WO2019176295A1 - 自動分析装置および自動分析装置の流路詰まり検出方法 - Google Patents
自動分析装置および自動分析装置の流路詰まり検出方法 Download PDFInfo
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- WO2019176295A1 WO2019176295A1 PCT/JP2019/001964 JP2019001964W WO2019176295A1 WO 2019176295 A1 WO2019176295 A1 WO 2019176295A1 JP 2019001964 W JP2019001964 W JP 2019001964W WO 2019176295 A1 WO2019176295 A1 WO 2019176295A1
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- vacuum
- automatic analyzer
- vacuum tank
- clogging
- flow path
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- 239000000523 sample Substances 0.000 claims abstract description 152
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- 238000001514 detection method Methods 0.000 claims description 6
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Definitions
- the present invention relates to an automatic analyzer and a flow path clogging detection method of the automatic analyzer.
- the automatic analyzer discharges a certain amount of sample and a certain amount of reagent into a reaction vessel, mixes and reacts them, and optically measures the reaction solution to analyze the components and concentration of the specimen. ing. Since the reaction waste liquid in which the sample and the reagent have reacted is generated in the reaction container after the analysis is completed, in order to remove the reaction waste liquid from the reaction container, there is one that sucks the waste liquid using a vacuum pump or the like. In addition, in automatic analyzers that perform qualitative and quantitative analysis of samples, the occurrence of cross-contamination is suppressed by appropriately cleaning the probe used for dispensing the sample to be analyzed, thereby maintaining analysis accuracy. Some have a cleaning liquid suction mechanism that removes cleaning liquid and the like adhering to the probe surface.
- An automatic analyzer having a mechanism for sucking reaction waste liquid and a mechanism for sucking cleaning liquid adhering to the surface after probe cleaning depressurizes the vacuum tank with a decompression pump, etc., and arranges an electromagnetic valve in the flow path from the vacuum tank.
- the solenoid valve is opened and closed, and the waste liquid is sucked by the pressure difference in the vacuum tank.
- the pressure in the vacuum tank reaches a certain negative pressure, the contact point of the vacuum switch provided in the vacuum tank is switched, and the analysis can be performed. If the flow path of each mechanism connected to the vacuum tank is clogged or the solenoid valve malfunctions, the suction operation cannot be performed normally, and the waste liquid remains in the reaction vessel or the cleaning water remains on the probe.
- the automatic analyzer disclosed in Patent Document 1 is provided with a separate pressure sensor in the suction nozzle in order to detect clogging of the drainage system of the waste liquid suction means.
- pressure sensors are required for all of the waste liquid suction units, and the risk of failure increases as the number of sensors increases. Further, when a new clogging detection function is added to an existing apparatus that does not have a pressure sensor, the installation location of the pressure sensor is limited, and the apparatus configuration becomes complicated.
- An object of the present invention is to provide an automatic analyzer capable of detecting clogging in a flow path and a flow path clogging detecting method of the automatic analyzer.
- an automatic analyzer of the present invention includes a vacuum tank and a vacuum pump for vacuum suction of a liquid, a first electromagnetic valve provided on a flow path connected to the vacuum tank,
- An automatic analyzer comprising: a determination unit that determines whether the vacuum value in the vacuum tank is equal to or greater than a predetermined threshold value or less than the predetermined threshold value; and a clogging detection unit that detects clogging in the flow path.
- the clogging detecting means changes the vacuum pump from ON to OFF in a state where the first electromagnetic valve is closed, and then turns the first electromagnetic valve from closed to open.
- the vacuum pump is operated until the negative pressure of the vacuum tank becomes constant with the solenoid valve arranged between the vacuum tank and the mechanism requiring vacuum closed.
- the negative pressure value in the vacuum tank is normally held at a constant negative pressure value if there is no leak. If the vacuum switch is turned off after a certain time, a leak has occurred somewhere in the flow path.
- the present invention when there is an abnormality in the flow path, it is possible to detect the abnormality of the flow path without using a sensor for measuring pressure.
- the vacuum pump is operated until the negative pressure of the vacuum tank becomes constant with the solenoid valve disposed between the vacuum tank and the mechanism requiring vacuum closed. .
