JP2022023952A - Composition for young female odor replenishment - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide products to prevent the odor of aging, which is suitable for women, and to provide evaluation methods of substances with anti-aging effect, focusing on changes in body odor with aging of women.

SOLUTION: The present invention is a composition for supplementing young female odors, which is used to supplement the odorous components that make up the body odor of young females, the composition containing at least a lactone compound represented by the following formula (I) (in the formula, R is an alkyl group having 2 to 9 carbon atoms).

SELECTED DRAWING: None

COPYRIGHT: (C)2022,JPO&INPIT

Description

The present invention relates to a composition for supplementing a young female odor.

In recent years, people of both men and women have become more interested in odor etiquette. Research on various body odors has been enthusiastically carried out, and major causative odors such as sweat odor, axillary odor, foot odor, and aging odor have been identified. For example, body odor is generally thought to be due in part to fatty acids and unsaturated aldehydes produced from sebum on the surface of the body. Similarly, in the case of odor called aging odor, ω-unsaturated fatty acids (palmitoleic acid and vaccenic acid) produced by decomposition of sebum are further oxidatively decomposed to generate unsaturated aldehyde called 2-nonenal on the body surface. It has been reported that it is deeply related to the above (Non-Patent Document 1).

As a technique for preventing such body odor such as aging odor, a method of masking with perfume or the like and a method of utilizing the odor adsorption effect of charcoal (Patent Document 1) are known. Further, a method using an extract from the root and rhizome of Sanguisorba officinalis (Patent Document 2), a method using condensed persimmon tannin (Patent Document 3), and the like have been proposed. Furthermore, the development of a cleaning agent for washing away unpleasant odor components is also underway.

On the other hand, although it is said that such body odors such as aging odors exist in both men and women, the fact is that research on changes in body odors associated with aging of women has not progressed sufficiently. Therefore, it is desired to develop a product for measures against the odor of aging suitable for women.

Japanese Unexamined Patent Publication No. 2002-145747 Japanese Unexamined Patent Publication No. 2011-183019 Japanese Unexamined Patent Publication No. 2001-302483

S. Haze et al. , The Journal of Investigative Dermatology, Vol. 116, No. 4, 520-524, 2001

The present invention has been made in view of such a situation, and an object of the present invention is to provide a product suitable for females for rejuvenating body odor and a product for measures against aging odor. Furthermore, it is also an object of the present invention to focus on changes in body odor with aging of females and to provide a method for evaluating a substance having an anti-aging effect.

As a result of analyzing the body odor component in females in their teens to 50s, the present inventors have sensually clearly sweet scent (SWEET odor) in females (young women) in their teens to 20s. Found that can be confirmed. After the sensory evaluation, the components were analyzed to identify specific body odor components. It was also clarified that nonenal odor, which is generally known as a causative substance of aging odor, is weaker in females than in males, and there is no difference between ages. Then, they find that by supplementing the odor component constituting the body odor of the above-mentioned young woman, which decreases with aging, the body odor can be rejuvenated and the odor of the woman can be suppressed, and the present invention is completed. It came to.

That is, the gist of the present invention is as follows.

[1] A composition containing at least a lactone compound represented by the following formula (I).
A composition for supplementing young female odor, which is used to supplement the odorous components that make up the body odor of young females.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［２］外用である、［１］に記載の組成物。
［３］女性用である、［２］に記載の組成物。
［４］体臭の若返りのために用いられる、［２］又は［３］に記載の組成物。
［５］繊維製品用、硬質表面用又は空間用である、［１］に記載の組成物。
［６］加齢臭対策用である、［１］から［５］のいずれかに記載の組成物。
［７］若年女性の体臭を構成する匂い成分を含有し、上記匂い成分として下記式（Ｉ）で表されるラクトン化合物を少なくとも含む、若年女性の体臭モデル組成物。

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.)
[2] The composition according to [1], which is for external use.
[3] The composition according to [2], which is for women.
[4] The composition according to [2] or [3], which is used for rejuvenating body odor.
[5] The composition according to [1], which is for textile products, for hard surfaces or for spaces.
[6] The composition according to any one of [1] to [5], which is for measures against the odor of aging.
[7] A body odor model composition for a young woman, which contains an odor component constituting the body odor of a young woman and at least contains a lactone compound represented by the following formula (I) as the odor component.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［８］下記式（Ｉ）で表されるラクトン化合物を少なくとも含む組成物であって、
女性の加齢臭判定の指標として用いられる、加齢臭判定用指標剤。

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.)
[8] A composition containing at least a lactone compound represented by the following formula (I).
An index agent for determining the odor of aging, which is used as an index for determining the odor of women.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［９］被験物質の使用による、体臭中に含まれる下記式（Ｉ）で表されるラクトン化合物の含有量の変化を指標として、被験物質のアンチエージング効果を評価する、アンチエージング効果評価方法。

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.)
[9] An anti-aging effect evaluation method for evaluating the anti-aging effect of a test substance using a change in the content of a lactone compound represented by the following formula (I) contained in body odor as an index due to the use of the test substance.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［１０］被験物質の使用による、体臭中に含まれる下記式（Ｉ）で表されるラクトン化合物の含有量の変化を指標として、アンチエージング効果を有する物質をスクリーニングする、アンチエージング物質スクリーニング方法。

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.)
[10] An anti-aging substance screening method for screening a substance having an anti-aging effect by using a change in the content of a lactone compound represented by the following formula (I) contained in body odor as an index due to the use of the test substance.

（式中、Ｒは、炭素数２～９のアルキル基である。）
［１１］体臭のアンチエージング効果を有する物質をスクリーニングする、［１０］に記載の方法。
［１２］下記式（Ｉ）で表されるラクトン化合物の産生促進物質及び／又は下記式（Ｉ）で表されるラクトン化合物の合成促進物質を含有することを特徴とする、体臭組成改善剤。

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.)
[11] The method according to [10], which screens a substance having an anti-aging effect on body odor.
[12] A body odor composition improving agent, which comprises a substance that promotes the production of a lactone compound represented by the following formula (I) and / or a substance that promotes the synthesis of a lactone compound represented by the following formula (I).

（式中、Ｒは、炭素数２～９のアルキル基である。）
［１３］［１２］に記載の体臭組成改善剤を含む、加齢臭対策剤。
［１４］女性用である、［１３］に記載の加齢臭対策剤。
［１５］下記式（Ｉ）で表されるラクトン化合物の作用を向上させる、ラクトン化合物作用向上剤。

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.)
[13] An anti-aging odor agent containing the body odor composition improving agent according to [12].
[14] The anti-aging odor agent according to [13], which is for women.
[15] An agent for improving the action of a lactone compound, which improves the action of the lactone compound represented by the following formula (I).

（式中、Ｒは、炭素数２～９のアルキル基である。）
［１６］［１５］に記載のラクトン化合物作用向上剤を含有する、体臭改善剤。

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.)
[16] A body odor improving agent containing the lactone compound action improving agent according to [15].

According to the present invention, it is possible to provide a product for measures against aging odor suitable for females, which can rejuvenate body odor. Further, according to the present invention, it is also possible to provide a method for evaluating a substance having an anti-aging effect.

SWEET odor sensory evaluation score of body odor of female subjects in their teens to 50s SWEET odor sensory evaluation score of body odor of female subjects in their teens to 50s Nonenal odor sensory evaluation score of body odor of female subjects in their teens to 50s Nonenal concentration of body odor in female subjects in their teens to 50s Lactone concentration of body odor of female subjects in their teens to 50s Effect on model aging odor The effect of scent on the appearance of women

Hereinafter, the present invention will be described in detail. The terms used herein are to be construed as commonly used in the art, unless otherwise noted.

