WO2019059023A1 - Composition for odor replenishment in younger women - Google Patents

Abstract

An object of the present invention is to provide a product as a countermeasure against aging note, which is suitable for younger women. Another object of the present invention is to provide a method for evaluating a substance having an antiaging effect by focusing attention on the age-related change in body odor in women. The present invention is a composition for odor replenishment in younger women, which contains at least a lactone compound represented by formula (I) and can be used for replenishing an odor component constituting the body odor of younger women. (In the formula, R represents an alkyl group having 2 to 9 carbon atoms.)

Description

Composition for young woman odor replenishment

The present invention relates to a composition for young female odor supplementation.

In recent years, people's interest in odorous etiquette has increased in both men and women. Studies on various body odors have been intensively advanced, and main cause odors such as sweat odor, odor odor, foot odor and aging odor have been identified. For example, body odor is generally considered to be caused by fatty acids and unsaturated aldehydes produced from sebum on the body surface. Also, in the odor called aging odor, similarly, ω-unsaturated fatty acids (palmitoleic acid and vacenic acid) produced by decomposition of sebum are further oxidatively decomposed to generate unsaturated aldehyde called 2-nonenal on the body surface It is reported that it is deeply related to the problem (non-patent document 1).

As a technique for preventing such a body odor such as age-related odor, a method of masking with perfume or the like, a method of utilizing odor adsorption effect of charcoal (Patent Document 1), and the like are known. In addition, a method using an extract from the root part and rhizome part of the silkworm moth (Patent Document 2), a method using condensed oyster tannin (Patent Document 3), and the like have also been proposed. In addition, development of cleaning agents for washing off offensive odor components is also in progress.

On the other hand, although body odor such as age-related odor is said to exist in both men and women, it is a fact that research on body odor change with aging of women has not been sufficiently advanced. Therefore, development of a product for age-related odor control suitable for women is desired.

JP 2002-145747 A JP, 2011-183019, A Japanese Patent Application Publication No. 2001-302483

The present invention has been made in view of such a situation, and an object of the present invention is to provide a product for rejuvenating body odor and a product for age-related odor control that are suitable for women. Another object of the present invention is to provide a method of evaluating a substance having an anti-aging effect, focusing on the change in body odor with aging of women.

The present inventors analyzed body odor components in women in their teens and 50s, and as a result, they apparently had a clearly sweet smell (SWEET odor) in women (young women) in their teens to 20s. Found that can be confirmed. After sensory evaluation, the components were analyzed to identify specific body odor components. In addition, it was also revealed that the nonenal odor generally known as a causative agent of the age-related odor was weaker in females than in males, and that no difference due to age was observed. Then, it is found that the body odor can be rejuvenated and the aging odor of a woman can be suppressed by supplementing the odor component constituting the body odor of the above-mentioned young woman which decreases with age, and the present invention is completed. It came to

That is, the gist of the present invention is as follows.

[1] A composition comprising at least a lactone compound represented by the following formula (I),
A composition for replenishing a young female odor, which is used to compensate for an odor component that constitutes a body odor of a young female.

(Wherein R is an alkyl group having 2 to 9 carbon atoms)
[2] The composition according to [1], which is for external use.
[3] The composition according to [2], which is for women.
[4] The composition according to [2] or [3], which is used for body odor rejuvenation.
[5] The composition according to [1], which is for textiles, hard surfaces or spaces.
[6] The composition according to any one of [1] to [5], which is for anti-aging odor.
[7] A body odor model composition for a young woman, containing an odor component that constitutes the body odor of a young woman, and containing at least a lactone compound represented by the following formula (I) as the odor component.

(Wherein R is an alkyl group having 2 to 9 carbon atoms)
[8] A composition comprising at least a lactone compound represented by the following formula (I),
An index agent for aging odor judgment, used as an indicator for the judgment of aging odor of women.

(Wherein R is an alkyl group having 2 to 9 carbon atoms)
[9] A method for evaluating an anti-aging effect, which evaluates the anti-aging effect of a test substance by using a change in the content of a lactone compound represented by the following formula (I) contained in body odor by use of the test substance as an indicator.

(Wherein R is an alkyl group having 2 to 9 carbon atoms)
[10] An anti-aging substance screening method of screening a substance having an anti-aging effect by using a change in the content of a lactone compound represented by the following formula (I) contained in body odor as a test substance.

(Wherein R is an alkyl group having 2 to 9 carbon atoms)
[11] The method according to [10], wherein a substance having an anti-aging effect on body odor is screened.
[12] A body odor composition improving agent comprising a production promoting substance of a lactone compound represented by the following formula (I) and / or a synthesis promoting substance of a lactone compound represented by the following formula (I).

(Wherein R is an alkyl group having 2 to 9 carbon atoms)
The anti-aging odor agent containing the body odor composition improving agent as described in [13] [12].
[14] The anti-aging odor agent according to [13], which is for women.
[15] A lactone compound action improver which improves the action of a lactone compound represented by the following formula (I).

(Wherein R is an alkyl group having 2 to 9 carbon atoms)
[16] A body odor improving agent containing the lactone compound activity improving agent according to [15].

According to the present invention, it is possible to provide a product for age-related odor control suitable for women, capable of rejuvenating body odor. Furthermore, according to the present invention, it is also possible to provide a method of evaluating a substance having an anti-aging effect.

SWEET odor sensory evaluation score for body odor in female subjects of teens to 50s SWEET odor sensory evaluation score for body odor in female subjects of teens to 50s Body odor nonenal odor sensory evaluation score for female subjects in teens to 50s Body odor nonenal concentration of female subjects in teens to 50s Body odor lactone concentrations in female subjects in their teens and 50s Effect on model aging odor The effect of odor on the impression of a woman

Hereinafter, the present invention will be described in detail. The terms used in the present specification are interpreted in the meaning commonly used in the art unless otherwise stated.

[Composition for youth female odor supplementation]
The composition of the present invention is a composition for replenishing the odor of a young woman, which is used to compensate for an odor component constituting body odor of a young woman, and contains at least a lactone compound represented by the following formula (I). The composition of the present invention can rejuvenate body odor of a woman, and therefore, can be suitably used as an external composition for preventing aging odor of a woman. On the other hand, by using the composition of the present invention for an object to which body odor components are likely to be attached, for example, by use of bedding, the effect of rejuvenating the odor emitted from the attached body odor components can be expected. It can be suitably used for products, hard surfaces or spaces. In the present invention, the body odor refers to the overall odor emitted by women, and includes odors from the back, nape, behind the ear, scalp odor, sweat odor, odor odor, foot odor and the like.

Although body odor is composed of various components, it has become clear from the study of the present inventors that in women, the amount of a specific lactone compound in body odor decreases with aging. That is, although specific lactone compounds are sufficiently contained in the body odor of young women in their twenties and early twenties, they decrease with age. On the other hand, the amount in body odor of nonenal which is the causative agent of the aging odor conventionally known was originally small in the case of women, and no tendency was observed to increase with age. Therefore, the present inventors are more included in the body odor of young women than the suppression of the nonenal odor usually performed as measures against the age-related odor of men as a measure against the age-old odor of women, and masking by perfumes and the like. However, it was found that it would be more effective to make up for a specific component that decreases with age, and research was conducted, and it was found that the present invention is completed and the effects of the invention as described above can be obtained. It is

In the formula, R is an alkyl group having 2 to 9 carbon atoms. The carbon number of R is preferably 3 to 9, more preferably 4 to 9, still more preferably 5 to 8, and particularly preferably 6 or 7. The hydrogen atom which the said alkyl group contains may be substituted.

