WO2017104664A1 - Composition liquide à usage oral - Google Patents

Composition liquide à usage oral Download PDF

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Publication number
WO2017104664A1
WO2017104664A1 PCT/JP2016/087068 JP2016087068W WO2017104664A1 WO 2017104664 A1 WO2017104664 A1 WO 2017104664A1 JP 2016087068 W JP2016087068 W JP 2016087068W WO 2017104664 A1 WO2017104664 A1 WO 2017104664A1
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WO
WIPO (PCT)
Prior art keywords
mass
component
less
liquid oral
sodium
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PCT/JP2016/087068
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English (en)
Japanese (ja)
Inventor
陽介 内野
Original Assignee
花王株式会社
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Application filed by 花王株式会社 filed Critical 花王株式会社
Priority to CN201680069781.7A priority Critical patent/CN108289800B/zh
Priority to JP2017556072A priority patent/JP6742339B2/ja
Publication of WO2017104664A1 publication Critical patent/WO2017104664A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Definitions

  • the present invention relates to a liquid oral composition.
  • Patent Document 1 discloses an oral cleansing agent having a pH of 8 or more and 12 or less to which calcium ions, phosphate ions, or bicarbonate ions are added, and in order to suppress dental decalcification, The film removal effect is enhanced.
  • Patent Document 2 discloses an oral composition having a pH of 8.0 or more, which contains a fragrance and uses a block copolymer type nonionic surfactant and an amphoteric surfactant in combination. Solubilization and stabilization over time are aimed at.
  • Patent Document 3 discloses a whitening agent containing a carbonate such as sodium carbonate or sodium hydrogen carbonate as a whitening component, thereby realizing safe and simple tooth whitening.
  • Patent Document 1 JP 2008-1657 (Patent Document 2) JP 10-77217 (Patent Document 3) JP 2014-152166
  • the present invention includes the following components (A), (B) and (C): (A) One or more carbonates selected from sodium hydrogen carbonate, sodium carbonate, and sodium sesquicarbonate Carbonate equivalents of 0.1% by mass or more and 2% by mass or less (B) Anionic surfactant 0.2 (C) Water 60 mass% or more and 99.5 mass% or less are contained, and content of a polyvalent metal cation (D) is 0.1 time mole with respect to a component (A). The value ((A) ⁇ (B)) of the product of the carbonic acid equivalent amount of component (A) and the content of component (B) (0.9) is 0.9 or less, and the pH at 25 ° C. is 8.5.
  • the present invention relates to a liquid oral composition that is 10.5 or less.
  • the present invention relates to a liquid oral composition that is excellent in the effect of removing colored stains while maintaining a good feeling of use.
  • the present inventor has made various studies, and has focused on the fact that the continuous supply of hydroxide ions (OH ⁇ ) greatly contributes to the removal of colored stains. It was newly found out that it is effective to use a specific carbonate having an ability. Then, the present inventor specified a specific amount and a specific amount of one or more carbonates selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate in the presence of a specific amount of water and an anionic surfactant, respectively. Liquid oral cavity excellent in the effect of removing colored stains while maintaining a good feeling of use by adjusting to a specific alkaline pH region while limiting the content of the polyvalent metal cation in combination to show the product value of It came to discover that the composition for use was obtained.
  • composition for liquid oral cavity of the present invention it is effective to prevent the expression of harmfulness due to enhancement of irritation to gingiva and oral mucosa, and the decrease in flavor due to bitterness etc.
  • the composition for liquid oral cavity of this invention contains 1 type, or 2 or more types of carbonate chosen from sodium hydrogencarbonate, sodium carbonate, and sodium sesquicarbonate as a component (A). These carbonates both have a buffer capacity and can be used as a pH adjuster. In the present invention, these carbonates are selected from sodium hydrogen carbonate, sodium carbonate, and sodium sesquicarbonate as component (A). One kind may be used, and more preferably, a carbonate selected from sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate is blended and contained.