[Composition for supplementing young female odor]
The composition of the present invention is a composition for supplementing a young female odor used for supplementing an odor component constituting the body odor of a young female, and contains at least a lactone compound represented by the following formula (I). Since the composition of the present invention can rejuvenate the body odor of women, it can be suitably used as an external composition for measures against the odor of aging of women. On the other hand, by using the composition of the present invention for an object to which a body odor component is likely to adhere due to the use of bedding, for example, the effect of rejuvenating the odor emitted from the attached body odor component can be expected. It can also be suitably used for products, hard surfaces, or spaces. The body odor in the present invention refers to all odors emitted by women, and includes odors from the back, nape, and behind the ears, scalp odor, sweat odor, axillary odor, and foot odor.

Although body odor is composed of various components, our studies have revealed that in females, the amount of certain lactone compounds in body odor decreases with age. That is, although a specific lactone compound is sufficiently contained in the body odor of young women in their teens to early twenties, it decreases with aging. On the other hand, the amount of nonenal, which is a conventionally known causative substance of aging odor, in the body odor was originally small in the case of females, and there was no tendency for it to increase with aging. Therefore, as a measure against the aging odor of women, the present inventors include more in the body odor of young women than the suppression of nonenal odor and masking with perfume, which are usually performed as a measure against the aging odor of men. However, I thought that it would be more effective to supplement a specific component that decreases with aging, and as a result of conducting research, it was found that the present invention was completed and the effects of the above-mentioned invention could be obtained. It is said that.

In the formula, R is an alkyl group having 2 to 9 carbon atoms. The carbon number of R is preferably 3 to 9, more preferably 4 to 9, further preferably 5 to 8, and particularly preferably 6 or 7. The hydrogen atom contained in the above alkyl group may be substituted.

Specific examples of the lactone compound represented by the above formula (I) include γ-hexalactone, γ-heptalactone, γ-octalactone, γ-nonalactone, γ-decalactone, γ-undecalactone, and γ-dodeca. Examples thereof include lactone and γ-toridecalactone. Of these, γ-nononalactone, γ-decalactone, γ-undecalactone and γ-dodecalactone are preferable, and γ-decalactone and γ-undecalactone are more preferable. These lactone compounds are components having a fruity scent such as peach, apricot, and coconut. The lactone compound may be used alone or in combination of two or more.

The content of the lactone compound represented by the formula (I) in the composition of the present invention is 0.00001% by weight to 10% by weight, and 0.00005% by weight from the viewpoint of the effect on measures against the aging odor of women. % To 5% by weight, more preferably 0.0001% by weight to 3% by weight, further preferably 0.0005% by weight to 2% by weight, and 0.001% by weight to 1% by weight. It is particularly preferable to be% by weight. When two or more lactone compounds are used in combination, the total amount thereof is within the above numerical range.

There are many types of odor components constituting the body odor of young women other than the lactone compound represented by the above formula (I). The composition of the present invention may contain other odorous components constituting the body odor of young women other than the lactone compound represented by the above formula (I). Examples of the odorous component constituting the body odor of other young women include aldehydes, fatty acids, ketones, sulfur compounds (S-based odor), nitrogen compounds (N-based odor) and the like. As the odor component constituting the body odor of other young women contained in the composition of the present invention, a component whose content in the body odor decreases with aging of the woman is preferable.

In addition to the above-mentioned components, the composition of the present invention may contain the following optional components as long as the effects of the present invention are not impaired.

Hereinafter, when the composition of the present invention is (1) an external composition used for humans and (2) used for non-humans, specifically, for textile products, hard surfaces, spaces, etc. The composition will be described separately from the case of the composition used.

(1) In the case of an external composition When the composition of the present invention is an external composition, examples of optional components that may be contained in addition to the above essential components include anti-inflammatory agents, refreshing agents, bactericidal agents, and vitamins. , Organic acid, moisturizing component, polyhydric alcohol, scrubbing agent, UV absorbing component, UV scattering component, astringent component, peptide or derivative thereof, amino acid or derivative thereof, cleaning component, keratin softening component, cell activating component, antiaging component , Blood circulation promoting action component, whitening component, powder and the like. In the composition of the present invention, each of these components may be used alone or in combination of two or more.

Examples of the anti-inflammatory agent include allantin and its derivatives, glycyrrhetinic acid and its derivatives, glycyrrhizinic acid and its derivatives, salicylic acid derivatives, aminocaproic acid, azulene and its derivatives, zinc oxide, tocopherol acetate, hydrocortisone, prednisolone and salts thereof. Can be mentioned. Of these, allantoin, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, glycyrrhetinic acid, glycyrrhizinic acid, stearyl glycyrrhetinate, glycol salicylate, methyl salicylate, epsilonaminocaproic acid, azulene, guaiazulene and salts thereof are preferable. Here, the "derivative" refers to an ester, an ether, an alkylated product, a glycoside, or the like of the described compound. The term "salt" as used herein means, for example, a salt of a mineral acid such as sulfuric acid, hydrochloric acid or phosphoric acid, a salt of an organic acid such as maleic acid or methanesulfonic acid, an alkali metal salt such as sodium or potassium, and an alkaline earth metal. Refers to salts, ammonium salts, etc.

Examples of the refreshing agent include terpenes such as menthol, camphor, borneol, geraniol, cineole, anethole, limonene, and eugenol (these may be d-form, l-form, or dl-form); eucalyptus oil, bergamot. Examples thereof include essential oils such as oil, peppermint oil, cool mint oil, spare mint oil, eugenol oil, camphor oil, keihi oil, rose oil, and terpene oil.

Examples of the disinfectant include isopropylmethylphenol, chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, ethanol, benzethonium chloride, cresol, gluconic acid and its derivatives, povidone iodine, potassium iodide, iodine, triclosan, triclosan, and photosensitive agents. Examples thereof include element 101, photosensitive element 201, paraben, phenoxyethanol, 1,2-pentanediol, alkyldiaminoglycine hydrochloride, pyroctoolamine, myconazole and the like.

The vitamins may be either water-soluble vitamins or oil-soluble vitamins, for example, pyridoxin, pyridoxal, pyridoxamine, 5'-pyridoxal phosphate, and salts thereof (eg, pyridoxin hydrochloride, pyridoxin acetate, hydrochloric acid). Vitamin B6s such as pyridoxal, pyridoxamine hydrochloride); pantothenic acid, calcium pantothenate, pantothenyl alcohol (pantenol), D-pantesin, D-pantetin, coenzyme A, pantothenyl ethyl ether, and salts thereof Pantothenic acids; nicotinic acid, dl-α-tocopherol nicotinate, benzyl nicotinate, methyl nicotinate, β-butoxyethyl nicotinate, 1- (4-methylphenyl) ethyl nicotinate, nicotinic acid amide, and salts thereof, etc. Nicotinic acids; γ-olizanol, thiamine, dibenzoylthiamine, thiaminecetyl, thiamine monophosphate, thiaminediphosphate, thiaminetriphosphate, and salts thereof (eg, dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiamine). Cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine triphosphate, thiamine monophosphate ester phosphate, thiamine diphosphate ester hydrochloride, thiamine triphosphate ester Vitamin B1s such as monophosphate); riboflavin, flavin mononucleotide, flavin adenin dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid, and salts thereof. Vitamin B2s; biotins such as biotin, biocithin, and salts thereof; folic acids such as folic acid, pteroylglutamic acid, and salts thereof; vitamins such as cyanicobalamine, hydroxocobalamine, deoxyadenosylcobalamine, and salts thereof. B12s; ascorbic acid derivatives such as ascorbic acid, dehydroascorbic acid, ascorbic acid phosphate ester, ascorbic acid-2-glucoside, 3-O-ethylascorbic acid, and salts thereof (eg, sodium ascorbic acid, phosphorus ascorbic acid). Water-soluble vitamin Cs such as sodium acid ester, magnesium ascorbic acid phosphate); dl-α-tocopherol, dl-α-tocopherol acetate, co. Vitamin Es such as dl-α-tocopherol succinate, dl-α-tocopherol succinate; ascorbicen-A, ascorbic acid stearate, ascorbic acid palmitate, dipalmitate L-ascorbyl, tetra2-hexyldecanoic acid Oil-soluble vitamin Cs such as ascorbic; vitamin Ds such as ergocalciferol and cholecalciferol; vitamin Ks such as phylloquinone and farnoquinone; vitamin-like action factors such as ferulic acid and the like can be mentioned.

