WO2019059023A1 - 若年女性臭補充用の組成物 - Google Patents

若年女性臭補充用の組成物 Download PDF

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Publication number
WO2019059023A1
WO2019059023A1 PCT/JP2018/033443 JP2018033443W WO2019059023A1 WO 2019059023 A1 WO2019059023 A1 WO 2019059023A1 JP 2018033443 W JP2018033443 W JP 2018033443W WO 2019059023 A1 WO2019059023 A1 WO 2019059023A1
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Prior art keywords
odor
weight
acid
composition
body odor
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PCT/JP2018/033443
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English (en)
French (fr)
Japanese (ja)
Inventor
佑次 望月
裕実 横山
夏子 山北
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ロート製薬株式会社
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Application filed by ロート製薬株式会社 filed Critical ロート製薬株式会社
Priority to CN201880061099.2A priority Critical patent/CN111107831B/zh
Priority to JP2019543559A priority patent/JP7036833B2/ja
Publication of WO2019059023A1 publication Critical patent/WO2019059023A1/ja
Priority to JP2021168599A priority patent/JP6970854B1/ja
Priority to JP2021168600A priority patent/JP6970855B1/ja
Priority to JP2021178295A priority patent/JP7199495B2/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L9/00—Disinfection, sterilisation or deodorisation of air
    • A61L9/01—Deodorant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q13/00—Formulations or additives for perfume preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/12—Preparations containing hair conditioners

Definitions

  • the present invention relates to a composition for young female odor supplementation.
  • body odor is generally considered to be caused by fatty acids and unsaturated aldehydes produced from sebum on the body surface.
  • ⁇ -unsaturated fatty acids (palmitoleic acid and vacenic acid) produced by decomposition of sebum are further oxidatively decomposed to generate unsaturated aldehyde called 2-nonenal on the body surface It is reported that it is deeply related to the problem (non-patent document 1).
  • Patent Document 1 As a technique for preventing such a body odor such as age-related odor, a method of masking with perfume or the like, a method of utilizing odor adsorption effect of charcoal (Patent Document 1), and the like are known. In addition, a method using an extract from the root part and rhizome part of the silkworm moth (Patent Document 2), a method using condensed oyster tannin (Patent Document 3), and the like have also been proposed. In addition, development of cleaning agents for washing off offensive odor components is also in progress.
  • body odor such as age-related odor
  • men and women it is a fact that research on body odor change with aging of women has not been sufficiently advanced. Therefore, development of a product for age-related odor control suitable for women is desired.
  • the present invention has been made in view of such a situation, and an object of the present invention is to provide a product for rejuvenating body odor and a product for age-related odor control that are suitable for women. Another object of the present invention is to provide a method of evaluating a substance having an anti-aging effect, focusing on the change in body odor with aging of women.
  • the present inventors analyzed body odor components in women in their teens and 50s, and as a result, they apparently had a clearly sweet smell (SWEET odor) in women (young women) in their teens to 20s. Found that can be confirmed. After sensory evaluation, the components were analyzed to identify specific body odor components. In addition, it was also revealed that the nonenal odor generally known as a causative agent of the age-related odor was weaker in females than in males, and that no difference due to age was observed.
  • SWEET odor clearly sweet smell
  • the body odor can be rejuvenated and the aging odor of a woman can be suppressed by supplementing the odor component constituting the body odor of the above-mentioned young woman which decreases with age, and the present invention is completed. It came to
  • the gist of the present invention is as follows.
  • a composition comprising at least a lactone compound represented by the following formula (I), A composition for replenishing a young female odor, which is used to compensate for an odor component that constitutes a body odor of a young female.
  • R is an alkyl group having 2 to 9 carbon atoms
  • a composition comprising at least a lactone compound represented by the following formula (I), An index agent for aging odor judgment, used as an indicator for the judgment of aging odor of women.
  • a method for evaluating an anti-aging effect which evaluates the anti-aging effect of a test substance by using a change in the content of a lactone compound represented by the following formula (I) contained in body odor by use of the test substance as an indicator.
  • a body odor composition improving agent comprising a production promoting substance of a lactone compound represented by the following formula (I) and / or a synthesis promoting substance of a lactone compound represented by the following formula (I).
  • the present invention it is possible to provide a product for age-related odor control suitable for women, capable of rejuvenating body odor. Furthermore, according to the present invention, it is also possible to provide a method of evaluating a substance having an anti-aging effect.
  • SWEET odor sensory evaluation score for body odor in female subjects of teens to 50s SWEET odor sensory evaluation score for body odor in female subjects of teens to 50s Body odor nonenal odor sensory evaluation score for female subjects in teens to 50s Body odor nonenal concentration of female subjects in teens to 50s Body odor lactone concentrations in female subjects in their teens and 50s Effect on model aging odor The effect of odor on the impression of a woman
  • the composition of the present invention is a composition for replenishing the odor of a young woman, which is used to compensate for an odor component constituting body odor of a young woman, and contains at least a lactone compound represented by the following formula (I).
  • the composition of the present invention can rejuvenate body odor of a woman, and therefore, can be suitably used as an external composition for preventing aging odor of a woman.
  • the composition of the present invention for an object to which body odor components are likely to be attached, for example, by use of bedding, the effect of rejuvenating the odor emitted from the attached body odor components can be expected. It can be suitably used for products, hard surfaces or spaces.