Specific examples of the lactone compound represented by the above formula (I) include, for example, γ-hexalactone, γ-heptalactone, γ-octalactone, γ-nonalactone, γ-decalactone, γ-undecalactone, γ-dodeca Lactone, γ-tridecalactone and the like can be mentioned. Among these, γ-nonalactone, γ-decalactone, γ-undecalactone and γ-dodecalactone are preferable, and γ-decalactone and γ-undecalactone are more preferable. These lactone compounds are ingredients having the smell of fruits such as peach, rattan and coconut. The lactone compounds may be used alone or in combination of two or more.

The content of the lactone compound represented by the formula (I) in the composition of the present invention is 0.00001% by weight to 10% by weight, and from the viewpoint of the effect on the aging odor control of women, 0.00005% by weight % To 5 wt% is preferable, 0.0001 wt% to 3 wt% is more preferable, 0.0005 wt% to 2 wt% is further preferable, and 0.001 wt% to 1 wt% is preferable. It is particularly preferred that it is wt%. When two or more lactone compounds are used in combination, the total amount is in the above numerical range.

There are many types of odor components constituting body odor of young women other than the lactone compounds represented by the above formula (I). The composition of the present invention may contain an odor component other than the lactone compound represented by the above formula (I), which constitutes the body odor of other young women. Examples of odor components constituting body odor of other young women include aldehydes, fatty acids, ketones, sulfur compounds (S-based odor), nitrogen compounds (N-based odor) and the like. As an odor component which comprises the body odor of the other young woman which the composition of this invention contains, the component in which content in body odor reduces with aging of a woman is preferable.

The composition of the present invention can contain the following optional components in addition to the components described above, as long as the effects of the present invention are not impaired.

Hereinafter, when the composition of the present invention is (1) an external composition used for human and (2) other than human, specifically, for textiles, hard surfaces, spaces, etc. The case of the composition to be used will be described separately.

(1) In the case of the composition for external use When the composition of the present invention is the composition for external use, examples of optional components other than the above-mentioned essential components may include anti-inflammatory agents, refreshing agents, bactericides, vitamins Organic acid, moisturizing component, polyhydric alcohol, scrub agent, ultraviolet light absorbing component, ultraviolet light scattering component, astringent component, peptide or derivative thereof, amino acid or derivative thereof, cleaning component, keratin soft component, cell activation component, antiaging component , Blood circulation promoting active ingredient, whitening ingredient, powder and the like. In addition, in the composition of this invention, these components may be used individually by 1 type, respectively, and may use 2 or more types together.

Examples of anti-inflammatory agents include allantoin and derivatives thereof, glycyrrhetinic acid and derivatives thereof, glycyrrhizinic acid and derivatives thereof, salicylic acid derivatives, aminocaproic acid, azulene and derivatives thereof, zinc oxide, tocopherol acetate, hydrocortisone, prednisolone and salts thereof Can be mentioned. Among them, allantoin, allantoin chlorohydroxyaluminum, allantoindihydroxyaluminum, glycyrrhetinic acid, glycyrrhizinic acid, stearyl glycyrrhetinate, glycol salicylate, methyl salicylate, epsilon aminocaproic acid, azulene, guaiazulene and salts thereof are preferable. Here, the term "derivative" refers to an ester, an ether, an alkylated product, a glycoside or the like of the described compound. Here, "salt" means, for example, salts of mineral acids such as sulfuric acid, hydrochloric acid or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metals Salt, ammonium salt etc.

As the above-mentioned refreshing agent, for example, terpenes such as menthol, camphor, borneol, geraniol, cineole, anethole, limonene, eugenol (these may be d-form, l-form or dl-form); Eucalyptus oil, bergamot Oil, peppermint oil, coolmint oil, spearmint oil, fennel oil, peppermint oil, peppermint oil, caffeine oil, rose oil, turpentine oil and other essential oils, etc. may be mentioned.

Examples of the above-mentioned germicides include isopropylmethylphenol, chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and derivatives thereof, popidone iodine, potassium iodide, iodine, triclocarban, triclosan, photosensitivity No. 101, Photosensitive No. 201, parabens, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyroctoalamine, miconazole and the like.

The vitamins may be any of water-soluble vitamins and oil-soluble vitamins, for example, pyridoxine, pyridoxal, pyridoxamine, 5'-pyridoxal phosphate, and salts thereof (eg, pyridoxine hydrochloride, pyridoxine acetate, hydrochloric acid hydrochloride) Vitamin B6 such as pyridoxal, pyridoxamine hydrochloride, etc. Pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesin, D-panthetin, coenzyme A, pantothenylethyl ether, and salts thereof Pantothenic acids; Nicotinic acid, dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1- (4-methylphenyl) ethyl nicotinate, nicotinic acid amide, and salts thereof Nico Tin acids; γ-oryzanol, thiamine, dibenzoyl thiamine, thiamine cetyl, thiamine monophosphate, thiamine diphosphate, thiamine triphosphate, and salts thereof (eg, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl Hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate phosphate, thiamine diphosphate hydrochloride, thiamine triphosphate monophosphate Acid salts, etc .; riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5′-phosphate ester Vitamins such as lirium, riboflavin tetranicotinate and their salts; biotins such as biotin, biocytin and their salts; folic acid, pteroyl glutamic acid and their folates; cyanocobalamin, hydroxocobalamin Vitamin B12 such as deoxyadenosyl cobalamin and salts thereof; ascorbic acid derivatives such as ascorbic acid, dehydroascorbic acid, ascorbic acid phosphate, ascorbic acid 2-glucoside, 3-O-ethyl ascorbic acid, and Water-soluble vitamin Cs such as salts thereof (eg, sodium ascorbate, sodium ascorbate phosphate, magnesium ascorbate phosphate); dl-α-tocopherol, dl-α-tocopherol acetate, Vitamin E such as dl-α-tocopherol succinate, dl-α-tocopherol succinate, ascorbic acid-A, ascorbic acid stearic acid ester, ascorbic acid palmitic acid ester, L-ascoryl dipalmitate acid, tetra 2-hexyl decanoic acid Oil-soluble vitamin Cs such as ascorbyl; vitamin Ds such as ergocalciferol and cholecalciferol; vitamin Ks such as phylloquinone and farnoquinone; vitamin-like agents such as ferulic acid and the like.

Examples of the organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, acetic acid , Lactic acid, and their salts. As the salt, for example, salts of mineral acids such as sulfuric acid, hydrochloric acid or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts etc. Can be mentioned.