- the negative pressure value in the vacuum tank is normally held at a constant negative pressure value if there is no leak. If the vacuum switch is turned off after a certain time, a leak has occurred somewhere in the flow path. Therefore, in order to confirm that there is no more in each flow path system, stop the vacuum pump from the state where the negative pressure of the vacuum tank is constant, and open the solenoid valve of the flow path of the part to be confirmed connected to the vacuum tank Then, the time for which the vacuum switch is turned off is measured and compared with a threshold value to determine whether or not the flow path system is abnormal. By making the determination in all the flow paths using vacuum, it is determined whether there is an abnormality in the flow path system.
- FIG. 1 is a diagram schematically showing an overall configuration of an automatic analyzer according to the present embodiment.
- an automatic analyzer 100 is a device that dispenses and reacts a sample and a reagent in a reaction vessel 2 and measures the reacted liquid.
- the reaction vessel 2 is arranged on the reaction disc 1 in a circumferential shape.
- the reaction container 2 is a container for storing a mixed liquid in which a sample and a reagent are mixed, and a plurality of reaction containers 2 are arranged on the reaction disk 1.
- a sample transport mechanism 17 is disposed that transports a sample rack 16 on which one or more sample containers 15 containing samples to be analyzed are mounted.
- a first sample dispensing mechanism 11 and a second sample dispensing mechanism 12 that can be rotated and moved up and down are arranged.
- the first sample dispensing mechanism 11 has a sample probe 11a arranged with its tip facing downward, and a sample pump 19 is connected to the sample probe 11a.
- the first sample dispensing mechanism 11 is configured to be able to discharge from the sample probe 11a wash water (hereinafter referred to as internal wash water) delivered by a sample pump 19 from a wash water tank (not shown). Further, the first sample dispensing mechanism 11 is configured to be capable of rotating in the horizontal direction and moving up and down.
- the sample probe 11a is inserted into the sample container 15 and the sample pump 19 is operated to operate the sample.
- the sample is dispensed from the sample container 15 to the reaction container 2 by inserting the sample probe 11a into the reaction container 2 and discharging the sample.
- a cleaning tank 13 for cleaning the sample probe 11a with a cleaning liquid and a cleaning container 23 for cleaning with a special cleaning liquid are arranged.
- the position where the sample probe 11a is inserted into the sample container 15 and the sample is sucked is defined as the first sample suction position
- the position where the sample probe 11a is inserted into the reaction container 2 and the sample is discharged is defined as the first sample discharge position.
- the tank 13 and the cleaning container 23 are disposed between the first sample suction position and the first sample discharge position.
- the second sample dispensing mechanism 12 has a sample probe 12a arranged with its tip facing downward, and a sample pump 19 is connected to the sample probe 12a.
- the second sample dispensing mechanism 12 is configured such that the wash water (internal wash water) sent from the wash water tank (not shown) by the sample pump 19 can be discharged from the sample probe 12a.
- the second sample dispensing mechanism 12 is configured so as to be able to rotate in the horizontal direction and move up and down.
- the sample probe 12a is inserted into the sample container 15 and the sample pump 19 is operated to suck the sample. Then, the sample probe 12a is inserted into the reaction vessel 2 and the sample is discharged, thereby dispensing the sample from the sample vessel 15 to the reaction vessel 2.
- a cleaning tank 14 for cleaning the sample probe 12a with a cleaning liquid and a cleaning container 24 for cleaning with a special cleaning liquid are arranged. If the position where the sample probe 12a is inserted into the sample container 15 and the sample is sucked is the second sample suction position, and the position where the sample probe 12a is inserted into the reaction container 2 and the sample is discharged is the second sample discharge position, the cleaning is performed.
- the tank 14 and the cleaning container 24 are disposed between the second sample suction position and the second sample discharge position.
- the washing tanks 13 and 14 are washing tanks for performing washing of the outside and inside of the sample probes 11a and 12a after the reagent dispensing every time the sample is dispensed.
- the cleaning containers 23 and 24 have the sample probes 11a and 12a before analyzing the sample when the sample of the sample type registered in advance is requested to measure the analysis item registered in advance. It is a part for the additional washing process performed with respect to.
- the reagent disk 9 is a storage in which a plurality of reagent bottles 10 containing the reagents therein can be placed on the circumference.
- the reagent disk 9 is kept cold.
- reagent dispensing mechanisms 7 and 8 for dispensing the reagent from the reagent bottle 10 to the reaction container 2 are configured.