  • a carbonate selected from sodium bicarbonate and sodium carbonate, and sodium sesquicarbonate uses a mixture of sodium bicarbonate and sodium carbonate, or uses sodium sesquicarbonate alone, or sodium bicarbonate, Either embodiment of using sodium carbonate or sodium sesquicarbonate is used.
  • a component (A) the buffering ability of each component is sufficiently exerted, and hydroxide ions are continuously supplied in the oral cavity, and the pH is adjusted to a predetermined alkaline region as described later. It is possible to sufficiently exhibit the effect of effectively removing the colored stains adhering to the tooth surface and the like while the feeling of use is good.
  • this component (A) it is preferable to use sodium hydrogen carbonate and sodium carbonate together from the viewpoint of enhancing the effect of removing colored stains.
  • the content of the component (A) is 0.1% by mass or more in terms of carbonic acid (H 2 CO 3 ) in the liquid oral composition of the present invention, from the viewpoint of securing a high effect of removing colored stains.
  • it is preferably 0.15% by mass or more, more preferably 0.18% by mass or more, and further preferably 0.20% by mass or more.
  • the content of the component (A) is 2 masses in terms of carbonic acid in the liquid oral composition of the present invention from the viewpoint of suppressing harmfulness in gingiva and oral mucosa and securing the flavor.
  • % Or less preferably 1.5% by mass or less, more preferably 1.3% by mass or less, still more preferably 1.0% by mass or less, and still more preferably 0.6% by mass.
  • the content of the component (A) is 0.1% by mass or more and 2% by mass or less, preferably 0.15 to 1.5% by mass in terms of carbonic acid in the liquid oral composition of the present invention. %, More preferably 0.18 to 1.3% by mass, still more preferably 0.20 to 1.0% by mass, and still more preferably 0.20 to 0.6% by mass.
  • the liquid oral composition of the present invention contains 0.2% by mass or more and 1.7% by mass or less of an anionic surfactant as the component (B).
  • an anionic surfactant as the component (B).
  • Examples of the component (B) include alkyl sulfate esters such as sodium alkyl sulfate, acyl amino acid salts such as sodium acyl glutamate and acyl sarcosine sodium, N-methyl long chain acyl taurine sodium salts such as sodium laurylmethyl taurate, alkyl Examples thereof include one or more selected from alkyl phosphates such as sodium phosphate, higher fatty acid sulfonated monoglyceride salts, fatty acid ester salts of isethionic acid, and polyoxyethylene monoalkyl phosphates.
  • alkyl sulfate esters such as sodium alkyl sulfate
  • acyl amino acid salts such as sodium acyl glutamate and acyl sarcosine sodium
  • N-methyl long chain acyl taurine sodium salts such as sodium laurylmethyl taurate
  • alkyl Examples thereof include one or more selected from alkyl phosphates such as sodium phosphate,
  • sodium alkyl sulfate examples include sodium alkyl sulfate having a saturated or unsaturated alkyl group having 8 to 18 carbon atoms. From the viewpoints of solubility, manufacturability, and feeling of use, 10 to 10 carbon atoms can be used.
  • Sodium alkyl sulfate having 14 saturated or unsaturated alkyl groups is preferable, more specifically, one or two selected from sodium lauryl sulfate and sodium myristyl sulfate is more preferable, and sodium lauryl sulfate is more preferable.
  • the content of the component (B) is 0.2% by mass or more, preferably 0.4% by mass or more, in the liquid oral composition of the present invention, from the viewpoint of effectively enhancing the effect of removing colored stains. And more preferably 0.5% by mass or more.
  • content of a component (B) is 1 in the composition for liquid oral cavity of this invention from a viewpoint which suppresses harmfulness etc. in a gum and a mucous membrane in an oral cavity effectively, and a viewpoint which maintains favorable flavor. It is 7 mass% or less, Preferably it is 1.6 mass% or less, More preferably, it is 1.5 mass% or less, More preferably, it is 1.2 mass% or less, More preferably, it is 1.0 It is below mass%.
  • the content of the component (B) is 0.2% by mass or more and 1.7% by mass or less, preferably 0.4 to 1.6% by mass in the liquid oral composition of the present invention. More preferably 0.5 to 1.5% by mass, still more preferably 0.5 to 1.2% by mass, and still more preferably 0.5 to 1.0% by mass.