  • the body odor refers to the overall odor emitted by women, and includes odors from the back, nape, behind the ear, scalp odor, sweat odor, odor odor, foot odor and the like.
  • body odor is composed of various components, it has become clear from the study of the present inventors that in women, the amount of a specific lactone compound in body odor decreases with aging. That is, although specific lactone compounds are sufficiently contained in the body odor of young women in their twenties and early twenties, they decrease with age. On the other hand, the amount in body odor of nonenal which is the causative agent of the aging odor conventionally known was originally small in the case of women, and no tendency was observed to increase with age.
  • the present inventors are more included in the body odor of young women than the suppression of the nonenal odor usually performed as measures against the age-related odor of men as a measure against the age-old odor of women, and masking by perfumes and the like.
  • R is an alkyl group having 2 to 9 carbon atoms.
  • the carbon number of R is preferably 3 to 9, more preferably 4 to 9, still more preferably 5 to 8, and particularly preferably 6 or 7.
  • the hydrogen atom which the said alkyl group contains may be substituted.
  • lactone compound represented by the above formula (I) examples include, for example, ⁇ -hexalactone, ⁇ -heptalactone, ⁇ -octalactone, ⁇ -nonalactone, ⁇ -decalactone, ⁇ -undecalactone, ⁇ -dodeca Lactone, ⁇ -tridecalactone and the like can be mentioned.
  • ⁇ -nonalactone, ⁇ -decalactone, ⁇ -undecalactone and ⁇ -dodecalactone are preferable, and ⁇ -decalactone and ⁇ -undecalactone are more preferable.
  • These lactone compounds are ingredients having the smell of fruits such as peach, rattan and coconut.
  • the lactone compounds may be used alone or in combination of two or more.
  • the content of the lactone compound represented by the formula (I) in the composition of the present invention is 0.00001% by weight to 10% by weight, and from the viewpoint of the effect on the aging odor control of women, 0.00005% by weight % To 5 wt% is preferable, 0.0001 wt% to 3 wt% is more preferable, 0.0005 wt% to 2 wt% is further preferable, and 0.001 wt% to 1 wt% is preferable. It is particularly preferred that it is wt%. When two or more lactone compounds are used in combination, the total amount is in the above numerical range.
  • the composition of the present invention may contain an odor component other than the lactone compound represented by the above formula (I), which constitutes the body odor of other young women.
  • odor components constituting body odor of other young women include aldehydes, fatty acids, ketones, sulfur compounds (S-based odor), nitrogen compounds (N-based odor) and the like.
  • an odor component which comprises the body odor of the other young woman which the composition of this invention contains the component in which content in body odor reduces with aging of a woman is preferable.
  • composition of the present invention can contain the following optional components in addition to the components described above, as long as the effects of the present invention are not impaired.
  • composition of the present invention is (1) an external composition used for human and (2) other than human, specifically, for textiles, hard surfaces, spaces, etc.
  • composition to be used will be described separately.
  • examples of optional components other than the above-mentioned essential components may include anti-inflammatory agents, refreshing agents, bactericides, vitamins Organic acid, moisturizing component, polyhydric alcohol, scrub agent, ultraviolet light absorbing component, ultraviolet light scattering component, astringent component, peptide or derivative thereof, amino acid or derivative thereof, cleaning component, keratin soft component, cell activation component, antiaging component , Blood circulation promoting active ingredient, whitening ingredient, powder and the like.
  • these components may be used individually by 1 type, respectively, and may use 2 or more types together.
  • anti-inflammatory agents examples include allantoin and derivatives thereof, glycyrrhetinic acid and derivatives thereof, glycyrrhizinic acid and derivatives thereof, salicylic acid derivatives, aminocaproic acid, azulene and derivatives thereof, zinc oxide, tocopherol acetate, hydrocortisone, prednisolone and salts thereof Can be mentioned.
  • allantoin, allantoin chlorohydroxyaluminum, allantoindihydroxyaluminum, glycyrrhetinic acid, glycyrrhizinic acid, stearyl glycyrrhetinate, glycol salicylate, methyl salicylate, epsilon aminocaproic acid, azulene, guaiazulene and salts thereof are preferable.
  • the term “derivative" refers to an ester, an ether, an alkylated product, a glycoside or the like of the described compound.
  • salt means, for example, salts of mineral acids such as sulfuric acid, hydrochloric acid or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metals Salt, ammonium salt etc.
  • terpenes such as menthol, camphor, borneol, geraniol, cineole, anethole, limonene, eugenol (these may be d-form, l-form or dl-form); Eucalyptus oil, bergamot Oil, peppermint oil, coolmint oil, spearmint oil, fennel oil, peppermint oil, peppermint oil, caffeine oil, rose oil, turpentine oil and other essential oils, etc. may be mentioned.
  • germicides examples include isopropylmethylphenol, chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and derivatives thereof, popidone iodine, potassium iodide, iodine, triclocarban, triclosan, photosensitivity No. 101, Photosensitive No. 201, parabens, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyroctoalamine, miconazole and the like.
  • the vitamins may be any of water-soluble vitamins and oil-soluble vitamins, for example, pyridoxine, pyridoxal, pyridoxamine, 5'-pyridoxal phosphate, and salts thereof (eg, pyridoxine hydrochloride, pyridoxine acetate, hydrochloric acid hydrochloride) Vitamin B6 such as pyridoxal, pyridoxamine hydrochloride, etc.