- reagent probes 7a and 8a arranged with their tips facing downward.
- a reagent pump 18 is connected to the reagent probes 7a and 8a. The reagent pump 18 dispenses the reagent, detergent, diluent, pretreatment reagent, and the like sucked from the reagent bottle 10 and the like through the reagent probes 7a and 8a into the reaction container 2.
- a cleaning tank 32 for cleaning the reagent probe 7a with a cleaning liquid is disposed, and in the operating range of the reagent dispensing mechanism 8, a cleaning tank 33 for cleaning the reagent probe 8a with a cleaning liquid is disposed.
- a spectrophotometer 4 that measures the absorbance of the reaction liquid by measuring the transmitted light obtained from the light source 4a through the reaction liquid of the reaction vessel 2 around the stirring mechanism 5, 6, A cleaning mechanism 3 for cleaning the used reaction vessel 2 is disposed.
- the stirring mechanisms 5 and 6 are configured so as to be able to rotate in the horizontal direction and move up and down, and agitate the mixed solution (reaction solution) of the sample and the reagent by being inserted into the reaction vessel 2.
- mixing tanks 30 and 31 for cleaning the stirring mechanisms 5 and 6 with the cleaning liquid are arranged.
- a detergent discharge mechanism 20 is connected to the cleaning mechanism 3.
- the control unit 22 is configured by a computer or the like, and controls the operation of each mechanism described above in the automatic analyzer and performs calculation processing for obtaining the concentration of a predetermined component in a liquid sample such as blood or urine.
- a part of the connection between each mechanism constituting the automatic analyzer and the control unit 22 is omitted.
- the above is the general configuration of the automatic analyzer 100.
- the analysis process of the inspection sample by the automatic analyzer 100 as described above is generally performed in the following order.
- the sample in the sample container 15 placed on the sample rack 16 transported near the reaction disk 1 by the sample transport mechanism 17 is sampled by the sample probe 11a of the first sample dispensing mechanism 11 or the second sample dispensing.
- the sample is dispensed into the reaction vessel 2 on the reaction disk 1 by the sample probe 12 a of the mechanism 12.
- the reagent used for the analysis is dispensed from the reagent bottle 10 on the reagent disk 9 to the reaction container 2 into which the sample has been dispensed by the reagent probes 7a, 8a of the reagent dispensing mechanisms 7, 8.
- the mixed solution of the sample and the reagent in the reaction vessel 2 is stirred by the stirring mechanisms 5 and 6.
- the light generated from the light source 4 a is transmitted through the reaction vessel 2 containing the mixed solution, and the luminous intensity of the transmitted light is measured by the spectrophotometer 4.
- the light intensity measured by the spectrophotometer 4 is transmitted to the control unit 22 via the A / D converter and the interface. Then, calculation is performed by the control unit 22, the concentration of a predetermined component of the analysis item corresponding to the reagent is obtained, and the result is displayed on a display unit (not shown) or stored in a storage unit (not shown).
- FIG. 2 is a schematic diagram for explaining an apparatus configuration for performing a waste liquid suction operation.
- an apparatus configuration for sucking waste liquid will be described.
- the vacuum tank is provided with a vacuum switch 36 that senses that the pressure in the vacuum tank has been reduced to a specified negative pressure, and when the specified negative pressure is reached and the vacuum switch is turned on, analysis can be performed in the control unit 22. To be judged.
- the vacuum switch includes a pressure receiving portion that receives pressure and a pressure receiving element that detects the pressure received by the pressure receiving portion, and includes a spring and a switch.
- the switch contacts are switched by a spring.
- Reaction waste liquid suction nozzles 37a and 37b or a cleaning waste liquid suction mechanism 39 are provided at the end of the flow path connected to the vacuum tank, and between the vacuum tank and the reaction waste liquid suction nozzles 37a and 37b or the cleaning waste liquid suction mechanism 39.
- a certain solenoid valve 35c, 35d is opened, vacuum suction can be performed.
- Vacuum bottles 34a and 34b for trapping the reaction waste liquid are provided between the flow path of the vacuum tank and the reaction waste liquid suction nozzles 37a and 37b and the electromagnetic valve 35c.
- the electromagnetic valves 35a and 35b connected to the vacuum bottles 34a and 34b are opened, the reaction waste liquid is discharged from the vacuum bottles 34a and 34b.
