WO2017138598A1 - がん予防・改善アドバイス装置 - Google Patents

がん予防・改善アドバイス装置 Download PDF

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WO2017138598A1
WO2017138598A1 PCT/JP2017/004701 JP2017004701W WO2017138598A1 WO 2017138598 A1 WO2017138598 A1 WO 2017138598A1 JP 2017004701 W JP2017004701 W JP 2017004701W WO 2017138598 A1 WO2017138598 A1 WO 2017138598A1
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Prior art keywords
advice
life element
element information
information
life
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English (en)
French (fr)
Japanese (ja)
Inventor
糧三 齋藤
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Individual
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Priority to JP2017555616A priority Critical patent/JPWO2017138598A1/ja
Priority to CN201780023152.5A priority patent/CN108885898A/zh
Priority to US16/077,038 priority patent/US20190139440A1/en
Publication of WO2017138598A1 publication Critical patent/WO2017138598A1/ja
Anticipated expiration legal-status Critical
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Definitions

  • the present invention relates to a cancer prevention / improvement advice device that outputs advice for bringing each life element closer to the optimum value of each life element for the purpose of cancer prevention / improvement.
  • Non-Patent Document 1 the website of the National Cancer Center's Cancer Control Information Center “Cancer Information Service” introduces the latest correct information about cancer to the general public (see Non-Patent Document 1).
  • This lifestyle-related disease is caused by long-term eating habits and lifestyle habits, including exercise habits. Therefore, it is necessary to record and examine the contents for a long period of time to prevent or improve this lifestyle-related disease. It is also necessary to report these records to medical personnel such as doctors for advice and guidance.
  • Patent Document 1 collects user's biological data and life data, and can quickly receive expert advice, and can accumulate and analyze data over a long period of time. It describes that it is possible to grasp the bias in life and to provide medical services (see Patent Document 1).
  • Non-Patent Document 2 states that, after three months of exercise, meditation, and a healthy diet (Mediterranean diet) for low-risk prostate cancer patients, 501 genes among the genes related to prostate cancer "The expression has improved,” and it has been shown that improving lifestyles improves cancer-related gene expression. This result suggests that cancer can be improved not only by the treatment of specialist doctors but also by improving lifestyle.
  • Non-Patent Document 3 states that “for 10 metastatic cancers, a ketosis (carbohydrate-restricted diet) under a carbohydrate-restricted diet that suppresses carbohydrates to 5% of the total calories of the diet to suppress insulin. In the physiological range, an increase in ketone bodies in the blood was attempted, and one of the 10 metastatic cancer cases was in remission, and the progression was suppressed in the other three. There was a description that cancer progressed in cases where insulin could not be suppressed, and it has been shown that the risk of metastasis can be reduced by ketosis.
  • Non-Patent Document 3 suggest that the risk of metastasis can be reduced by dietary guidance such as limiting the carbohydrates to be taken.
  • the excessive secretion of ketone bodies can be confirmed by qualitative analysis or quantification of ketone bodies in urine. It is known that ketosis can be evaluated by combining the analysis of ketone bodies. This suggests that cancer can be improved if dietary information and biological data can be grasped and advice on improvement measures can be obtained without direct guidance from a specialist doctor.
  • cancer prevention and improvement for example, when eating and drinking, mainly eat vegetable foods and raw foods, reduce dairy consumption, and reduce low sugar and low salt content. And to reduce alcohol consumption or to ban alcohol.
  • moderate exercise and reducing stress and maintaining a stable mental state are said to help prevent and improve cancer. Therefore, although cancer specialists are beginning to focus on lifestyle improvement, they are not being able to give guidance to patients and their families on lifestyle improvement, following treatment and medical care. .
  • Life style improvement is expected not only to prevent cancer but also to be effective in improving cancer, but life style cannot be improved so easily. It is important to check daily diet, exercise, and sleep for bias and stress, to verify changes in biological data such as weight and blood pressure, and to improve and continue little by little. For this purpose, it is important to detect conditions such as meals, exercise, sleep, stress, and biometric data, and receive advice for improvement as appropriate.
  • the conventional devices and systems described in Patent Document 1 are only intended to make it easier for experts to receive advice, and do not realize a function for issuing advice for the purpose of preventing or improving cancer. Absent.
  • the problem to be solved by the present invention is that the present invention allows selection and output of advice for bringing life factors such as meals and exercise closer to the optimum values for the purpose of cancer prevention / improvement. It is to provide a device, and to provide a cancer prevention / improvement advice device that allows a user to always receive advice from an electronic device such as a smartphone that is close to the user.
  • the first invention is a life element that obtains from the user life element information that is information affecting the physiological activity of the user and / or information indicating the degree of health of the user.
  • the information acquisition unit, the life element information storage unit that stores the acquired life element information as history information, and the life element information optimum value that is the optimum value of each life element for the purpose of cancer prevention / improvement The life element information optimum value holding part, the advice holding part for holding a plurality of advices for approaching the optimum value of each life element information, the life element information history information and the life element information optimum value in which the life element is held
  • an advice selection rule holding unit for holding an advice selection rule that is a rule for selecting the held advice using a variable as a variable, and a life element information
  • An advice selection unit that selects advice using the retained advice selection rule using the history information of the current life information and the life element information optimum value of the life element as a variable, and the advice selected by the selection unit
  • the second aspect of the invention provides the cancer prevention / improvement advice device according to claim 1, wherein the life element information acquisition unit has meal information acquisition means for acquiring meal information as life element information from a photograph of a meal. To do.
  • the third aspect of the invention is the cancer according to claim 1 or 2, wherein the life element information acquisition unit has exercise data acquisition means for acquiring exercise data as life element information from an exercise amount measuring instrument such as a pedometer. Providing prevention / improvement advice devices.
  • the fourth aspect of the invention is the cancer according to any one of claims 1 to 3, wherein the life element information acquisition unit includes sleep data acquisition means for acquiring sleep data that is life element information from the sleep measuring instrument. Providing prevention / improvement advice devices.
  • the fifth aspect of the invention is the cancer according to any one of claims 1 to 4, wherein the life element information acquisition unit has stress data acquisition means for acquiring stress data as life element information from the stress measuring instrument. Providing prevention / improvement advice devices.
  • the sixth aspect of the invention is the cancer according to any one of claims 1 to 5, wherein the life element information acquisition unit has a biological data acquisition means for acquiring biological data as life element information from a body composition meter. Providing prevention / improvement advice devices.
  • a life element information acquisition step for acquiring life element information from the user, which is information that affects the physiological activity of the user or / and information indicating the degree of health, and the acquired life element information as history information
  • the life element information accumulation step for storing, the life element information optimum value holding step for holding the life element information optimum value that is the optimum value of each life element for the purpose of cancer prevention / improvement, and each retained
  • An advice selection rule that is a rule for selecting, as a variable, history information of life element information and life element information optimum value held in the life element information from a plurality of advices for approaching the optimum value of life element information
  • An advice selection step for selecting an advice by using an advice output step for outputting the advice selected by the selection unit.
  • Providing an operation program of cancer computer is prophylaxis or improvement advice device including a flop, a.
  • the following system can be considered as a system for improving advice accuracy by big data processing.
  • the life element information storage unit calculates the average value, the variance, the deviation value of each data, the t distribution, F based on the past numerical value.
  • the cancer prevention / improvement advice device according to claim 1, further comprising first statistical processing means for obtaining a distribution and a chi-square distribution.
  • a life element for acquiring a life element information cross-correlation coefficient that is a correlation coefficient between the life element information accumulated in the life element information storage unit A cancer prevention / improvement advice device based on the eighth invention further having an information cross-correlation coefficient acquisition unit is proposed.
  • the advice selection rule holding unit has an average value, a variance, a deviation value of each time of data obtained by the first statistical processing means of the life element information storage unit, and t
  • a cancer prevention / improvement advice device based on the eighth to ninth inventions having advice first selection rule changing means for changing based on distribution, F distribution, and chi-square distribution is proposed.
  • the life element information storage unit in each of the devices of the eighth to ninth inventions accumulates life element information acquired in association with the advice output from the advice output unit.
  • a cancer prevention / improvement advice device further comprising: an information storage means, and an advice life element information correlation coefficient acquisition unit that acquires an advice life element information correlation coefficient that is a correlation coefficient between the associated advice and life element information suggest.
  • the advice selection rule holding unit based on the eleventh invention as the twelfth invention the advice life element information correlation acquired by the advice life element information correlation coefficient acquisition unit for the held advice selection rule
  • a cancer prevention / improvement advice device having a second advice selection rule changing means that changes based on the number is proposed.
  • the cancer prevention / improvement advice device described in 1), the history information acquisition unit that acquires the history information output from the history information output unit via the network, and the life information obtained by statistically processing the acquired history information A cancer prevention / improvement advice system comprising a central server having a central server correlation coefficient calculation unit for calculating the number of relationships and a central server correlation coefficient output unit for outputting the calculated correlation coefficient is proposed.
  • the central server obtains the average value, variance, deviation value of each data, t distribution, F distribution, and chi-square distribution of each life element information based on the acquired history information.
  • a cancer prevention / improvement advice system based on the thirteenth invention having the second statistical processing section is proposed.
  • the central server is held in the advice selection rule holding unit of each cancer prevention / improvement advice device based on the correlation coefficient calculated by the central server correlation coefficient calculation unit.