Examples of the moisturizing component include diglycerin trehalose; sodium hyaluronate, heparin analogue, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, high molecular compounds such as chitosan; amino acids such as glycine, aspartic acid and arginine; Natural moisturizing factors such as sodium, urea and sodium pyrrolidonecarboxylate; lipids such as ceramide, cholesterol and phospholipids; plant extracts such as chamomile extract, hamamelis extract, tea extract and perilla extract and the like.

The polyhydric alcohol preferably has 2 to 10 carbon atoms, and examples thereof include glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1 And 3-butylene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, neopentyl glycol and the like. Among these, glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol Glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol and hexanediol are more preferable.

As the above-mentioned scrub agent, for example, apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride particles, olive kernel powder, dried seawater particles, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, charcoal powder And husk powder, polyethylene powder, silicic acid anhydride and the like.

Examples of the ultraviolet ray absorbing component include octyl triazone, octyl dimethoxybenzylidene dioxoimidazolidine propionate, 2-ethylhexyl paramethoxycinnamate, phenyl benzimidazole sulfonic acid and the like.

Examples of the ultraviolet light scattering component include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, titanium oxide, zirconium oxide, cerium oxide, titanium oxide, iron oxide, anhydrous silicic acid, and such inorganic compounds. Those coated with inorganic powder such as hydrous silicic acid, aluminum hydroxide, mica and talc, compounded with resin powder such as polyamide, polyethylene, polyester, polystyrene and nylon, and further silicone oil and fatty acid aluminum salt etc What was processed etc. are mentioned.

Examples of the astringent component include zinc sulfate, aluminum chloride, zinc sulfocarbonate and tannic acid.

Examples of the peptide or derivatives thereof include keratinolytic peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin degrading peptides, collagenolytic peptides, hydrolyzed collagen, hydroxypropyl ammonium chloride hydrolyzed collagen, Elastin-degrading peptide, Conchiolin-degrading peptide, Hydrolyzed conquioline, Silk-proteolytic peptide, Hydrolyzed silk, Lauroyl-hydrolyzed silk sodium, Soy-proteolytic peptide, Hydrolyzed soy protein, Wheat protein, Wheat-proteolytic peptide, Hydrolyzed wheat protein, Caseinolytic peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.) and the like can be mentioned.

Examples of the above amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, Cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine and the like.

Examples of the washing component include soaps selected from alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts, etc .; cocoylglutamate Na, cocoyl methyltaurine Na Amino acid surfactant such as ether sulfate ester salt such as sodium laureth sulfate ether carboxylate salt such as sodium lauryl ether acetate salt sulfosuccinic acid ester salt such as alkyl sulfosuccinic ester Na such as coconut oil fatty acid monoethanolamide, coconut oil Fatty acid alkanolamides such as fatty acid diethanolamide; monoalkyl phosphate ester salts such as sodium lauryl phosphate, polyoxyethylene lauryl ether sodium phosphate; coconut oil fatty acid amido propyl dime L-aminoacetic acid betaine, lauryl dimethylaminoacetic acid betaine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl hydroxysulfobetaine and lauroylamidoethyl hydroxyethyl carboxymethyl betaine sodium hydroxypropyl phosphate and other betaines Amphoteric surfactants; amino acid type amphoteric surfactants such as sodium lauryl aminopropionate and the like can be mentioned.

Examples of the keratin softness component include lactic acid, salicylic acid, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea, sulfur and the like.

Examples of the cell activation component include amino acids such as γ-aminobutyric acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannin, flavonoid, Saponin, photosensitive element No. 301 and the like can be mentioned.

Examples of the antiaging component include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, mevalonolactone and the like.

Examples of the above-mentioned blood circulation promoting active ingredient include plants (eg, Panax ginseng, hornhead, Arnica, Ginkgo biloba, Ginkgo biloba, Ginkgo biloba, Ginkgo biloba, Chamomile, Roman chamomile, Carrot, Gentian, Burdock, Rice, Hawthorn, Shiitake, Ginger, Hawthorn, Prunus berry , Senkyu, assembly, thyme, chopsticks, chimpanzee, chili pepper, touki, toonin, spruce, carrot, garlic, butcherbroom, grape, button, marronie, melissa, yuzu, yokuinin, ryokucha, rosemary, rosehip, chimpo, touki, Ingredients derived from spruce, peach, apricot, walnut, corn etc); acetylcholine, ictamol, cantaristinki, gamma-oryzanol, cepharantine, trazoline, nicotinic acid toco Eroru, hesperidin, and the like.

Examples of the whitening component include tocopherol and tranexamic acid.

Examples of the powder component include starch octenyl succinic acid Al (stark aluminum octenyl succinic acid), talc, corn starch, magnesium hydroxide, anhydrous silicic acid, light anhydrous silicic acid, mica, hydroxyapatite, zinc oxide, titanium oxide, nylon powder And charcoal.

<PH>
The pH of the composition for external use of the present invention is usually 3.0 to 8.0, and preferably 3.5 to 7.5. In addition, this pH can be adjusted, for example by use of the pH adjuster mentioned later.

<Method of producing composition for external use>
The method for producing the composition for external use according to the present invention is not particularly limited, and the lactone compound represented by the above-mentioned formula (I) which is an essential component, an odor component constituting body odor of other young women blended as needed Various components necessary for producing the composition for external use (the above-mentioned optional components, the base or carrier to be described later, a carrier, additives, etc.) can be appropriately selected and blended, and the composition can be produced by a conventional method. The composition for external use of the present invention may be an emulsified composition, a solubilized composition, or a dissolved composition.

<Application of composition for external use>
The composition for external use according to the present invention constitutes body odor of young women by using the composition for external use according to the present invention containing an odor component which decreases with age, for example, for women who are concerned about age-related odor after middle age. To compensate for the odor component, to rejuvenate body odor, and to suppress the odor that makes you feel as an aging odor. Thus, the composition for external use of the present invention can be used for measures against aging odor of women. The composition for external use according to the present invention used for such purpose includes, for example, body soap, cleansing agent such as face cleanser, shampoo, treatment, hair care agent such as dry shampoo, cleansing agent, deodorant, antiperspirant, ointment, It can be suitably used as a liquid, suspension, emulsifier (emulsion and cream), gel, liniment, lotion, patch, mist, aerosol, powder, granules and the like.

<Formulation>
The composition for external use according to the present invention is a base or carrier usually used for cosmetics, medicines, quasi-drugs, and the additives described later as required, and its essential components and other components described above, etc. The mixture may be mixed according to a conventional method, and may be emulsified or solubilized as necessary, to form various external preparation compositions.

