JP2023051985A - Composition for young female odor replenishment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide products to prevent the odor of aging, which is suitable for women, and to provide evaluation methods of substances with anti-aging effect, focusing on changes in body odor with aging of women.

SOLUTION: The present invention is a composition for supplementing young female odors, which is used to supplement the odorous components that make up the body odor of young females, the composition containing at least a lactone compound represented by the following formula (I) (in the formula, R is an alkyl group having 2 to 9 carbon atoms).

SELECTED DRAWING: None

COPYRIGHT: (C)2023,JPO&INPIT

Description

The present invention relates to a composition for replenishing young female odor.

In recent years, people's interest in odor etiquette has increased, regardless of gender. Research on various body odors has been intensively advanced, and major causative odors such as sweat odor, armpit odor, foot odor, and aging odor have been identified. For example, body odor is generally considered to be caused by fatty acids and unsaturated aldehydes produced from sebum on the body surface. Similarly, the odor called aging odor is also generated on the body surface by oxidative decomposition of ω-unsaturated fatty acids (palmitoleic acid and vaccenic acid) produced by the decomposition of sebum, and unsaturated aldehydes called 2-nonenal are generated on the body surface. It has been reported that it is deeply related to doing (Non-Patent Document 1).

Techniques for preventing body odors such as aging odors include a method of masking with perfume or the like and a method of utilizing the odor adsorption effect of charcoal (Patent Document 1). A method using extracts from the root and rhizome of burnet (Patent Document 2) and a method using condensed persimmon tannin (Patent Document 3) have also been proposed. Furthermore, the development of detergents for washing off unpleasant odor components is also underway.

On the other hand, although it is said that body odors such as age-related odors are present in both men and women, the actual situation is that research on changes in body odors in women due to aging has not progressed sufficiently. Therefore, the development of anti-ageing odor products suitable for women is desired.

JP-A-2002-145747 JP 2011-183019 A JP-A-2001-302483

S. Haze et al. , The Journal of Investigative Dermatology, Vol. 116, No. 4, 520-524, 2001

The present invention has been made in view of such circumstances, and an object of the present invention is to provide a product for rejuvenating body odor and a product for combating aging odor suitable for women. Another object of the present invention is to provide a method for evaluating a substance having an anti-aging effect, focusing on changes in female body odor with aging.

The present inventors have analyzed the body odor components of women in their teens to 50s, and found that women in their teens to 20s (young women) have a sensuously sweet scent (SWEET odor). found that it is possible to confirm After sensory evaluation, the components were analyzed to identify specific body odor components. In addition, it was clarified that nonenal odor, which is generally known as a causative agent of aging odor, is weaker in females than in males, and that there is no age difference. Then, by supplementing the odor components that make up the body odor of young women, which decreases with age, the body odor can be rejuvenated, and the aging odor of women can be suppressed, and the present invention has been completed. reached.

That is, the gist of the present invention is as follows.

[1] A composition containing at least a lactone compound represented by the following formula (I),
A composition for replenishing the odor of young women, which is used for supplementing odor components constituting the body odor of young women.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［２］外用である、［１］に記載の組成物。
［３］女性用である、［２］に記載の組成物。
［４］体臭の若返りのために用いられる、［２］又は［３］に記載の組成物。
［５］繊維製品用、硬質表面用又は空間用である、［１］に記載の組成物。
［６］加齢臭対策用である、［１］から［５］のいずれかに記載の組成物。
［７］若年女性の体臭を構成する匂い成分を含有し、上記匂い成分として下記式（Ｉ）で表されるラクトン化合物を少なくとも含む、若年女性の体臭モデル組成物。

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.)
[2] The composition of [1], which is for external use.
[3] The composition according to [2], which is for women.
[4] The composition according to [2] or [3], which is used for rejuvenating body odor.
[5] The composition according to [1], which is for textile products, hard surfaces or spaces.
[6] The composition according to any one of [1] to [5], which is an anti-aging odor.
[7] A body odor model composition for young women, which contains an odor component that constitutes the body odor of young women, and at least a lactone compound represented by the following formula (I) as the odor component.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［８］下記式（Ｉ）で表されるラクトン化合物を少なくとも含む組成物であって、
女性の加齢臭判定の指標として用いられる、加齢臭判定用指標剤。

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.)
[8] A composition containing at least a lactone compound represented by the following formula (I),
An index agent for judging aging odor, which is used as an index for judging aging odor in women.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［９］被験物質の使用による、体臭中に含まれる下記式（Ｉ）で表されるラクトン化合物の含有量の変化を指標として、被験物質のアンチエージング効果を評価する、アンチエージング効果評価方法。

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.)
[9] An anti-aging effect evaluation method, wherein the anti-aging effect of a test substance is evaluated using the change in the content of a lactone compound represented by the following formula (I) contained in body odor due to the use of the test substance as an index.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［１０］被験物質の使用による、体臭中に含まれる下記式（Ｉ）で表されるラクトン化合物の含有量の変化を指標として、アンチエージング効果を有する物質をスクリーニングする、アンチエージング物質スクリーニング方法。

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.)
[10] An anti-aging substance screening method, which comprises screening for a substance having an anti-aging effect using, as an indicator, changes in the content of a lactone compound represented by the following formula (I) contained in body odor due to the use of a test substance.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［１１］体臭のアンチエージング効果を有する物質をスクリーニングする、［１０］に記載の方法。
［１２］下記式（Ｉ）で表されるラクトン化合物の産生促進物質及び／又は下記式（Ｉ）で表されるラクトン化合物の合成促進物質を含有することを特徴とする、体臭組成改善剤。

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.)
[11] The method of [10], wherein a substance having an anti-aging effect on body odor is screened.
[12] A body odor composition-improving agent comprising a substance promoting the production of a lactone compound represented by the following formula (I) and/or a substance promoting the synthesis of a lactone compound represented by the following formula (I).

（式中、Ｒは、炭素数２～９のアルキル基である。）
［１３］［１２］に記載の体臭組成改善剤を含む、加齢臭対策剤。
［１４］女性用である、［１３］に記載の加齢臭対策剤。
［１５］下記式（Ｉ）で表されるラクトン化合物の作用を向上させる、ラクトン化合物作用向上剤。

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.)
[13] An anti-aging odor agent containing the body odor composition improving agent according to [12].
[14] The anti-aging odor agent according to [13], which is for women.
[15] A lactone compound action improver that improves the action of a lactone compound represented by the following formula (I).

（式中、Ｒは、炭素数２～９のアルキル基である。）
［１６］［１５］に記載のラクトン化合物作用向上剤を含有する、体臭改善剤。

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.)
[16] A body odor improving agent containing the lactone compound effect improver according to [15].

ADVANTAGE OF THE INVENTION According to this invention, the product for aging odor measures suitable for a woman which can rejuvenate a body odor can be provided. Furthermore, according to the present invention, it is also possible to provide a method for evaluating a substance having an anti-aging effect.