  • Pantothenic acid calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesin, D-panthetin, coenzyme A, pantothenylethyl ether, and salts thereof Pantothenic acids; Nicotinic acid, dl- ⁇ -tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, ⁇ -butoxyethyl nicotinate, 1- (4-methylphenyl) ethyl nicotinate, nicotinic acid amide, and salts thereof Nico Tin acids; ⁇ -oryzanol, thiamine, dibenzoyl thiamine, thiamine cetyl, thiamine monophosphate, thiamine diphosphate, thiamine triphosphate, and salts thereof (eg, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl Hydrochloride, thiamine
  • organic acids examples include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid , Lactic acid, and their salts.
  • salts of mineral acids such as sulfuric acid, hydrochloric acid or phosphoric acid
  • salts of organic acids such as maleic acid or methanesulfonic acid
  • alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts etc.
  • the moisturizing component examples include diglycerin trehalose; sodium hyaluronate, heparin analogue, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, high molecular compounds such as chitosan; amino acids such as glycine, aspartic acid and arginine; Natural moisturizing factors such as sodium, urea and sodium pyrrolidonecarboxylate; lipids such as ceramide, cholesterol and phospholipids; plant extracts such as chamomile extract, hamamelis extract, tea extract and perilla extract and the like.
  • the polyhydric alcohol preferably has 2 to 10 carbon atoms, and examples thereof include glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1 And 3-butylene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, neopentyl glycol and the like.
  • diglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol and hexanediol are more preferable.
  • apricot kernel powder for example, apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride particles, olive kernel powder, dried seawater particles, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, charcoal powder And husk powder, polyethylene powder, silicic acid anhydride and the like.
  • Examples of the ultraviolet ray absorbing component include octyl triazone, octyl dimethoxybenzylidene dioxoimidazolidine propionate, 2-ethylhexyl paramethoxycinnamate, phenyl benzimidazole sulfonic acid and the like.
  • the ultraviolet light scattering component examples include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, titanium oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, anhydrous silicic acid, and such inorganic compounds.
  • inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, titanium oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, anhydrous silicic acid, and such inorganic compounds.
  • inorganic powder such as hydrous silicic acid, aluminum hydroxide, mica and talc
  • resin powder such as polyamide, polyethylene, polyester, polystyrene and nylon, and further silicone oil and fatty acid aluminum salt etc What was processed etc. are mentioned.
  • Examples of the astringent component include zinc sulfate, aluminum chloride, zinc sulfocarbonate and tannic acid.
  • Examples of the peptide or derivatives thereof include keratinolytic peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin degrading peptides, collagenolytic peptides, hydrolyzed collagen, hydroxypropyl ammonium chloride hydrolyzed collagen, Elastin-degrading peptide, Conchiolin-degrading peptide, Hydrolyzed conquioline, Silk-proteolytic peptide, Hydrolyzed silk, Lauroyl-hydrolyzed silk sodium, Soy-proteolytic peptide, Hydrolyzed soy protein, Wheat protein, Wheat-proteolytic peptide, Hydrolyzed wheat protein, Caseinolytic peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.) and the like can be mentioned
  • amino acids or derivatives thereof examples include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, glycine, alanine, phenylalanine, ⁇ -alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, Cystine, methionine, leucine, isoleucine, valine, histidine, taurine, ⁇ -aminobutyric acid, ⁇ -amino- ⁇ -hydroxybutyric acid, carnitine, carnosine, creatine and the like.
  • washing component examples include soaps selected from alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts, etc .; cocoylglutamate Na, cocoyl methyltaurine Na Amino acid surfactant such as ether sulfate ester salt such as sodium laureth sulfate ether carboxylate salt such as sodium lauryl ether acetate salt sulfosuccinic acid ester salt such as alkyl sulfosuccinic ester Na such as coconut oil fatty acid monoethanolamide, coconut oil Fatty acid alkanolamides such as fatty acid diethanolamide; monoalkyl phosphate ester salts such as sodium lauryl phosphate, polyoxyethylene lauryl ether sodium phosphate; coconut oil fatty acid amido propyl dime L-aminoacetic acid betaine, lauryl dimethylaminoacetic acid betaine, 2-al
  • keratin softness component examples include lactic acid, salicylic acid, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea, sulfur and the like.
  • the cell activation component examples include amino acids such as ⁇ -aminobutyric acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids; ⁇ -hydroxy acids such as glycolic acid and lactic acid; tannin, flavonoid, Saponin, photosensitive element No. 301 and the like can be mentioned.
  • amino acids such as ⁇ -aminobutyric acid
  • vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids
  • ⁇ -hydroxy acids such as glycolic acid and lactic acid
  • tannin, flavonoid, Saponin, photosensitive element No. 301 and the like can be mentioned.
  • antiaging component examples include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone and the like.