Examples of the base or carrier include hydrocarbons such as liquid paraffin, squalane, petrolatum, gelled hydrocarbon (plasti base etc.), ozokerite, α-olefin oligomer, light liquid paraffin, etc .; methyl polysiloxane, highly polymerized methyl polysiloxane Cyclic silicone, alkyl modified silicone, amino modified silicone, polyether modified silicone, polyglycerin modified silicone, silicone alkyl chain comodified polyether modified silicone, silicone alkyl chain comodified polyglycerin modified silicone, polyether modified branched silicone, Polyglycerin modified branched silicone, acrylic silicone, phenyl modified silicone, silicone resin such as silicone resin; coconut oil, olive oil, rice bran oil, shea butter etc; Oils, waxes such as Mirow, candelilla wax, lanolin; Setanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyl dodecanol, isostearyl alcohol, phytosterols, higher alcohols such as cholesterol; ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose Cellulose derivatives such as polyvinyl pyrrolidone; carrageenan; polyvinyl butylate; polyethylene glycol; dioxane; butylene glycol adipate polyester; diisopropyl adipate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, etc. Tetra-2-ethylhexanoic acid pentaerythritol Esters such as dextrin; polysaccharides such as dextrin and maltodextrin; vinyl polymers such as carboxyvinyl polymers and alkyl-modified carboxyvinyl polymers; lower alcohols such as ethanol and isopropanol; ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, Ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether, etc. Glycol ether; water etc It is below.

When the composition for external use of the present invention contains a base or carrier other than water and lower alcohol, examples of the base or carrier include higher alcohols, hydrocarbons, oils and fats, esters, silicone oils, waxes, vinyls. Polymers are preferred, and higher alcohols, ester oils, silicone oils and vinyl polymers are more preferred. Among these components, cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl tri-2-ethylhexanoate, dimethicone, cyclomethicone, polyether modified silicone, polyglycerin modified silicone and carboxyvinyl polymer are more preferable.

The base or carrier described above may be used alone or in combination of two or more. In addition, the amount used thereof is appropriately selected from the range known to those skilled in the art.

<Additives>
The composition for external use according to the present invention may be a known additive added to cosmetics, medicines, quasi-drugs, as long as the effects of the present invention are not impaired, such as surfactants, stabilizers, antioxidants, Coloring agents, pearlescent agents, dispersing agents, chelating agents, pH adjusters, preservatives, thickeners, irritation reducing agents and the like can be added. These additives may be used alone or in combination of two or more.

The surfactant may be any of nonionic surfactant, cationic surfactant, anionic surfactant, amphoteric surfactant and the like, and examples thereof include sorbitan monoisostearate and sorbitan monolaurate. Sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexyl acid, sorbitan fatty acid esters such as diglycerol sorbitan tetra-2-ethylhexyl acid; propylene glycol fatty acid esters such as propylene glycol monostearate; Cured castors of polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80, etc. Oil derivatives; Monolaurate polyoxyethylene (20) sorbitan (polysorbate 20), monostearate polyoxyethylene (20) sorbitan (polysorbate 60), monooleate polyoxyethylene (20) sorbitan (polysorbate 80), isostearate Polyoxyethylene (20) polyoxyethylene sorbitan fatty acid esters such as sorbitan; polyoxyethylene mono-cocoyl oil fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; stearylamine, oleylamine Amines such as polyoxyethylene / methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG- Silicone surfactants such as poly dimethicone and the like. Among these, nonionic surfactants are preferable, and hydrogenated castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, and polyoxyalkylene alkyl ethers are more preferable.

Examples of the above-mentioned stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride and the like.

As said coloring agent, an inorganic pigment, a natural pigment | dye etc. are mentioned, for example.

Examples of the pearlescent agent include ethylene glycol distearate, ethylene glycol monostearate, triethylene glycol distearate and the like.

Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinyl pyrrolidone, methyl vinyl ether / maleic anhydride cross-linked copolymer, organic acid and the like.

Examples of the above-mentioned chelating agent include EDTA.disodium salt, EDTA.calcium.disodium salt and the like.

Examples of the pH adjuster include inorganic acids (hydrochloric acid, sulfuric acid etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, sodium citrate, succinic acid, sodium succinate etc.), inorganic bases (potassium hydroxide, hydroxide Sodium etc., organic bases (triethanolamine, diisopropanolamine, triisopropanolamine etc.) and the like. Among them, inorganic bases and / or organic bases are preferable, and potassium hydroxide and triethanolamine are more preferable.

Examples of the preservative include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, parahydroxybenzoic acid, and the like. Examples thereof include benzyl, methyl parahydroxybenzoate and phenoxyethanol.

Examples of the thickener include vinyl thickeners such as polyvinyl alcohol, polyvinyl pyrrolidone and carboxyvinyl polymer, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxyethyl cellulose and the like. Cellulose thickeners, guar gum, pectin, pullulan, gelatin, locust bean gum, carrageenan, agar, xanthan gum, acrylic acid methacrylic acid alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, chondroitin sulfate Sodium, hyaluronic acid, sodium hyaluronate, Hydroxyethylmethacrylate / acryloyldimethyltaurinato Na) copolymer, and (ammonium acryloyldimethyltaurate / vinyl pyrrolidone) copolymers and the like. Among these, vinyl thickeners and cellulose thickeners are preferred, and carboxyvinyl polymers, polyvinyl alcohol, polyvinyl pyrrolidone, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, carboxy Ethyl cellulose is more preferred.

Examples of the above-mentioned irritation reducing agent include licorice extract, sodium alginate, gum arabic, polyvinyl pyrrolidone and the like.

<Formulation form>
The formulation form of the composition for external use according to the present invention is not particularly limited. For example, ointments, solutions, suspensions, emulsifiers (emulsion and cream), gels, liniments, lotions, patches, mists, aerosols, Powders, granules and the like can be mentioned. Among these, liquid to semisolid preparation forms are preferable, and in particular, it is useful when applied to solutions, lotions, ointments, gels and emulsifiers. These preparations can be manufactured according to a conventional method, for example, the method described in the 17th revised Japanese Pharmacopoeia General Rules, and the like.

(2) When the composition is used other than human When the composition of the present invention is used other than human, specifically when used as a composition for fiber products, hard surfaces, spaces, etc. As optional components which may be contained in addition to the above-mentioned essential components, for example, polyhydric alcohols, surfactants, deodorants, various solvents generally used, oils, gelling agents, sodium sulfate, N, N, N- Salts such as trimethylglycine, pH adjusters, antioxidants, preservatives, disinfectants / antibacterial agents, perfumes, dyes, UV absorbers and the like can be mentioned. In addition, in the said composition, these components may be used individually by 1 type, respectively, and may use 2 or more types together. Furthermore, polyhydric alcohols and surfactants not only suppress volatilization of malodorous components attached to textiles, hard surfaces, human bodies, pets, etc., but also stabilize stable amino monosaccharides or salts thereof as odor eliminating components. The deodorizing effect can be further enhanced by dispersing and improving the contact with the offensive odor component.

The said polyhydric alcohol is a component which has an effect which suppresses volatilization of the offensive odor component adhering to textiles, a hard surface, space, etc. Examples of such polyhydric alcohols include glycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butanediol, diethylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol and the like. Among these, diethylene glycol and dipropylene glycol are preferable.

When the composition of the present invention is used other than human, specifically, when it is a composition used for textiles, hard surfaces, spaces, etc., the above polyhydric alcohol in such a composition of the present invention The content of the group varies depending on the use form, but is usually 0.001% by mass or more, preferably 0.001 to 30% by mass, and more preferably 0.005 to 10% by mass.