SWEET odor sensory evaluation score of body odor of female subjects in their teens to 50s SWEET odor sensory evaluation score of body odor of female subjects in their teens to 50s Nonenal odor sensory evaluation score for body odor of female subjects in their teens to 50s Concentration of nonenal in body odor of female subjects in their teens to fifties Concentration of lactones in body odor of female subjects in their teens to fifties Effect on model aging odor Effect of fragrance on women's visual impression

The present invention will be described in detail below. In addition, the terms used in this specification are interpreted as meanings commonly used in the technical field unless otherwise specified.

[Composition for replenishing the odor of young women]
The composition of the present invention is a composition for replenishing the odor of young women, which is used to supplement the odor components that make up the body odor of young women, and contains at least a lactone compound represented by the following formula (I). INDUSTRIAL APPLICABILITY The composition of the present invention can rejuvenate women's body odor, and therefore can be suitably used as an external composition for women's anti-aging odor. On the other hand, for example, by using the composition of the present invention on an object to which body odor components tend to adhere due to the use of bedding, etc., the effect of rejuvenating the odor emitted from the attached body odor components can be expected. It can be suitably used for products, hard surfaces, or spaces. The body odor in the present invention refers to all odors emitted by women, and includes odors from the back, nape, behind the ears, scalp odor, sweat odor, armpit odor, foot odor, and the like.

Body odor is composed of various components, and studies by the present inventors have revealed that the amount of a specific lactone compound in body odor decreases with age in women. That is, although a specific lactone compound is sufficiently contained in the body odor of young women in their teens to early twenties, it decreases with age. On the other hand, the amount of nonenal, which is a conventionally known causative agent of aging odor, in the body odor of women is originally small, and there was no tendency to increase with aging. Therefore, as a countermeasure against aging odor for women, the present inventors found that it is contained in a large amount in the body odor of young women rather than suppressing nonenal odor, which is usually performed as a countermeasure for men's aging odor, or masking with perfume or the like. I thought that it would be more effective to compensate for the specific ingredients that decrease with age, even though I have a lot of them, but when I proceeded with research and research, I completed the present invention and found that the above-mentioned effects of the invention can be obtained. It is said that

In the formula, R is an alkyl group having 2 to 9 carbon atoms. The number of carbon atoms in R is preferably 3 to 9, more preferably 4 to 9, even more preferably 5 to 8, and particularly preferably 6 or 7. A hydrogen atom contained in the above alkyl group may be substituted.

Specific examples of the lactone compound represented by the formula (I) include γ-hexalactone, γ-heptalactone, γ-octalactone, γ-nonalactone, γ-decalactone, γ-undecalactone, γ-dodeca lactone, γ-tridecalactone and the like. Among these, γ-nonalactone, γ-decalactone, γ-undecalactone and γ-dodecalactone are preferred, and γ-decalactone and γ-undecalactone are more preferred. These lactone compounds are components having the aroma of fruits such as peach, apricot, and coconut. In addition, a lactone compound may be used individually by 1 type, and may use 2 or more types together.

The content of the lactone compound represented by formula (I) in the composition of the present invention is 0.00001% by weight to 10% by weight, and from the viewpoint of the effect on women's aging odor countermeasures, it is 0.00005% by weight. % to 5% by weight, more preferably 0.0001% to 3% by weight, even more preferably 0.0005% to 2% by weight, and 0.001% to 1% by weight. % by weight is particularly preferred. In addition, when using 2 or more types of lactone compounds together, the total amount falls within the above numerical range.

In addition to the lactone compound represented by the above formula (I), there are many types of odor components that constitute the body odor of young women. The composition of the present invention may contain odor components other than the lactone compound represented by formula (I), which constitute the body odor of young women. Other odor components that make up the body odor of young women include, for example, aldehydes, fatty acids, ketones, sulfur compounds (S-based odor), nitrogen compounds (N-based odor), and the like. As the other odor component that constitutes the body odor of young women contained in the composition of the present invention, a component whose content in the body odor decreases with aging of the woman is preferable.

In addition to the components described above, the composition of the present invention may contain the following optional components within a range that does not impair the effects of the present invention.

Hereinafter, when the composition of the present invention is (1) an external composition for use on humans, and (2) when it is used for something other than humans, it is specifically used for textile products, hard surfaces, spaces, etc. The description will be made separately for the case of the composition to be used.

(1) When the composition of the present invention is a composition for external use When the composition of the present invention is a composition for external use, optional ingredients that may be included in addition to the above essential ingredients include, for example, anti-inflammatory agents, cooling agents, bactericidal agents, and vitamins. , organic acid, moisturizing ingredient, polyhydric alcohol, scrubbing agent, ultraviolet absorbing ingredient, ultraviolet scattering ingredient, astringent ingredient, peptide or its derivative, amino acid or its derivative, cleansing ingredient, keratin softening ingredient, cell activating ingredient, anti-aging ingredient , blood circulation-promoting ingredients, whitening ingredients, powders, and the like. In addition, in the composition of this invention, these components may each be used individually by 1 type, and may use 2 or more types together.

Anti-inflammatory agents include, for example, allantoin and its derivatives, glycyrrhetinic acid and its derivatives, glycyrrhizic acid and its derivatives, salicylic acid derivatives, aminocaproic acid, azulene and its derivatives, zinc oxide, tocopherol acetate, hydrocortisone, prednisolone and salts thereof. is mentioned. Among them, allantoin, allantoin chlorohydroxyaluminum, allantoin dihydroxyaluminum, glycyrrhetinic acid, glycyrrhizic acid, stearyl glycyrrhetinate, glycol salicylate, methyl salicylate, epsilonaminocaproic acid, azulene, guaiazulene and salts thereof are preferred. Here, the term "derivatives" refers to esters, ethers, alkylated products, glycosides, etc. of the described compounds. Here, the term "salt" includes, for example, salts of mineral acids such as sulfuric acid, hydrochloric acid or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal A salt, an ammonium salt, etc.

Examples of the cooling agent include terpenes such as menthol, camphor, borneol, geraniol, cineol, anethole, limonene, and eugenol (these may be d-, l-, or dl-forms); eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, spearmint oil, fennel oil, peppermint oil, cinnamon oil, rose oil, and turpentine oil.

Examples of the disinfectant include isopropylmethylphenol, chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone-iodine, potassium iodide, iodine, triclocarban, triclosan, and photosensitizer. 101, 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyroctoolamine, miconazole and the like.