  • the value ((A) ⁇ (B)) of the product of the carbonic acid equivalent amount of the component (A) and the content of the component (B) (A) ⁇ (B) has a good use feeling due to the high removal effect and harmful effect of colored stains. Is 0.9 or less, preferably 0.8 or less, more preferably 0.5 or less, still more preferably 0.4 or less, and preferably 0.8 or less. It is 08 or more, more preferably 0.10 or more.
  • the value ((A) ⁇ (B)) of the product of the component (A) in terms of carbonic acid and the content of the component (B) (0.9) is 0.9 or less, preferably 0.08 to 0.9.
  • the product of the carbonic acid equivalent amount of the component (A) and the content of the component (B) is a product of the values expressed in mass% in 100 mass% of the respective compositions.
  • the component (A) has a characteristic of increasing the risk that the pH value of the liquid oral composition mainly exceeds a specific alkali region described later or the flavor is lowered as the carbonic acid equivalent amount increases.
  • the content of the component (B) increases not only because it is mainly toxic, but also has a property of increasing the risk that the flavor is impaired and the feeling of use is reduced.
  • the present inventor considers the properties of the component (A) and the component (B), and in the liquid oral composition, in order to achieve both an excellent effect of removing colored stains and a good feeling of use, In addition to containing (A) and component (B) in the above-mentioned specific amounts, it is an excellent colored stain that the product value of these contents ((A) ⁇ (B)) is in the above-mentioned specific range.
  • the present inventors have found that it is very effective in securing both the removal effect and good usability.
  • the total amount of the component (A) in terms of carbonic acid and the content of the component (B) is preferably 0.5 mass in the liquid oral cavity composition of the present invention from the viewpoint of effectively enhancing the effect of removing colored stains. % Or more, more preferably 0.55 mass% or more, still more preferably 0.7 mass% or more, and even more preferably 0.75 mass% or more.
  • the total amount of the component (A) in terms of carbonic acid and the content of the component (B) is from the viewpoint of effectively suppressing harmfulness in the gums and the oral mucosa, and maintaining a good flavor.
  • composition for liquid oral cavity of the invention it is preferably 2.4% by mass or less, more preferably 2.2% by mass or less, further preferably 2.0% by mass or less, and still more preferably 1%. .6% by mass or less.
  • the total amount of the component (A) in terms of carbonic acid and the content of the component (B) is preferably 0.5 to 2.4% by mass in the liquid oral composition of the present invention, more preferably. Is 0.55 to 2.2% by mass, more preferably 0.7 to 2.0% by mass, and still more preferably 0.75 to 1.6% by mass.
  • the liquid oral composition of the present invention contains 60% by mass or more and 99.5% by mass or less of water as the component (C).
  • the water of component (C) in the present invention includes not only purified water and ion exchange water blended in the liquid oral composition, but also water contained in each blended component in the liquid oral composition. Means the total moisture contained.
  • each component can be dispersed or dissolved satisfactorily, and the liquid oral composition can be diffused well throughout the oral cavity even during use. The effect of removing colored stains can be exhibited.
  • the entire oral cavity is obtained by rinsing for a certain period of time in the oral cavity as in the present invention.
  • a liquid oral composition that is easy to apply while maintaining the content of each component as much as possible is preferable.
  • Content of a component (C) is 60 mass% or more in the liquid oral cavity composition of this invention from a viewpoint of disperse
  • the content of the polyvalent metal cation (D) is less than 0.1-fold mol with respect to the component (A).
  • a polyvalent metal cation limits the content of the composition for liquid oral cavity according to the present invention because it may render the component (A) insoluble or reduce the effect of removing colored stains.
  • the total content of the polyvalent metal cation was measured by an ICP emission analysis method (ICP emission analysis apparatus: PerkinmElmer OptimaD5300 DV), and was less than 0.1-fold mol with respect to the carbonic acid equivalent of component (A). The amount is preferably 0.02 times mol or less.