  • Examples of the above-mentioned blood circulation promoting active ingredient include plants (eg, Panax ginseng, hornhead, Arnica, Ginkgo biloba, Ginkgo biloba, Ginkgo biloba, Ginkgo biloba, Ginkgo biloba, Chamomile, Roman chamomile, Carrot, Gentian, Burdock, Rice, Hawthorn, Shiitake, Ginger, Hawthorn, Prunus berry , Senkyu, assembly, thyme, chopsticks, chimpanzee, chili pepper, touki, toonin, spruce, carrot, garlic, butcherbroom, grape, button, marronie, melissa, yuzu, yokuinin, ryokucha, rosemary, rosehip, chimpo, touki, Ingredients derived from spruce, peach, apricot, walnut, corn etc); acetylcholine, ictamol, cantaristinki, gamma-or
  • Examples of the whitening component include tocopherol and tranexamic acid.
  • the powder component examples include starch octenyl succinic acid Al (stark aluminum octenyl succinic acid), talc, corn starch, magnesium hydroxide, anhydrous silicic acid, light anhydrous silicic acid, mica, hydroxyapatite, zinc oxide, titanium oxide, nylon powder And charcoal.
  • starch octenyl succinic acid Al stark aluminum octenyl succinic acid
  • talc corn starch
  • magnesium hydroxide anhydrous silicic acid
  • light anhydrous silicic acid mica
  • hydroxyapatite zinc oxide
  • titanium oxide nylon powder And charcoal
  • the pH of the composition for external use of the present invention is usually 3.0 to 8.0, and preferably 3.5 to 7.5.
  • this pH can be adjusted, for example by use of the pH adjuster mentioned later.
  • the method for producing the composition for external use according to the present invention is not particularly limited, and the lactone compound represented by the above-mentioned formula (I) which is an essential component, an odor component constituting body odor of other young women blended as needed Various components necessary for producing the composition for external use (the above-mentioned optional components, the base or carrier to be described later, a carrier, additives, etc.) can be appropriately selected and blended, and the composition can be produced by a conventional method.
  • the composition for external use of the present invention may be an emulsified composition, a solubilized composition, or a dissolved composition.
  • composition for external use according to the present invention constitutes body odor of young women by using the composition for external use according to the present invention containing an odor component which decreases with age, for example, for women who are concerned about age-related odor after middle age. To compensate for the odor component, to rejuvenate body odor, and to suppress the odor that makes you feel as an aging odor.
  • the composition for external use of the present invention can be used for measures against aging odor of women.
  • composition for external use according to the present invention used for such purpose includes, for example, body soap, cleansing agent such as face cleanser, shampoo, treatment, hair care agent such as dry shampoo, cleansing agent, deodorant, antiperspirant, ointment, It can be suitably used as a liquid, suspension, emulsifier (emulsion and cream), gel, liniment, lotion, patch, mist, aerosol, powder, granules and the like.
  • the composition for external use according to the present invention is a base or carrier usually used for cosmetics, medicines, quasi-drugs, and the additives described later as required, and its essential components and other components described above, etc.
  • the mixture may be mixed according to a conventional method, and may be emulsified or solubilized as necessary, to form various external preparation compositions.
  • the base or carrier examples include hydrocarbons such as liquid paraffin, squalane, petrolatum, gelled hydrocarbon (plasti base etc.), ozokerite, ⁇ -olefin oligomer, light liquid paraffin, etc .; methyl polysiloxane, highly polymerized methyl polysiloxane Cyclic silicone, alkyl modified silicone, amino modified silicone, polyether modified silicone, polyglycerin modified silicone, silicone alkyl chain comodified polyether modified silicone, silicone alkyl chain comodified polyglycerin modified silicone, polyether modified branched silicone, Polyglycerin modified branched silicone, acrylic silicone, phenyl modified silicone, silicone resin such as silicone resin; coconut oil, olive oil, rice bran oil, shea butter etc; Oils, waxes such as Mirow, candelilla wax, lanolin; Setanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyl dodecanol, isostearyl alcohol
  • Tetra-2-ethylhexanoic acid pentaerythritol Esters such as dextrin; polysaccharides such as dextrin and maltodextrin; vinyl polymers such as carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers; lower alcohols such as ethanol and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, Ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether, etc. Glycol ether; water etc It is below.
  • composition for external use of the present invention contains a base or carrier other than water and lower alcohol
  • examples of the base or carrier include higher alcohols, hydrocarbons, oils and fats, esters, silicone oils, waxes, vinyls. Polymers are preferred, and higher alcohols, ester oils, silicone oils and vinyl polymers are more preferred.
  • cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl tri-2-ethylhexanoate, dimethicone, cyclomethicone, polyether modified silicone, polyglycerin modified silicone and carboxyvinyl polymer are more preferable.
  • the base or carrier described above may be used alone or in combination of two or more.
  • the amount used thereof is appropriately selected from the range known to those skilled in the art.
  • composition for external use according to the present invention may be a known additive added to cosmetics, medicines, quasi-drugs, as long as the effects of the present invention are not impaired, such as surfactants, stabilizers, antioxidants, Coloring agents, pearlescent agents, dispersing agents, chelating agents, pH adjusters, preservatives, thickeners, irritation reducing agents and the like can be added.
  • additives may be used alone or in combination of two or more.
  • the surfactant may be any of nonionic surfactant, cationic surfactant, anionic surfactant, amphoteric surfactant and the like, and examples thereof include sorbitan monoisostearate and sorbitan monolaurate. Sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexyl acid, sorbitan fatty acid esters such as diglycerol sorbitan tetra-2-ethylhexyl acid; propylene glycol fatty acid esters such as propylene glycol monostearate; Cured castors of polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80, etc.