- the above is the apparatus configuration for sucking the waste liquid.
- reaction waste liquid suction operation will be described.
- the reaction waste liquid is sucked by the reaction waste liquid suction mechanism 21.
- the reaction disk 1 rotates, and the reaction container 2 containing the reaction waste liquid is moved to the position of the cleaning mechanism 3.
- the cleaning mechanism 3 is lowered and the reaction waste liquid suction nozzles 37a and 37b enter the reaction vessel 2, the electromagnetic valve 35c connected to the vacuum tank is opened to suck the reaction waste liquid.
- the sucked reaction waste liquid is trapped in the vacuum bottles 34a and 34b, and is discharged to a waste liquid tank outside the apparatus or a waste water sewage system by opening the electromagnetic valves 35a and 35b.
- the reaction waste liquid suction nozzle 37a sucks a high concentration reaction waste liquid in which the sample and the reagent are mixed.
- the reaction waste liquid suction nozzle 37b the reaction waste liquid is sucked, and then the low-concentration reaction waste liquid thinned by the detergent discharged by the detergent discharge mechanism 20 during the cleaning operation of the reaction container 2 is sucked. This completes the description of the reaction waste liquid suction operation.
- the cleaning waste liquid suction operation will be described.
- the cleaning waste liquid is sucked by the probe cleaning mechanism 40.
- the second sample dispensing mechanism 12 that has finished dispensing moves the sample probe 12 a to the cleaning tank 14. Cleaning water is discharged from the cleaning water discharge mechanism 14a, and the sample adhering to the surface of the sample probe 12a is washed away. Thereafter, the second sample dispensing mechanism 12 moves the sample probe 12 a to the cleaning waste liquid suction mechanism 39.
- the washing water remaining on the surface of the sample probe 12a is sucked by opening the electromagnetic valve 35d. Since the amount of cleaning water to be sucked is extremely small, it is trapped in a vacuum tank.
- the suction operation of the cleaning waste liquid is also performed in the cleaning tank 13 for the first sample dispensing mechanism 11. This completes the description of the cleaning waste liquid suction operation.
- FIG. 3A the relationship between the negative pressure in the vacuum tank and the signal of the vacuum switch when there is no abnormality such as clogging in the flow path connected to the vacuum tank and the vacuum tank is opened to the atmosphere will be described.
- the vertical axis indicates the negative pressure in the vacuum tank, and the horizontal axis indicates time.
- the vacuum pump is stopped at an arbitrary time T while the negative pressure in the vacuum tank is stable, and one of a plurality of solenoid valves connected to the vacuum tank is opened to open the atmosphere.
- the negative pressure in the vacuum tank that has been opened to the atmosphere decreases, and the vacuum switch is turned OFF when the vacuum switch threshold is exceeded.
- the time t n from the arbitrary time T until the vacuum switch is turned off is measured.
- the negative pressure in the vacuum tank is made constant by turning on the vacuum pump and closing the solenoid valve.
- the setting of the reference value t n is a condition that measurement is performed with a new flow path configuration.
- FIG. 3B when there is an abnormality such as clogging in the flow path connected to the vacuum tank, the negative pressure in the vacuum tank and the opening / closing of the electromagnetic valve connecting to the vacuum tank, ON / OFF of the vacuum pump, and vacuum
- the vacuum pump is stopped at an arbitrary time T, and one of a plurality of electromagnetic valves connected to the vacuum tank is opened to bring the air into an open state. If the flow path is clogged, the negative pressure in the vacuum tank that is open to the atmosphere will decrease more slowly than if there is no clogging, so the time t n ′ until the vacuum switch turns off will be longer. . Therefore, the relationship between the reference values t n and t n ′ is t n ⁇ t n ′, so that clogging can be detected.
- the above is the clogging determination method.
- FIG. 4 a shows a flowchart for determining clogging in the probe cleaning mechanism 40.
- the process proceeds to an analysis operation (S9).
- the determination result is displayed as an alarm on the operation unit (S10), and the apparatus is stopped (S11). This clogging determination is effective even if a mechanism for sucking a plurality of cleaning waste liquids is connected to the vacuum tank.
- S1 the blockage clogging determination
- S2 the solenoid valves connected to the vacuum tank are closed
- S3 the vacuum pump starts operating
- S4 the vacuum switch is turned on and the pressure in the vacuum tank becomes constant
- S5 the solenoid valve of the flow path corresponding to the reference value t 1 is opened (S16).