  • the liquid oral composition of the present invention it is desirable not to contain a component that supplies a polyvalent metal cation such as aluminum, calcium, magnesium, iron, zinc or the like. It may not contain a metal cation.
  • the polyvalent metal cation described above is a component containing a polyvalent metal, for example, an insoluble polyvalent metal salt, and even if it is present in the composition as a granular material, the component (A) of the present invention can be used. There is a tendency to reduce the effect. For example, even an abrasive powder such as aluminum hydroxide supplies aluminum ions into the liquid oral composition.
  • the liquid oral composition of the present invention contains a polyvalent metal salt
  • a small amount of cations are supplied to the water contained in the liquid oral composition, or the polyvalent metal salt and component (A) It is thought that the component (A) is adsorbed also by the contact of, thereby causing a decrease in the performance of removing colored stains due to the component (A).
  • the term “granular body” is a general term for abrasive powders and granules, and means abrasive powders and granules exhibiting granules having an average particle diameter of 5 to 800 ⁇ m.
  • the abrasive powder is a powder that can function as an abrasive.
  • examples of the abrasive powder include, in addition to the above-described aluminum hydroxide, dicalcium phosphate, tricalcium phosphate, insoluble metalin. Examples thereof include sodium acid, magnesium phosphate, calcium carbonate, calcium pyrophosphate, and composite aluminosilicate.
  • a granule is an aggregate obtained by granulating a predetermined material. Examples of such a material include light calcium carbonate, heavy calcium carbonate, zeolite, dicalcium phosphate, tricalcium phosphate, insoluble sodium metaphosphate.
  • the total content of the granular material selected from the abrasive powder and the granule is preferably 1% by mass or less, more preferably 0.2% by mass or less in the liquid oral composition of the present invention. More preferably, it is 0.1 mass% or less, and it is preferable that the liquid oral composition of this invention does not contain a granular material.
  • the organic acid or its salt (e-3), the inorganic acid other than the component (e-2) or its salt (e-4), and the pH adjuster (E) selected from urea are also specific depending on the type.
  • the buffering capacity of the component (A) may be lowered depending on the case, and it may be difficult to adjust to a specific alkaline pH region described later, so the content is limited. Is preferred.
  • the content of the component (E) is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and further preferably 10 parts by mass with respect to 100 parts by mass of the carbon dioxide conversion amount of the component (A). It is as follows. In addition, since circumstances differ somewhat depending on the type of the pH adjuster (E), the specific content value to be limited also varies depending on the type.
  • the amino acid (e-1) include basic amino acids such as arginine and lysine, and acidic amino acids such as aspartic acid.
  • the basic amino acid content may cause yellowing when a sugar alcohol such as sorbitol is contained, for example, in order to improve flavor and stability.
  • the amount is preferably 5 parts by mass or less with respect to 100 parts by mass of the component (A) in terms of carbonic acid. Yes, more preferably 3 parts by mass or less, still more preferably 1 part by mass or less, and preferably no basic amino acids.
  • the alkali metal hydroxide (e-2) include sodium hydroxide and potassium hydroxide.
  • the content of the component (e-2) is to suppress the influence on the flavor and harm caused by the increase in pH, or to suppress the decrease in colored stain removal performance due to the decrease in the buffer capacity of the component (A).
  • the amount is preferably 10 parts by mass or less, more preferably 5 parts by mass or less, relative to 100 parts by mass of the component (A) in terms of carbonic acid. More preferably, it is 3 parts by mass or less, still more preferably 1 part by mass or less, and it is preferable not to contain the component (e-2).
  • the content of the component (e-2) is the blending amount when the blending amount is clear, and is estimated from the carbonic acid equivalent amount of the component (A) in the composition when the blending amount is unknown.
  • the amount of component (A) to be calculated is calculated from the amount of sodium and potassium in the composition and the pH.
  • organic acid or a salt thereof examples include citric acid, malic acid, lactic acid, tartaric acid, succinic acid, acetic acid, glycerophosphoric acid, gluconic acid, fumaric acid, phytic acid, and salts thereof. Can be mentioned.