  • HCO-40 polyoxyethylene hydrogenated castor oil 40
  • HCO-50 polyoxyethylene hydrogenated castor oil
  • HCO-60 polyoxyethylene
  • nonionic surfactants are preferable, and hydrogenated castor oil derivatives, polyoxyethylene
  • Examples of the above-mentioned stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.
  • antioxidants examples include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride and the like.
  • coloring agent an inorganic pigment, a natural pigment
  • pearlescent agent examples include ethylene glycol distearate, ethylene glycol monostearate, triethylene glycol distearate and the like.
  • dispersant examples include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinyl pyrrolidone, methyl vinyl ether / maleic anhydride cross-linked copolymer, organic acid and the like.
  • Examples of the above-mentioned chelating agent include EDTA.disodium salt, EDTA.calcium.disodium salt and the like.
  • Examples of the pH adjuster include inorganic acids (hydrochloric acid, sulfuric acid etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, sodium citrate, succinic acid, sodium succinate etc.), inorganic bases (potassium hydroxide, hydroxide Sodium etc., organic bases (triethanolamine, diisopropanolamine, triisopropanolamine etc.) and the like. Among them, inorganic bases and / or organic bases are preferable, and potassium hydroxide and triethanolamine are more preferable.
  • preservative examples include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, parahydroxybenzoic acid, and the like.
  • examples thereof include benzyl, methyl parahydroxybenzoate and phenoxyethanol.
  • thickener examples include vinyl thickeners such as polyvinyl alcohol, polyvinyl pyrrolidone and carboxyvinyl polymer, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose and the like.
  • vinyl thickeners such as polyvinyl alcohol, polyvinyl pyrrolidone and carboxyvinyl polymer, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose and the like.
  • Cellulose thickeners guar gum, pectin, pullulan, gelatin, locust bean gum, carrageenan, agar, xanthan gum, acrylic acid methacrylic acid alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, chondroitin sulfate Sodium, hyaluronic acid, sodium hyaluronate, Hydroxyethylmethacrylate / acryloyldimethyltaurinato Na) copolymer, and (ammonium acryloyldimethyltaurate / vinyl pyrrolidone) copolymers and the like.
  • vinyl thickeners and cellulose thickeners are preferred, and carboxyvinyl polymers, polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxy Ethyl cellulose is more preferred.
  • Examples of the above-mentioned irritation reducing agent include licorice extract, sodium alginate, gum arabic, polyvinyl pyrrolidone and the like.
  • the formulation form of the composition for external use according to the present invention is not particularly limited.
  • ointments, solutions, suspensions, emulsifiers (emulsion and cream), gels, liniments, lotions, patches, mists, aerosols, Powders, granules and the like can be mentioned.
  • liquid to semisolid preparation forms are preferable, and in particular, it is useful when applied to solutions, lotions, ointments, gels and emulsifiers.
  • These preparations can be manufactured according to a conventional method, for example, the method described in the 17th revised Japanese Pharmacopoeia General Rules, and the like.
  • composition of the present invention when used other than human, specifically when used as a composition for fiber products, hard surfaces, spaces, etc.
  • optional components which may be contained in addition to the above-mentioned essential components, for example, polyhydric alcohols, surfactants, deodorants, various solvents generally used, oils, gelling agents, sodium sulfate, N, N, N- Salts such as trimethylglycine, pH adjusters, antioxidants, preservatives, disinfectants / antibacterial agents, perfumes, dyes, UV absorbers and the like can be mentioned.
  • these components may be used individually by 1 type, respectively, and may use 2 or more types together.
  • polyhydric alcohols and surfactants not only suppress volatilization of malodorous components attached to textiles, hard surfaces, human bodies, pets, etc., but also stabilize stable amino monosaccharides or salts thereof as odor eliminating components.
  • the deodorizing effect can be further enhanced by dispersing and improving the contact with the offensive odor component.
  • the said polyhydric alcohol is a component which has an effect which suppresses volatilization of the offensive odor component adhering to textiles, a hard surface, space, etc.
  • polyhydric alcohols include glycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butanediol, diethylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol and the like. Among these, diethylene glycol and dipropylene glycol are preferable.
  • the composition of the present invention is used other than human, specifically, when it is a composition used for textiles, hard surfaces, spaces, etc., the above polyhydric alcohol in such a composition of the present invention
  • the content of the group varies depending on the use form, but is usually 0.001% by mass or more, preferably 0.001 to 30% by mass, and more preferably 0.005 to 10% by mass.
  • the surfactant is not particularly limited, and examples thereof include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants.
  • the molecule has at least an alkyl group or alkenyl group having 8 to 18 carbon atoms in the molecule, and the hydrophilic portion contains a carboxylate, a sulfonate, a sulfate, a phosphate, a quaternary ammonium salt And sulfobetaines, carbobetaines, amine oxides, (poly) oxyalkylenes, (poly) alkanolamines, (poly) glycosides, compounds having a (poly) glycerin skeleton, and the like.
  • alkyl group or alkenyl group having 8 to 18 carbon atoms and the hydrophilic portion may be bonded via one or more selected from an ether group, an ester group, an amide group and an alkyl group.
  • surfactants include surfactants of sulfonic acid salt, sulfuric acid ester salt, phosphoric acid ester salt, quaternary ammonium salt, carbobetaine, amine oxide, (poly) glycoside and (poly) glycerin type are preferable.