  • Advice selection instruction acquisition unit that acquires an advice selection rule change instruction that is an instruction for changing the advice selection rule, and advice selection rule change that outputs the acquired advice selection rule change instruction to each cancer prevention / improvement advice device
  • Each cancer prevention / improvement advice device has an advice selection rule change instruction acquisition unit that acquires an advice selection rule change instruction output from the advice selection rule change instruction output unit.
  • the address held in the advice selection rule holding unit We propose and advice selection rule changing unit for changing the chair selection rule, the thirteenth or fourteenth Cancer Prevention and improvement advice system further comprises a.
  • AI artificial intelligence
  • a life element information acquisition unit that acquires life element information that is information that affects the physiological activities of the user or / and information that indicates the degree of health of the user from the user, and the acquired life element information
  • the life element information accumulating unit that accumulates as history information in association with the advice information output later, corresponding to the acquisition time of the life element information, and the life element information is evaluated using the life element information optimum value, and the evaluation result is obtained.
  • Life component information evaluation unit to obtain, advice result learning unit to learn the relationship between the evaluation result and advice information corresponding to the evaluated life component information, and the optimum of each life component for the purpose of cancer prevention and improvement
  • the life element information optimum value holding unit for holding the life element information optimum value that is a value, and a plurality of advices for approaching the optimum value of each life element information Advice that is a rule for selecting the held advice using the Dubai holding unit, the history information of the life element information, the life element information optimum value of the life element, and the learning result Advice is provided using the advice selection rule stored as an advice selection rule storage unit that stores selection rules, history information of life element information, and life element information optimum values stored in the life elements.
  • a cancer prevention / improvement advice device including an advice selection unit to be selected and an advice output unit for outputting advice selected by the selection unit.
  • the cancer prevention / improvement advice device according to claim 2, further comprising a new advice recording unit for recording new advice in the advice holding unit.
  • These life element information includes, for example, physical measurement results (BMI, abdominal circumference, visceral fat, body fat percentage), physical condition inspection results (blood pressure, visual acuity, intraocular pressure, lung function, hearing, hair Situation), urinalysis results, stool test results, stool frequency, stool color, stool properties, blood biochemical test results, serological test results, tumor marker test results, diabetes test results, cytological test results, fundus camera Test results, breast test results, ultrasound test results, gastrointestinal test results, chest x-ray test results, CT test results, MRI test results, PET test results, rectal diagnostic test results, rectal temperature, electrocardiogram test results, balance function test results , Arteriosclerosis evaluation result, osteoporosis test result, female hormone test result, risk marker test result, gene information may be one or more information.
  • BMI abdominal circumference, visceral fat, body fat percentage
  • physical condition inspection results blood pressure, visual acuity, intraocular pressure, lung function, hearing, hair Situation
  • urinalysis results stool test results, stool
  • the quality and quantity of the injuries / illness As information on illness / injury, the quality and quantity of the injuries / illness, the type and quantity of medicines taken according to the injuries / illness, the frequency and length of time to go to the hospital according to the injuries / illness, and the injuries / illnesses.
  • the quality and quantity of the diagnosis performed, the quality and quantity of the surgery performed according to the injury / illness, the quality and quantity of the equipment, auxiliary equipment, bandage, etc. that accompanies the body according to the injury / illness It may be the information.
  • user voice quality As mental state information, user voice quality, user voice volume, user utterance volume, autonomic state, user feeling, sexual life satisfaction, image of things, mood when waking up , Feeling of falling asleep, mood during sleep, mood during work, mood during holidays, mood during meals, mood during defecation, sensory temperature, limbs, ease of breathing, or more It may be information.
  • a cancer prevention / improvement advice device capable of acquiring life element information from a user and outputting advice for bringing each life element closer to the optimum value for the purpose of cancer prevention / improvement Can be provided
  • the figure which shows an example of the functional block of the cancer prevention and improvement advice apparatus of this invention Schematic showing an example of the hardware configuration of the cancer prevention / improvement advice device of the present invention
  • the figure which shows an example of the flow of a process in the cancer prevention and improvement advice apparatus of this invention The figure which shows an example for acquiring the meal information which is the life element information in Example 1
  • Example 4 The figure which shows an example of the component table
  • Schematic diagram of eyes for capturing pupil changes in Example 4 The figure which shows an example of the flow of a treatment of life element information acquisition in Example 4.
  • the figure which shows an example for acquiring the biometric data which is the life element information in Example 5 The figure which shows another example of the functional block of the cancer prevention and improvement advice apparatus of this invention The figure explaining the mechanism for advice acquisition in Example 6
  • Diagram showing an example of genetic information Fig. 1 shows the life element information optimum value FIG. 2 showing the life element information optimum value
  • FIG. 3 showing the life element information optimum value
  • FIG. 4 showing the life element information optimum value
  • the “cancer prevention / improvement advice device of the present invention” of the present invention collects information that affects physiological activities from daily life, prevents the onset or recurrence of cancer, Even if there is, advice to reduce or eliminate this is output on a daily basis to prevent the maintenance of the user's health, the onset of cancer, and the recurrence.
  • the “cancer prevention / improvement advice device” of the present invention (hereinafter may be abbreviated as “this device” or “this device”) has a life element information acquisition unit, a life element information storage unit, and a life element information optimum value holding unit.
  • the functional blocks of the apparatus and system described below can be realized as a combination of hardware and software.
  • a computer a CPU, a main memory, a bus, or a secondary storage device (a hard disk, a non-volatile memory, a storage medium such as a CD or a DVD, and a read drive for the medium)
  • information Input devices used for input, printing equipment, display devices, other hardware components such as external peripheral devices, interfaces for external peripheral devices, communication interfaces, driver programs for controlling these hardware, Other examples include application programs and user interface applications.
  • the functional blocks of this system may be realized by dedicated hardware.
  • each embodiment described in the present specification can be realized not only as an apparatus but also as a method.
  • a part of such a device can be configured as software.
  • a software product used for causing a computer to execute such software and a recording medium on which the product is fixed are naturally included in the technical scope of each embodiment described in this specification (this specification The same throughout.)
  • Embodiments of the present invention are devices having the above-described configuration, and can be realized by various terminal devices such as smartphones, wearable terminals, tablet terminals, and PC terminals, and servers on the network, but are not limited to these embodiments.
  • the present invention can be implemented in various forms without departing from the scope of the invention.
  • Various terminal devices such as a smartphone, a wearable terminal, a tablet terminal, and a PC terminal are representative devices that perform information processing using a built-in computer.
  • various terminals include mobile phones, game machines, navigation devices, and the like.
  • Smartphone refers to a high-function mobile phone having a touch panel as a main user interface device.
  • FIG. 1 is a diagram showing an example of functional blocks in the cancer prevention / improvement advice device according to the present invention. Each component will be described with reference to this figure.
  • the life element information acquisition unit (0101) directly receives life element information that is information that affects the physiological activity of the user and / or information that indicates the degree of health directly from the user or an external device. Or indirectly.
  • the acquired life element information is sent to a life element information storage unit (0102) that stores it as history information.
  • these life element information or life element information synthesized internally has the life element information optimum value that is the optimum value of each life element for the purpose of cancer prevention / improvement. It is held in the element information optimum value holding unit (0103).
  • an advice holding unit (0104) that holds a plurality of advices for approaching the optimum value of each life element information, and the history information of the acquired life element information and the life element information optimum value in which the life element is held
  • an advice selection rule which is a rule for selecting the retained advice, as a variable, is retained in the advice selection rule retaining unit (0105).
  • an advice selection rule that is a rule for selecting the held advice using the history information of the acquired life element information as a variable may be held in the advice selection rule holding unit. Then, using the retained advice selection rule with the history information of the life element information and the life element information optimum value held for the life element as a variable or the history information of the life element information as a variable.
  • An advice selection unit (0106) for selecting an advice is provided, and the advice selected by the selection unit is output from the advice output unit (0107).
  • the cancer prevention / improvement advice device is configured.
  • the “life element information acquisition unit” has a function of acquiring, from the user, life element information that is information that affects the physiological activity of the user and / or information that indicates the degree of health. Generally, it is realized by a camera function, a communication function, a recording function, a sound collecting function, a motion sensor function, a temperature measuring function, an illuminance measuring function, a humidity measuring function, and the like.
  • the acquired life element information is sent to and stored in the life element information storage unit. Accumulation is performed in association with date and user.
  • the life element information acquisition unit is equipped with a camera function, recording function, sound collecting function, motion sensor function, temperature measuring function, illuminance measuring function, humidity measuring function, etc. It becomes an interface on the server to acquire the information.
  • Life element information here is information that may affect the physiological activities of the user and / or information that can be used to measure the degree of health of the user. Therefore, the life element information can include both information that causes the degree of health and information that indicates the degree of health obtained as a result of the cause. In the present invention, for example, meal information, exercise data, sleep data, stress data, biometric data, and the like.
  • the life element information may further include radiation dose, radiation intensity, ultraviolet ray amount, ultraviolet ray intensity, electromagnetic wave intensity, and the like. These may be acquired from a life element information acquisition unit via a network, or a radiation sensor, an ultraviolet sensor, an electromagnetic wave sensor, or the like may be provided as a life element information acquisition unit in the present apparatus.
  • “Meal information” includes, for example, the time when eating and drinking started, the time when eating and drinking ended, the type and amount of food and beverage consumed, the calories consumed, and the type and amount of food components in the food.
  • Examples of the types of food ingredients include carbohydrates, dietary fibers, minerals, vitamins, other proteins, lipids, and types and ratios of fatty acids contained in lipids.