  • Such salts include potassium salts, sodium salts, and ammonium salts.
  • the content of the component (e-3) is 100 parts by mass of the component (A) in terms of carbonic acid from the viewpoint of facilitating the adjustment to the specific alkaline pH region described later in the liquid oral composition of the present invention. On the other hand, it is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, and still more preferably 10 parts by mass or less. Further, the component (e-3) may be contained in an amount of 5 parts by mass or more based on 100 parts by mass of the component (A) in terms of carbonic acid.
  • the inorganic acid or salt (e-4) include orthophosphoric acid or a salt thereof, condensed phosphoric acid selected from pyrophosphoric acid, tripolyphosphoric acid, or hexametaphosphoric acid, or a salt thereof.
  • examples of the inorganic acid (e-4) other than these orthophosphoric acid, condensed phosphoric acid, and salts thereof include hydrochloric acid, sulfuric acid, nitric acid, sulfonic acid, and salts thereof.
  • the contents of orthophosphoric acid, condensed phosphoric acid, and salts thereof are the components of component (A) from the viewpoint of ensuring high color stain removal performance while providing a good feeling of use.
  • it is 20 mass parts or less with respect to 100 mass parts of carbonic acid conversion amount, More preferably, it is 15 mass parts or less.
  • the content of orthophosphoric acid, condensed phosphoric acid, and salts thereof is preferably 3 parts by mass or more with respect to 100 parts by mass of the component (A) in terms of carbonic acid, from the viewpoint of removal performance of colored stains and organic stains. More preferably, it is 5 parts by mass or more, and more preferably 7 parts by mass or more.
  • the content of component (e-4) other than orthophosphoric acid, condensed phosphoric acid, and salts thereof, such as hydrochloric acid and sulfuric acid, is reduced to a specific alkaline pH range described later.
  • the amount is preferably 5 parts by mass or less, more preferably 3 parts by mass or less, and still more preferably 1 part by mass or less with respect to 100 parts by mass of the component (A) in terms of carbonic acid.
  • urea is mentioned as another pH adjuster (E),
  • the content of this urea is a carbonic acid conversion amount of 100 mass of component (A) from a viewpoint which does not inhibit adjustment to the specific alkaline pH area mentioned later.
  • the amount is preferably 5 parts by mass or less, more preferably 3 parts by mass or less, still more preferably 1 part by mass or less, and preferably contains no urea.
  • the nonionic surfactant (F) restricts the content of the component (F) from the viewpoint of improving the effect of removing colored stains and suppressing the increase of harmfulness.
  • the nonionic surfactant of component (F) include polyoxyethylene hydrogenated castor oil; sucrose fatty acid ester; sorbitan fatty acid ester; glycerin fatty acid ester such as monostearic acid glyceride; alkyl glucoside; monostearic acid decaglyceride, mono Polyglycerin fatty acid esters such as myristic acid decaglycerides; polyoxyethylene alkylphenyl ethers such as polyoxyethylene monoalkyl (or alkenyl) ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene nonylphenyl ethers; amine oxides Surfactant; Fatty acid alkanolamides such as coconut oil fatty acid diethanolamide; and one
  • the liquid oral cavity composition of the present invention while maintaining an excellent effect of removing colored stains, it is possible to suppress excessive irritation in the oral cavity to ensure a good feeling of use, and to suppress the increase in harmfulness Therefore, it is preferable to limit the content of a disinfectant selected from peroxides and chlorine dioxide.
  • the total content of the disinfectant is preferably 0.1% by mass or less, more preferably 0.01% by mass or less in the liquid oral composition of the present invention.
  • the liquid oral composition of the invention preferably does not contain a disinfectant selected from peroxides and chlorine dioxide.
  • the liquid oral composition of the present invention is, in the range not inhibiting the effects of the present invention, in addition to the above components, for example, surfactants other than the anionic surfactants and nonionic surfactants of the above component (B), sugar alcohols , Fragrances, preservatives, binders, pigments, dyes and the like.