- the time t 1 ′ until the vacuum switch is turned off is measured (S17), and clogging is determined (S18).
- the determination result is accumulated in the storage unit (S25).
- the opened solenoid valve is closed (S19), the vacuum pump is turned on, and it is confirmed that the vacuum switch is turned on (S20). Opening the only solenoid valve corresponding to the reference value t 2 stops the vacuum pump (S21).
- Time t 2 ′ until the vacuum switch is turned off is measured (S22), and clogging is determined (S23).
- the time until the vacuum switch is turned off is measured (S37), and clogging is determined (S38). If there is no clogging, the process proceeds to an analysis operation (S30). If there is a blockage, the opened solenoid valve is closed (S39), the vacuum pump is turned on, and it is confirmed that the vacuum switch is turned on (S40). The vacuum pump is turned off, and one of the solenoid valves 35c and the previous solenoid valve (the solenoid valve 35a) is opened simultaneously (S41). The time until the vacuum switch is turned off is measured (S42), and clogging is determined (S43). By repeating this series of operations n times, clogging is determined for each branched flow path (S44), the determination result is displayed as an alarm (S46), and the apparatus is stopped (S47).
- the above clogging judgment operation and flowchart are performed during analysis preparation and maintenance.
- the time until the vacuum switch is turned off measured during maintenance is recorded in the apparatus so that it can be compared with the previous value at every maintenance.
- By recording the measured time until the vacuum switch is turned off from the time of shipment it is possible to grasp the deterioration of each flow path, and it is possible to use the clogging determination operation as a preventive maintenance function.
- FIG. 6 shows the relationship between the pressure in the vacuum tank and the altitude when the clogging determination method is used. Since the atmospheric pressure is lower in an area at an altitude of 2000 m than at an altitude of 0 m, the vacuum pump cannot be sufficiently pulled down to a negative pressure, and the waste liquid suction operation using the vacuum has no tolerance. Therefore, when the vacuum pump is stopped while the negative pressure in the vacuum tank is constant, and all the solenoid valves connected to the vacuum tank are opened and the vacuum tank is opened to the atmosphere, the vacuum switch at altitude hm is turned off. If the reference value until is t h , then t 0 > t 2000 .
- the reference value t h corresponding to this elevation may be set in the apparatus as a value obtained by same for all devices, compared to the vacuum switch when mounting the device measures the time t h 'until the OFF reference value t h To do. If the comparison result is t h > t h ′, it can be determined that there is no tolerance for the suction operation of the waste liquid using the vacuum, so add a vacuum pump or replace it with a vacuum pump that can draw high vacuum Can be determined.