  • Minerals include sodium, potassium, calcium, magnesium, phosphorus, silicon, zinc, iron, copper, manganese, selenium, chromium, sulfur, and vitamins include vitamin B group, vitamin D, vitamin A, vitamin K, etc. There is.
  • meal information can be analyzed and analyzed by image recognition technology using photos taken using the photographing functions of smartphones, tablet terminals, etc., which are life element information acquisition units.
  • the photograph is a photograph of spaghetti
  • the product components and the amount that are included in the spaghetti as standard are meal information that is life element information.
  • meal information may be acquired by selecting a corresponding meal from a pull-down menu that is a life element information acquisition unit, or verbally with respect to a microphone that is a life element information acquisition unit and a voice recognition function. You may acquire by inputting a meal menu.
  • “Exercise data” includes, for example, the type and content of exercise, exercise time, exercise amount (weight ⁇ movement distance, etc.), exercise quality, number of steps, movement amount, body movement, heart rate variability, posture, acceleration, time at which the exercise was started, It includes the time of completion, the place where the exercise was performed, temperature, humidity, presence or absence of an instructor, and equipment used for the exercise. Furthermore, for example, there are fluctuations in sweat volume, blood pressure, and blood glucose level before and after exercise.
  • These data may be obtained by analyzing the moving image using image recognition technology using the video capturing function of the smartphone, which is also a life element information acquisition unit, or by the microphone and the sound which are also the life element information acquisition unit.
  • You may analyze and acquire by a recognition function, and you may acquire by selecting from the pull-down menu which is a life element information acquisition part.
  • Other exercise equipment may communicate with a smartphone or the like to acquire these exercise data. This can be achieved by adding a communication function to the gym training machine.
  • you may utilize the function with which smart phones, such as a pedometer, a heart rate monitor (it may measure using the light and camera of a smart phone), GPS, etc. are provided.
  • “Sleep data” includes, for example, bedtime, sleep time, wake-up time, wake-up time, sleep time, sleep depth, mid-wake, sleep volume, sleep debt, sleep phase change, sleep latency, breathing, body movement, snoring,
  • the lighting conditions during non-sleeping and sleeping include, for example, the transition of ambient illuminance, the light spectrum and amount of blue light, and the time when the light is lit.
  • the presence / absence and time and contents of toilet use during sleep the presence / absence of ingestion of sleep inducers, the time and amount of ingestion, and the rhythm and quality of sleep.
  • These data are acquired by acquiring the values measured by the electroencephalogram measurement apparatus via a communication unit (for example, Bluetooth (registered trademark)) that functions as a life element information acquisition unit such as a smartphone.
  • a communication unit for example, Bluetooth (registered trademark)
  • the size and duration of snoring may be acquired through a microphone of a smartphone that functions as a life element information acquisition unit, and the number of times of turning over is measured based on the contact sound between bedding and sleepwear. Also good.
  • the information may be acquired via a communication unit (for example, Bluetooth (registered trademark)) that functions as a life element information acquisition unit using a sleep measuring instrument sold by OMRON.
  • Stress data includes the following data as autonomic nerve and stress-related biological information, and is divided into non-invasive data and invasive data.
  • Non-invasive data includes, for example, heart rate variability, skin electrical resistance value and its variation, pupil diameter and its variation, urine and saliva organic acid values, hormone values and their metabolites and their daily variations
  • biological basics Information includes blood pressure fluctuation and body temperature fluctuation.
  • Invasion data includes, for example, blood glucose fluctuations.
  • the stress data can record a change in a medical condition caused by voice by using a mobile terminal normally by using, for example, voice emotion recognition technology. Speech emotion recognition technology is a technology that allows you to easily check the proportion of “anger”, “joy”, “sadness”, “normal” (4 emotions) contained in speech, and the degree of “excitement”.
  • optical topography can be used to assess depression and stress.
  • An optical topography test is a test that uses a small amount of near-infrared light outside the body to measure blood flow in the brain and numerically understand the state of depression. Furthermore, it can also acquire by measuring the opening / closing speed of a pupil using the moving image function of cameras, such as a smart phone which is a life element information acquisition part, and illuminations, such as a smart phone.
  • stress data includes voiceprints and their fluctuations, bathing conditions, mood, fatigue, and subjective symptoms such as fatigue.
  • Bathing conditions include, for example, bathing time, bathing environment such as a bathtub or shower (including bathing posture), hot water temperature, bathing time, time required for bathing, body temperature, heart rate, and oxygen saturation.
  • mental activities such as distractions, hobbies, travel, SNS, meditation, spirituality, and social statuses such as family, company, friends, and community.
  • These can be acquired by using the recognition function for the video function and copper of a camera such as a smartphone that is a life element information acquisition unit, or can be acquired by selecting from a pull-down menu that is also a life element information acquisition unit. it can.
  • the stress data includes the amount of sweating, display gazing work continuation time, car, truck, airplane, ship, train, on-site transport vehicle, plant, etc. This may include time, duration of manual labor, duration of assembly work in the factory, etc. Furthermore, it may be obtained by performing a predetermined calculation based on these.
  • Bio data includes, for example, body composition data and in vivo nutrient metabolism information.
  • the body composition data includes, for example, body weight, height, and body fat.
  • In vivo nutrient metabolism information includes, for example, the number of urinations and defecations, amount, properties, and color.
  • nutrients, hormones, minerals, vitamins, organic acids, harmful substances, types and amounts of bacteria, ph, etc. contained in biological materials such as hair, nails, blood, urine and feces and stool.
  • the information acquired by the method of predicting the food component in the tissue by analyzing the laser reflection characteristics of the skin can be acquired as biological data.
  • image examination data such as CT and MRI can be acquired as biological data.
  • cancer is detected by examination by image diagnosis, and the subsequent progression is generally evaluated by image diagnosis.
  • CTCs-which are cancer cells that appear in the blood in early cancers that do not pass through the image Evaluation data of circulating blood cancer cells can be obtained as biological data.
  • genetic information using samples of peripheral blood or cells in the oral cavity of saliva, and gene expression information such as the presence or absence of expression of cancer-related genes using peripheral blood as samples are also biological data. Tumor marker values and inflammation marker values can also be handled as biological data.
  • Biometric data can be acquired by using a scale, height meter, vital capacity measuring device, body composition system, CT device, MRI device, PET diagnostic device, X-ray imaging device, ultrasound diagnostic device, bone density "Measurement device” "Heart rate measurement device” “Blood analyzer” “Urine analyzer” “Saliva analyzer” “Stool analyzer” “Vision measuring device” “Sweat analyzer” “Hair analyzer” “Endoscope” " It can be acquired from the body temperature measuring device, hearing ability measuring device, sweat rate measuring device, etc. using the communication function of a smartphone that is a life element information acquisition unit, and from the pull-down menu that is also a life element information acquisition unit It can also be acquired by selecting.
  • the life element information storage unit has a function of storing the acquired life element information as history information.
  • the accumulation period may be appropriately designed according to the performance of the apparatus, but it is preferable that accumulation can be performed in units of years. Because it makes sense to compare with the same season of the previous year.
  • the life element information accumulation interval may be 1 second, 10 seconds, 1 minute, 5 minutes, 30 minutes, 60 minutes, 120 minutes, 240 minutes, intervals, etc., and the accumulation interval may vary depending on the life element information to be accumulated. May be different. For example, a pulse is accumulated in units of 1 second, food and drink are accumulated in units of 120 minutes, and sleep time is accumulated in units of 240 minutes.
  • the “history information” is preferably stored as history information in association with the acquired life element information and the acquisition time.
  • the specific life element information only once may be referred to as history information, or the life element information of two or more times-multiple times may be referred to as history information.
  • life element information it is conceivable to use information obtained by averaging multiple times, or to use whether the numerical trend is rising or falling. This is because there is a case where the judgment may be shaken with only one life element information.
  • life element information is acquired numerically, for example, heart rate, body temperature, blood pressure, BMI, waist circumference, visceral fat, body fat percentage, visual acuity, intraocular pressure, vital capacity, hearing, urinary protein, urine sugar, urine ketone body, Urine occult blood, uropyrinogen, urine specific gravity, urine bacteria, blood total bilirubin, blood ZTT, blood TTT, blood ALP, blood CK (CPK), blood LAP, blood LDH, blood ⁇ -GTP, blood cholinesterase, blood AST, blood ALT, Blood total cholesterol, blood neutral fat, blood HDL cholesterol, blood LDL cholesterol, serum amylase, blood uric acid, blood urea nitrogen, blood total protein, blood serum albumin, blood protein A / G ratio, protein fraction, blood creatinine, blood eGFR, blood TSH, blood serum iron, blood BNP, blood sodium, blood potassium, blood Lucium, blood chlor, blood inorganic phosphorus, blood total homocysteine, serum CRP
  • the advice selection unit may have a statistic selection unit so as to select an advice that is most likely to have the effect of the advice. Further, a correlation coefficient between these pieces of life element information is obtained (correlation coefficient calculation unit). When the degree of correlation exceeds a certain level, for example, 0.7 or more, the pieces of life element information are collectively given as one advice. There may be an advice selection rule changing unit that changes the advice selection rule to select. The same applies to cases where the correlation coefficient is high and the cause and effect are related.