  • Surfactants other than the anionic surfactant and nonionic surfactant of the above component (B) include betaine acetate such as lauryldimethylaminoacetic acid betaine; 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazo Imidazolinium betaines such as L-betaine; alkyl sulfobetaines such as lauryl sulfobetaine and lauryl hydroxysulfobetaine; coconut oil fatty acid amide alkylbetaines such as coconut oil fatty acid amidopropyl betaine; N-alkyl-1-hydroxyethylimidazoline betaine sodium and the like Long chain alkyl imidazoline betaine salts.
  • betaine acetate such as lauryldimethylaminoacetic acid betaine
  • 2-alkyl-N-carboxymethyl-N-hydroxyethyl-N-imidazo Imidazolinium betaines such as L-betaine
  • sugar alcohols examples include sorbitol, erythritol, xylitol, lactitol, reduced palatinose, and maltitol.
  • the fragrance may be any fragrance exhibiting oil solubility, for example, peppermint oil, spearmint oil, cinnamon oil, anise oil, eucalyptus oil, winter green oil, cassia oil, clove oil, thyme oil, sage oil, sage clary oil.
  • Natural flavoring ingredients such as caraway oil, marjoram oil, bay oil, lemongrass oil, lemon balm oil, pimento berry oil, palmarosa oil, olibanum oil, pine needle oil, pettigren oil, neroli oil, rose oil, jasmine oil, and Perfume ingredients processed from these natural perfume ingredients; , Pregol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3-1 -menthoxypropane-1,2-diol, thymol, citronellyl acetate, linalool, linalyl acetate, geraniol, geranyl acetate, citronellol
  • Preservatives include, for example, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, benzoic acid, sodium benzoate, methyl salicylate, potassium sorbate And sodium dehydroacetate.
  • binder sodium alginate, carboxymethyl cellulose or a salt thereof, carrageenan, xanthan gum, sodium polyacrylate, hydroxyethyl cellulose, hydroxypropyl cellulose, pectin, tragacanth gum, gum arabic, guar gum, karaya gum, locust bean gum, gellan gum, tamarind gum , Psyllium seed gum, polyvinyl alcohol, sodium chondroitin sulfate, and methoxyethylene maleic anhydride copolymer.
  • the pH at 25 ° C. in the liquid oral cavity composition of the present invention is 8.5 or more, preferably 9 from the viewpoint of securing a high color removal effect exhibited by the component (A) and the component (B). It is above, More preferably, it exceeds 9, More preferably, it is 9.5 or more. Further, the pH at 25 ° C. in the liquid oral cavity composition of the present invention is 10.5 or less from the viewpoint of effectively suppressing the expression of harmfulness and maintaining a good flavor while maintaining a good flavor. And preferably 10 or less.
  • the pH at 25 ° C. of the liquid oral composition of the present invention is 8.5 or more and 10.5 or less, preferably 9 to 10, more preferably more than 9 and 10 or less, and still more preferably. Is 9.5-10.
  • the liquid oral composition of the present invention is a liquid oral composition in which components (A) and (B) are dissolved or dispersed in component (C) water from the viewpoint of further improving the effects of the present invention. It is preferable that it is a transparent liquid composition for oral cavity.
  • being transparent or translucent means that the transmittance of light having an absorption wavelength of 550 nm in a cell having an optical path length of 10 mm is 80% or more, preferably 90% or more, and having a transmittance of 95 % Or more is preferable, and it may be colored transparent or colorless transparent.
  • the transmittance can be measured using a quartz cell having an optical path length of 1 mm and a wavelength of 550 nm using an ultraviolet-visible spectrophotometer, for example, “UV-2500PC type measuring instrument” manufactured by Shimadzu Corporation.
  • the liquid oral composition of the present invention can be applied to a mouthwash, liquid dentifrice, water dentifrice, mouse spray, mouthwash, etc., and the liquid oral composition of the present invention can be used as a sheet. It can also be applied to impregnated toothpaste sheets, and can also be a foam preparation filled in a foam discharge container and discharged in the form of foam, and can be used as a liquid applied to the oral cavity .