The above vitamins may be either water-soluble vitamins or oil-soluble vitamins. pyridoxal, pyridoxamine hydrochloride); pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthesaine, D-pantethine, coenzyme A, pantothenyl ethyl ether, salts thereof, etc. Pantothenic acids; nicotinic acid, dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1-(4-methylphenyl)ethyl nicotinate, nicotinamide, and salts thereof, etc. nicotinic acids; γ-oryzanol, thiamine, dibenzoylthiamine, thiamine cetyl, thiamine monophosphate, thiamine diphosphate, thiamine triphosphate, and salts thereof (e.g., dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine Cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine, thiamine triphosphate, thiamine monophosphate phosphate, thiamine diphosphate hydrochloride, thiamine triphosphate riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5′-phosphate sodium, riboflavin tetranicotinate, salts thereof, etc. biotins such as biotin, biocytin and salts thereof; folic acids such as folic acid, pteroylglutamic acid and salts thereof; vitamins such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin and salts thereof B12 class; ascorbic acid, dehydroascorbic acid, ascorbic acid phosphate, ascorbic acid-2-glucoside, 3-O-ethylascorbic acid and other ascorbic acid derivatives, and salts thereof (e.g., sodium ascorbate, phosphorous ascorbate Water-soluble vitamin Cs such as sodium acid ester, magnesium ascorbic acid phosphate); vitamin E; ascorbigen-A, ascorbyl stearate, ascorbate palmitate, L-ascorbyl dipalmitate, oil-soluble vitamin C such as ascorbyl tetra-2-hexyldecanoate; ergocalciferol, cholecalciferol vitamin Ds such as phylloquinone and farnoquinone; vitamin Ks such as ferulic acid;

Examples of the organic acid include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartaric acid, and acetic acid. , lactic acid, and salts thereof. Salts include, for example, salts of mineral acids such as sulfuric acid, hydrochloric acid or phosphoric acid, salts of organic acids such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts and the like. is mentioned.

Examples of the moisturizing ingredients include diglycerin trehalose; sodium hyaluronate, heparin analogs, sodium chondroitin sulfate, collagen, elastin, keratin, chitin, chitosan, and other high-molecular compounds; glycine, aspartic acid, arginine, and other amino acids; lactic acid. natural moisturizing factors such as sodium, urea and sodium pyrrolidonecarboxylate; lipids such as ceramide, cholesterol and phospholipids; and plant extracts such as chamomile extract, hamamelis extract, tea extract and perilla extract.

As the polyhydric alcohol, those having 2 to 10 carbon atoms are preferable, and examples thereof include glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1 , 3-butylene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, neopentyl glycol and the like. Among these, glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol are preferred, and glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol and hexanediol are more preferred.

Examples of the scrubbing agent include apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride grains, olive kernel powder, seawater dried grains, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, and charcoal powder. , husk powder, polyethylene powder, silicic anhydride, and the like.

Examples of the ultraviolet absorbing component include octyltriazone, dimethoxybenzylidenedioxoimidazolidinepropionate, 2-ethylhexyl paramethoxycinnamate, and phenylbenzimidazole sulfonic acid.

Examples of the ultraviolet scattering component include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and silicic anhydride, and these inorganic compounds. Coated with inorganic powder such as hydrated silicic acid, aluminum hydroxide, mica and talc, compounded with resin powder such as polyamide, polyethylene, polyester, polystyrene, nylon, silicone oil and fatty acid aluminum salt etc. processed ones, and the like.

Examples of the astringent component include zinc sulfate, aluminum chloride, zinc sulfonate, and tannic acid.

Examples of the peptides or derivatives thereof include keratin-degrading peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin-degrading peptides, collagen-degrading peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, Elastin-degrading peptide, conchiolin-degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, Examples include casein-degraded peptides, acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.).

Examples of the above amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, Cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, creatine and the like.

Examples of the cleaning component include soaps selected from alkaline metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts; sodium cocoyl glutamate, sodium cocoyl methyltaurate. Amino acid-based surfactants such as amino acid-based surfactants; ether sulfate salts such as sodium laureth sulfate; ether carboxylates such as sodium lauryl ether acetate; sulfosuccinate salts such as alkyl sulfosuccinate Na; coconut oil fatty acid monoethanolamide, coconut oil Fatty acid alkanolamides such as fatty acid diethanolamide; monoalkyl phosphate ester salts such as sodium lauryl phosphate and sodium polyoxyethylene lauryl ether phosphate; coconut oil fatty acid amidopropyl dimethylamino acetate betaine, lauryl dimethylamino acetate betaine, 2-alkyl -N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryl hydroxysulfobetaine and lauroylamidoethyl hydroxyethyl carboxymethyl betaine betaine-type amphoteric surfactants such as sodium hydroxypropyl phosphate; amino acids such as sodium laurylaminopropionate type amphoteric surfactants, and the like.

Examples of the keratin softening component include lactic acid, salicylic acid, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea, and sulfur.

Examples of the cell-activating components include amino acids such as γ-aminobutyric acid; vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannins, flavonoids, saponin, photosensitizer No. 301, and the like.

Examples of the antiaging component include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone.

Examples of the blood circulation-promoting ingredients include plants (e.g., Panax ginseng, Angelica keiskei, Arnica, Ginkgo biloba, Fennel, Trichophyllum japonicum, Holland oak, Chamomile, Roman chamomile, Carrot, Gentian, Burdock, Rice, Hawthorn, Shiitake mushroom, Ginger, Hawthorn, Juniperus juniper). , Cnidium, Senburi, Thyme, Clove, Chimp, Chili Pepper, Angelica, Tonin, Spruce, Carrot, Garlic, Butcher Bloom, Grape, Button, Horse Chestnut, Melissa, Yuzu, Yokuinin, Ryokucha, Rosemary, Rosehip, Chimp, Angelica, spruce, peach, apricot, walnut, corn, etc.); acetylcholine, ictamol, cantharis tincture, gamma oryzanol, cepharanthine, tolazoline, tocopherol nicotinate, glucosyl hesperidin, and the like.

Examples of the whitening ingredients include tocopherol and tranexamic acid.

Examples of the powder component include starch octenylsuccinate Al (starch aluminum octenylsuccinate), talc, corn starch, magnesium hydroxide, silicic anhydride, light silicic anhydride, mica, hydroxyapatite, zinc oxide, titanium oxide, and nylon powder. , charcoal and the like.

<pH>
The pH of the topical composition of the present invention is generally pH 3.0 to 8.0, preferably pH 3.5 to 7.5. In addition, this pH can be adjusted, for example, by using a pH adjuster to be described later.

<Method for producing composition for external use>
The method for producing the composition for external use of the present invention is not particularly limited. Various components necessary for producing the composition for external use (the above optional components, the base or carrier described later, additives, etc.) can be appropriately selected and blended, and the composition can be produced by a conventional method. The composition for external use of the present invention may be an emulsified composition, a solubilized composition, or a dissolved composition.

<Uses of the composition for external use>
The composition for external use of the present invention, for example, for middle-aged and older women who are concerned about body odor caused by aging, uses the composition for external use of the present invention containing an odor component that decreases with age, thereby forming a body odor for young women. It supplements the odor components that cause body odor, rejuvenates body odor, and suppresses odors that make you feel like you are aging. Thus, the composition for external use of the present invention can be used as a countermeasure against aging odor in women. The composition for external use of the present invention used for such purposes includes, for example, cleaning agents such as body soaps and facial cleansers, hair care agents such as shampoos, treatments and dry shampoos, cleansing agents, deodorants, antiperspirants, ointments, It can be suitably used as liquids, suspensions, emulsifiers (emulsions and creams), gels, liniments, lotions, poultices, mists, aerosols, powders, granules and the like.