  • the present apparatus may be configured to communicate with the statistical processing server, and may be configured to collect the history of life element information for each user from the present apparatus throughout Japan and around the world. Further, the advice information output by synchronizing the history of the life element information and the time axis may be collected. Since the correlation coefficient can be calculated by so-called big data processing rather than viewing the correlation of the life element information by the user alone, a correlation coefficient between the life element information with higher reliability can be obtained (correlation coefficient calculation unit). The relationship between life element information and the output advice is the same. Therefore, it is possible to obtain advice that is effective in preventing cancer, preventing recurrence, and improving by statistical processing. It is also possible to discover new cancer risk parameters by using statistical processing or AI (artificial intelligence) processing.
  • AI artificial intelligence
  • the correlation coefficient is high, there are both cases where the life element information is a result based on a common cause, and when the relationship is between the cause and the result. It is also conceivable that processing is performed by associating identification information for each life element information as to which relationship may be established as data. Then, new cancer risk parameters can be found with high reliability.
  • the correlation coefficient between life element information, the estimation of the relationship between the cause and the result, the estimation that the result is based on the common cause, and the effective advice are fed back from the server to each device or used as data. Each device can be operated so that it can hold and accumulate as much as possible and output more effective advice. It is the creation of unknown information based on so-called big data processing.
  • new advice information is output from the central server to each device and added to the advice information holding unit, or unnecessary or less effective advice held in the advice information holding unit is deleted. It is preferable that the central server and the present apparatus are configured so that the advice selection rules held in the advice selection rule holding unit along with these processes can be added, changed, and deleted.
  • the device is configured to communicate with the statistical processing server and collects the history of life element information for each user from the device in Japan and around the world, the user attributes must be matched. It is preferably configured to transmit.
  • the attributes of the user here include the residence area (country name, area name), job type, labor form, gender, age, race, and the like.
  • Cancer is said to have regional characteristics, and is also said to be dependent on occupation, type of work, gender, age, race, and so on. Therefore, it is considered that the analysis of each attribute can analyze the output of advice information and the correlation between life element information more effectively than analyzing the big data as it is.
  • the transmitted data is associated with the time information, and it is preferable that the dependence on the country, region and season can be taken into consideration.
  • there is a peculiar accident such as the Fukushima Daiichi nuclear accident, it is desirable to include that information in the attribute data.
  • information related to radiation exposure includes nuclear accidents, nuclear breakdowns, radioactive waste treatment facility accidents, breakdowns, radioactive waste transport accidents, breakdowns, etc.
  • the life element information optimum value holding unit has a function of holding the life element information optimum value which is the optimum value of each life element information for the purpose of cancer prevention / improvement.
  • the life element information optimum value may correspond to life element information obtained by combining a plurality of life element information. Further, the life element information optimum value has a predetermined width, and when the life element information enters the width, the life element information optimum value may be determined to be in the optimum state.
  • Life element information optimum value is the optimum value of each life element for the purpose of cancer prevention / improvement.
  • the “optimum value of life element” is an optimum value of each life element such as meal information, exercise data, sleep data, stress data, biometric data, and the like. It is desirable that the optimum value for each life element be an optimum value that varies depending on age, sex, etc., such as blood pressure, by registering the state of each user.
  • the optimum value can be determined by statistically processing the life element information of a healthy person and setting the average value and a value within a predetermined range from the average value (for example, plus or minus sigma).
  • the accuracy increases if the optimum value is determined by using not only healthy people but also values of people suffering from cancer. That is, since the reliability of the optimum value can be measured, it can be used as an optimum value with reliability.
  • the optimal value for people with cancer may be a value specific to cancer patients. For cancer patients, for example, it is better to bring the ph value of urine closer to the alkali side than a healthy person.
  • the “advice holding unit” has a function of holding a plurality of advices for approaching the optimum value of each life element information. Multiple advices are retained.
  • a plurality of meanings is a concept including both a case where a plurality of advices are held for one life element information and a case where a plurality of advices are held for a plurality of life element information.
  • the reason for designing to include a plurality is to select the optimum advice according to the degree of separation from the life element information optimum value.
  • the conventional method of giving advice for devices is to give alternative choices of whether the conditions are satisfied or not satisfied. However, this may not provide sufficient motivation for the user. Because there is.
  • an appropriate advice can be selected from an advice group suitable for the mood by inputting the mood of the user on the day.
  • the contents of the email sent by the user are morphologically analyzed, and the mood and the user's atmosphere of the day are determined according to the keywords that appear, and are suitable for that mood and atmosphere.
  • An appropriate advice may be selected from the selected advice group.
  • the mood of the day may be estimated based on the attribute information of the browsed web page, or the mood of the day may be estimated based on weather information or news information.
  • the mood is dark
  • the Hanshin fan is a user
  • the Hanshin Tigers wins it may be inferred that the mood is clear.
  • voice emotion estimation technology may be used. This is to infer the person's feelings and emotions with the tone of the person's voice. For example, if the tone of the voice is high, it is assumed that the person is nervous.
  • the content of the advice is not particularly limited, and not only lifestyle habits such as eating, exercising, sleeping and bathing, but also supplements may be advised.
  • FIG. 14 shows a functional block of the present invention that obtains various types of information through the network in order to select an advice.
  • the advice selection unit obtains, for example, weather forecasts, news, map information (including GPS data), mail information, mood information, etc., and holds them in the advice selection rule holding unit in order to select advice in consideration of these external information
  • the advice is selected according to the advice selection rule that has been set.
  • the advice selection rule is not limited to a form in which selection is made directly based on the degree of deviation, difference value, ratio, etc. between the life element information optimum value and the acquired life element information.
  • it may be a table usage format rule in which one or more advices are selected from a plurality of advices according to the value of the life element information. For example, when 10 (multiple) advices can be selected corresponding to one life element information, the advice is selected by random numbers, the relationship with other life element information, or information (weather,
  • the rules may be configured so that what is selected in the news, characters included in the email, like mark, mood selection, information from GPS, geographical information) is determined.
  • Curry and rice cannot be recommended when carbohydrates are restricted. However, if the user wants curry and rice, use turmeric containing curcumin, which has an anti-cancer effect, to increase the absorption of curcumin, which has a poor absorption rate. You can give advice such as “Make a coconut milk curry rich in medium chain fatty acids with rice and“ die diet rice ”with low sugar content.”
  • the current location information may be acquired by GPS and used for advice, or information on a scheduler (schedule software) built into a smartphone or the like may be used for advice.
  • a scheduler schedulingr
  • ⁇ Sleep advice> An example of advice for sleep is “Sleep is ideal for about 7 hours. It ’s a good rhythm.” “The sleep rhythm is good. The rhythm of the meal is also important for the proper movement of the body clock. “It ’s better to use indirect lighting at night.” “It ’s better to darken the lights 30 minutes to 1 hour before going to sleep.” “Let's shine in the morning when you get up! Light resets the brain and nerve clocks. "Let's eat at least 3 hours before going to bed”"Avoid seeing blue light at night”"Sleeping time tends to be a little longer.
  • Stress advice examples include: “Relax with a good quality sleep” “Half-bath has a calming effect” “Why don't you travel around Tohoku? It seems that you have been busy recently, so why don't you travel sometimes? "” There is a recommended karaoke shop nearby. You can get a reservation now. “ “It ’s a good season to move your body on an easy short course?” “Are you not sleeping enough? Sleep is ideal for about 7 hours.” “If you are frustrated, take a deep breath once. "Sho””There are plans to play golf next week. Let's send the club by courier at least 2 days in advance.””The SNS has a good reputation.””There are recommended spiritual books.
  • ⁇ Advisory for biometric data> it is desirable to acquire ph of urine as one of the biological data. This is because it has been shown that body fluids are preferable to alkaline for the prevention and improvement of cancer.
  • the acidic environment is a microenvironment that is advantageous for the activities of cancer cells, and in order to realize the acidic environment, cancer cells carry lactic acid out of the cell. Sodium is required for its transport, and sodium restriction is thought to inhibit the microenvironment suitable for cancer cells. Therefore, if you can obtain urine ph and receive advice, it will lead to cancer prevention and improvement.
  • advice on the pH of urine is listed in order from optimal to worsening. For example, “Urine ph is low and the body fluid is inclined to acidity.
  • the ratio of sodium to urine potassium in urine is desirable to acquire the ratio of sodium to urine potassium in urine as one of the biological data. Because sodium restriction inhibits the microenvironment in which cancer cells live, salt restriction and intake of potassium that excretes salt are effective, and a high ratio of sodium to urine potassium is not desirable. It is because that the amount of sodium with respect to the amount of potassium is 1 or less is effective in preventing or improving cancer.
  • the value of sodium is high. Let's eat a lot of foods that contain vegetables and potassium. “Let ’s refrain from salt.” “Potassium and sodium are good.”
  • advice group may be configured to increase the number of options in descending order of severity and output as advice . For example, if the severity is the lowest, simply “Let's not gain weight”, and if it ’s the next lowest severity, “Let's not gain weight” or “Seaweed (Wakame) , Hijiki, kelp, etc.) and let ’s take dietary fiber with vegetables ”. Examples of advice are as follows.
  • the following advice group can be used to increase the number of options in the order of severity and output as advice .
  • a configuration may be considered in which the options are increased and output as advice from the following advice groups in descending order of severity.
  • advice for eating a low-salt diet if the signs of high blood pressure are considered to be high based on comprehensive assessment of life factor information, increase the number from 1 according to the severity from the following advice group. It may be configured to output advice.
  • a configuration may be considered in which options are increased and output as advice in the order of decreasing severity from the following advice group.