  • the above-mentioned surfactant in such a composition of the present invention is usually 0.001% by mass or more, preferably 0.001 to 30% by mass, and more preferably 0.01 to 10% by mass.
  • the solvent for example, ethanol, monoethyl or monobutyl ether of ethylene glycol or propylene glycol, monoethyl or monobutyl ether of diethylene glycol or dipropylene glycol, benzyl alcohol, benzyloxyethanol, ethylene oxide or propylene oxide adduct of phenolic compound, etc. It can be mentioned.
  • the pH of the above composition of the present invention is usually pH 5.0 to 9.0, preferably pH 6 to 8.5.
  • the pH can be adjusted by using a pH adjuster or the like.
  • the method for producing the above composition is not particularly limited, and the lactone compound represented by the above formula (I) which is an essential component, an odor component which constitutes the body odor of other young women blended as needed, a composition Various components (the above-mentioned optional components and the like) necessary for production can be appropriately selected and blended, and the composition can be produced by a conventional method.
  • the composition of the present invention may be an emulsified composition or a solubilized composition.
  • the use form of the above composition of the present invention can be in the form of liquid, gel, powder, solid or the like, but it is preferable to use it as liquid.
  • liquid in particular sprays, lotions, etc. cloths such as handkerchiefs and towels, clothes such as suits and sweaters, pillows, bedclothes such as sheets, curtains, textiles such as sofas, cooking utensils such as dishes and pans, It is suitable to use for those having a hard surface such as a cooktop, a floor, a floor, a wall, wallpaper, a trash can, a toilet bowl, a bath tub, a drain, and a space.
  • composition of the present invention can be suitably used, for example, as a deodorant for the above-mentioned textiles, hard surface, space and the like used by women who are concerned about aged odor after middle age. Even objects that can not be washed frequently can be used comfortably for a fixed period of time in terms of odor.
  • the above composition of the present invention is preferably, for example, filled in a mist type spray container, and the spray amount thereof is adjusted to 0.1 to 1 ml.
  • a spray container to be used well-known spray containers, such as a trigger spray container (direct pressure or pressure accumulation type) and a dispenser type pump spray container, can be used.
  • Body odor model composition for young women also includes a body odor model composition for a young woman, which contains an odor component that constitutes the body odor of the young woman, and at least containing a lactone compound represented by the following formula (I) as the odor component.
  • a body odor model composition for a young woman which contains an odor component that constitutes the body odor of the young woman, and at least containing a lactone compound represented by the following formula (I) as the odor component.
  • the odor component constituting the body odor of the young woman and the odor component constituting the body odor of the female after middle age are compared, the above-mentioned specific lactone compound is contained more in the young woman, It was found to decrease with age.
  • the body odor model composition of a young woman of the present invention is closer to the body odor of an actual young woman, and can be used as a reference in the determination of an age odor, the determination of an age odor suppression effect, and the like.
  • R is an alkyl group having 2 to 9 carbon atoms
  • the body odor model composition for young women of the present invention preferably contains an odor component constituting the body odor of other young women other than the lactone compound represented by the above formula (I).
  • an odor component which comprises the body odor of other young women aldehydes, fatty acids, ketones, ammonia etc. are mentioned, for example.
  • the odor component constituting the body odor of other young women contained in the composition for external use of the present invention preferably includes a component whose content in body odor decreases with the age of the woman.
  • the present invention also relates to a composition comprising at least the lactone compound represented by the above-mentioned formula (I), which is used as an indicator for determining the age odor of women, and also includes an indicator for determining the age odor.
  • the present invention also includes a composition for determining body odor age, which is a composition containing at least the lactone compound represented by the above formula (I) and used as an indicator for determining body odor age of a woman.
  • the specific lactone compound when the odor component constituting the body odor of a young woman and the odor component constituting the body odor of a woman whose age is anxious to middle-aged or later, the specific lactone compound is It is found to be more abundant in women and that they decrease with age.
  • the index agent for determining the age odor according to the present invention and the index agent for determining the body odor age according to the difference between the body odor of a young woman and a woman whose age is concerned about the age odor after middle age It can be used as a standard in the determination of the age odor suppression effect, the determination of body odor age, etc.
  • the present invention evaluates the anti-aging effect of a test substance by using the change in the content of the lactone compound represented by the above-mentioned formula (I) contained in body odor as the indicator by the use of the test substance Also includes.
  • the specific lactone compound is It is found to be more abundant in women and that they decrease with age.
  • the present invention has been completed based on this finding, and its use in the evaluation of the anti-aging effect of test substances (pharmaceuticals, supplements, various foods and drinks, etc.) causes changes in body odor of women,
  • the index is used to increase the content of odor components that are contained in women's body odors and decrease with age to make them effective in rejuvenating body odors.
  • the lactone compound represented by the said Formula (I) description of the term of [the external composition for youth female odor supplementation] is applicable.
  • the present invention provides an anti-aging substance screening method of screening a substance having an anti-aging effect by using as a indicator a change in the content of the lactone compound represented by the above-mentioned formula (I) contained in body odor by using a test substance Also includes.
  • the odor component constituting the body odor of a young woman and the odor component constituting the body odor of a woman whose age is anxious to middle-aged or later the specific lactone compound is It is found to be more abundant in women and that they decrease with age.