- Cleaning containers 30, 31, 32, 33 ...
- Cleaning tanks 34a, 34b ... Vacuum bottle 35a 35b, 35c, 35d ...
- Solenoid valve 36 ... Vacuum switch 37a, 37b .
- Reaction waste liquid suction nozzle 39 ...
- Cleaning waste liquid suction mechanism 40 ... Probe cleaning mechanism 100 ... Automatic analyzer
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Abstract
Description
分析終了後には試料と試薬とが反応した反応廃液が反応容器内に生じるため、この反応廃液を反応容器から除去するため、減圧ポンプ等を用いて廃液を吸引するものがある。また試料の定性・定量分析を行う自動分析装置においては、分析対象である試料の分注に用いるプローブを適宜洗浄することによりクロスコンタミネーションの発生を抑制して分析精度の維持を図っており、プローブ表面に付着した洗浄液等を除去する洗浄液吸引機構を備えたものもある。
2…反応容器
3…洗浄機構
4…分光光度計
4a…光源
5,6…攪拌機構
7,8…試薬分注機構
7a,8a…試薬プローブ
9…試薬ディスク
10…試薬ボトル
11…第1試料分注機構
11a…試料プローブ
12…第2試料分注機構
12a…試料プローブ
13,14…洗浄槽
14a…洗浄水吐出口
15,15a,15b…試料容器
16…試料ラック
17…試料搬送機構
18…試薬用ポンプ
19…試料用ポンプ
20…洗剤吐出機構
21…反応廃液吸引機構
22…制御部
23,24…洗浄容器
30,31,32,33,…洗浄槽
34a,34b…真空瓶
35a,35b,35c,35d…電磁弁
36…真空スイッチ
37a,37b…反応廃液吸引ノズル
39…洗浄廃液吸引機構
40…プローブ洗浄機構
100…自動分析装置
Claims (10)
- 液体を真空吸引するための真空タンク及び真空ポンプと、
前記真空タンクに接続された流路上に備えられた第1の電磁弁と、
真空タンク内の真空値が所定の閾値以上であるか、当該所定の閾値より小さいかを判定する判定手段と、
前記流路内の詰まりを検知する詰まり検知手段と、を備えた自動分析装置であって、
前記詰まり検知手段は、
第1の電磁弁を閉にした状態で、真空ポンプをONからOFFへ変更し、
その後、第1の電磁弁を閉から開にし、第1の電磁弁を閉から開にした時点から、前記判定手段により真空タンク内の真空値が所定の閾値以上になった時までの時間を、所定の閾値を比較することにより、流路の詰まりの有無を検知することを特徴とする、自動分析装置。 - 請求項1に記載の自動分析装置において、
前記第1の電磁弁における前記真空タンクの反対側には、試料プローブの表面の洗浄液を前記真空ポンプにより吸引するための洗浄廃液吸引機構が備えられていることを特徴とする、自動分析装置。 - 請求項2に記載の自動分析装置において、
前記洗浄廃液吸引機構に隣接して、試薬プローブの洗浄液を収容した洗浄槽が備えられていることを特徴とする、自動分析装置。 - 請求項1に記載の自動分析装置において、
前記第1の電磁弁及び流路の組合せが複数備えられており、
前記詰まり検知手段は、前記詰まり検知を各流路について、第1の電磁弁の開閉を制御することにより順次行なうことを特徴とする、自動分析装置。 - 請求項1に記載の自動分析装置において、
前記第1の電磁弁における前記真空タンクの反対側には、真空タンクに近いほうから廃液を収容する廃液瓶、および反応容器を備えていることを特徴とする、自動分析装置。 - 請求項5に記載の自動分析装置において、
前記廃液瓶が複数備えられており、それぞれの廃液瓶には廃液を排出する排出側に第2の電磁弁を備えており、
前記廃液瓶ごとに反応容器から真空タンクまでの流路が備えられていることを特徴とする、自動分析装置。 - 請求項6に記載の自動分析装置において、
前記詰まり検知手段は、流路の詰まりが有と判断した場合には、第1の電磁弁を閉にし、真空ポンプをOFFからONにし、前記判定手段により真空タンク内の真空値が所定の閾値より小さくなることを確認し、その後、真空ポンプをONからOFFにし、第1の電磁弁と、いずれかの第2の電磁弁を閉から開にし、閉から開にした時点から前記判定手段により真空タンク内の真空値が所定の閾値以上になった時までの時間を、所定の閾値を比較することにより、流路の詰まりの有無を検知することを特徴とする、自動分析装置。 - 請求項7に記載の自動分析装置において、
第1の電磁弁といずれかの第2の電磁弁の閉から開の動作を、順次行なうことにより、いずれの流路に詰まりがあるかを検出することを特徴とする、自動分析装置。 - 前記判定手段により詰まりを検知するときに用いる閾値は、装置が設置されている標高の高さを基に設定されていることを特徴とする、自動分析装置。
- 液体を真空吸引するための真空タンク及び真空ポンプと、
前記真空タンクに接続された流路上に備えられた第1の電磁弁と、
真空タンク内の真空値が所定の閾値以上であるか、当該所定の閾値より小さいかを判定する判定手段と、
前記流路内の詰まりを検知する詰まり検知手段と、を備えた自動分析装置の流路詰まり検出方法であって、
前記詰まり検知手段は、
第1の電磁弁を閉にした状態で、真空ポンプをONからOFFへ変更し、
その後、第1の電磁弁を閉から開にし、第1の電磁弁を閉から開にした時点から、前記判定手段により真空タンク内の真空値が所定の閾値以上になった時までの時間を、所定の閾値を比較することにより、流路の詰まりの有無を検知することを特徴とする、自動分析装置の流路詰まり検出方法。
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US16/645,600 US11079402B2 (en) | 2018-03-15 | 2019-01-23 | Automatic analyzing apparatus, and method for detecting flow path clogging of the automatic analyzing apparatus |
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