  • advice on cutting carbohydrates may be output step by step. “Let's make the amount of rice 2 times a day” “Let the amount of rice 1 time a day” “Let the amount of rice half a day” “Let's refrain from eating rice” “Rice Refrain from eating root vegetables, refrain from eating rice and noodles, refrain from eating rice, noodles and flour, and refrain from eating rice, noodles and flour “Let ’s take clothes,” “Let ’s refrain from eating rice, noodles, flour, and sugar.”
  • BMI life element information
  • weight (kg) ⁇ (height (m) ⁇ height (m)) is 25 or more. Therefore, the larger the value, the more the advice given earlier is selected step by step. To do.
  • the body fat mass, body fat percentage, and lean body mass can be used as an index for determination.
  • the “advice selection rule holding unit” is an advice selection rule for selecting the held advice using the history information of the life element information and the life element information optimum value held for the life element as variables. It has a function to hold rules.
  • the “advice selection rule” is a rule for selecting the held advice using the history information of the life element information and the life element information optimum value held for the life element as variables. Basically, it is a rule for selecting appropriate advice in accordance with the deviation between the life element information acquired and accumulated and the life element information optimum value that is the optimum value of the life element. It is a rule for selecting advice that fills the divergence according to the degree of divergence and makes it fun to achieve the goal. Accordingly, each of the plurality of advices is associated with the above-described deviation degree. When the degree of divergence is large, advice that gives a strong motivation is associated, and when the degree of divergence is small, advice that can easily cause the action is associated. However, in general, giving a strong advice just because the degree of divergence is large is counterproductive, and it is desirable to give advice that gives motivation so as not to understand it.
  • the divergence may be a difference between the life element information and the life element information optimum value, a ratio with the life element information optimum value, or a predetermined weight.
  • the weighting may be designed to change from day to day. The change of weight may be determined in relation to other life element information, or may be changed according to the mood and atmosphere estimated on the day. It may also be changed depending on the circumstances such as whether the patient already has cancer, whether the cancer has been completely cured after being treated, or whether recurrence is being prevented.
  • the “advice selection unit” is configured to select an advice using the retained advice selection rule using the history information of the life element information and the life element information optimum value held for the life element as variables. Has been.
  • the advice selection rule can be changed in the same manner as the optimum value of the life factor. For example, when CTCs-biological data that the expression of cancer cells in the circulating blood is recognized as life element information or the biological data that the expression of a cancer-related gene is recognized is acquired as life element information Therefore, it is desirable to set stricter conditions for optimal values of life elements and advice selection rules. This is because it is expected to improve the quality and speed of life improvement and improve cancer.
  • This device can select advice using the advice selection rule using the history information of the single life element information stored in the life element information storage unit and the single life element information optimum value as variables.
  • This device can also select advice using advice selection rules using the history information of a plurality of life element information stored in the life element information storage unit and a single life element information optimum value as variables.
  • the present apparatus can select an advice using an advice selection rule using the history information of a plurality of life element information stored in the life element information storage unit and the plurality of life element information optimum values as variables.
  • the “advice output unit” is configured to output the advice selected by the selection unit.
  • the output may be performed on a display of a television or a smartphone as text, video (either a moving image or a still image), graphics, or the like, or may be performed by sound from a speaker or an earphone.
  • it is performed by using a QR code (registered trademark) (registered trademark) in which URL, URL information, etc., indicating the location of text, video (either moving images or still images), graphics, etc. on a server on the network are written. May be.
  • the screen may be spoken using an idol such as an animation or an avatar such as an animal, advice may be given in a manga format, or advice may be provided in a video or game format.
  • the preventive / improvement advice device is arranged as a server on the network, and a character as a user's alternation is registered in a social network such as LINE (registered trademark) or FACEBOOK (registered trademark), and the character speaks to the person himself / herself.
  • LINE registered trademark
  • FACEBOOK registered trademark
  • the advice output unit may include an output request receiving unit that receives an output request from the user. This is to allow the user to start communication, and to make the personified person feel as if he / she is a talking partner. Cancer patients are often lonely, and it is preferable to use this configuration to distract loneliness. Therefore, when communication is requested by the user, it is not always necessary to output only information related to “cancer”.
  • Such information may be provided as second advice information output means in the advice information output unit with the second advice information as output function means. If it is configured to output information that is not directly related to cancer in this way, it may be difficult to distinguish from advice related to cancer, so that you may forget that you are suffering from cancer. , Psychological resistance to the device can be reduced. Also, it is preferable that the advice output timing is not as definite as possible.
  • advice output unit has an output timing determination means.
  • a configuration in which advice is not intentionally output once every plural times using random number data or the like is also conceivable. This is because a sense closer to humans is given. In some cases, pretending to be forgotten and output advice. In other words, use a phrase such as “I didn't say it before ...”. This also avoids a series of similar advices, and can reduce the rate at which the device feels persistent to the user.
  • counseling for cognitive behavioral therapy may be recommended, and actual efforts for improvement may be actively implemented.
  • the advice output section has been described above in various ways. From the viewpoint that this device is an advice device related to "cancer", the viewpoint that it does not give stress to the user, makes the user feel friendly, and distracts the feeling of loneliness. Therefore, the form of output is very important, and it has a great difference in this respect from other devices for prevention and improvement of diseases.
  • the purpose of advice output regarding cancer is to convey advice information to the user so that countermeasures can be taken, it is desirable to output the advice information as soon as it is acquired. Therefore, for example, when the output destination is a display of a smartphone, it is desirable to output so as not to disturb the user's use of the smartphone as much as possible. For example, it is desirable to output to a part of the screen of a smartphone. Similarly, it may be displayed in a partial area of a display called a widget screen, browser screen, information screen, or the like. Alternatively, the advice information may be displayed after waiting for the user's input operation because it does not hinder the user's use of the smartphone.
  • a button or icon for displaying advice information is provided on a smartphone or personal computer, and when such a button is operated by the user, the input is received and the advice information is displayed. It can be realized by setting.
  • the advice output unit may purchase food and book activities based on the advice information.
  • the storage device ((0201) such as a hard disk or ROM device) has a life element information acquisition program, a life element information storage program, a life element information optimum value holding program, an advice holding program, and an advice selection rule holding program. , Advice selection program and advice output program are stored, and further, life element information, life element information optimum value, advice, advice selection rule, and advice selection result are held as data.
  • each program and necessary data are loaded from the storage device into the main memory (0202), and the present apparatus as a computer can be operated.
  • FIG. 3 shows the processing flow of the present apparatus.
  • the life element information is acquired (S0301), the acquired life information is stored (S0302), and the history information of the stored life element information (there may be a single life other information or decryption)
  • the advice is selected according to the advice selection rule (S0303). Then, the selected advice is output (S0304).
  • FIG. 4 is a specific example for acquiring the contents of meals (meal information) that are life element information.
  • the life element information acquisition unit is, for example, a smartphone camera, an image recognition function, and a food database according to recognition.
  • a curry rice photograph is acquired by a camera that is a life element information acquisition unit.
  • characteristic image portions features
  • foods having these feature quantities are identified on the recognition-specific food database.
  • curry rice is hit as a food having these characteristic amounts.
  • the curry and rice food ingredient database is accessed, and the food ingredients per 100 grams of curry and rice are acquired.
  • Fig. 6 shows the food ingredients of curry and rice obtained in this way.
  • the total amount of curry and rice is acquired using image recognition technology. For example, if it is assumed to be 430 grams, a value obtained by multiplying this value by 4.3 is acquired by the life element information acquisition unit. . If the image is unclear, the user can select and input the amount of rice “How many grams of rice?”.
  • FIG. 5 shows the flow of this process.
  • image recognition is performed, then feature points are extracted (ST1), a database search (ST2) is performed, and a food name is hit (ST3).
  • curry rice is a hit.
  • the amount of curry and rice is estimated (ST4), the food component and amount of 100 g of curry and rice are acquired (ST5), and the food component and amount eaten by multiplying the amount and the component are acquired (ST6). . That is, the life element information acquisition unit acquires life element information in this way.
  • the acquired life element information is sent to the life element information storage unit and stored, and is used to select advice at a scheduled timing. For example, if a rule that determines that this curry and rice is too large and excessive sugar intake is held as an advice selection rule, for example, “Today ’s dinner is conservative and omega Advice such as “Let's enjoy pasture cattle rich in 3 fatty acids” is selected by the advice selection unit, and is output to the screen of the smartphone, for example, by the advice output unit. If the meal of curry and rice is lunch, it can be scheduled to be output at around 4pm, just starting to worry about dinner.
  • FIG. 7 shows an example of acquiring exercise data as life element information.
  • FIG. 7 shows a situation where the user is walking with the momentum sensor (0701) wrapped around the arm.
  • the momentum sensor incorporates an accelerometer, a pulse meter, a sweat meter, a GPS system, etc., and these sensors function by the movement of a hand to acquire user's exercise data, and use a communication function for a smartphone.
  • the life element information acquisition unit of the smartphone cancer prevention / improvement advice device (0702) transmits the acquired exercise data as life element information to the life element information storage unit, and displays the latest exercise data on the smartphone screen. It is configured.
  • the exercise time is 138 minutes
  • the exercise amount is 210 Kcalories
  • the exercise quality is slow
  • the number of steps is 12610 steps.
  • This amount of exercise is compared with the life element information optimum value, and advice is selected at a predetermined timing by the advice selection unit and output from the advice output unit.
  • FIG. 8 shows an example of acquiring sleep data as life element information.
  • the cancer prevention / improvement advice device which is a smartphone placed at the bedside of the user (0802), has a life element information acquisition unit (0803) as a user's sleep sound, snoring sound, sneezing sound, sleep sound, etc. And obtain life element information such as sleep depth and time length from the information and the accumulated sleep database.