The surfactant is not particularly limited, and examples thereof include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants. Specifically, the molecule has at least an alkyl group or alkenyl group having 8 to 18 carbon atoms in the molecule, and the hydrophilic portion contains a carboxylate, a sulfonate, a sulfate, a phosphate, a quaternary ammonium salt And sulfobetaines, carbobetaines, amine oxides, (poly) oxyalkylenes, (poly) alkanolamines, (poly) glycosides, compounds having a (poly) glycerin skeleton, and the like. Further, the alkyl group or alkenyl group having 8 to 18 carbon atoms and the hydrophilic portion may be bonded via one or more selected from an ether group, an ester group, an amide group and an alkyl group. Among these surfactants, surfactants of sulfonic acid salt, sulfuric acid ester salt, phosphoric acid ester salt, quaternary ammonium salt, carbobetaine, amine oxide, (poly) glycoside and (poly) glycerin type are preferable.

When the composition of the present invention is used other than human, specifically when it is used as a composition for fiber products, hard surfaces, spaces, etc., the above-mentioned surfactant in such a composition of the present invention Although the content of () varies depending on the form of use, it is usually 0.001% by mass or more, preferably 0.001 to 30% by mass, and more preferably 0.01 to 10% by mass.

As the solvent, for example, ethanol, monoethyl or monobutyl ether of ethylene glycol or propylene glycol, monoethyl or monobutyl ether of diethylene glycol or dipropylene glycol, benzyl alcohol, benzyloxyethanol, ethylene oxide or propylene oxide adduct of phenolic compound, etc. It can be mentioned.
<PH>
The pH of the above composition of the present invention is usually pH 5.0 to 9.0, preferably pH 6 to 8.5. The pH can be adjusted by using a pH adjuster or the like.

<Method of producing the above composition>
The method for producing the above composition is not particularly limited, and the lactone compound represented by the above formula (I) which is an essential component, an odor component which constitutes the body odor of other young women blended as needed, a composition Various components (the above-mentioned optional components and the like) necessary for production can be appropriately selected and blended, and the composition can be produced by a conventional method. The composition of the present invention may be an emulsified composition or a solubilized composition.

<Use of the above composition>
The use form of the above composition of the present invention can be in the form of liquid, gel, powder, solid or the like, but it is preferable to use it as liquid. In the case of liquid, in particular sprays, lotions, etc. cloths such as handkerchiefs and towels, clothes such as suits and sweaters, pillows, bedclothes such as sheets, curtains, textiles such as sofas, cooking utensils such as dishes and pans, It is suitable to use for those having a hard surface such as a cooktop, a floor, a floor, a wall, wallpaper, a trash can, a toilet bowl, a bath tub, a drain, and a space. Moreover, it can also be used as a stationary type, such as using it as a filter of an air cleaner, making it immerse and spray in paper, a nonwoven fabric, etc., and using it. The composition of the present invention can be suitably used, for example, as a deodorant for the above-mentioned textiles, hard surface, space and the like used by women who are concerned about aged odor after middle age. Even objects that can not be washed frequently can be used comfortably for a fixed period of time in terms of odor.

<Usage form>
The above composition of the present invention is preferably, for example, filled in a mist type spray container, and the spray amount thereof is adjusted to 0.1 to 1 ml. As a spray container to be used, well-known spray containers, such as a trigger spray container (direct pressure or pressure accumulation type) and a dispenser type pump spray container, can be used.

Body odor model composition for young women
The present invention also includes a body odor model composition for a young woman, which contains an odor component that constitutes the body odor of the young woman, and at least containing a lactone compound represented by the following formula (I) as the odor component. According to the inventors of the present invention, when the odor component constituting the body odor of the young woman and the odor component constituting the body odor of the female after middle age are compared, the above-mentioned specific lactone compound is contained more in the young woman, It was found to decrease with age. The body odor model composition of a young woman of the present invention is closer to the body odor of an actual young woman, and can be used as a reference in the determination of an age odor, the determination of an age odor suppression effect, and the like.

(Wherein R is an alkyl group having 2 to 9 carbon atoms)

For the lactone compound represented by the above-mentioned formula (I), the explanation in the section [External Composition for Young Women's Odor Supplementation] can be applied.

There are many types of odor components constituting body odor of young women other than the lactone compounds represented by the above formula (I). The body odor model composition for young women of the present invention preferably contains an odor component constituting the body odor of other young women other than the lactone compound represented by the above formula (I). As an odor component which comprises the body odor of other young women, aldehydes, fatty acids, ketones, ammonia etc. are mentioned, for example. The odor component constituting the body odor of other young women contained in the composition for external use of the present invention preferably includes a component whose content in body odor decreases with the age of the woman.

[Index agent for aging odor judgment]
The present invention also relates to a composition comprising at least the lactone compound represented by the above-mentioned formula (I), which is used as an indicator for determining the age odor of women, and also includes an indicator for determining the age odor. The present invention also includes a composition for determining body odor age, which is a composition containing at least the lactone compound represented by the above formula (I) and used as an indicator for determining body odor age of a woman. According to the inventors of the present invention, when the odor component constituting the body odor of a young woman and the odor component constituting the body odor of a woman whose age is anxious to middle-aged or later, the specific lactone compound is It is found to be more abundant in women and that they decrease with age. The index agent for determining the age odor according to the present invention and the index agent for determining the body odor age according to the difference between the body odor of a young woman and a woman whose age is concerned about the age odor after middle age It can be used as a standard in the determination of the age odor suppression effect, the determination of body odor age, etc.

For the lactone compound represented by the above-mentioned formula (I), the explanation in the section [External Composition for Young Women's Odor Supplementation] can be applied.

[Anti-aging effect evaluation method]
The present invention evaluates the anti-aging effect of a test substance by using the change in the content of the lactone compound represented by the above-mentioned formula (I) contained in body odor as the indicator by the use of the test substance Also includes. According to the inventors of the present invention, when the odor component constituting the body odor of a young woman and the odor component constituting the body odor of a woman whose age is anxious to middle-aged or later, the specific lactone compound is It is found to be more abundant in women and that they decrease with age. The present invention has been completed based on this finding, and its use in the evaluation of the anti-aging effect of test substances (pharmaceuticals, supplements, various foods and drinks, etc.) causes changes in body odor of women, The index is used to increase the content of odor components that are contained in women's body odors and decrease with age to make them effective in rejuvenating body odors. In addition, about the lactone compound represented by the said Formula (I), description of the term of [the external composition for youth female odor supplementation] is applicable.

[Anti-aging substance screening method]
The present invention provides an anti-aging substance screening method of screening a substance having an anti-aging effect by using as a indicator a change in the content of the lactone compound represented by the above-mentioned formula (I) contained in body odor by using a test substance Also includes. According to the inventors of the present invention, when the odor component constituting the body odor of a young woman and the odor component constituting the body odor of a woman whose age is anxious to middle-aged or later, the specific lactone compound is It is found to be more abundant in women and that they decrease with age. The present invention has been completed based on this finding, and it is used for evaluating the anti-aging effect of test substances (pharmaceuticals, supplements, various foods and drinks, etc.) and screening excellent substances. It is used as an indicator whether it causes body odor change and increases the content of odor components that are included in the body odor of young women and decreases with age, and that the body odor is rejuvenated. In addition, about the lactone compound represented by the said Formula (I), description of the term of [the external composition for youth female odor supplementation] is applicable.