Examples of the organic acid include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, propionic acid, malic acid, salicylic acid, glycolic acid, phytic acid, tartrate acid and acetic acid. , Lactic acid, and salts thereof. Examples of the salt include mineral acid salts such as sulfuric acid, hydrochloric acid or phosphoric acid, organic acid salts such as maleic acid or methanesulfonic acid, alkali metal salts such as sodium or potassium, alkaline earth metal salts, ammonium salts and the like. Can be mentioned.

Examples of the moisturizing component include diglycerin trehalose; sodium hyaluronate, heparinoids, chondroitin sodium sulfate, collagen, elastin, keratin, chitin, chitosan and other high molecular weight compounds; glycine, aspartic acid, arginine and other amino acids; lactic acid. Natural moisturizing factors such as sodium, urea and sodium pyrrolidone carboxylate; lipids such as ceramide, cholesterol and phospholipids; plant extracts such as chamomile extract, hamamelis extract, cha extract and perilla extract.

The polyhydric alcohol preferably has 2 to 10 carbon atoms, and is, for example, glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, 1 , 3-butylene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, hexanediol, octanediol, decanediol, neopentylglycol and the like. Among these, glycerin, diglycerin, triglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentandiol, hexanediol, octanediol. Is preferable, and glycerin, diglycerin, propylene glycol, dipropylene glycol, 1,3-butanediol, diethylene glycol, isoprene glycol, sorbitol, xylitol, erythritol, mannitol, pentanediol, and hexanediol are more preferable.

Examples of the scrubbing agent include apricot kernel powder, almond shell powder, apricot kernel powder, sodium chloride granules, olive kernel powder, seawater dried product granules, candelilla wax, walnut shell powder, cherry kernel powder, coral powder, and charcoal powder. , Hashibami shell powder, polyethylene powder, anhydrous silicic acid and the like.

Examples of the ultraviolet absorbing component include octylriazone, octyl dimethoxybenzidioxoimidazolidinepropionate, 2-ethylhexyl paramethoxysilicate, and phenylbenzimidazole sulfonic acid.

Examples of the ultraviolet scattering component include inorganic compounds such as hydrous silicic acid, zinc silicate, cerium silicate, titanium silicate, zirconium oxide, cerium oxide, titanium oxide, iron oxide, and silicic anhydride, and these inorganic compounds. Coated with water-containing silicic acid, aluminum hydroxide, inorganic powder such as mica and talc, compounded with resin powder such as polyamide, polyethylene, polyester, polystyrene and nylon, and with silicone oil and fatty acid aluminum salt. Examples include processed ones.

Examples of the convergent component include zinc sulfate, aluminum chloride, zinc sulfocolate, tannic acid and the like.

Examples of the peptide or its derivative include keratin-degrading peptide, hydrolyzed keratin, collagen, fish-derived collagen, atelocollagen, gelatin, elastin, elastin-degrading peptide, collagen-degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, and the like. Elastin-degrading peptide, conchiolin-degrading peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl-hydrolyzed silk sodium, soybean proteolytic peptide, hydrolyzed soybean protein, wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, Examples thereof include casein-degrading peptides and acylated peptides (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.).

Examples of the amino acid or a derivative thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamine acid, glutamine, asparagine, aspartic acid, and cysteine. Examples thereof include cystine, methionine, leucine, isoleucine, valine, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosin, creatine and the like.

Examples of the cleaning component include soaps selected from alkali metal salts such as potassium laurate, potassium myristate, potassium palmitate or potassium stearate, alkanolamide salts or amino acid salts; Na cocoyl glutamate, Na cocoyl methyl taurine. Amino acid-based surfactants such as; ether sulfate ester salts such as laureth sulfate Na; ether carboxylates such as lauryl ether acetate Na; sulfosuccinic acid ester salts such as alkyl sulfosuccinic acid ester Na; palm oil fatty acid monoethanolamide, palm oil Amino acid alkanolamides such as fatty acid diethanolamide; monoalkyl phosphate ester salts such as sodium lauryl phosphate and sodium polyoxyethylene lauryl ether phosphate; palm oil fatty acid amide propyldimethylaminoacetic acid betaine, lauryldimethylaminoacetic acid betaine, 2-alkyl -N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauryl hydroxysulfobetaine and lauroylamide ethyl hydroxyethyl carboxymethyl betaine betaine-type amphoteric surfactants such as sodium hydroxypropyl phosphate; amino acids such as sodium laurylaminopropionate. Examples include type amphoteric surfactants.

Examples of the keratin softening component include lactic acid, salicylic acid, gluconic acid, citric acid, malic acid, fruit acid, phytic acid, urea, and sulfur.

Examples of the cell activating component include amino acids such as γ-aminobutyric acid; vitamins such as retinol, thiamine, riboflavin, pyridoxin hydrochloride, and pantothenic acids; α-hydroxy acids such as glycolic acid and lactic acid; tannins and flavonoids. Examples thereof include saponin and photosensitive element No. 301.

Examples of the antiaging component include pangamic acid, kinetin, ursolic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, N-methyl-L-serine, and mevalonolactone.

Examples of the blood circulation promoting action component include plants (eg, ginseng, ashtaba, arnica, ginkgo, uikyo, enmeisou, Dutch oak, chamomile, rosemary, carrot, gentiana, gobo, rice, sanzashi, shiitake, ginger, sardine, and sardine. , Senkyu, Senburi, Thyme, Chouji, Chimpi, Togarashi, Touki, Tounin, Tohi, Carrot, Garlic, Butcher Bloom, Grape, Button, Maronnier, Melissa, Yuzu, Yokuinin, Ryokucha, Rosemary, Rosehip, Chimpi, Touki, Ingredients derived from (tohi, peach, apricot, walnut, corn, etc.); acetylcholine, ictamol, cantalistinki, gamma oryzanol, cepharanthin, trazoline, tocopherol nicotinate, glucosyl hesperidin and the like.

Examples of the whitening ingredient include tocopherol and tranexamic acid.

Examples of the powder component include octenyl succinate starch Al (octenyl succinate starch aluminum), talc, cornstarch, magnesium hydroxide, silicic anhydride, light anhydrous silicic acid, mica, hydroxyapatite, zinc oxide, titanium oxide, and nylon powder. , Charcoal, etc.

<pH>
The pH of the external composition of the present invention is usually pH 3.0 to 8.0, preferably pH 3.5 to 7.5. This pH can be adjusted, for example, by using a pH adjuster described later.

<Manufacturing method of external composition>
The method for producing the external composition of the present invention is not particularly limited, and the lactone compound represented by the above formula (I), which is an essential component, and other odor components constituting the body odor of young women, which are blended as necessary, are used. Various components (optional components described above, bases or carriers described below, additives, etc.) necessary for producing an external composition can be appropriately selected and blended, and produced by a conventional method. The external composition of the present invention may be an emulsified composition, a solubilized composition, or a dissolved composition.