  • the present invention has been completed based on this finding, and it is used for evaluating the anti-aging effect of test substances (pharmaceuticals, supplements, various foods and drinks, etc.) and screening excellent substances. It is used as an indicator whether it causes body odor change and increases the content of odor components that are included in the body odor of young women and decreases with age, and that the body odor is rejuvenated.
  • test substances pharmaceuticalals, supplements, various foods and drinks, etc.
  • screening excellent substances It is used as an indicator whether it causes body odor change and increases the content of odor components that are included in the body odor of young women and decreases with age, and that the body odor is rejuvenated.
  • lactone compound represented by the said Formula (I) description of the term of [the external composition for youth female odor supplementation] is applicable.
  • the present invention contains a substance promoting the production of a lactone compound represented by the above formula (I) and / or a substance promoting the synthesis of a lactone compound represented by the above formula (I), a body odor composition improving agent Also includes.
  • the body odor composition improving agent of the present invention includes, for example, substances selected by the above-mentioned anti-aging substance screening method.
  • the agent for improving body odor composition according to the present invention may be used either internally or externally, and when it is used, the lactone compound in the body odor is increased, and the odor similar to the body odor of a young woman having a high lactone compound content can be generated.
  • description of the term of [the external composition for youth female odor supplementation] is applicable.
  • the present invention also includes an anti-aging agent containing the above-mentioned body odor composition improving agent, particularly an anti-aging agent for women.
  • the present invention also includes lactone compound action improvers, which improve the action of the lactone compound represented by the above formula (I).
  • the lactone compound action improver of the present invention may be either internal use or external use, and when it is used, the action of the lactone compound in body odor is improved, and the odor similar to the body odor of a young woman with high lactone compound content is generated. Can.
  • description of the term of [the external composition for youth female odor supplementation] is applicable.
  • the present invention also includes a body odor improving agent comprising the lactone compound action improving agent described above.
  • odor analysis was performed on the recovered fabric using a headspace gas chromatography mass spectrometer (HSS-GC / MS).
  • HSS-GC / MS headspace gas chromatography mass spectrometer
  • the examination result about the correlation with the concentration (ppm) of a nonenal and the age of a test subject (sample) was shown in FIG.
  • the correlation between the concentration (ppm) of each lactone component ( ⁇ -decalactone, ⁇ -undecalactone) and the age of the subject (sample) was also examined, and the results are shown in FIG.
  • FIGS. 1 and 2 it was found that the SWEET odor is high until the early twenties with the woman in the late twenties as the peak, and the odor decreases with age.
  • FIG. 1 each data of FIG. 2 was bar graph-ized according to age.
  • FIG. 3 and FIG. 4 it was found that there was no clear correlation between age and sensory score, and that the odor intensity itself was lower than that of men. Further, it was found by HSS-GC / MS that the main components of the SWEET odor are ⁇ -decalactone and ⁇ -undecalactone.
  • ⁇ Formulation example 1 Body soap> Any of the lactone compound combinations listed in Table 8 5% by weight of lauric acid Palmitic acid 5% by weight Stearic acid 5% by weight Potassium hydroxide appropriate amount glycerin 5% by weight Dibutylhydroxytoluene 0.01% by weight Edetate disodium 0.05 wt% Phenoxyethanol 0.3% by weight 0.1% by weight of benzalkonium chloride Sodium laureth sulfate 5% by weight Coconut oil fatty acid amidopropyl betaine 5% by weight Polyquaternium-10 0.5% by weight Polyquaternium-7 0.2% by weight Kaolin 0.5% by weight 0.05% by weight of charcoal Ascorbic acid magnesium phosphate 0.5% by weight Hydroxyethylcellulose 0.3% by weight Water remaining 100% in total
  • ⁇ Formulation example 2 Foam discharge type body wash> Any of the lactone compound combinations listed in Table 8 PEG-80 sorbitan laurate 5% by weight Cocoyl glutamate disodium 4% by weight Cocoyl glycine sodium 2% by weight Sorbitol 5% by weight Cocoyl methyl taurine taurine sodium 2% by weight Citric acid dosage 0.05% by weight of sodium edetate Cocamide DEA 1% by weight Cocoamphoacetate sodium 3% by weight Polyquaternium-7 0.05% by weight 0.3% by weight of dipotassium glycyrrhizinate Water remaining 100% in total
  • Formulation Example 3 Cleansing agent Any of the lactone compound combinations listed in Table 8 5% by weight of lauric acid 10 wt% myristic acid Palmitic acid 7% by weight Stearic acid 7% by weight Potassium hydroxide appropriate amount butylene glycol 5% by weight Glycerin 5% by weight Tocopherol 0.05% by weight Edetate disodium 0.05 wt% Phenoxyethanol 0.3% by weight Salicylic acid 0.2% by weight Coconut oil fatty acid amidopropyl betaine 5% by weight Polyquaternium-10 0.3% by weight Polyquaternium-7 0.1% by weight l-menthol 0.3% by weight Flavor 0.2% by weight Water remaining 100% in total
