agent is the same as the above-mentioned method for screening pigments. The difference is that the pigment is selected purple sweet potato red, and the color-preserving agent-purple sweet potato red 50wt% (that is, 500g) by weight, is prepared with different color-preserving agents
- the color of the soft capsule shell is used as a measure of the color protection effect of the color protection agent. The results are shown in Table 9-A:
- ND means that no color protection agent is added, as a control; "——” means that no test has been carried out; 0 days refers to the soft capsules prepared on the same day; 40°C acceleration for 3 months refers to the prepared soft capsules Use PVC plastic bottle packaging (simulating commercial packaging), place it in the dark at (40 ⁇ 2)°C for 3 months, and observe the color change of the capsule shell.
- the resulting product has a rupture time of 5 minutes, and the oil leakage rate is controlled below 1%.
- the process has extremely high production efficiency and meets USP standards.
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Abstract
Description
卡拉胶 | I型 | K型 | L型 | I型+K型 |
胶皮接缝率 | 70% | 0% | 0% | 75% |
内容物装量 | 800mg | 0 | 0 | 850mg |
漏油率 | 小于1% | 100% | 100% | 小于1% |
卡拉胶Mw | 1.0×10 6 | 1.2×10 6 | 1.5×10 6 | 2.0×10 6 | 2.5×10 6 |
胶皮接缝率 | 40% | 60% | 70% | 50% | 20% |
内容物装量 | 600mg | 800mg | 850mg | 800mg | 400mg |
漏油率 | 20% | 小于1% | 小于1% | 小于1% | 50% |
转鼓温度 | 15℃ | 20℃ | 30℃ | 40℃ | 50℃ |
胶皮接缝率 | 50% | 60% | 70% | 70% | 40% |
内容物装量 | 600mg | 800mg | 850mg | 850mg | 700 |
漏油率 | 20% | 小于1% | 小于1% | 小于1% | 40% |
增塑剂 | 甘油 | 山梨糖醇 | 木糖醇 | 聚乙二醇 |
胶皮接缝率 | 70% | 60% | 40% | 30% |
内容物装量 | 850mg | 700mg | 500mg | 400mg |
漏油率 | 小于1% | 小于1% | 20% | 40% |
淀粉 | 氧化淀粉 | 酸性淀粉 | 羟丙基淀粉 | 氧化羟丙基淀粉 |
胶皮接缝率 | 10% | 20% | 70% | 70% |
内容物装量 | 300mg | 500mg | 850mg | 900mg |
漏油率 | 80% | 60% | 小于1% | 小于1% |
胶皮厚度 | 0.20 | 0.30 | 0.45 | 0.60 | 0.80 |
胶皮接缝率 | 70% | 70% | 70% | 70% | 70% |
内容物装量 | 750mg | 1000mg | 1000mg | 950mg | 850mg |
漏油率 | 5% | 小于1% | 小于1% | 小于1% | 小于1% |
破裂时间 | 1min | 3min | 5min | 13min | 25min |
硬度 | 30N | 50N | 70N | 70N | 70N |
机速 | 1.5rpm | 2.5rpm | 3.0rpm | 4.0rpm | 5.0rpm |
胶皮接缝率 | 80% | 75% | 70% | 60% | 50% |
内容物装量 | 1000mg | 1000mg | 1000mg | 1000mg | 1000mg |
漏油率 | 小于1% | 小于1% | 小于1% | 小于1% | 小于1% |
离子 | 氯化钠 | 氯化钾 | 氯化钙 | 不加离子 |
胶皮接缝率 | 90% | 85% | 85% | 70% |
内容物装量 | 1000mg | 1000mg | 1000mg | 1000mg |
漏油率 | 小于1% | 小于1% | 小于1% | 小于1% |
破裂时间 | 18min | 20min | 25min | 5min |
胶皮接缝率 | 70% |
内容物装量 | 800mg |
漏油率 | 小于1% |
破裂时间 | 3min |
硬度 | 55N |
胶皮接缝率 | 60% |
内容物装量 | 750mg |
漏油率 | 小于1% |
破裂时间 | 6min |
硬度 | 65N |
Claims (13)
- 一种植物软胶囊,包括卡拉胶、淀粉、增塑剂和水,其特征在于:所述卡拉胶为的重均分子量Mw为1.2×10 6~2.0×10 6。
- 根据权利要求1所述的植物软胶囊,其特征在于:按照重量份数计算,所述植物软胶囊包括3-20重量份的卡拉胶、10-50重量份的淀粉、10-35重量份的增塑剂、30-70重量份的水。
- 根据权利要求1所述的植物软胶囊,其特征在于:所述卡拉胶为I型或I型与K型的组合;所述I型与K型的组合中,按重量比计算I型∶K型=9.9∶0.1~7.0∶3.0。
- 根据权利要求1所述的植物软胶囊,其特征在于:所述增塑剂为甘油、山梨糖醇、木糖醇、聚乙二醇中的一种或两种以上的任意组合。
- 根据权利要求1所述的植物软胶囊,其特征在于:所述淀粉为改性淀粉,所述改性淀粉为羟丙基淀粉、氧化羟丙基淀粉中的一种或两种的任意重量比例组合。
- 根据权利要求1-5任一项所述的植物软胶囊,其特征在于:所述植物软胶囊中还可以包括色素、遮光剂或香味剂中的一种或多种。
- 根据权利要求6所述的植物软胶囊,其特征在于:所述色素为天然色素或合成色素,所述天然色素为藻蓝、胭脂树橙或紫薯红,所述合成色素为胭脂红、柠檬黄、日落黄或靛蓝;所述紫薯红中加入葡甲胺作为护色剂。
- 一种植物软胶囊的制备方法,包括如下步骤:1)化胶工艺称取配方量的卡拉胶、淀粉、增塑剂和水,加热至胶液溶胀后保温,脱气至胶液澄清透亮得胶液;2)轧丸工艺将轧丸机的胶盒加热,转鼓加热,供胶,设定胶皮厚度,设定轧丸机机速后进行轧丸,然后干燥至胶丸达到一定硬度,选丸,最后包装。
- 根据权利要求8所述的制备方法,其特征在于:步骤2)所述转鼓加热温度为20~40℃。
- 根据权利要求9所述的制备方法,其特征在于:步骤1)所述加热的温度为80~90℃;所述保温的时间为20~120min。
- 根据权利要求9所述的制备方法,其特征在于:步骤2)中所述将轧丸机的胶盒加热的温度为80~95℃。
- 一种权利要求1所述述植物软胶囊的用途,其特征在于:植物软胶囊中填充活性组分为内容物,用于制备药品、功能性食品或膳食营养补充剂。
- 根据权利要求12所述的用途,其特征在于:所述药品为丹七软胶囊;所述功能性食品或膳食营养补充剂为亚麻籽油植物软胶囊、维生素E植物软胶囊、月见草油植物软胶囊、生物素植物软胶囊、叶黄素植物软胶囊、辅酶Q10植物软胶囊、维生素K2植物软胶囊、磷脂植物软胶囊、共轭亚油酸植物软胶囊、椰子油植物软胶囊、复合维生素矿物质植物软胶囊、DHA藻油植物软胶囊或鱼油植物软胶囊。
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