<Use of external composition>
The external composition of the present invention constitutes the body odor of a young woman by using the external composition of the present invention containing an odor component that decreases with aging, for example, for a woman who is concerned about the odor of aging after middle age. It can supplement the odor component, rejuvenate the body odor, and suppress the odor that makes you feel the odor of aging. As described above, the external composition of the present invention can be used as a measure against the odor of aging in women. The external composition of the present invention used for such a purpose is, for example, a body soap, a cleaning agent such as a face wash, a hair care agent such as a shampoo, a treatment, a dry shampoo, a cleansing agent, a deodorant, an antiperspirant, an ointment, and the like. It can be suitably used as a liquid agent, a suspending agent, an emulsifier (milky lotion and cream), a gel agent, a liniment agent, a lotion agent, a poultice agent, a mist, an aerosol agent, a powder, a granule and the like.

<Formulation>
The external composition of the present invention contains the essential components and other components described above as a base or carrier usually used for cosmetics, pharmaceuticals and quasi-drugs, and, if necessary, additives described below. And can be mixed according to a conventional method and emulsified or solubilized as necessary to prepare an external composition in various pharmaceutical forms.

Examples of the base or carrier include hydrocarbons such as liquid paraffin, squalane, vaseline, gelled hydrocarbon (plastibase, etc.), ozokelite, α-olefin oligomer, light liquid paraffin, etc .; methylpolysiloxane, highly polymerized methylpolysiloxane. , Cyclic silicone, alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, silicone-alkyl chain co-modified polyether-modified silicone, silicone-alkyl chain co-modified polyglycerin-modified silicone, polyether-modified branched silicone, Silicone oils such as polyglycerin-modified branched silicones, acrylic silicones, phenyl-modified silicones, and silicone resins; fats and oils such as palm oil, olive oil, rice bran oil, and shea butter; waxes such as jojoba oil, miuro, candelilla wax, and lanolin; , Higher alcohols such as cetostearyl alcohol, stearyl alcohol, behenyl alcohol, octyldodecanol, isostearyl alcohol, phytosterol, cholesterol; cellulose derivatives such as ethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose; polyvinylpyrrolidone; carrageenan; polyvinylbutyrate; polyethylene Glycols; Dioxane; Polyxyl butylene glycol Adipate polyester; Diisopropyl adipate, isopropyl myristate, octyldodecyl myristate, isopropyl palmitate, cetyl palmitate, isononyl isononanoate, pentaerythritte tetra2-ethylhexanoate and other esters; dextrin , Polysaccharides such as maltodextrin; Vinyl polymers such as carboxyvinyl polymer and alkyl modified carboxyvinyl polymer; Lower alcohols such as ethanol and isopropanol; Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol Glycol ethers such as monomethyl ether, diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, diethylene glycol monobutyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether; Kou I can get rid of it.

When the external composition of the present invention contains a base or carrier other than water and a lower alcohol, the base or carrier may be, for example, a higher alcohol, a hydrocarbon, an oil or fat, an ester, a silicone oil, a brazing oil, or a vinyl-based composition. Higher weights are preferable, and higher alcohols, ester oils, silicone oils, and vinyl-based polymers are more preferable. Among these components, cetanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, glyceryl tri2-ethylhexanoate, dimethicone, cyclomethicone, polyether-modified silicone, polyglycerin-modified silicone, and carboxyvinyl polymer are more preferable.

The base or carrier described above may be used alone or in combination of two or more. Further, the amount used thereof is appropriately selected from a range known to those skilled in the art.

<Additives>
The composition for external use of the present invention includes known additives to be added to cosmetics, pharmaceuticals and quasi-drugs, for example, surfactants, stabilizers, antioxidants, etc., as long as the effects of the present invention are not impaired. Coloring agents, pearl luster imparting agents, dispersants, chelating agents, pH adjusters, preservatives, thickeners, irritation reducing agents and the like can be added. These additives may be used alone or in combination of two or more.

The surfactant may be any of nonionic surfactants, cationic surfactants, anionic surfactants, amphoteric surfactants and the like, and for example, sorbitan monoisostearate and sorbitan monolaurate. , Solbitan monopalmitate, sorbitan monostearate, penta-2-ethylhexylate diglycerol sorbitan, tetra-2-ethylhexylate diglycerol sorbitan and other sorbitan fatty acid esters; propylene glycol fatty acid esters such as monostearate propylene glycol; Hardened polyoxyethylene hydrogenated castor oil 40 (HCO-40), polyoxyethylene hydrogenated castor oil 50 (HCO-50), polyoxyethylene hydrogenated castor oil 60 (HCO-60), polyoxyethylene hydrogenated castor oil 80, etc. Oil derivatives; polyoxyethylene monolaurate (20) sorbitan (polysorbate 20), polyoxyethylene monostearate (20) sorbitan (polysorbate 60), polyoxyethylene monooleate (20) sorbitan (polysorbate 80), isostearic acid. Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan; polyoxyethylene monococonut oil fatty acid glyceryl; glycerin alkyl ether; alkyl glucoside; polyoxyalkylene alkyl ether such as polyoxyethylene cetyl ether; stearylamine, oleylamine Amines such as: polyoxyethylene / methylpolysiloxane copolymer, laurylPEG-9 polydimethylsiloxyethyl dimethicone, silicone-based surfactants such as PEG-9 polydimethylsiloxyethyl dimethicone and the like. Of these, nonionic surfactants are preferred, and cured castor oil derivatives, polyoxyethylene sorbitan fatty acid esters, and polyoxyalkylene alkyl ethers are more preferred.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, erythorbic acid, L-cysteine hydrochloride and the like.

Examples of the colorant include inorganic pigments and natural pigments.

Examples of the pearl gloss imparting agent include ethylene glycol distearate, ethylene glycol monostearate, and triethylene glycol distearate.

Examples of the dispersant include sodium pyrophosphate, sodium hexametaphosphate, polyvinyl alcohol, polyvinylpyrrolidone, methyl vinyl ether / maleic anhydride crosslinked copolymer, organic acid and the like.

Examples of the chelating agent include EDTA / 2 sodium salt, EDTA / calcium / 2 sodium salt and the like.

Examples of the pH adjusting agent include inorganic acids (hydrochloride, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citric acid, sodium citrate, succinic acid, sodium succinate, etc.), and inorganic bases (potassium hydroxide, hydroxylation). (Sodium, etc.), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.) and the like can be mentioned. Of these, inorganic bases and / or organic bases are preferable, and potassium hydroxide and triethanolamine are more preferable.

Examples of the preservative include benzoic acid, sodium benzoate, dehydroacetate, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and paraoxybenzoic acid. Examples thereof include benzyl, methyl paraoxybenzoate, and phenoxyethanol.

Examples of the thickener include vinyl thickeners such as polyvinyl alcohol, polyvinylpyrrolidone, and carboxyvinyl polymers, methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, carboxymethyl cellulose, and carboxyethyl cellulose. Cellulose thickeners, guar gum, pectin, purulan, gelatin, locust bean gum, carrageenan, agar, xanthan gum, alkyl methacrylate copolymer, polyethylene glycol, bentonite, alginic acid, propylene glycol alginate, macrogol, chondroitin sulfate. Examples thereof include sodium, hyaluronic acid, sodium hyaluronate, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) polymer, (acryloyldimethyltaurine ammonium / vinylpyrrolidone) polymer and the like. Of these, vinyl-based thickeners and cellulose-based thickeners are preferable, and carboxyvinyl polymers, polyvinyl alcohol, polyvinylpyrrolidone, methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and carboxy. Ethyl cellulose is more preferred.

Examples of the irritation reducing agent include licorice extract, sodium alginate, gum arabic, polyvinylpyrrolidone and the like.