<Formulation>
The composition for external use of the present invention contains the essential ingredients and other ingredients described above, etc., as a base or carrier commonly used in cosmetics, pharmaceuticals, and quasi-drugs, and if necessary, additives described later. In accordance with a conventional method, emulsification or solubilization is carried out as necessary to prepare compositions for external use in various formulation forms.

Examples of the base or carrier include liquid paraffin, squalane, petrolatum, gelling hydrocarbons (Plastibase, etc.), ozokerite, α-olefin oligomers, hydrocarbons such as light liquid paraffin; methylpolysiloxane, highly polymerized methylpolysiloxane. , cyclic silicone, alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, silicone/alkyl chain co-modified polyether-modified silicone, silicone/alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, Silicone oils such as polyglycerin-modified branched silicones, acrylic silicones, phenyl-modified silicones, and silicone resins; oils and fats such as coconut oil, olive oil, rice bran oil, and shea butter; waxes such as jojoba oil, bee wax, candelilla wax, and lanolin; cetanol , cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, higher alcohols such as cholesterol; cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose; polyvinylpyrrolidone; carrageenan; polyvinyl butyrate; polyethylene glycol; dioxane; butylene glycol adipate polyester; esters such as diisopropyl adipate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythrityl tetra-2-ethylhexanoate; dextrin , Polysaccharides such as maltodextrin; Vinyl polymers such as carboxyvinyl polymer and alkyl-modified carboxyvinyl polymer; Lower alcohols such as ethanol and isopropanol; Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol Glycol ethers such as monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether; mentioned.

When the composition for external use of the present invention contains a base or carrier other than water and a lower alcohol, examples of the base or carrier include higher alcohols, hydrocarbons, fats, esters, silicone oils, waxes, vinyl-based Polymers are preferred, and higher alcohols, ester oils, silicone oils and vinyl polymers are more preferred. Among these components, cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl tri-2-ethylhexanoate, dimethicone, cyclomethicone, polyether-modified silicone, polyglycerin-modified silicone, and carboxyvinyl polymer are more preferred.

One of the bases or carriers described above may be used alone, or two or more thereof may be used in combination. In addition, the amount of these to be used is appropriately selected from the range known to those skilled in the art.

<Additive>
The composition for external use of the present invention may contain known additives added to cosmetics, pharmaceuticals, and quasi-drugs, such as surfactants, stabilizers, antioxidants, to the extent that the effects of the present invention are not impaired. Coloring agents, pearl luster imparting agents, dispersing agents, chelating agents, pH adjusting agents, preservatives, thickening agents, irritation reducing agents and the like can be added. These additives may be used singly or in combination of two or more.

Examples of the surfactant include nonionic surfactants, cationic surfactants, anionic surfactants, amphoteric surfactants, and the like. Examples include sorbitan monoisostearate and sorbitan monolaurate. , sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate; propylene glycol fatty acid esters such as propylene glycol monostearate; Hydrogenated castor such as polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80 Oil derivatives; polyoxyethylene (20) sorbitan monolaurate (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80), isostearic acid Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan; polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; amines such as polyoxyethylene/methylpolysiloxane copolymer, lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone and other silicone surfactants. Among these, nonionic surfactants are preferred, and hydrogenated castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, and polyoxyalkylene alkyl ethers are more preferred.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride and the like.

Examples of the coloring agent include inorganic pigments and natural pigments.

Examples of the pearl luster imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether/maleic anhydride crosslinked copolymer, organic acid and the like.

Examples of the chelating agent include EDTA.disodium salt, EDTA.calcium.disodium salt, and the like.

Examples of the pH adjuster include inorganic acids (hydrochloric acid, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), inorganic bases (potassium hydroxide, hydroxide sodium, etc.), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.), and the like. Among them, inorganic bases and/or organic bases are preferred, and potassium hydroxide and triethanolamine are more preferred.

Examples of the preservative include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl parahydroxybenzoate, isopropyl parahydroxybenzoate, butyl parahydroxybenzoate, ethyl parahydroxybenzoate, propyl parahydroxybenzoate, and parahydroxybenzoic acid. benzyl, methyl paraoxybenzoate, phenoxyethanol and the like.

Examples of the thickener include vinyl thickeners such as polyvinyl alcohol, polyvinylpyrrolidone and carboxyvinyl polymer, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxyethylcellulose, and the like. cellulose thickener, guar gum, pectin, pullulan, gelatin, locust bean gum, carrageenan, agar, xanthan gum, alkyl acrylate methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, chondroitin sulfate. sodium, hyaluronic acid, sodium hyaluronate, (hydroxyethyl acrylate/acryloyldimethyltaurate Na) copolymer, (acryloyldimethyltaurate ammonium/vinylpyrrolidone) copolymer, and the like. Among these, vinyl-based thickeners and cellulose-based thickeners are preferable, and carboxyvinyl polymer, polyvinyl alcohol, polyvinylpyrrolidone, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, carboxy Ethyl cellulose is more preferred.

Examples of the irritation reducing agent include licorice extract, sodium alginate, gum arabic, polyvinylpyrrolidone, and the like.

<Formulation form>
The formulation form of the composition for external use of the present invention is not particularly limited. powders, granules, and the like. Among these, liquid to semi-solid formulations are preferred, and are particularly useful when applied to liquids, lotions, ointments, gels, and emulsifiers. These formulations can be produced according to a conventional method, for example, the method described in the Japanese Pharmacopoeia General Rules for Pharmaceutical Preparations, 17th Edition.

(2) When the composition is used for non-humans When the composition of the present invention is used for non-humans, specifically when it is a composition for textile products, hard surfaces, spaces, etc. Examples of optional components that may be included in addition to the above essential components include polyhydric alcohols, surfactants, deodorants, various commonly used solvents, oils, gelling agents, sodium sulfate, N, N, N- Salts such as trimethylglycine, pH adjusters, antioxidants, preservatives, bactericidal/antibacterial agents, perfumes, pigments, ultraviolet absorbers, and the like. In addition, in the said composition, these components may each be used individually by 1 type, and may use 2 or more types together. Furthermore, polyhydric alcohols and surfactants not only suppress volatilization of malodorous components adhering to textiles, hard surfaces, human bodies, pets, etc., but also stabilize amino monosaccharides or salts thereof, which are deodorizing components. By dispersing it, the contact with the malodorous component can be improved, and the deodorant effect can be further enhanced.

The above polyhydric alcohol is a component that has the effect of suppressing volatilization of malodorous components adhering to textile products, hard surfaces, spaces, and the like. Examples of such polyhydric alcohols include glycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butanediol, diethylene glycol, dipropylene glycol, polyethylene glycol and polypropylene glycol. Among these, diethylene glycol and dipropylene glycol are preferred.

When the composition of the present invention is used for non-humans, specifically when it is a composition used for textile products, hard surfaces, spaces, etc., the above polyhydric alcohol in the composition of the present invention Although the content of the class varies depending on the form of use, it is usually at least 0.001% by mass, preferably 0.001 to 30% by mass, more preferably 0.005 to 10% by mass.