[Body odor composition improver]
The present invention contains a substance promoting the production of a lactone compound represented by the above formula (I) and / or a substance promoting the synthesis of a lactone compound represented by the above formula (I), a body odor composition improving agent Also includes. The body odor composition improving agent of the present invention includes, for example, substances selected by the above-mentioned anti-aging substance screening method. The agent for improving body odor composition according to the present invention may be used either internally or externally, and when it is used, the lactone compound in the body odor is increased, and the odor similar to the body odor of a young woman having a high lactone compound content can be generated. In addition, about the lactone compound represented by the said Formula (I), description of the term of [the external composition for youth female odor supplementation] is applicable.

[Aging odor control agent]
The present invention also includes an anti-aging agent containing the above-mentioned body odor composition improving agent, particularly an anti-aging agent for women.

[Lacton compound action improver]
The present invention also includes lactone compound action improvers, which improve the action of the lactone compound represented by the above formula (I). The lactone compound action improver of the present invention may be either internal use or external use, and when it is used, the action of the lactone compound in body odor is improved, and the odor similar to the body odor of a young woman with high lactone compound content is generated. Can. In addition, about the lactone compound represented by the said Formula (I), description of the term of [the external composition for youth female odor supplementation] is applicable.

[Body odor improver]
The present invention also includes a body odor improving agent comprising the lactone compound action improving agent described above.

Hereinafter, the present invention will be described in more detail by way of examples, but the present invention is not limited thereto at all.

[Test 1]
A t-shirt with a cloth sewn on the back is applied to a Japanese woman (n = 50) in the late teens and 50s until after the next day's bathing, and after collecting the cloth, it is classified into 5 categories (nonenal smell) Sensory evaluation was carried out with a fatty acid odor, an amine / ammonia odor, an S-type odor, a SWEET odor) by a six-point score by a professional paneler (professional). The criteria for the above six-step score (odor intensity: 0 to 5) are shown in Table 1, and the results are shown in FIGS. 1 to 4. 1 and 2 show the SWEET odor sensory evaluation score, and FIG. 3 shows the nonenal odor sensory evaluation score. In addition, odor analysis was performed on the recovered fabric using a headspace gas chromatography mass spectrometer (HSS-GC / MS). The examination result about the correlation with the concentration (ppm) of a nonenal and the age of a test subject (sample) was shown in FIG. In addition, the correlation between the concentration (ppm) of each lactone component (γ-decalactone, γ-undecalactone) and the age of the subject (sample) was also examined, and the results are shown in FIG.

As shown in FIGS. 1 and 2, it was found that the SWEET odor is high until the early twenties with the woman in the late twenties as the peak, and the odor decreases with age. In addition, it is FIG. 1 that each data of FIG. 2 was bar graph-ized according to age. Moreover, as shown in FIG. 3 and FIG. 4, it was found that there was no clear correlation between age and sensory score, and that the odor intensity itself was lower than that of men. Further, it was found by HSS-GC / MS that the main components of the SWEET odor are γ-decalactone and γ-undecalactone.

As a result of examining the correlation between the total amount of γ-decalactone and γ-undecalactone and age, as shown in FIG. It was also confirmed that the concentration decreased after the 30s. It turned out that a 35 year old is a big change point (bent angle of odor) of SWEET smell.

[Test 2]
A cotton ball (White Cross No. 10) impregnated with 10 μL of model aged odor containing Trans-2-nonenal and 1 μL of each raw material of various γ-lactones was put in a container and sealed. After 30 minutes, the degree of pleasure and discomfort for the model age odor was evaluated. The evaluation was conducted by a panel of 4 people centered on the evaluator. Various γ-lactones were used diluted to 1% or 10% with dipropylene glycol. The criteria for the evaluation score are shown in Table 2 below, and the results are shown in Table 3 and FIG.

Although the degree of discomfort to the model aging odor was not improved by γ-valerolactone (Comparative Example 1), γ-hexalactone (Example 1), γ-heptalactone (Example 2), γ-octalactone ( Example 3) When γ-decalactone (Example 4) and γ-undecalactone (Example 5) were added, the odor quality was improved and a pleasant odor was obtained.

[Test 3]
While smelling various smells, the impression of the woman in the photograph (total 4 pieces) was evaluated. Specifically, "2-nonenal", "soap flavor", and "lactone C10 / lactone C11-containing flavor", which are aligned to the odor intensity 2 of the "non-scented" and six-step odor intensity display method, are prepared. While looking at the smell of one kind of smell, I saw a photo of a woman (average age 40 years old) and carried out a questionnaire survey on "femininity", "youngness" and "attractiveness" (n = 52). The evaluation was conducted for general men and women (30 years of age or older). The impression (%) about "femininity", "the youthfulness", and "attractiveness" at the time of making an fragrance free 100% was shown in FIG.

When there was a smell containing γ-decalactone (R = 6) and / or γ-undecalactone (R = 7), the appearance age of the woman in the photograph was evaluated to be evaluated as to decrease the youthfulness. In addition, it received an evaluation that femininity, attractiveness, and conviction increased. Many common women are known to feel their own body odor changes with age, but one of the causes is that “SWEET odor” is included in the body odor component peculiar to young women. It was surmised that the change in body odor was caused by the decrease of lactone C10 / lactone C11 "after 30s. Furthermore, from the above test results, it was also found that as a function of "lactone C10 / lactone C11", there is an effect of enhancing femininity, youthfulness and attractiveness. According to this research, as an approach to the aging odor of women, not only simply removing by washing but by giving the smell of "lactone C10 / lactone C11", it is more effective against the trouble of aging odor of women Different approaches were considered possible.

[Test 4]
The cleaning agent (body soap) of the composition of the following Table 4 was prepared by a conventional method.

The change in female impression was evaluated before and after use of the cleaning agent (body soap) having the composition of Table 4 above. Specifically, looking at women (n = 2), we conducted a questionnaire survey on "femininity," "attractiveness," "youngness," and "freshness." Table 5 shows the impression (%) of “femininity,” “attractiveness,” “youngness,” and “freshness” after sample use, with 100% before sample use.

[Test 5]
The antiperspirant of the composition of following Table 6 was prepared by the conventional method.

The change in female impression was evaluated before and after the use of the antiperspirant of the composition in Table 6 above. Specifically, looking at women (n = 2), we conducted a questionnaire survey on "femininity," "attractiveness," "youngness," and "freshness." Before the use of the sample, 100% was used, and the impressions (%) on the "femininity", "attractiveness", "youngness" and "freshness" after use of the sample are shown in Table 7.

Below, the formulation formulation example of the external composition of this invention is shown. In addition, the numerical value (%) of each lactone described in Table 8 indicates the final concentration (% by weight) in the whole composition when each combination is used for each formulation example.