<Form of formulation>
The pharmaceutical form of the external composition of the present invention is not particularly limited, and for example, an ointment, a liquid, a suspending agent, an emulsifier (milky lotion and cream), a gel, a liniment, a lotion, a pap, a mist, an aerosol, etc. Examples include powders and granules. Of these, liquid to semi-solid pharmaceutical forms are preferable, and they are particularly useful when applied to liquids, lotions, ointments, gels, and emulsifiers. These formulations can be manufactured according to a conventional method, for example, the method described in the 17th revised Japanese Pharmacopoeia General Regulations for Formulations.

(2) When the composition is used for non-humans When the composition of the present invention is used for non-humans, specifically, when the composition is used for textile products, hard surfaces, spaces, etc. Optional components other than the above essential components may include, for example, polyhydric alcohols, surfactants, deodorants, various commonly used solvents, oils, gelling agents, sodium sulfate and N, N, N-. Examples thereof include salts such as trimethylglycine, pH adjusters, antioxidants, preservatives, bactericidal / antibacterial agents, fragrances, pigments, and ultraviolet absorbers. In the above composition, each of these components may be used alone or in combination of two or more. Furthermore, polyhydric alcohols and surfactants not only suppress the volatilization of malodorous components adhering to textile products, hard surfaces, human bodies, pets, etc., but also stabilize amino monosaccharides or salts thereof, which are deodorant components. It can be dispersed, the contact with the malodorous component can be improved, and the deodorizing effect can be further enhanced.

The polyhydric alcohol is a component that has an effect of suppressing volatilization of malodorous components adhering to textile products, hard surfaces, spaces and the like. Examples of such polyhydric alcohols include glycerin, ethylene glycol, propylene glycol, 1,3-propanediol, butanediol, diethylene glycol, dipropylene glycol, polyethylene glycol, polypropylene glycol and the like. Among these, diethylene glycol and dipropylene glycol are preferable.

When the composition of the present invention is used for non-humans, specifically, for textile products, for hard surfaces, for spaces, etc., the polyhydric alcohol in the composition of the present invention. The content of the class varies depending on the mode of use, but is usually 0.001% by mass or more, preferably 0.001 to 30% by mass, and further preferably 0.005 to 10% by mass.

The surfactant is not particularly limited, and examples thereof include anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants. Specifically, the molecule has an alkyl group or an alkenyl group having at least 8 to 18 carbon atoms, and the hydrophilic portion includes a carboxylate, a sulfonate, a sulfate ester salt, a phosphoric acid ester salt, and a quaternary ammonium salt. , Sulfobetaine, carbobetaine, amine oxide, (poly) oxyalkylene, (poly) alkanolamine, (poly) glycoside, (poly) glycerin skeleton-bearing compounds and the like. Further, the alkyl group or alkenyl group having 8 to 18 carbon atoms and the hydrophilic portion may be bonded via one or more selected from an ether group, an ester group, an amide group and an alkyl group. Among these surfactants, sulfonates, sulfate esters, phosphate ester salts, quaternary ammonium salts, carbobetaines, amine oxides, (poly) glycosides, and (poly) glycerin-type surfactants are preferable.

When the composition of the present invention is used for non-humans, specifically, for textile products, for hard surfaces, for spaces, etc., the above-mentioned surfactant in the composition of the present invention is used. Although the content of the above varies depending on the mode of use, it is usually 0.001% by mass or more, preferably 0.001 to 30% by mass, and more preferably 0.01 to 10% by mass.

Examples of the solvent include ethanol, monoethyl or monobutyl ether of ethylene glycol and propylene glycol, monoethyl or monobutyl ether of diethylene glycol and dipropylene glycol, benzyl alcohol, benzyloxyethanol, ethylene oxide or propylene oxide adduct of phenolic compounds, and the like. Can be mentioned.
<pH>
The pH of the above composition of the present invention is usually pH 5.0 to 9.0, preferably pH 6 to 8.5. This pH can be adjusted by using a pH adjuster or the like.

<Manufacturing method of the above composition>
The method for producing the above composition is not particularly limited, and the lactone compound represented by the above formula (I), which is an essential component, and other odor components and compositions constituting the body odor of young women, which are blended as necessary, are used. Various components (the above-mentioned optional components and the like) necessary for production can be appropriately selected and blended, and can be produced by a conventional method. The composition of the present invention may be an emulsified composition or a solubilized composition.

<Use of the above composition>
The composition of the present invention can be used in a solid state such as liquid, gel, powder, or granular, but it is preferably used as a liquid. In the case of liquid, especially as sprays, lotions, etc., handkerchiefs, towels and other fabrics, suits, sweaters and other clothing, pillows, sheets and other bedding, curtains, sofas and other textile products, tableware, pans and other cooking utensils, etc. Suitable for use in kitchenware, ranges, floors, walls, wallpaper, trash cans, toilet bowls, bathtubs, drains, and other items with a hard surface, and in spaces. It can also be used as a stationary type, such as by immersing it in paper or non-woven fabric and spraying it to use it as a filter for an air purifier. The composition of the present invention can be suitably used as a deodorant for the above-mentioned textile products, hard surfaces, spaces and the like used by women who are concerned about the odor of aging after middle age, for example. Even for objects that cannot be washed frequently, it can be used comfortably for a certain period of time in terms of odor.

<Usage pattern>
The composition of the present invention is preferably, for example, filled in a mist type spray container and the amount of one spray is adjusted to 0.1 to 1 ml. As the spray container to be used, a known spray container such as a trigger spray container (direct pressure or accumulator type) or a dispenser type pump spray container can be used.

[Young female body odor model composition]
The present invention also includes a young female body odor model composition containing an odor component constituting the body odor of a young woman and at least containing a lactone compound represented by the following formula (I) as the odor component. Comparing the odorous components constituting the body odor of young women with the odorous components constituting the body odor of middle-aged and older females by the present inventors, the above-mentioned specific lactone compound is contained more in young females. It was revealed that it decreased with aging. The body odor model composition of a young woman of the present invention is closer to the actual body odor of a young woman and can be used as a reference in determining an aging odor, determining an effect of suppressing an aging odor, and the like.

（式中、Ｒは、炭素数２～９のアルキル基である。）

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.)

For the lactone compound represented by the above formula (I), the description in the section [External composition for supplementing young female odor] can be applied.

There are many types of odor components constituting the body odor of young women other than the lactone compound represented by the above formula (I). The body odor model composition for young women of the present invention preferably contains other odor components constituting the body odor of young women other than the lactone compound represented by the above formula (I). Examples of odor components constituting the body odor of other young women include aldehydes, fatty acids, ketones, ammonia and the like. As the other odorous components constituting the body odor of young women contained in the external composition of the present invention, it is preferable to include a component whose content in the body odor decreases with the aging of the female.

[Indicator for determining odor of aging]
The present invention also includes an index agent for determining the aging odor, which is a composition containing at least the lactone compound represented by the above formula (I) and is used as an index for determining the aging odor of females. The present invention also includes a composition for determining body odor age, which is a composition containing at least the lactone compound represented by the above formula (I) and is used as an index for determining the body odor age of females. By the present inventors, comparing the odor component constituting the body odor of a young woman with the odor component constituting the body odor of a woman in the age group who is concerned about the odor of aging after middle age, the above-mentioned specific lactone compound is young. It was found to be more abundant in females and decreased with age. The index agent for determining aging odor and the index agent for determining body odor of the present invention determine and add aging odor depending on the difference between the body odor of young women and women of the age group who are concerned about aging odor after middle age. It can be used as a reference when determining the effect of suppressing the odor of aging, determining the age of body odor, and the like.