The surfactant is not particularly limited, and includes anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants. Specifically, it has an alkyl or alkenyl group having at least 8 to 18 carbon atoms in the molecule, and the hydrophilic portion includes carboxylate, sulfonate, sulfate, phosphate, and quaternary ammonium salt. , sulfobetaine, carbobetaine, amine oxide, (poly)oxyalkylene, (poly)alkanolamine, (poly)glycoside, compounds having a (poly)glycerol skeleton, and the like. Also, the alkyl group or alkenyl group having 8 to 18 carbon atoms and the hydrophilic portion may be bonded through one or more selected from an ether group, an ester group, an amide group and an alkyl group. Among these surfactants, sulfonate, sulfate, phosphate, quaternary ammonium salt, carbobetaine, amine oxide, (poly)glycoside, and (poly)glycerin type surfactants are preferred.

When the composition of the present invention is used for non-humans, specifically when it is a composition used for textile products, hard surfaces, spaces, etc., the above-mentioned surfactant in the composition of the present invention The content of is usually 0.001% by mass or more, preferably 0.001 to 30% by mass, and more preferably 0.01 to 10% by mass, although it varies depending on the form of use.

Examples of the solvent include ethanol, monoethyl or monobutyl ether of ethylene glycol or propylene glycol, monoethyl or monobutyl ether of diethylene glycol or dipropylene glycol, benzyl alcohol, benzyloxyethanol, ethylene oxide or propylene oxide adducts of phenolic compounds, and the like. mentioned.
<pH>
The pH of the composition of the present invention is generally pH 5.0 to 9.0, preferably pH 6 to 8.5. In addition, this pH can be adjusted by using a pH adjuster or the like.

<Method for producing the above composition>
The method for producing the above composition is not particularly limited, and the lactone compound represented by the above formula (I), which is an essential component, and other odor components that constitute the body odor of young women to be blended as necessary, and the composition. Various components necessary for the production (such as the optional components described above) can be appropriately selected and blended, and the production can be carried out by a conventional method. The composition of the present invention may be an emulsified composition or a solubilized composition.

<Application of the above composition>
The composition of the present invention may be used in a solid form such as liquid, gel, powder, and granules, but it is preferably used in a liquid form. In the case of liquid, especially as a spray, lotion, etc., cloth such as handkerchiefs, towels, clothes such as suits and sweaters, bedding such as pillows and sheets, textile products such as curtains and sofas, kitchen utensils such as tableware and pans, etc. It is suitable for objects and spaces with hard surfaces such as countertops, ranges, floors, walls, wallpaper, trash cans, toilet bowls, bathtubs, and drains. It can also be used as a stationary type, for example, by immersing it in paper or a non-woven fabric or spraying it, and using it as a filter for an air purifier. The composition of the present invention can be suitably used, for example, as a deodorant for the textile products, hard surfaces, spaces, etc. used by middle-aged and older women who are concerned about aging odor. Even for an object that cannot be washed frequently, it can be comfortably used for a certain period of time in terms of odor.

<Usage form>
The composition of the present invention is preferably, for example, filled in a mist-type spray container, and the amount of one spray is adjusted to 0.1 to 1 ml. As the spray container to be used, known spray containers such as a trigger spray container (direct pressure or pressure accumulation type) and a dispenser type pump spray container can be used.

[Young female body odor model composition]
The present invention also includes a body odor model composition for young women, which contains an odor component that constitutes the body odor of young women, and at least a lactone compound represented by the following formula (I) as the odor component. When the present inventors compared the odor components that make up the body odor of young women with the odor components that make up the body odor of middle-aged and older women, the above-mentioned specific lactone compound is contained more in young women, It was found to decrease with aging. The body odor model composition for young women of the present invention is closer to the actual body odor of young women, and can be used as a reference for determining aging-related odors, determining effects of suppressing aging-related odors, and the like.

（式中、Ｒは、炭素数２～９のアルキル基である。）

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.)

For the lactone compound represented by the above formula (I), the description in the section [Composition for external use for replenishing the odor of young women] can be applied.

In addition to the lactone compound represented by the above formula (I), there are many types of odor components that constitute the body odor of young women. The body odor model composition for young women of the present invention preferably contains an odor component that constitutes the body odor of young women other than the lactone compound represented by the above formula (I). Other odor components that make up the body odor of young women include, for example, aldehydes, fatty acids, ketones, and ammonia. Other odor components that constitute the body odor of young women contained in the composition for external use of the present invention preferably include components whose content in the body odor decreases with aging of the woman.

[Index agent for determining aged odor]
The present invention also includes a composition containing at least the lactone compound represented by the above formula (I), and an index agent for determining aged odor, which is used as an index for determining aged odor in women. The present invention also includes a composition containing at least the lactone compound represented by the above formula (I), which is used as an index for determining the age of body odor in women. When the present inventors compared the odor components that make up the body odor of young women with the odor components that make up the body odor of middle-aged and later women who are concerned about aging odor, it was found that the above-mentioned specific lactone compound It was found that females contained more and that they decreased with age. The index agent for judging aging odor and the index agent for judging age of body odor of the present invention can be used for judging aging odor and increasing body odor according to the difference between the body odor of young women and women in the middle-aged and older generations. It can be used as a reference when determining the effect of suppressing old age odor, determining the age of body odor, and the like.

For the lactone compound represented by the above formula (I), the description in the section [Composition for external use for replenishing the odor of young women] can be applied.

[Anti-aging effect evaluation method]
The present invention provides an anti-aging effect evaluation method in which the anti-aging effect of a test substance is evaluated using the change in the content of the lactone compound represented by the above formula (I) contained in body odor due to the use of the test substance as an index. Also includes When the present inventors compared the odor components that make up the body odor of young women with the odor components that make up the body odor of middle-aged and later women who are concerned about aging odor, it was found that the above-mentioned specific lactone compound It was found that females contained more and that they decreased with age. The present invention was completed based on this knowledge, and when evaluating the anti-aging effects of test substances (drugs, supplements, various foods and drinks, etc.), their use causes changes in women's body odor, The index is whether or not there is an effect of rejuvenating body odor by increasing the content of odor components that are abundantly contained in women's body odor and decrease with age. As for the lactone compound represented by the above formula (I), the description in the section [Composition for external use for replenishing the odor of young women] can be applied.

[Anti-aging substance screening method]
The present invention provides an anti-aging substance screening method, which comprises screening for a substance having an anti-aging effect using the change in the content of the lactone compound represented by the above formula (I) contained in body odor due to the use of a test substance as an indicator. Also includes When the present inventors compared the odor components that make up the body odor of young women with the odor components that make up the body odor of middle-aged and later women who are concerned about aging odor, it was found that the above-mentioned specific lactone compound It was found that females contained more and that they decreased with age. The present invention was completed based on this knowledge, and when evaluating the anti-aging effect of test substances (drugs, supplements, various food and drink, etc.) and screening excellent substances, their use It is an indicator of whether or not there is an effect of changing body odor, increasing the content of odor components that are abundant in the body odor of young women and decreasing with age, and rejuvenating the body odor. As for the lactone compound represented by the above formula (I), the description in the section [Composition for external use for replenishing the odor of young women] can be applied.