  • the microphone of the device collects friction sounds with the futon (0801) generated by the user's body movement, friction sounds between the futons, etc., and also obtains sleep depth, length of time, etc. as life element information from the sleep database. .
  • the acquired life element information is transferred to the life element information storage unit and stored as history information.
  • FIG. 9 is an example of life element information acquired and accumulated and displayed on a smartphone screen based on sleep data that is life element information.
  • the depth and quality of sleep are expressed on the time axis from the bedtime to the awakening time, and the sleep efficiency is displayed in comparison with the past user data.
  • the advice selection unit compares these data with the life element information optimum value, and selects and outputs an appropriate advice according to the advice selection rule. For example, on the morning of the day when it was determined that sleep was sufficient, advice such as “I was able to sleep well, let's concentrate and exercise today” is selected and output from the advice output unit.
  • FIG. 10 shows an example of acquiring stress data as life element information.
  • the response speed to the light of the user's pupil is acquired from a video camera that is a life element information acquisition unit of a cancer prevention / improvement advice device that is a smartphone, and stress data as life element information is acquired.
  • FIG. 10 shows an example in which a stress evaluation result is displayed in a calendar format as acquired life element information. This is created based on the life element information stored in the life element information storage unit.
  • FIG. 11 is a schematic diagram of the eyes for capturing changes in the pupil.
  • the portion indicated by A in the figure is gradually reduced, but this rate of reduction gradually decreases according to the amount of stress. That is, when there is a lot of stress, the light tracking performance of the pupil is deteriorated.
  • FIG. 12 is a diagram showing a flow of processing for acquiring pupil light tracking, that is, stress data, which is this life element information with a smartphone.
  • the moving image ON step S1201
  • shooting of a moving image is started.
  • the pupil needs to be photographed.
  • a configuration in which the pupil is photographed by a sound or the like that the pupil is photographed by an image recognition technique can be considered.
  • a light ON step S1202 This is a step of increasing the amount of light to narrow the pupil. Use the lighting function of the smartphone.
  • a pupil recognition step for measuring the pupil S1203
  • a pupil change calculation step S1204 for performing a time until the pupil stabilizes after seeing a predetermined contraction, or a time for contracting to a predetermined ratio
  • the time for contraction to a predetermined size is measured and converted to a stress value (stress data).
  • FIG. 13 is a diagram illustrating a specific example of acquiring body composition data as biometric data.
  • intracellular water content, extracellular water content, protein content, mineral content, body fat mass, body weight, skeletal muscle mass, BMI, body fat percentage, waist measured by body composition system (1301) ⁇ Hip ratio, muscle balance (right arm, left arm, trunk, right leg, left leg) ECW / TBW, Obesity, BCM, BMC, BMR, AC, AMC values are communication elements of cancer prevention / improvement advice device life
  • the information is acquired by the information acquisition unit (1302).
  • the captured life element information is stored in the life element information storage unit, and is compared with the life element information optimum value, or a plurality of data is synthesized to generate an evaluation value as life element information. Based on the degree of deviation from the information optimum value, advice is selected according to the advice selection rule. For example, if the body fat mass has increased more rapidly than the previous day, advice such as “Let's exercise plenty today” is selected and output.
  • FIG. 15 is a diagram for explaining a mechanism for comprehensively using meal information, exercise data, sleep data, stress data, and biological data and selecting advice in accordance with the purpose of carbohydrate restriction.
  • the sugar intake is the optimal value 100
  • the exercise amount is the optimal value 50
  • the sleep rhythm is the optimal value 50
  • the stress amount (stress evaluation result) is the optimal value 60
  • the blood glucose level is
  • the optimum value 120, the acquired value 173, the deviation degree +53, and the evaluation formula is an evaluation formula as shown in the figure
  • the life element information optimum value represented by the evaluation formula is 0, based on the evaluation formula Since the life element information is ⁇ 171, the advice G is selected based on the advice selection rule in the lower part of the figure.
  • the following system can be considered as a system for improving the advice accuracy by the big data processing.
  • the life element information storage unit calculates the average value, the variance, the deviation value of each data, the t distribution, F based on the past numerical value.
  • the cancer prevention / improvement advice device according to claim 1, further comprising first statistical processing means for obtaining a distribution and a chi-square distribution.
  • a life element for acquiring a life element information cross-correlation coefficient that is a correlation coefficient between the life element information accumulated in the life element information storage unit A cancer prevention / improvement advice device based on the eighth invention further having an information cross-correlation coefficient acquisition unit is proposed.
  • the advice selection rule holding unit has an average value, a variance, a deviation value of each time of data obtained by the first statistical processing means of the life element information storage unit, and t
  • a cancer prevention / improvement advice device based on the eighth to ninth inventions having advice first selection rule changing means for changing based on distribution, F distribution, and chi-square distribution is proposed.
  • the life element information storage unit in each of the devices of the eighth to ninth inventions accumulates life element information acquired in association with the advice output from the advice output unit.
  • a cancer prevention / improvement advice device further comprising an information storage means and an advice life element information correlation coefficient acquisition unit for acquiring an advice life element information correlation coefficient that is a correlation coefficient between the associated advice and life element information suggest.
  • the advice selection rule holding unit based on the eleventh invention as the twelfth invention the advice life element information correlation acquired by the advice life element information correlation coefficient acquisition unit for the held advice selection rule
  • a cancer prevention / improvement advice device having a second advice selection rule changing means that changes based on the number is proposed.
  • the cancer prevention / improvement advice device described in 1), the history information acquisition unit that acquires the history information output from the history information output unit via the network, and the life information obtained by statistically processing the acquired history information A cancer prevention / improvement advice system comprising a central server having a central server correlation coefficient calculation unit for calculating the number of relationships and a central server correlation coefficient output unit for outputting the calculated correlation coefficient is proposed.
  • the central server obtains the average value, variance, deviation value of each data, t distribution, F distribution, and chi-square distribution of each life element information based on the acquired history information.
  • a cancer prevention / improvement advice system based on the thirteenth invention having the second statistical processing section is proposed.
  • the central server is held in the advice selection rule holding unit of each cancer prevention / improvement advice device based on the correlation coefficient calculated by the central server correlation coefficient calculation unit.
  • Advice selection instruction acquisition unit that acquires an advice selection rule change instruction that is an instruction for changing the advice selection rule, and advice selection rule change that outputs the acquired advice selection rule change instruction to each cancer prevention / improvement advice device
  • Each cancer prevention / improvement advice device has an advice selection rule change instruction acquisition unit that acquires an advice selection rule change instruction output from the advice selection rule change instruction output unit.
  • the address held in the advice selection rule holding unit We propose and advice selection rule changing unit for changing the chair selection rule, the thirteenth or fourteenth Cancer Prevention and improvement advice system further comprises a.
  • the cancer prevention / improvement advice device in this embodiment acquires life element information, which is information indicating the user's physiological activities and health levels, from the user, and associates the acquired life element information with advice information corresponding to the acquisition time. Accumulated as history information, life element information is evaluated using life element information optimum values that are the optimum values of each life element for the purpose of cancer prevention and improvement, and evaluation results are obtained. Learning the relationship with the advice information corresponding to the life element information, and using the advice selection rule, which is a rule for selecting an advice for approaching the optimum value, from the plurality of life element information history information This is a device that selects advice using the life element information optimum value held in the life element as a variable and outputs the selected advice. Furthermore, it may be configured to record new advice.
  • the cancer prevention / improvement advice device includes a life element information acquisition unit (1601), a life element information storage unit (1602), a life element information evaluation unit (1603), and an advice result learning unit (1604).
  • the life element information accumulating unit is a function of accumulating acquired life element information as history information in association with advice information output later, corresponding to the acquisition time of the life element information. Unlike the life element information storage unit in the above-described embodiment, it is stored as history information “in association with advice information output later, corresponding to the acquisition time of the life element information”.
  • the history information may be for a long period of the past 5 years, 3 years, or 1 year, or may be a medium period such as 1 month, 2 weeks, or 1 week, or a short period of only the most recent time. It's okay. Thereby, learning using AI (artificial intelligence) can be performed.
  • the life element information evaluation unit is a function for evaluating life element information using the life element information optimum value described later and obtaining an evaluation result.
  • the evaluation result obtained here is used for learning the relationship with the advice information.
  • the advice result learning unit is a function for learning the relationship between the evaluation result and the advice information corresponding to the evaluated life element information. For example, the correlation is analyzed from the aspect of the effect of approaching the optimum value of the life element information from the change of the advice content and the accumulated life element information, and the advice having a large effect is learned from the analysis result.
  • the advice selection rule holding unit is a rule for selecting the held advice using the history information of the life element information, the life element information optimum value held in the life element, and the learning result. This is a function for holding an advice selection rule.
  • the advice selection rule is changed based on the content learned in the advice result learning unit. Thereby, the accuracy of advice can be improved.
  • the advice selection unit is a function for selecting advice using the held advice selection rule using the history information of the life element information and the life element information optimum value held for the life element as variables.
  • FIG. 17 is a diagram illustrating a specific process for selecting an advice.
  • life element information will be described as a BMI value.
  • the optimum value of the life element information of the BMI value is 18.5 to 25.0.
  • the advice that is held is “(1) Eat vegetables first” “(2) Eat regular meals” “(3) Keep the total number of calories under 2000 Kcal / day” “(4 ) Decrease the amount of sugar ”“ (5) Drink sake less than once a week ”“ (6) Cut sugar ”“ (7) Fast one day a week "(8) Please eat a lot of meat”.