  • the liquid oral composition of the present invention is a mouthwash, a liquid dentifrice, or a foam preparation, it is preferably applied to the oral cavity 1 to 5 times a day, for example, 5 mL to 100 mL.
  • the oral cavity More preferably, it is used by containing 10 mL to 50 mL in the oral cavity.
  • the time included in the oral cavity is preferably 10 seconds to 5 minutes, more preferably 20 seconds to 3 minutes, and even more preferably 30 seconds to 1 minute.
  • the dirt on the teeth can be removed by wrapping the wet sheet around the fingers and wiping the surface of the teeth.
  • the carbonate of component (A) is 0.2 to 3% by mass in terms of carbonic acid
  • the anionic surfactant of component (B) is 0.2 to 1% by mass. 0.7% by mass or less and obtained by a production method including a step of blending water of component (C) in an amount of 70% by mass to 99.5% by mass and adjusting the pH to 8.5 to 10.5. Can do.
  • Component (A) is, as described above, one or more carbonates selected from sodium bicarbonate, sodium carbonate, and sesquisodium carbonate, and the total amount in terms of carbonic acid is in the above range, Whether a mixture of sodium bicarbonate and sodium carbonate is added so that the pH is in the above range, sodium sesquicarbonate is added alone, or all of sodium bicarbonate, sodium carbonate, and sodium sesquicarbonate are added Any one of the embodiments may be used.
  • the compounding amounts of the components (A) to (C) are the same as the above contents, respectively, and the compounding amounts of other components used as necessary are the same as the above contents.
  • the blending order of these components is not particularly limited, and the liquid oral composition of the present invention can be obtained by passing through the blending step and then the mixing step.
  • the following liquid oral composition and a method for producing the same are disclosed with respect to the embodiment of the present invention described above.
  • the value ((A) ⁇ (B)) of the product of the carbonic acid equivalent amount of component (A) and the content of component (B) (0.9) is 0.9 or less, and the pH at 25 ° C. is 8.5.
  • the liquid oral composition which is 10.5 or less.
  • the content of component (A) in terms of carbonic acid (H 2 CO 3 ) is preferably 0.15% by mass or more, more preferably 0.18% by mass or more, and still more preferably 0. 20% by mass or more, preferably 1.5% by mass or less, more preferably 1.3% by mass or less, still more preferably 1.0% by mass or less, and still more preferably 0.6% by mass.
  • the liquid oral cavity composition of the above-mentioned [1] which is not more than mass%.
  • the component (B) is preferably one or more selected from sodium alkyl sulfate, sodium acyl glutamate, and sodium laurylmethyl taurate, and more preferably contains at least sodium alkyl sulfate.
  • the content of component (B) is preferably 0.4% by mass or more, more preferably 0.5% by mass or more, preferably 1.6% by mass or less, more preferably 1%.
  • the product ((A) ⁇ (B)) of the carbonic acid equivalent amount of component (A) and the content of component (B) is preferably 0.8 or less, more preferably 0.5 or less.
  • the total amount of the carbonic acid equivalent amount of component (A) and the content of component (B) is preferably 0.5% by mass or more, more preferably 0.55% by mass or more, and still more preferably.
  • the content of the component (C) is preferably 65% by mass or more, more preferably 70% by mass or more, preferably 99.2% by mass or less, more preferably 99.15% by mass.
  • the content of the pH adjuster (E) other than the component (A) is preferably 20 parts by mass or less, more preferably 15 parts by mass or less, with respect to 100 parts by mass of the component (A) in terms of carbonic acid.
  • the pH adjuster (E) other than the component (A) is an amino acid (e-1), an alkali metal hydroxide (e-2), an organic acid other than the component (e-1) or a salt thereof (e -3), a liquid oral composition according to any one of the above [1] to [10], which is a pH adjuster selected from inorganic acids other than component (e-2) or a salt thereof (e-4) and urea .
  • the content of the basic amino acid is preferably 5 parts by mass or less, more preferably 3 parts by mass or less, relative to 100 parts by mass of the component (A) in terms of carbonic acid. More preferably, the liquid oral composition according to any one of the above [1] to [11], which is 1 part by mass or less and does not contain a basic amino acid.