[Body odor composition improving agent]
The present invention is a body odor composition-improving agent characterized by containing a substance promoting the production of the lactone compound represented by the above formula (I) and/or a substance promoting the synthesis of the lactone compound represented by the above formula (I). Also includes The body odor composition-improving agent of the present invention contains, for example, a substance selected by the anti-aging substance screening method described above. The body odor composition-improving agent of the present invention may be used either internally or externally, and when it is used, the lactone compound in the body odor increases, and an odor similar to the body odor of young women with a high lactone compound content can be generated. As for the lactone compound represented by the above formula (I), the description in the section [Composition for external use for replenishing the odor of young women] can be applied.

[Anti-aging odor agent]
The present invention also includes an anti-aging odor agent, particularly an anti-aging odor agent for women, containing the body odor composition improving agent described above.

[Lactone compound action improver]
The present invention also includes a lactone compound action improver that improves the action of the lactone compound represented by formula (I) above. The lactone compound effect improver of the present invention may be used either internally or externally, and when used, the effect of the lactone compound in the body odor is improved, and an odor similar to the body odor of young women with a high lactone compound content is produced. can be done. As for the lactone compound represented by the above formula (I), the description in the section [Composition for external use for replenishing the odor of young women] can be applied.

[Body odor improving agent]
The present invention also includes a body odor improving agent containing the lactone compound action enhancer described above.

EXAMPLES The present invention will be described in more detail below with reference to examples, but the present invention is not limited by these examples.

[Test 1]
Japanese women (n = 50) in their late teens to 50s wore T-shirts with cloth sewn on their backs after bathing until before bathing the next day. , fatty acid odor, amine/ammonia odor, S-based odor, and SWEET odor), sensory evaluation was performed by professional panelists on a 6-point scale. Table 1 shows the criteria for the 6-level score (odor intensity; 0 to 5), and the results are shown in FIGS. 1 and 2 show SWEET odor sensory evaluation scores, and FIG. 3 shows nonenal odor sensory evaluation scores. Furthermore, an odor analysis was performed on the recovered cloth using a headspace gas chromatography-mass spectrometer (HSS-GC/MS). FIG. 4 shows the results of a study on the correlation between the concentration (ppm) of nonenal and the age of the subject (sample). Also, the correlation between the concentration (ppm) of each lactone component (γ-decalactone, γ-undecalactone) and the age of the subject (sample) was examined, and the results are shown in FIG.

As shown in FIGS. 1 and 2, it was found that the SWEET odor was high in females in their late teens until their early twenties, and that the odor decreased with aging. FIG. 1 is a bar graph of each data in FIG. 2 by age group. In addition, as shown in FIGS. 3 and 4, no clear correlation was observed between age and sensory score for nonenal odor, and it was found that the odor intensity itself was lower than that of men. HSS-GC/MS also revealed that the main components of the SWEET odor were γ-decalactone and γ-undecalactone.

As a result of examining the correlation between the total amount of γ-decalactone and γ-undecalactone and age, as shown in FIG. It was also confirmed that the concentration decreased after the age of 30. It turned out that around 35 years old is a big change point of SWEET odor (turning point of odor).

[Test 2]
A cotton ball (white cross No. 10) impregnated with 10 μL of model aging odor containing trans-2-nonenal and 1 μL of single raw materials of various γ-lactones was placed in a container and sealed. After 30 minutes, the pleasantness/unpleasantness of the model aging odor was evaluated. The evaluation was performed by a panel of four people, mainly evaluators. Various γ-lactones were diluted with dipropylene glycol to 1% or 10% and used. The evaluation score criteria are shown in Table 2 below, and the results are shown in Table 3 and FIG.

Discomfort against model aging odor was not improved by γ-valerolactone (Comparative Example 1), but γ-hexalactone (Example 1), γ-heptalactone (Example 2), γ-octalactone ( When adding Example 3), γ-decalactone (Example 4), and γ-undecalactone (Example 5), the odor quality was improved and the odor was pleasant.

[Test 3]
While smelling various scents, the impressions of the women in the photographs (four in total) were evaluated. Specifically, "fragrance-free" and "2-nonenal", "soap fragrance", "lactone C10 / lactone C11-containing fragrance" with an odor intensity of 2 according to the 6-step odor intensity indication method are prepared. While looking at photographs of women (average real age of 40) while smelling one type of scent, a questionnaire survey on "femininity", "youthfulness", and "attractiveness" was conducted (n = 52). The evaluation was performed by general males and general females (aged 30 and over). Fig. 7 shows the impressions (%) of "femininity", "youthfulness", and "attractiveness" when the fragrance-free is taken as 100%.

When there was a scent containing γ-decalactone (R=6) and/or γ-undecalactone (R=7), the women in the photograph were evaluated to be younger and more youthful. In addition, it was evaluated that femininity, attractiveness, and favorability increased. It is known that many ordinary women feel changes in their own body odor as they age. It was inferred that body odor changes occur due to the decrease in lactone C10/lactone C11 after the age of 30. Furthermore, from the above test results, it was also found that the function of "Lactone C10/Lactone C11" is to increase femininity, youthfulness, and attractiveness. Through this research, as an approach to women's aging odor, not only removing it by washing, but also adding the scent of "Lactone C10 / Lactone C11" is more effective for women's aging odor. approach was considered possible.

[Test 4]
A cleansing agent (body soap) having the composition shown in Table 4 below was prepared by a conventional method.

Before and after using the cleansing agent (body soap) having the composition shown in Table 4, changes in the impression of women were evaluated. Specifically, looking at women (n=2), a questionnaire survey was conducted on "femininity," "attractiveness," "youthfulness," and "freshness." Table 5 shows the impressions (%) of "femininity", "attractiveness", "youthfulness" and "freshness" after using the samples, with the values before using the samples as 100%.

[Test 5]
An antiperspirant having the composition shown in Table 6 below was prepared by a conventional method.

Before and after using the antiperspirant having the composition shown in Table 6, changes in the impression of women were evaluated. Specifically, looking at women (n=2), a questionnaire survey was conducted on "femininity," "attractiveness," "youthfulness," and "freshness." Table 7 shows the impressions (%) of "femininity", "attractiveness", "youthfulness", and "freshness" after using the samples, with the values before using the samples taken as 100%.

Below, formulation examples of the composition for external use of the present invention are shown. The numerical value (%) of each lactone shown in Table 8 indicates the final concentration (% by weight) in the entire composition when each combination is used in each formulation example.