  • a new advice recording unit for recording new advice in the advice holding unit may be further included. By doing so, it is possible to automatically record appropriate advice when it is considered that advice other than the existing advice is appropriate as a result of learning. By doing so, more optimal advice is included in the advice selected by the advice selection unit, and the accuracy of the advice to be output can be further improved.
  • the measuring method and the input method of the life element information are not particularly limited, and for example, the configuration may be such that data is obtained by an external measuring device of the device of the present invention and the data is received by the device of the present invention.
  • supplements and medicines that are ingested may be configured so that supplements and medicines can be identified by camera recognition.
  • the life element information acquired from the life element information includes physical measurement results (BMI, abdominal circumference, visceral fat, body fat percentage), physical condition inspection results (blood pressure, visual acuity, intraocular pressure, lung function, hearing ability). Hair condition), urine test results, stool test results, stool frequency, stool color, stool properties, blood biochemical test results, serological test results, tumor marker test results, diabetes test results, cytological test results, Fundus camera test result, breast test result, ultrasound test result, digestive tract test result, chest X-ray test result, CT test result, MRI test result, PET test result, rectal diagnostic test result, rectal temperature, electrocardiogram test result, balance function It may be any one or more of test results, atherosclerosis evaluation results, osteoporosis test results, female hormone test results, risk marker test results, and genetic information.
  • BMI abdominal circumference, visceral fat, body fat percentage
  • physical condition inspection results blood pressure, visual acuity, intraocular pressure, lung function, hearing ability. Hair condition
  • urine test results stool test results, stool
  • Specific urinalysis results include urinary protein, urine sugar, urinary occult blood reaction, presence / absence of urinary bilirubin, urinary urobilinogen, urine pH value, urinary sediment value, etc. It is also possible to provide a measuring device so that the measurement is carried out when adding. Stool test results include the presence or absence of occult blood reactions and the presence or absence of parasites. In addition, the number of stools, color, and properties may be obtained by acquiring an image taken with a camera device.
  • Blood biochemical test results include total protein, albumin, cholinesterase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, total bilirubin, amylase, urea nitrogen , Creatinine, creatine kinase, total cholesterol, neutral fat, HDL cholesterol, LDL cholesterol, uric acid, sodium, potassium, chlor, calcium, inorganic phosphorus, serum iron, and unsaturated iron binding capacity.
  • Serological test results include the presence and amount of antibodies that resist bacteria and foreign bodies, the contents of allergens, and the presence or absence of immune abnormalities.
  • Tumor marker test results include CA125, CA19-9, CEA, ⁇ -fetoprotein (AFP), ferritin, PSA (prostate specific antigen), TPA, and the like.
  • Diabetes test results include fasting blood glucose levels, 2-hour glucose levels, ad libitum blood glucose levels, and HbA1c levels. Examples of cytodiagnosis results include whether the sample belongs to a classification such as NILM, ASC-US, ASC-H, LSIL, HSIL, or SCC.
  • Fundus camera test results include enlarged papillary depression, reticular retinal fundus, rigid vitiligo, drusen, suspected glaucoma, bleeding, glaucoma, suprachoroidal atrophy, suspected cataract, crossover phenomenon, cataract, suspected bleeding, vitiligo, retinal degeneration , Meandering, preretinal membrane, suspected macular degeneration, macular findings, conus, abnormalities such as papillary findings and content.
  • Breast examination results include findings such as calcification, mass, and local asymmetric shading. Mammograms include mammary cysts, breast fibroadenoma, calcification, mass, duct dilatation, mastitis, and mastopathy.
  • the results of gastrointestinal examination include achalasia, esophageal varices, esophageal hiatal hernia, gastric drooping / stomach stomach, atrophic gastritis, erosive gastritis, raised lesion / translucent image, depressed lesion / Nissi, mucosal irregularity, fold concentration Presence of marginal irregularities, exclusion, diverticulum, ulcer scars, presence of H. pylori antibodies, and pepsinogen concentration.
  • Chest X-ray examination results include the presence or absence of abnormal shadows.
  • CT test results examples include CT test results, MRI test results, PET test results, rectal diagnostic test results, electrocardiogram test results, arteriosclerosis evaluation results, and risk marker test results include the presence and content of abnormal findings.
  • Equilibrium function test results include the presence / absence, degree, and tendency to fall in the body when the eyes are open and closed, and the results of observation of differences between the open and closed eyes.
  • Osteoporosis test results include bone density, bone microstructure, speed of bone turnover, presence or absence of microfracture, density of calcification.
  • Female hormone test results include estradiol levels, gonadotropin LH and FSH levels, and prolactin levels.
  • the life element information acquired from the life element information includes daily life information, such as the light quality and brightness of the living environment, the noise level of the living environment, the room temperature of the living environment, the humidity of the living environment, and the light of the working environment.
  • light quality and brightness include values such as luminous flux [lm: lumen], luminous intensity [cd: candela], luminance [cd / m 2 : candela / square meter], and illuminance [lx: lux].
  • Examples of the amount of noise include a Pascal (Pa) indicating a physical quantity indicating the loudness (pressure), a decibel (dB) indicating a sound pressure level, and the like.
  • Pa indicating a physical quantity indicating the loudness (pressure)
  • dB decibel
  • the contents of meals there are combinations such as meals, instants, retorts, home-cooked foods, and family restaurants.
  • Dietary food components and amounts include energy, water, protein, protein with amino acid composition, lipid, triacylglycerol equivalent, saturated fatty acid, monounsaturated fatty acid, polyunsaturated fatty acid, cholesterol, carbohydrate, water-soluble food Fiber, insoluble dietary fiber, ash, sodium, potassium, calcium, magnesium, phosphorus, iron, zinc, copper, manganese, iodine, selenium, chromium, molybdenum, vitamin A (retinol, ⁇ -carotene, ⁇ -carotene, ⁇ -crypt) Xanthine, ⁇ -carotene equivalent, retinol activity equivalent), vitamin D, vitamin E ( ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocopherol, ⁇ -tocopherol), vitamin K, vitamin B 1 , vitamin B 2 , vitamin niacin, vitamin B 6, vitamin B 12, Glutamic folic acid, vitamin pantothenic acid, vitamin Pio Chin
  • Intake supplements include vitamin A, vitamin B, vitamin C, vitamin D, vitamin E, vitamin H, vitamin K, vitamin P, vitamin U, cobalamin, zinc, iron, copper, chromium, selenium, magnesium, calcium, Potassium, sodium, cobalt, molybdenum, iodine, phosphorus, MSM, tryptophan, threonine, leucine, isoleucine, lysine, methionine, phenylalanine, histidine, asparagine, serine, proline, glutamine, tyrosine, DNA, ⁇ -linolenic acid, EPA, DHA, Arachidonic acid, gamma linolenic acid, DNJ, green juice, egg yolk choline, maiko, hemp yellow, red yeast rice, germinated brown rice, lactic acid bacteria, natto, natto, rice ginseng, ginseng, evening primrose, phytosterol, purple syrup, linseed oil , Gin
  • the quality of sleep includes sleep time.
  • Specific types of exercise include aerobic and anaerobic exercise, specific exercise content such as stretching and muscle training.
  • the amount of exercise includes exercise time and calorie consumption.
  • the quality of work includes the type of work such as whether it is a clerical job or a sales job, and the type of job related to the importance of roles and responsibilities.
  • the amount of work includes work time and the amount of deliverables.
  • the amount of movement at work includes the distance traveled and the time required for movement.
  • the quality of commuting includes different types of commuting and the degree of congestion in the case of trains, for example.
  • the quality and quantity of training to maintain and enhance physical fitness include training content, training time and frequency.
  • the quality and quantity of city walking includes the location and speed of city walking, time and frequency.
  • Examples of the quality and quantity of shopping include the location of shopping, the contents of purchased products, the quantity and price of purchased products, and the like.
  • the quality and quantity of contact with the natural environment includes the content, frequency, and time of the animals and plants that are in contact.
  • the quality and quantity of entertainment includes the contents of the entertainment, the contents of the winning and losing if there is a win or loss, the frequency of entertainment, and the time / cost spent.
  • the quality and quantity of friendships and marital relationships include contact and contact frequency, contact content, conversation content, and contact time.
  • the quality and quantity of the accident includes the details of the accident, the presence and content of the injury and illness, the classification of the perpetrator / victim of the accident, the content of the other party's response, and the frequency of the accident.
  • the quality and quantity of learning for qualification includes the difficulty of the qualification examination, the degree of influence that qualification has on life, whether or not goals are achieved, and the amount of learning.
  • the life element information acquired by life element information is illness / injury information, depending on the quality and quantity of the injuries / illnesses, the type and quantity of medicines taken in accordance with the injuries / illnesses, and the injuries / illnesses.
  • the information may be one or more of the quality and quantity of the bandage.
  • the life element information acquired from the life element information is mental state information, such as user voice quality, user voice volume, user utterance volume, autonomic state, user feeling, satisfaction of sex life.
  • mental state information such as user voice quality, user voice volume, user utterance volume, autonomic state, user feeling, satisfaction of sex life.
  • Image to hold things, mood when getting up, mood when sleeping, mood during sleep, mood during work, mood during holiday, mood during defecation, temperature during sensation, temperature of hands and feet, It may be one or more pieces of information on ease of breathing.
  • the voice quality of the user includes voice pitch, elasticity, and nose.