For the lactone compound represented by the above formula (I), the description in the section [External composition for supplementing young female odor] can be applied.

[Anti-aging effect evaluation method]
The present invention is an anti-aging effect evaluation method for evaluating the anti-aging effect of a test substance using a change in the content of the lactone compound represented by the above formula (I) contained in body odor as an index due to the use of the test substance. Also includes. By the present inventors, comparing the odor component constituting the body odor of a young woman with the odor component constituting the body odor of a woman in the age group who is concerned about the odor of aging after middle age, the above-mentioned specific lactone compound is young. It was found to be more abundant in females and decreased with age. The present invention was completed based on this finding, and when evaluating the anti-aging effect of test substances (pharmaceuticals, supplements, various foods and drinks, etc.), their use causes changes in the body odor of females, resulting in a young person. The index is whether or not there is an effect of rejuvenating body odor by increasing the content of odor components that are abundant in female body odor and decrease with aging. For the lactone compound represented by the above formula (I), the description in the section [External composition for supplementing young female odor] can be applied.

[Anti-aging substance screening method]
The present invention is an anti-aging substance screening method for screening a substance having an anti-aging effect by using a change in the content of the lactone compound represented by the above formula (I) contained in body odor as an index due to the use of the test substance. Also includes. By the present inventors, comparing the odor component constituting the body odor of a young woman with the odor component constituting the body odor of a woman in the age group who is concerned about the odor of aging after middle age, the above-mentioned specific lactone compound is young. It was found to be more abundant in females and decreased with age. The present invention has been completed based on this finding, and by evaluating the anti-aging effect of test substances (pharmaceutical products, supplements, various foods and drinks, etc.) and screening for excellent substances, females can use them. The index is whether or not there is an effect of rejuvenating the body odor by increasing the content of the odor component that causes a change in the body odor and is abundant in the body odor of young women and decreases with aging. For the lactone compound represented by the above formula (I), the description in the section [External composition for supplementing young female odor] can be applied.

[Body odor composition improving agent]
The present invention is characterized by containing a substance that promotes the production of a lactone compound represented by the above formula (I) and / or a substance that promotes the synthesis of a lactone compound represented by the above formula (I). Also includes. The body odor composition improving agent of the present invention includes, for example, a substance selected by the above-mentioned anti-aging substance screening method. The body odor composition improving agent of the present invention may be taken internally or externally, and when used, the lactone compound in the body odor increases, and the same odor as the body odor of a young woman having a high lactone compound content can be generated. For the lactone compound represented by the above formula (I), the description in the section [External composition for supplementing young female odor] can be applied.

[Aging odor control agent]
The present invention also includes an anti-aging odor agent containing the above-mentioned body odor composition improving agent, particularly an anti-aging odor agent for females.

[Lactone compound action improver]
The present invention also includes an agent for improving the action of the lactone compound, which improves the action of the lactone compound represented by the above formula (I). The lactone compound action improver of the present invention may be taken internally or externally, and when used, the action of the lactone compound in the body odor is improved, and an odor similar to that of a young woman having a high lactone compound content is generated. Can be done. For the lactone compound represented by the above formula (I), the description in the section [External composition for supplementing young female odor] can be applied.

[Body odor improver]
The present invention also includes a body odor improving agent containing the above-mentioned lactone compound action improving agent.

Hereinafter, the present invention will be described in more detail by way of examples, but the present invention is not limited thereto.

[Test 1]
T-shirts with cloth sewn on the back are dressed by Japanese women (n = 50) in their late teens to 50s from after bathing to before bathing the next day, and after collecting the cloth, there are 5 categories (nonenal odor). , Fatty acid odor, amine / ammonia odor, S-based odor, SWEET odor) were evaluated by a professional panelist (professional) on a 6-point scale. The criteria for the above 6-step score (odor intensity; 0 to 5) are shown in Table 1, and the results are shown in FIGS. 1 to 4. 1 and 2 show the SWEET odor sensory evaluation score, and FIG. 3 shows the nonenal odor sensory evaluation score. Furthermore, the recovered cloth was subjected to odor analysis using a headspace gas chromatography mass spectrometer (HSS-GC / MS). The results of the study on the correlation between the concentration of nonenal (ppm) and the age of the subject (sample) are shown in FIG. We also examined the correlation between the concentration (ppm) of each lactone component (γ-decalactone, γ-undecalactone) and the age of the subject (sample), and the results are shown in FIG.

As shown in FIGS. 1 and 2, it was found that the SWEET odor was high from the female in the late teens to the early 20s, and the odor decreased with aging. Note that FIG. 1 is a bar graph of each data in FIG. 2 by age group. Further, as shown in FIGS. 3 and 4, no clear correlation was observed between the age and the sensory score of nonenal odor, and it was found that the odor intensity itself was lower than that of males. In addition, HSS-GC / MS revealed that the main components of the SWEET odor were γ-decalactone and γ-undecalactone.

As a result of investigating the correlation between the total amount of γ-decalactone and γ-undecalactone and age, as shown in FIG. 5, as shown in FIG. It was also confirmed that the concentration decreased after the thirties. It was found that around 35 years old was a major change point (smell corner) of SWEET odor.

[Test 2]
A cotton ball (White Cross No. 10) impregnated with 10 μL of model aging odor containing Trans-2-nonenal and 1 μL of a single raw material of various γ-lactones was placed in a container and sealed. After 30 minutes, the degree of comfort and discomfort with respect to the model's odor was evaluated. The evaluation was carried out by a panel of four people centered on the evaluator. Various γ-lactones were diluted with dipropylene glycol to 1% or 10% before use. The criteria for the evaluation score are shown in Table 2 below, and the results are shown in Table 3 and FIG.

The discomfort with the model aging odor was not improved by γ-valerolactone (Comparative Example 1), but γ-hexalactone (Example 1), γ-heptalactone (Example 2), and γ-octalactone (Example 2). When γ-decalactone (Example 4) and γ-undecalactone (Example 5) were added, the quality of the odor was improved and the odor became pleasant.

[Test 3]
While sniffing various scents, I evaluated the impression of the female in the photo (4 photos in total). Specifically, "2-nonenal", "soap fragrance", and "lactone C10 / lactone C11-containing fragrance", which are "unscented" and have odor intensity 2 of the 6-step odor intensity display method, are prepared. We conducted a questionnaire survey on "femininity,""youthfulness," and "attractiveness" by looking at photographs of women (actual age average 40 years old) while sniffing one of the scents (n = 52). The evaluation was performed by general males and general females (30 years old and over). Figure 7 shows the impressions (%) of "femininity,""youthfulness," and "attractiveness" when the fragrance-free content is 100%.

When there was a scent containing γ-decalactone (R = 6) and / or γ-undecalactone (R = 7), the female in the photograph was evaluated to have a lower apparent age and an increased youthfulness. In addition, it was evaluated to improve femininity, attractiveness, and likability. It is known that many general women feel their own body odor changes with aging, and one of the causes is "SWEET odor", which is a body odor component peculiar to young women. It was speculated that the decrease in "lactone C10 / lactone C11" after the thirties caused a change in body odor. Furthermore, from the above test results, it was also found that the function of "lactone C10 / lactone C11" has the effect of increasing femininity, youthfulness, and attractiveness. According to this study, as an approach to women's aging odor, it is more effective for women's aging odor by adding the scent of "Lactone C10 / Lactone C11" instead of simply removing it by washing. It was thought that a new approach was possible.

[Test 4]
The detergent (body soap) having the composition shown in Table 4 below was prepared by a conventional method.