  • Formulation Example 4 Shampoo Any of the lactone compound combinations listed in Table 8 Sodium laureth sulfate 30% by weight Cocoyl glutamate triethanolamine 5% by weight Lauroyl methylalanine sodium 5% by weight 5% by weight of lauramidopropyl hydroxysultine Citric acid Appropriate amount Dimethicone 0.3% by weight Methyl paraben 0.2% by weight Edetate disodium 0.1% by weight Polyquaternium-10 0.5% by weight Polyquaternium-39 0.1 wt% Polyquaternium-7 0.1% by weight Perfume 0.8% by weight Water remaining 100% in total
  • Formulation Example 6 Hair Conditioner Any of the lactone compound combinations listed in Table 8 Glycerin 5% by weight Hyaluronic acid 0.1% by weight 0.1% by weight of dipotassium glycyrrhizinate 0.1% by weight squalane Stearyl trimethyl ammonium chloride 4% by weight Polyquaternium-10 0.5% by weight Settanol 2% by weight POE-monostearyl glyceryl ether 1% by weight Dibutylhydroxytoluene 0.01% by weight Phenoxyethanol 0.3% by weight EDTA-2Na 0.05 wt% l-menthol 0.2% by weight Flavoring 0.3% by weight Water remaining 100% in total
  • ⁇ Preparation Example 15 Antiperspirant Stick> Any of the lactone compound combinations listed in Table 8 Benzalkonium chloride 0.055% by weight Isopropyl methyl phenol 0.05% by weight Chlorhydroxy aluminum 5% by weight Polyethylene wax 5% by weight Microcrystalline wax 5% by weight Glyceryl monostearate 3% by weight 5% by weight isononyl isononanoate Talc 12% by weight Methylpolysiloxane 2% by weight Decamethylpentasiloxane 0.3% by weight Silylation treated silica 15% by weight Settanol 2% by weight Hydroxyapatite 0.3% by weight Cetyl trimethyl ammonium bromide solution 0.5% by weight l-menthol 0.5% by weight Zinc oxide 0.3% by weight Flavoring 0.3% by weight Stearyl alcohol remaining 100% in total
  • ⁇ Preparation Example 16 Deodorizing Toner> Any of the lactone compound combinations listed in Table 8 Ethanol 15% by weight Polyoxyethylene polyoxypropylene decyl tetradecyl ether 1 wt% 0.01% by weight of hydrolyzed jojoba ester 0.01% by weight of methyl siloxane network polymer Magnesium ascorbate 0.3% by weight 0.05% by weight of perfume Paraben 0.3% by weight Citric acid Refined water balance 100% in total
  • Formulation Example 17 Deodorant Sheet Any of the lactone compound combinations listed in Table 8 Isopropylmethylphenol 0.05% by weight Zinc paraphenol sulfonate 1% by weight Ethanol 30% by weight Cetyl trimethyl ammonium bromide solution 0.5% by weight 1% by weight of butylene glycol Sericite complex 0.1% by weight Kaolin 0.3% by weight Phenoxyethanol 0.1% by weight Flavoring agent 0.1% by weight Citric acid Refined water balance 100% in total
  • ⁇ Preparation example 18 Deodorant for clothing and textile products> Any of the lactone compound combinations listed in Table 8 Green tea extract 0.5% by weight Biguanide compound 0.2% by weight 10.0 wt% ethanol Refined water balance 100% in total
  • ⁇ Formulation example 19 Deodorant for space> Any of the lactone compound combinations listed in Table 8 Dipropylene glycol 0.1% by weight 10.0 wt% ethanol Citric acid 0.1% by weight Cyclodextrin 0.05% by weight Sodium hydroxide Refined water balance 100% in total
  • Formulation Example 20 Dry Shampoo 1 Any of the lactone compound combinations listed in Table 8 LPG (Liquefied Petroleum Gas) 50% by weight Ethanol remaining amount Octenyl succinate starch Al 5% by weight Talc 3% by weight Silica 2% by weight 0.2% by weight of menthol Isopropyl methyl phenol 0.005% by weight Flavoring agent 0.1% by weight 100% in total
  • Formulation Example 21 Dry Shampoo 2 Any of the lactone compound combinations listed in Table 8 Dimethyl ether 60% by weight Ethanol remaining amount 2% by weight of jojoba oil Octenyl succinate starch Al 3% by weight Cornstarch 3% by weight Water 5% by weight Methyl paraben 0.1% by weight Dibutyl hydroxytoluene 0.05% by weight Flavor 0.2% by weight 100% in total
  • the present invention it is possible to rejuvenate body odor of a woman, so it is possible to provide a composition for external use suitable for preventing aging odor of a woman. Further, by using the composition of the present invention for an object to which body odor components are likely to be attached due to use of bedding etc., for example, the effect of rejuvenating the odor emitted from the attached body odor components can be expected.
  • the composition can also be suitably used for textiles, for hard surfaces or for spaces. Furthermore, according to the present invention, it is also possible to provide a method of evaluating a substance having an anti-aging effect.

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CN111107831A (zh) 2020-05-05
CN111107831B (zh) 2022-11-25
JP2022029456A (ja) 2022-02-17
JP7036833B2 (ja) 2022-03-15
JPWO2019059023A1 (ja) 2020-12-17
JP7199495B2 (ja) 2023-01-05
JP2023051985A (ja) 2023-04-11
JP2024149717A (ja) 2024-10-18
JP2022009136A (ja) 2022-01-14
JP6970855B1 (ja) 2021-11-24
JP2022023952A (ja) 2022-02-08

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