<Formulation example 1: Body soap>
Any of the lactone compound combinations listed in Table 8 5% by weight of lauric acid
Palmitic acid 5% by weight
Stearic acid 5% by weight
Potassium hydroxide appropriate amount glycerin 5% by weight
Dibutylhydroxytoluene 0.01% by weight
Edetate disodium 0.05 wt%
Phenoxyethanol 0.3% by weight
0.1% by weight of benzalkonium chloride
Sodium laureth sulfate 5% by weight
Coconut oil fatty acid amidopropyl betaine 5% by weight
Polyquaternium-10 0.5% by weight
Polyquaternium-7 0.2% by weight
Kaolin 0.5% by weight
0.05% by weight of charcoal
Ascorbic acid magnesium phosphate 0.5% by weight
Hydroxyethylcellulose 0.3% by weight
Water remaining
100% in total

<Formulation example 2: Foam discharge type body wash>
Any of the lactone compound combinations listed in Table 8 PEG-80 sorbitan laurate 5% by weight
Cocoyl glutamate disodium 4% by weight
Cocoyl glycine sodium 2% by weight
Sorbitol 5% by weight
Cocoyl methyl taurine taurine sodium 2% by weight
Citric acid dosage 0.05% by weight of sodium edetate
Cocamide DEA 1% by weight
Cocoamphoacetate sodium 3% by weight
Polyquaternium-7 0.05% by weight
0.3% by weight of dipotassium glycyrrhizinate
Water remaining
100% in total

Formulation Example 3: Cleansing agent
Any of the lactone compound combinations listed in Table 8 5% by weight of lauric acid
10 wt% myristic acid
Palmitic acid 7% by weight
Stearic acid 7% by weight
Potassium hydroxide appropriate amount butylene glycol 5% by weight
Glycerin 5% by weight
Tocopherol 0.05% by weight
Edetate disodium 0.05 wt%
Phenoxyethanol 0.3% by weight
Salicylic acid 0.2% by weight
Coconut oil fatty acid amidopropyl betaine 5% by weight
Polyquaternium-10 0.3% by weight
Polyquaternium-7 0.1% by weight
l-menthol 0.3% by weight
Flavor 0.2% by weight
Water remaining
100% in total

Formulation Example 4: Shampoo
Any of the lactone compound combinations listed in Table 8 Sodium laureth sulfate 30% by weight
Cocoyl glutamate triethanolamine 5% by weight
Lauroyl methylalanine sodium 5% by weight
5% by weight of lauramidopropyl hydroxysultine
Citric acid Appropriate amount Dimethicone 0.3% by weight
Methyl paraben 0.2% by weight
Edetate disodium 0.1% by weight
Polyquaternium-10 0.5% by weight
Polyquaternium-39 0.1 wt%
Polyquaternium-7 0.1% by weight
Perfume 0.8% by weight
Water remaining
100% in total

<Preparation Example 5: Shampoo>
Any of the lactone compound combinations listed in Table 8 Olefin (C14-16) sodium sulfonate 15% by weight
POE lauryl ether acetate Na 5% by weight
Coconut oil fatty acid diethanolamide 5% by weight
Coconut oil fatty acid TEA liquid 5% by weight
Coconut oil fatty acid amidopropyl betaine solution 5% by weight
Citric acid Suitable amount Disodium edetate 0.1% by weight
1% by weight of benzalkonium chloride
Polyquaternium-10 0.6% by weight
Polyquaternium-7 0.1% by weight
Flavoring 0.5% by weight
Water remaining
100% in total

Formulation Example 6: Hair Conditioner
Any of the lactone compound combinations listed in Table 8 Glycerin 5% by weight
Hyaluronic acid 0.1% by weight
0.1% by weight of dipotassium glycyrrhizinate
0.1% by weight squalane
Stearyl trimethyl ammonium chloride 4% by weight
Polyquaternium-10 0.5% by weight
Settanol 2% by weight
POE-monostearyl glyceryl ether 1% by weight
Dibutylhydroxytoluene 0.01% by weight
Phenoxyethanol 0.3% by weight
EDTA-2Na 0.05 wt%
l-menthol 0.2% by weight
Flavoring 0.3% by weight
Water remaining
100% in total

<Formulation Example 7: Hair Treatment>
Any of the lactone compound combinations listed in Table 8 5% by weight of propylene glycol
Acetylated hyaluronic acid 0.01% by weight
Allantoin 0.3% by weight
1% by weight of tetra 2-ethylhexanoic acid
Cetyltrimethylammonium bromide 2.5% by weight
Polyquaternium-7 0.1% by weight
Setostearyl alcohol 2% by weight
Stearyl alcohol 2% by weight
POE-Hardened castor oil 1% by weight
Dibutylhydroxytoluene 0.01% by weight
Methyl parahydroxybenzoate 0.3% by weight
EDTA-2Na 0.05 wt%
Flavoring 0.5% by weight
Water remaining
100% in total

Formulation Example 8 Hair Essence
Any of the lactone compound combinations listed in Table 8 5% by weight of butylene glycol
Hydrolyzed hyaluronic acid 0.1% by weight
0.05% by weight of epsilon aminocaproic acid
Alkyl trimethyl ammonium chloride 0.7% by weight
O- [2-hydroxy-3- (trimethylammonio) chloride
Propyl] guar gum 0.5% by weight
Diethylene glycol monoethyl ether 2% by weight
POE-Sorbitan monoisostearate 0.8% by weight
Ethanol 20% by weight
Phenoxyethanol 0.3% by weight
Flavoring agent 0.1% by weight
Water remaining
100% in total

Formulation Example 9 Hair Mist
Any of the combinations of lactone compounds listed in Table 8 1% by weight of hydrolyzed collagen
5% by weight of butylene glycol
Hydrolyzed hyaluronic acid 0.1% by weight
0.05% by weight of dipotassium glycyrrhizinate
Polyquaternium-51 0.5 wt%
Liquid paraffin 0.5% by weight
Monoisostearyl glyceryl ether 1% by weight
Ethanol 30% by weight
Propyl parahydroxybenzoate 0.3% by weight
Flavoring 0.3% by weight
Water remaining
100% in total

<Preparation Example 10: Antiperspirant cream>
Any of the lactone compound combinations listed in Table 8 Benzalkonium chloride 0.07% by weight
Isopropyl methyl phenol 0.07% by weight
Chlorhydroxy aluminum 4% by weight
Cyclopentasiloxane 25% by weight
6% by weight of alkyl polyacrylate
POE · POP dimethicone copolymer 3.5 wt%
0.05% by weight of dipotassium glycyrrhizinate
Concentrated glycerin 7% by weight
5% by weight isononyl isononanoate
Sorbitan isostearate 5% by weight
l-menthol 0.5% by weight
Flavoring 0.3% by weight
Water remaining
100% in total

<Preparation Example 11: Antiperspirant Gel>
Any of the lactone compound combinations listed in Table 8 benzalkonium chloride 0.06% by weight
Isopropyl methyl phenol 0.05% by weight
Chlorhydroxy aluminum 8% by weight
0.5% by weight magnesium aluminometasilicate
Dipropylene glycol 10% by weight
Polyoxypropylene glycol 0.5% by weight
Hydroxypropyl methylcellulose 0.5% by weight
Xanthan gum 0.5% by weight
10 wt% ethanol
l-menthol 0.3% by weight
l-Mentyl glyceryl ether 0.3% by weight
Peppermint oil 0.3% by weight
Flavoring 0.3% by weight
Water remaining
100% in total