Changes in the impression of females were evaluated before and after the use of the cleaning agent (body soap) having the composition shown in Table 4 above. Specifically, we conducted a questionnaire survey on "femininity," "attractiveness," "youthfulness," and "freshness" by looking at women (n = 2). Table 5 shows the impressions (%) of "femininity", "attractiveness", "youthfulness", and "freshness" after using the sample, with 100% being used before the sample was used.

[Test 5]
The antiperspirant having the composition shown in Table 6 below was prepared by a conventional method.

Changes in the impression of females were evaluated before and after the use of the antiperspirant having the composition shown in Table 6 above. Specifically, we conducted a questionnaire survey on "femininity," "attractiveness," "youthfulness," and "freshness" by looking at women (n = 2). Table 7 shows the impressions (%) of "femininity", "attractiveness", "youthfulness", and "freshness" after using the sample, with 100% being used before the sample was used.

An example of a pharmaceutical formulation of the external composition of the present invention is shown below. The numerical value (%) of each lactone shown in Table 8 indicates the final concentration (% by weight) in the entire composition when each combination is used in each formulation example.

<Formulation example 1: Body soap>
Any of the combinations of lactone compounds listed in Table 8 Lauric acid 5% by weight
Palmitic acid 5% by weight
Stearic acid 5% by weight
Potassium hydroxide Appropriate amount Glycerin 5% by weight
Dibutylhydroxytoluene 0.01% by weight
Disodium edetate 0.05% by weight
Phenoxyethanol 0.3% by weight
Benzalkonium chloride 0.1% by weight
Sodium Laureth Sulfate 5% by weight
Coconut oil fatty acid amide propyl betaine 5% by weight
Polyquaternium-10 0.5% by weight
Polyquaternium-7 0.2% by weight
Kaolin 0.5% by weight
Charcoal 0.05% by weight
Magnesium Phosphate Ascorbic Acid 0.5% by Weight
Hydroxyethyl cellulose 0.3% by weight
Water balance
100% by weight in total

<Pharmaceutical prescription example 2: Foam ejection type body wash>
Any of the combinations of lactone compounds listed in Table 8 PEG-80 sorbitan laurate 5% by weight
2 Sodium Cocoyl Glutamic Acid 4% by Weight
Cocoyl glycine sodium 2% by weight
Sorbitol 5% by weight
Cocoyl Methyl Taurine Taurine Sodium 2% by Weight
Appropriate amount of citric acid 2 sodium edetate 0.05% by weight
Cocamide DEA 1% by weight
Sodium cocoamphoacetate 3% by weight
Polyquaternium-7 0.05% by weight
Dipotassium glycyrrhizinate 0.3% by weight
Water balance
100% by weight in total

<Pharmaceutical prescription example 3: Facial cleanser>
Any of the combinations of lactone compounds listed in Table 8 Lauric acid 5% by weight
Myristic acid 10% by weight
Palmitic acid 7% by weight
Stearic acid 7% by weight
Potassium hydroxide Appropriate amount Butylene glycol 5% by weight
Glycerin 5% by weight
Tocopherol 0.05% by weight
Disodium edetate 0.05% by weight
Phenoxyethanol 0.3% by weight
Salicylic acid 0.2% by weight
Coconut oil fatty acid amide propyl betaine 5% by weight
Polyquaternium-10 0.3% by weight
Polyquaternium-7 0.1% by weight
l-Menthol 0.3% by weight
Fragrance 0.2% by weight
Water balance
100% by weight in total

<Pharmaceutical prescription example 4: Shampoo>
Any of the combinations of lactone compounds listed in Table 8 Sodium Laureth Sulfate 30% by weight
Triethanolamine cocoyl glutamate 5% by weight
Lauroylmethylalanine sodium 5% by weight
Lauramide Propyl hydroxysultaine 5% by weight
Citric acid Appropriate amount Dimethicone 0.3% by weight
Methylparaben 0.2% by weight
Disodium edetate 0.1% by weight
Polyquaternium-10 0.5% by weight
Polyquaternium-39 0.1% by weight
Polyquaternium-7 0.1% by weight
Fragrance 0.8% by weight
Water balance
100% by weight in total

<Formulation example 5: shampoo>
Any of the combinations of lactone compounds listed in Table 8 Sodium Olefin (C14-16) Sulfonate 15% by weight
POE lauryl ether sodium acetate 5% by weight
Coconut oil fatty acid diethanolamide 5% by weight
Coconut oil fatty acid TEA liquid 5% by weight
Coconut oil fatty acid amide propyl betaine solution 5% by weight
Appropriate amount of citric acid 2 sodium edetate 0.1% by weight
Benzalkonium chloride 1% by weight
Polyquaternium-10 0.6% by weight
Polyquaternium-7 0.1% by weight
Fragrance 0.5% by weight
Water balance
100% by weight in total

<Formulation example 6: Hair conditioner>
Any of the combinations of lactone compounds listed in Table 8 Glycerin 5% by weight
Hyaluronic acid 0.1% by weight
Dipotassium glycyrrhizinate 0.1% by weight
Squalene 0.1% by weight
Stearyl Trimethylammonium Chloride 4% by weight
Polyquaternium-10 0.5% by weight
Cetanol 2% by weight
POE-monostearyl glyceryl ether 1% by weight
Dibutylhydroxytoluene 0.01% by weight
Phenoxyethanol 0.3% by weight
EDTA-2Na 0.05% by weight
l-Menthol 0.2% by weight
Fragrance 0.3% by weight
Water balance
100% by weight in total

<Formulation example 7: Hair treatment>
Any of the combinations of lactone compounds listed in Table 8 Propylene glycol 5% by weight
Acetylated hyaluronic acid 0.01% by weight
Allantoin 0.3% by weight
Tetra 2-ethylhexanoic acid pentasliette 1% by weight
Cetyltrimethylammonium bromide 2.5% by weight
Polyquaternium-7 0.1% by weight
Setostearyl alcohol 2% by weight
Stearyl alcohol 2% by weight
POE-hardened castor oil 1% by weight
Dibutylhydroxytoluene 0.01% by weight
Methyl paraoxybenzoate 0.3% by weight
EDTA-2Na 0.05% by weight
Fragrance 0.5% by weight
Water balance
100% by weight in total

<Prescription example 8: Hair essence>
Any of the combinations of lactone compounds listed in Table 8 Butylene glycol 5% by weight
Hydrolyzed hyaluronic acid 0.1% by weight
Epsilon aminocaproic acid 0.05% by weight
Alkyltrimethylammonium chloride 0.7% by weight
O- [2-Hydroxy-3- (trimethylammonio) chloride
Propyl] Guar gum 0.5% by weight
Diethylene glycol monoethyl ether 2% by weight
POE-Sorbitan Monoisostearate 0.8% by weight
Ethanol 20% by weight
Phenoxyethanol 0.3% by weight
Fragrance 0.1% by weight
Water balance
100% by weight in total

<Formulation example 9: Hair mist>
Any of the combinations of lactone compounds shown in Table 8 Hydrolyzed collagen 1% by weight
Butylene glycol 5% by weight
Hydrolyzed hyaluronic acid 0.1% by weight
Dipotassium glycyrrhizinate 0.05% by weight
Polyquaternium-51 0.5% by weight
Liquid paraffin 0.5% by weight
Monoisostearyl glyceryl ether 1% by weight
Ethanol 30% by weight
Propyl paraoxybenzoate 0.3% by weight
Fragrance 0.3% by weight
Water balance
100% by weight in total

<Prescription example 10: Antiperspirant cream>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.07% by weight
Isopropylmethylphenol 0.07% by weight
Chlorhydroxyaluminum 4% by weight
Cyclopentasiloxane 25% by weight
Alkyl polyacrylic acid 6% by weight
POE / POP dimethicone copolymer 3.5% by weight
Dipotassium glycyrrhizinate 0.05% by weight
Concentrated glycerin 7% by weight
Isononyl isononanoate 5% by weight
Sorbitan isostearate 5% by weight
l-Menthol 0.5% by weight
Fragrance 0.3% by weight
Water balance
100% by weight in total