<Formulation Formulation Example 1: Body Soap>
Any of the combinations of lactone compounds listed in Table 8 Lauric acid 5% by weight
Palmitic acid 5% by weight
Stearic acid 5% by weight
Potassium hydroxide appropriate amount Glycerin 5% by weight
Dibutyl hydroxytoluene 0.01% by weight
Disodium edetate 0.05% by weight
Phenoxyethanol 0.3% by weight
Benzalkonium chloride 0.1% by weight
Sodium laureth sulfate 5% by weight
Coconut fatty acid amidopropyl betaine 5% by weight
Polyquaternium-10 0.5% by weight
Polyquaternium-7 0.2% by weight
Kaolin 0.5% by weight
Charcoal 0.05% by weight
Magnesium ascorbyl phosphate 0.5% by weight
Hydroxyethyl cellulose 0.3% by weight
water
Total 100% by weight

<Formulation Formulation Example 2: Foaming type body wash>
Any of the combinations of lactone compounds listed in Table 8 PEG-80 sorbitan laurate 5% by weight
Disodium cocoyl glutamate 4% by weight
Sodium cocoylglycinate 2% by weight
Sorbitol 5% by weight
Cocoyl methyl taurate taurine sodium 2% by weight
Citric acid Appropriate amount Disodium edetate 0.05% by weight
Cocamide DEA 1% by weight
Sodium cocoamphoacetate 3% by weight
Polyquaternium-7 0.05% by weight
Dipotassium glycyrrhizinate 0.3% by weight
water
Total 100% by weight

<Formulation Formulation Example 3: Face wash>
Any of the combinations of lactone compounds listed in Table 8 Lauric acid 5% by weight
Myristic acid 10% by weight
Palmitic acid 7% by weight
Stearic acid 7% by weight
Potassium hydroxide Appropriate amount Butylene glycol 5% by weight
Glycerin 5% by weight
Tocopherol 0.05% by weight
Disodium edetate 0.05% by weight
Phenoxyethanol 0.3% by weight
Salicylic acid 0.2% by weight
Coconut fatty acid amidopropyl betaine 5% by weight
Polyquaternium-10 0.3% by weight
Polyquaternium-7 0.1% by weight
l-menthol 0.3% by weight
Perfume 0.2% by weight
water
Total 100% by weight

<Formulation Formulation Example 4: Shampoo>
Any of the combinations of lactone compounds listed in Table 8 Sodium Laureth Sulfate 30% by weight
Cocoyl glutamic acid triethanolamine 5% by weight
Sodium lauroylmethylalanine 5% by weight
Lauramidopropyl hydroxysultaine 5% by weight
Citric acid Appropriate amount Dimethicone 0.3% by weight
Methylparaben 0.2% by weight
Disodium edetate 0.1% by weight
Polyquaternium-10 0.5% by weight
Polyquaternium-39 0.1% by weight
Polyquaternium-7 0.1% by weight
Perfume 0.8% by weight
water
Total 100% by weight

<Formulation Formulation Example 5: Shampoo>
Any of the combinations of lactone compounds listed in Table 8 Sodium olefin (C14-16) sulfonate 15% by weight
POE Na lauryl ether acetate 5% by weight
Coconut fatty acid diethanolamide 5% by weight
Coconut oil fatty acid TEA liquid 5% by weight
Coconut fatty acid amidopropyl betaine liquid 5% by weight
Citric acid Appropriate amount Disodium edetate 0.1% by weight
Benzalkonium chloride 1% by weight
Polyquaternium-10 0.6% by weight
Polyquaternium-7 0.1% by weight
Perfume 0.5% by weight
water
Total 100% by weight

<Formulation Formulation Example 6: Hair Conditioner>
Any of the combinations of lactone compounds listed in Table 8 Glycerin 5% by weight
Hyaluronic acid 0.1% by weight
Dipotassium glycyrrhizinate 0.1% by weight
Squalane 0.1% by weight
Stearyltrimethylammonium chloride 4% by weight
Polyquaternium-10 0.5% by weight
Cetanol 2% by weight
POE-monostearyl glyceryl ether 1% by weight
Dibutyl hydroxytoluene 0.01% by weight
Phenoxyethanol 0.3% by weight
EDTA-2Na 0.05% by weight
l-menthol 0.2% by weight
Perfume 0.3% by weight
water
Total 100% by weight

<Formulation Formulation Example 7: Hair Treatment>
Any of the combinations of lactone compounds listed in Table 8 Propylene glycol 5% by weight
Acetylated hyaluronic acid 0.01% by weight
Allantoin 0.3% by weight
Tetra-2-ethylhexanoic acid pentathuriet 1% by weight
Cetyltrimethylammonium bromide 2.5% by weight
Polyquaternium-7 0.1% by weight
2% by weight of cetostearyl alcohol
Stearyl alcohol 2% by weight
POE - hydrogenated castor oil 1% by weight
Dibutyl hydroxytoluene 0.01% by weight
Methyl paraoxybenzoate 0.3% by weight
EDTA-2Na 0.05% by weight
Perfume 0.5% by weight
water
Total 100% by weight

<Formulation Formulation Example 8: Hair Essence>
Any of the combinations of lactone compounds listed in Table 8 Butylene glycol 5% by weight
Hydrolyzed hyaluronic acid 0.1% by weight
Epsilon aminocaproic acid 0.05% by weight
Alkyltrimethylammonium chloride 0.7% by weight
O-[2-hydroxy-3-(trimethylammonio) chloride
Propyl]guar gum 0.5% by weight
Diethylene glycol monoethyl ether 2% by weight
POE-sorbitan monoisostearate 0.8% by weight
Ethanol 20% by weight
Phenoxyethanol 0.3% by weight
Perfume 0.1% by weight
water
Total 100% by weight

<Formulation Formulation Example 9: Hair Mist>
Any of the combinations of lactone compounds listed in Table 8 Hydrolyzed Collagen 1% by weight
butylene glycol 5% by weight
Hydrolyzed hyaluronic acid 0.1% by weight
Dipotassium glycyrrhizinate 0.05% by weight
Polyquaternium-51 0.5% by weight
Liquid paraffin 0.5% by weight
Monoisostearyl glyceryl ether 1% by weight
Ethanol 30% by weight
Propyl paraoxybenzoate 0.3% by weight
Perfume 0.3% by weight
water
Total 100% by weight

<Formulation Formulation Example 10: Antiperspirant Cream>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.07% by weight
Isopropylmethylphenol 0.07% by weight
Aluminum chlorohydroxyl 4% by weight
Cyclopentasiloxane 25% by weight
Polyalkyl acrylate 6% by weight
POE/POP dimethicone copolymer 3.5% by weight
Dipotassium glycyrrhizinate 0.05% by weight
Concentrated glycerin 7% by weight
isononyl isononanoate 5% by weight
Sorbitan isostearate 5% by weight
l-menthol 0.5% by weight
Perfume 0.3% by weight
water
Total 100% by weight

<Formulation Formulation Example 11: Antiperspirant Gel>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.06% by weight
Isopropylmethylphenol 0.05% by weight
Chlorohydroxy aluminum 8% by weight
Magnesium aluminometasilicate 0.5% by weight
Dipropylene glycol 10% by weight
Polyoxypropylene glycol 0.5% by weight
Hydroxypropyl methylcellulose 0.5% by weight
Xanthan gum 0.5% by weight
Ethanol 10% by weight
l-menthol 0.3% by weight
l-menthyl glyceryl ether 0.3% by weight
Peppermint oil 0.3% by weight
Perfume 0.3% by weight
water
Total 100% by weight