Formulation Example 12 Antiperspirant Spray
Any of the lactone compound combinations listed in Table 8 Isopropylmethylphenol 0.1% by weight
Zinc paraphenol sulfonate 1% by weight
Diethyl sebacate 4% by weight
5% by weight of talc
1% by weight of nylon powder
Flavoring 0.5% by weight
Ethanol 15% by weight
Dimethyl ether remaining
100% in total

Formulation Example 13 Antiperspirant Roll-On
Any of the lactone compound combinations listed in Table 8 benzalkonium chloride 0.06% by weight
Isopropyl methyl phenol 0.06% by weight
Zinc paraphenol sulfonate 5% by weight
5% by weight of butylene glycol
Chlorhydroxy aluminum 0.05% by weight
Talc 3% by weight
Nylon powder 0.5% by weight
1 wt% of cetyltrimethylammonium bromide solution
Hydroxypropyl methylcellulose 0.5% by weight
l-menthol 0.1% by weight
Flavoring 0.3% by weight
Water 40% by weight
The balance of ethanol
100% in total

<Preparation Example 14: Antiperspirant Mist>
Any of the lactone compound combinations listed in Table 8 Benzalkonium chloride 0.05 wt%
Isopropyl methyl phenol 0.06% by weight
Zinc paraphenol sulfonate 1% by weight
5% by weight of butylene glycol
Chlorhydroxy aluminum 0.02% by weight
Sericite complex 0.3% by weight
Cetyl trimethyl ammonium bromide solution 0.5% by weight
l-menthol 0.3% by weight
Flavoring 0.3% by weight
Water 10% by weight
The balance of ethanol
100% in total

<Preparation Example 15: Antiperspirant Stick>
Any of the lactone compound combinations listed in Table 8 Benzalkonium chloride 0.055% by weight
Isopropyl methyl phenol 0.05% by weight
Chlorhydroxy aluminum 5% by weight
Polyethylene wax 5% by weight
Microcrystalline wax 5% by weight
Glyceryl monostearate 3% by weight
5% by weight isononyl isononanoate
Talc 12% by weight
Methylpolysiloxane 2% by weight
Decamethylpentasiloxane 0.3% by weight
Silylation treated silica 15% by weight
Settanol 2% by weight
Hydroxyapatite 0.3% by weight
Cetyl trimethyl ammonium bromide solution 0.5% by weight
l-menthol 0.5% by weight
Zinc oxide 0.3% by weight
Flavoring 0.3% by weight
Stearyl alcohol remaining
100% in total

<Preparation Example 16: Deodorizing Toner>
Any of the lactone compound combinations listed in Table 8 Ethanol 15% by weight
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 1 wt%
0.01% by weight of hydrolyzed jojoba ester
0.01% by weight of methyl siloxane network polymer
Magnesium ascorbate 0.3% by weight
0.05% by weight of perfume
Paraben 0.3% by weight
Citric acid
Refined water balance
100% in total

Formulation Example 17 Deodorant Sheet
Any of the lactone compound combinations listed in Table 8 Isopropylmethylphenol 0.05% by weight
Zinc paraphenol sulfonate 1% by weight
Ethanol 30% by weight
Cetyl trimethyl ammonium bromide solution 0.5% by weight
1% by weight of butylene glycol
Sericite complex 0.1% by weight
Kaolin 0.3% by weight
Phenoxyethanol 0.1% by weight
Flavoring agent 0.1% by weight
Citric acid
Refined water balance
100% in total

<Preparation example 18: Deodorant for clothing and textile products>
Any of the lactone compound combinations listed in Table 8 Green tea extract 0.5% by weight
Biguanide compound 0.2% by weight
10.0 wt% ethanol
Refined water balance
100% in total

<Formulation example 19: Deodorant for space>
Any of the lactone compound combinations listed in Table 8 Dipropylene glycol 0.1% by weight
10.0 wt% ethanol
Citric acid 0.1% by weight
Cyclodextrin 0.05% by weight
Sodium hydroxide
Refined water balance
100% in total

Formulation Example 20: Dry Shampoo 1
Any of the lactone compound combinations listed in Table 8 LPG (Liquefied Petroleum Gas) 50% by weight
Ethanol remaining amount Octenyl succinate starch Al 5% by weight
Talc 3% by weight
Silica 2% by weight
0.2% by weight of menthol
Isopropyl methyl phenol 0.005% by weight
Flavoring agent 0.1% by weight
100% in total

Formulation Example 21: Dry Shampoo 2
Any of the lactone compound combinations listed in Table 8 Dimethyl ether 60% by weight
Ethanol remaining amount 2% by weight of jojoba oil
Octenyl succinate starch Al 3% by weight
Cornstarch 3% by weight
Water 5% by weight
Methyl paraben 0.1% by weight
Dibutyl hydroxytoluene 0.05% by weight
Flavor 0.2% by weight
100% in total

According to the present invention, it is possible to rejuvenate body odor of a woman, so it is possible to provide a composition for external use suitable for preventing aging odor of a woman. Further, by using the composition of the present invention for an object to which body odor components are likely to be attached due to use of bedding etc., for example, the effect of rejuvenating the odor emitted from the attached body odor components can be expected. The composition can also be suitably used for textiles, for hard surfaces or for spaces. Furthermore, according to the present invention, it is also possible to provide a method of evaluating a substance having an anti-aging effect.

Claims (11)

1. A composition comprising at least a lactone compound represented by the following formula (I),
   A composition for replenishing a young female odor, which is used to compensate for an odor component that constitutes a body odor of a young female.
   

   

   
   (Wherein R is an alkyl group having 2 to 9 carbon atoms)
2. The composition according to claim 1, which is for external use.
3. The composition according to claim 2, which is for women.
4. The composition according to claim 2 or 3, which is used for body odor rejuvenation.
5. The composition according to claim 1, which is for textiles, for hard surfaces or for spaces.
6. The composition according to any one of claims 1 to 5, which is for anti-aging odor.
7. A model composition for body odor of a young woman, comprising an odor component constituting body odor of a young woman, and containing at least a lactone compound represented by the following formula (I) as the odor component.
   

   

   
   (Wherein R is an alkyl group having 2 to 9 carbon atoms)
8. A composition comprising at least a lactone compound represented by the following formula (I),
   An index agent for aging odor judgment, used as an indicator for the judgment of aging odor of women.
   

   

   
   (Wherein R is an alkyl group having 2 to 9 carbon atoms)
9. The anti-aging effect evaluation method which evaluates the anti-aging effect of a to-be-tested substance by making into a parameter change of content of the lactone compound represented by following formula (I) contained in body odor by use of a to-be-tested substance.
   

   

   
   (Wherein R is an alkyl group having 2 to 9 carbon atoms)
10. The anti-aging substance screening method which screens the substance which has an anti-aging effect on the basis of change of content of the lactone compound represented by following formula (I) contained in body odor by use of a test substance as a parameter | index.
    

    

    
    (Wherein R is an alkyl group having 2 to 9 carbon atoms)
11. The method according to claim 10, wherein the substance having an anti-aging effect of body odor is screened.

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