  • the loudness of the user's voice can be measured in units of db (decibel).
  • Autonomic states include sympathetic dominant and parasympathetic dominant.
  • the user's feelings include comfort / discomfort and positive / negative.
  • the degree of satisfaction with the sex life may be quantified, or may be ranked as “dissatisfied”, “normal”, “satisfied”, “very satisfied” or the like.
  • Images of things include emotions such as joy, anger, grief, comfort, love, compassion, evil, and greed.
  • Pleasure / discomfort may be quantified as the mood when waking up, the mood when falling asleep, the mood during sleep, the mood during work, the mood during holidays, the mood during meals, and the mood during defecation.
  • the temperature at the end of the limbs may be measured by thermography.
  • Gene information may be acquired. Some genes have a particular tendency, such as being prone to cancer. For this reason, it is desirable to select advice that takes this genetic information into account when selecting advice. Even in the advice selection rules that are held, the history information of life element information and the life element information that holds the life element are optimal. In addition to the value, it is desirable that gene information is also ruled as a variable.
  • FIG. 18 is a diagram illustrating an example of gene information.
  • the gene “ ⁇ 3AR (Trp64Arg)” reduces fat breakdown and heat production, and the basal metabolic rate is 200 Kcal (150 Kcal lower than the standard) and fat.
  • ⁇ Life element information optimal value ⁇ 19A to 19D are diagrams illustrating specific examples of the life element information optimum values.
  • a high value is “less than 120”, unsuitable, “120-130” is a standard range, “greater than 130” is unsuitable, and a low value is “less than 80” Inappropriate, “80 to 85” is unsuitable for standard range, and “over 85” is unsuitable.
  • visual acuity “less than 0.7” is inappropriate, and “0.7 to 2.0” is the standard range.
  • intraocular pressure “less than 10 mmhg” is unsuitable, “10-20 mmhg” is unsuitable for the standard range, and “over 20 mmhg” is unsuitable.
  • % vital capacity less than 80, 1 second rate less than 70% is unsuitable, and “% vital capacity 80 or more, 1 second rate of 70% or more” is a standard range.
  • urinary albumin “less than 30 mg / g” is unsuitable for the standard range and “30 mg / g or more”.
  • the total bilirubin is unsuitable for “less than 0.2 mg / dl”, “0.2 to 1.2 mg / dl” for the standard range, and “over 1.2 mg / dl” for the total bilirubin.
  • Kunkel test “less than 2.0” is unsuitable, “2.0 to 12.0” is unsuitable for the standard range, and “over 12.0” is unsuitable.
  • cholinesterase it is unsuitable if it is “less than 213 IU / I”, it is unsuitable if it is “213 to 501 IU / I”, and it is unsuitable if it is “over 501 IU / I”.
  • amount of intracellular water “less than 24.6” is inappropriate, “24.6 to 30.0” is unsuitable for the standard range, and “over 30.0” is unsuitable.
  • amount of extracellular water “less than 15.1” is unsuitable, “15.1 to 18.5” is unsuitable for the standard range, and “over 18.5” is unsuitable.
  • the amount of protein “less than 10.6” is unsuitable, “10.6 to 13.0” is unsuitable for the standard range, and “greater than 13.0” is unsuitable.
  • the amount of minerals “less than 3.67” is unsuitable, “3.67 to 4.49” is unsuitable for the standard range, and “over 4.49” is unsuitable.
  • the amount of body fat “less than 8.5” is inappropriate, “8.5 to 16.9” is unsuitable for the standard range, and “over 16.9” is unsuitable.
  • body weight “less than 60.0” is unsuitable, “60.0 to 81.2” is unsuitable for the standard range, and “over 81.2” is unsuitable.
  • skeletal muscle mass “less than 30.3” is unsuitable, “30.3-37.0” is unsuitable for the standard range, and “greater than 37.0” is unsuitable.
  • BMI “less than 18.5” is unsuitable, “18.5 to 25.0” is unsuitable for the standard range, and “greater than 25.0” is unsuitable.
  • body fat percentage “less than 10.0” is unsuitable, “10.0 to 20.0” is unsuitable for the standard range, and “greater than 20.0” is unsuitable.
  • waist-hip difference “less than 0.75” is unsuitable, “0.75 to 0.85” is unsuitable for the standard range, and “over 0.85” is unsuitable.
  • AST “35 IU / I or less” is not suitable for the standard range and “35 IU / I or more” is not suitable.
  • ALT “40 IU / I” is not suitable for the standard range, and “over 40 IU / I” is inappropriate.
  • total cholesterol “less than 140 mg / dl” is unsuitable, “140 to 219 mg / dl” is unsuitable for the standard range, and “greater than 219 mg / dl” is unsuitable.
  • neutral fat “less than 30 mg / dl” is unsuitable, “30 to 149 mg / dl” is unsuitable for the standard range, and “greater than 149 mg / dl” is unsuitable.
  • HDL cholesterol As for HDL cholesterol, it is unsuitable if it is “less than 40 mg / dl”, it is inappropriate if it is “40 to 119 mg / dl”, and it is unsuitable if it is “above 119 mg / dl”.
  • LDL cholesterol it is unsuitable if it is “less than 60 mg / dl”, it is unsuitable if it is “60 to 139 mg / dl”, and it is unsuitable if it is “over 139 mg / dl”.
  • Thyroid-stimulating hormone is unsuitable for “less than 0.54 ⁇ U / ml”, “0.54 to 4.54 ⁇ U / ml” for the standard range, and unsuitable for “over 4.54 ⁇ U / ml” .
  • serum iron “less than 40 ⁇ g / dl” is unsuitable, “40-199 ⁇ g / dl” is unsuitable for the standard range, and “over 199 ⁇ g / dl” is unsuitable.
  • hemoglobin it is inappropriate for men to be “less than 13.1 g / dl”, “13.1 to 17.9 g / dl” to be in the standard range, and “17.9 g / dl” to be inappropriate.
  • women “less than 12.1 g / dl” is unsuitable, “12.1 to 15.9 g / dl” is unsuitable for the standard range, and “15.9 g / dl” is unsuitable. is there.
  • hematocrit it is inappropriate for men to be “less than 38.5%”, “38.5 to 52.8%” to be in the standard range, and “more than 52.8%” to be inappropriate, In the case of women, “less than 35.5%” is unsuitable, “35.5-46.9%” is unsuitable for the standard range, and “over 46.9%” is unsuitable.
  • CEA “5.0 ng / ml or less” is unsuitable for the standard range, and “above 5.0 ng / ml” is unsuitable.
  • ⁇ -FP “0 to 10 ng / ml” is unsuitable for the standard range and “greater than 10 ng / ml”.
  • CA19-9 it is unsuitable if it is “37 U / ml or less” and it is “standard range” or “above 37 U / ml”.
  • CA125 female
  • 35 U / ml or less is inappropriate for the standard range and “above 35 U / ml”.
  • CA15-3 female
  • “30 U / ml or less” is inappropriate for the standard range, and “above 30 U / ml”.
  • PSA “0 to 4.0 ng / ml” is unsuitable for the standard range, and “over 4.0 ng / ml”.
  • the gastrin releasing peptide precursor “less than 46.0 pg / ml” is unsuitable for the standard range and “46.0 pg / ml or more”.
  • cytokeratin 19 fragment it is unsuitable if it is “3.5 ng / ml or less” and it is “standard range” or “above 3.5 ng / ml”.
  • SCC “2.0 ng / ml or less” is unsuitable for the standard range and “over 2.0 ng / ml”.
  • NSE “10.0 ng / ml or less” is unsuitable for the standard range, and “over 10.0 ng / ml” is unsuitable.
  • the storage device ((2001), eg, hard disk, ROM device) has a life element information acquisition program, a life element information storage program, a life element information optimal value holding program, a life element information evaluation program, and an advice result learning.
  • Program, advice holding program, advice selection rule holding program, advice selection program, advice output program are stored, and life element information, life element information optimum value, evaluation result, learning result, history information, advice information, advice Selection rules and advice selection results are retained.
  • each program and necessary data are loaded from the storage device to the main memory (2002), and the present apparatus as a computer can be operated. Furthermore, a new advice recording program for recording new advice may be stored.
  • FIG. 21 is a diagram showing the flow of processing in the present embodiment.
  • the flow of processing in this embodiment includes a life element information acquisition step (S2101), an advice selection step (S2102), an advice output step (S2103), a life element information evaluation result acquisition step (S2104), and advice result learning. It consists of a step (S2105) and a history information accumulation step (S2106).
  • the life element information acquisition step is a stage in which life element information, which is information that affects the physiological activity of the user and / or information indicating the health level of the user, is acquired from the user.
  • the advice selection step is a stage in which advice is selected using the retained advice selection rule using the history information of the life element information and the life element information optimum value held for the life element as variables.
  • the advice output step is a stage for outputting the advice selected in the advice selection step.
  • the life element information evaluation result acquisition step is a stage in which life element information is evaluated using the life element information optimum value to obtain an evaluation result.
  • the advice result learning step is a step of learning the relationship between the evaluation result and the advice information corresponding to the evaluated life element information.
  • the history information accumulation step is a step of accumulating the acquired life element information as history information in association with the output advice information corresponding to the acquisition time of the life element information.
  • the process After the history information accumulation step, the process returns to the advice selection step based on the learning result and history information, and these steps are repeated.

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JP7069959B2 (ja) 2018-03-29 2022-05-18 セイコーエプソン株式会社 生体情報測定機器、および生体情報処理方法
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