<Formulation example 11: Antiperspirant gel>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.06% by weight
Isopropylmethylphenol 0.05% by weight
Chlorhydroxyaluminum 8% by weight
Magnesium aluminometasilicate 0.5% by weight
Dipropylene glycol 10% by weight
Polyoxypropylene glycol 0.5% by weight
Hydroxypropyl Methyl Cellulose 0.5% by weight
Xanthan gum 0.5% by weight
Ethanol 10% by weight
l-Menthol 0.3% by weight
l-Mentyl glyceryl ether 0.3% by weight
Mentha oil 0.3% by weight
Fragrance 0.3% by weight
Water balance
100% by weight in total

<Formulation example 12: Antiperspirant spray>
Any of the combinations of lactone compounds listed in Table 8 Isopropylmethylphenol 0.1% by weight
Zinc paraphenol sulfonate 1% by weight
Diethyl sebacate 4% by weight
Talc 5% by weight
Nylon powder 1% by weight
Fragrance 0.5% by weight
Ethanol 15% by weight
Dimethyl ether balance
100% by weight in total

<Formulation example 13: Antiperspirant roll-on>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.06% by weight
Isopropylmethylphenol 0.06% by weight
Zinc paraphenol sulfonate 5% by weight
Butylene glycol 5% by weight
Chlorhydroxyaluminum 0.05% by weight
Talc 3% by weight
Nylon powder 0.5% by weight
Cetrimonium bromide trimethylammonium solution 1% by weight
Hydroxypropyl Methyl Cellulose 0.5% by weight
l-Menthol 0.1% by weight
Fragrance 0.3% by weight
40% by weight of water
Ethanol balance
100% by weight in total

<Formula prescription example 14: Antiperspirant mist>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.05% by weight
Isopropylmethylphenol 0.06% by weight
Zinc paraphenol sulfonate 1% by weight
Butylene glycol 5% by weight
Chlorhydroxyaluminum 0.02% by weight
Sericite complex 0.3% by weight
Cetrimonium bromide trimethylammonium solution 0.5% by weight
l-Menthol 0.3% by weight
Fragrance 0.3% by weight
10% by weight of water
Ethanol balance
100% by weight in total

<Formulation example 15: Antiperspirant stick>
Any of the combinations of lactone compounds listed in Table 8 Benzalkonium chloride 0.055% by weight
Isopropylmethylphenol 0.05% by weight
Chlorhydroxyaluminum 5% by weight
Polyethylene wax 5% by weight
Microcrystalline wax 5% by weight
Glyceryl monostearate 3% by weight
Isononyl isononanoate 5% by weight
Talc 12% by weight
Methylpolysiloxane 2% by weight
Decamethylpentasiloxane 0.3% by weight
Cyrilization treatment Siliconic acid anhydride 15% by weight
Cetanol 2% by weight
Hydroxyapatite 0.3% by weight
Cetrimonium bromide trimethylammonium solution 0.5% by weight
l-Menthol 0.5% by weight
Zinc oxide 0.3% by weight
Fragrance 0.3% by weight
Stearyl alcohol balance
100% by weight in total

<Prescription example 16: Wiping lotion>
Any of the combinations of lactone compounds listed in Table 8 Ethanol 15% by weight
Polyoxyethylene polyoxypropylene decyltetradecyl ether 1% by weight
Hydrolyzed jojoba ester 0.01% by weight
Methylsiloxane reticulated polymer 0.01% by weight
Magnesium Phosphate Ascorbic Acid 0.3% by Weight
Fragrance 0.05% by weight
Paraben 0.3% by weight
Appropriate amount of citric acid
Purified water balance
100% by weight in total

<Formulation example 17: Deodorant sheet>
Any of the combinations of lactone compounds listed in Table 8 Isopropylmethylphenol 0.05% by weight
Zinc paraphenol sulfonate 1% by weight
Ethanol 30% by weight
Cetrimonium bromide trimethylammonium solution 0.5% by weight
Butylene glycol 1% by weight
Sericite complex 0.1% by weight
Kaolin 0.3% by weight
Phenoxyethanol 0.1% by weight
Fragrance 0.1% by weight
Appropriate amount of citric acid
Purified water balance
100% by weight in total

<Formulation example 18: Deodorant for clothing and cloth products>
Any of the combinations of lactone compounds listed in Table 8 Green tea extract 0.5% by weight
Biguanide compound 0.2% by weight
Ethanol 10.0% by weight
Purified water balance
100% by weight in total

<Pharmaceutical prescription example 19: Deodorant for space>
Any of the combinations of lactone compounds listed in Table 8 Dipropylene glycol 0.1% by weight
Ethanol 10.0% by weight
Citric acid 0.1% by weight
Cyclodextrin 0.05% by weight
Appropriate amount of sodium hydroxide
Purified water balance
100% by weight in total

<Formulation example 20: Dry shampoo 1>
Any of the combinations of lactone compounds shown in Table 8 LPG (liquefied petroleum gas) 50% by weight
Ethanol Remaining amount Octenyl Succinate Starch Al 5% by weight
Talc 3% by weight
Silica 2% by weight
Menthol 0.2% by weight
Isopropylmethylphenol 0.005% by weight
Fragrance 0.1% by weight
100% by weight in total

<Formulation example 21: Dry shampoo 2>
Any of the combinations of lactone compounds listed in Table 8 Dimethyl ether 60% by weight
Ethanol Remaining amount Jojoba oil 2% by weight
Starch octenyl succinate Al 3% by weight
Cornstarch 3% by weight
5% by weight of water
Methylparaben 0.1% by weight
Dibutylhydroxytoluene 0.05% by weight
Fragrance 0.2% by weight
100% by weight in total

According to the present invention, since the body odor of a woman can be rejuvenated, it is possible to provide an external composition suitable for measures against the odor of a woman. Further, by using the composition of the present invention on an object to which a body odor component is likely to adhere due to the use of, for example, bedding, the effect of rejuvenating the odor emitted from the attached body odor component can be expected. The composition can also be suitably used for textile products, for hard surfaces or for spaces. Further, according to the present invention, it is also possible to provide a method for evaluating a substance having an anti-aging effect.

Claims (11)

A composition containing at least a lactone compound represented by the following formula (I).
A composition for supplementing young female odor, which is used to supplement the odorous components that make up the body odor of young females.

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.) The composition according to claim 1, which is for external use. The composition according to claim 2, which is for women. The composition according to claim 2 or 3, which is used for rejuvenating body odor. The composition according to claim 1, which is for textile products, for hard surfaces or for spaces. The composition according to any one of claims 1 to 5, which is for measures against the odor of aging. A body odor model composition for a young woman, which contains an odor component constituting the body odor of a young woman and at least contains a lactone compound represented by the following formula (I) as the odor component.

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.) A composition containing at least a lactone compound represented by the following formula (I).
An index agent for determining the odor of aging, which is used as an index for determining the odor of women.

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.) An anti-aging effect evaluation method for evaluating the anti-aging effect of a test substance using a change in the content of a lactone compound represented by the following formula (I) contained in body odor as an index due to the use of the test substance.

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.) An anti-aging substance screening method for screening a substance having an anti-aging effect by using a change in the content of a lactone compound represented by the following formula (I) contained in body odor as an index due to the use of a test substance.

(In the formula, R is an alkyl group having 2 to 9 carbon atoms.) The method of claim 10, wherein a substance having an anti-aging effect on body odor is screened.

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