<Formulation Formulation Example 12: Antiperspirant Spray>
Any of the combinations of lactone compounds listed in Table 8 Isopropylmethylphenol 0.1% by weight
Zinc paraphenolsulfonate 1% by weight
Diethyl sebacate 4% by weight
Talc 5% by weight
Nylon powder 1% by weight
Perfume 0.5% by weight
Ethanol 15% by weight
dimethyl ether balance
Total 100% by weight

<Formulation Formulation Example 13: Antiperspirant roll-on>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.06% by weight
Isopropylmethylphenol 0.06% by weight
Zinc paraphenolsulfonate 5% by weight
butylene glycol 5% by weight
Aluminum chlorohydroxyl 0.05% by weight
Talc 3% by weight
Nylon powder 0.5% by weight
Cetyltrimethylammonium bromide liquid 1% by weight
Hydroxypropyl methylcellulose 0.5% by weight
l-menthol 0.1% by weight
Perfume 0.3% by weight
Water 40% by weight
ethanol balance
Total 100% by weight

<Formulation Formulation Example 14: Antiperspirant Mist>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.05% by weight
Isopropylmethylphenol 0.06% by weight
Zinc paraphenolsulfonate 1% by weight
butylene glycol 5% by weight
Aluminum chlorohydroxyl 0.02% by weight
Sericite complex 0.3% by weight
Cetyltrimethylammonium bromide liquid 0.5% by weight
l-menthol 0.3% by weight
Perfume 0.3% by weight
10% by weight of water
ethanol balance
Total 100% by weight

<Formulation Formulation Example 15: Antiperspirant Stick>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.055% by weight
Isopropylmethylphenol 0.05% by weight
Chlorohydroxy aluminum 5% by weight
Polyethylene wax 5% by weight
Microcrystalline wax 5% by weight
Glyceryl monostearate 3% by weight
isononyl isononanoate 5% by weight
Talc 12% by weight
2% by weight of methylpolysiloxane
Decamethylpentasiloxane 0.3% by weight
Silylated anhydrous silicic acid 15% by weight
Cetanol 2% by weight
Hydroxyapatite 0.3% by weight
Cetyltrimethylammonium bromide liquid 0.5% by weight
l-menthol 0.5% by weight
Zinc oxide 0.3% by weight
Perfume 0.3% by weight
stearyl alcohol balance
Total 100% by weight

<Formulation Formulation Example 16: Wiping Lotion>
Any of the combinations of lactone compounds listed in Table 8 Ethanol 15% by weight
Polyoxyethylene polyoxypropylene decyltetradecyl ether 1% by weight
Hydrolyzed jojoba ester 0.01% by weight
Methylsiloxane network polymer 0.01% by weight
Magnesium ascorbyl phosphate 0.3% by weight
Perfume 0.05% by weight
Paraben 0.3% by weight
Citric acid appropriate amount
Remainder of purified water
Total 100% by weight

<Formulation Formulation Example 17: Deodorant sheet>
Any of the combinations of lactone compounds listed in Table 8 Isopropylmethylphenol 0.05% by weight
Zinc paraphenolsulfonate 1% by weight
Ethanol 30% by weight
Cetyltrimethylammonium bromide liquid 0.5% by weight
Butylene glycol 1% by weight
Sericite complex 0.1% by weight
Kaolin 0.3% by weight
Phenoxyethanol 0.1% by weight
Perfume 0.1% by weight
Citric acid appropriate amount
Remainder of purified water
Total 100% by weight

<Formulation Formulation Example 18: Deodorant for clothing and fabric products>
Any of the combinations of lactone compounds listed in Table 8 Green tea extract 0.5% by weight
Biguanide compound 0.2% by weight
Ethanol 10.0% by weight
Remainder of purified water
Total 100% by weight

<Formulation Formulation Example 19: Space deodorant>
Any of the combinations of lactone compounds listed in Table 8 Dipropylene glycol 0.1% by weight
Ethanol 10.0% by weight
Citric acid 0.1% by weight
Cyclodextrin 0.05% by weight
Sodium hydroxide appropriate amount
Remainder of purified water
Total 100% by weight

<Formulation Formulation Example 20: Dry Shampoo 1>
Any of the combinations of lactone compounds listed in Table 8 LPG (Liquefied Petroleum Gas) 50% by weight
Ethanol balance Starch octenyl succinate Al 5% by weight
Talc 3% by weight
Silica 2% by weight
Menthol 0.2% by weight
Isopropylmethylphenol 0.005% by weight
Perfume 0.1% by weight
Total 100% by weight

<Formulation Formulation Example 21: Dry Shampoo 2>
Any of the combinations of lactone compounds listed in Table 8 Dimethyl ether 60% by weight
Ethanol remaining amount Jojoba oil 2% by weight
Starch octenyl succinate Al 3% by weight
Cornstarch 3% by weight
Water 5% by weight
Methylparaben 0.1% by weight
Dibutyl hydroxytoluene 0.05% by weight
Perfume 0.2% by weight
Total 100% by weight

INDUSTRIAL APPLICABILITY According to the present invention, since it is possible to rejuvenate body odor of women, it is possible to provide a composition for external use suitable as a countermeasure against aging odor for women. In addition, by using the composition of the present invention on an object to which body odor components tend to adhere due to the use of bedding, etc., the effect of rejuvenating the odor emitted from the adhered body odor components can be expected. The composition can also be suitably used for textiles, hard surfaces or spaces. Furthermore, according to the present invention, it is also possible to provide a method for evaluating a substance having an anti-aging effect.

Claims (11)

A composition containing at least a lactone compound represented by the following formula (I),
A composition for replenishing the odor of young women, which is used for supplementing odor components constituting the body odor of young women.

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.) 2. The composition of claim 1, which is for external use. 3. A composition according to claim 2, for use by women. 4. A composition according to claim 2 or 3, used for body odor rejuvenation. 2. The composition of claim 1 for textiles, hard surfaces or spaces. 6. The composition according to any one of claims 1 to 5, which is used as a countermeasure against aging odor. A body odor model composition for young women, comprising an odor component that constitutes the body odor of young women, and at least a lactone compound represented by the following formula (I) as the odor component.

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.) A composition containing at least a lactone compound represented by the following formula (I),
An index agent for judging aging odor, which is used as an index for judging aging odor in women.

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.) A method for evaluating the anti-aging effect of a test substance, wherein the anti-aging effect of a test substance is evaluated using the change in the content of the lactone compound represented by the following formula (I) contained in the body odor as an index due to the use of the test substance.

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.) An anti-aging substance screening method comprising screening for a substance having an anti-aging effect using, as an index, a change in the content of a lactone compound represented by the following formula (I) contained in body odor due to the use of a test substance.

(Wherein, R is an alkyl group having 2 to 9 carbon atoms.) 11. The method according to claim 10, wherein substances having an anti-aging effect on body odor are screened.

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