  • the content of the alkali metal hydroxide (e-2) is preferably 10 parts by mass or less, more preferably 5 parts by mass or less, relative to 100 parts by mass of the component (A) in terms of carbonic acid.
  • the content of the organic acid or a salt thereof (e-3) is preferably 20 parts by mass or less, more preferably 15 parts by mass or less with respect to 100 parts by mass of the component (A) in terms of carbonic acid. More preferably, it is 10 parts by mass or less, and may be 5 parts by mass or more.
  • the contents of orthophosphoric acid, condensed phosphoric acid, and salts thereof are preferably 20 masses per 100 mass parts of the component (A) in terms of carbonic acid. [1] to [14], more preferably 15 parts by mass or less, preferably 3 parts by mass or more, more preferably 5 parts by mass or more, and further preferably 7 parts by mass or more. Any one composition for liquid oral cavity.
  • the content of the nonionic surfactant (F) is preferably 1% by mass or less, more preferably 0.5% by mass or less, still more preferably 0.2% by mass or less, and still more.
  • the total content of the granular material selected from the abrasive powder and the granules is preferably 1% by mass or less, more preferably 0.2% by mass or less, and further preferably 0.1% by mass.
  • the liquid oral composition according to any one of the above [1] to [16] which is the following or does not contain a granular material.
  • the total content of the disinfectant selected from peroxide and chlorine dioxide is preferably 0.1% by mass or less, more preferably 0.01% by mass in the liquid oral composition of the present invention. %, Or a liquid oral composition according to any one of [1] to [17] above, which does not contain a disinfectant selected from peroxides and chlorine dioxide. [19] Any one of the above [1] to [18], wherein the pH at 25 ° C. is preferably 9 or more, more preferably more than 9, further preferably 9.5 or more, and preferably 10 or less. Liquid oral composition.
  • Examples 1 to 16, Comparative Examples 1 to 9 Each liquid oral composition was prepared according to the formulations shown in Tables 1-2. Subsequently, according to the following method, the colored stain removal effect, flavor, and harmfulness were evaluated. In the liquid oral compositions of Examples 1 to 16 and Comparative Examples 1 to 9, the content of the polyvalent metal cation was 0.02 times mol or less with respect to the component (A). The results are shown in Tables 1-2.
  • the HAP plate (HOYA Corp., APP-100) used for the test was polished with abrasive paper (# 400), immersed in 0.1N hydrochloric acid for 30 seconds and subjected to acid treatment, and then 3 times with 1 mL of water three times. Washed. Next, the HAP plate was dipped in a bovine serum albumin 1% solution (manufactured by BSA Wako Pure Chemical Industries, Ltd.) 40 mL, artificial saliva 40 mL, and black tea solution 40 mL in this order for 5 minutes and dried.
  • a bovine serum albumin 1% solution manufactured by BSA Wako Pure Chemical Industries, Ltd.
  • the spectrophotometer (CM-700d, manufactured by Konica Minolta Co., Ltd.) was used to express the degree of coloring in the L * a * b color system (Marcel color system). The value (b * value before immersion) was measured. Next, after the obtained HAP plate was immersed in each liquid oral composition for 2 minutes, the b * value (b * value after immersion) was measured in the same manner, and the colored stain was removed according to the following formula (X). The rate (%) was calculated, and the value of Comparative Example 1 was set as 100 and indicated as an index.
  • Removal rate (%) (b * value before immersion ⁇ b * value after immersion) / b * value before immersion ⁇ 100 (X)
  • 6 tea bags (Nitto tea) were placed in 300 mL of hot water, extracted for 5 minutes, and cooled to room temperature. The black tea solution was filtered by WHATMAN No. 1 filter paper was used.
  • Comparative Example 1 containing no component (B), Comparative Examples 2 to 3 having a pH outside the range of 8.5 to 10.5, the content of the component (B) Comparative Examples 4 to 5 in which the amount of carbon dioxide conversion of component (A) exceeds the above range, Comparative Examples 6 and 8 in which the value of (A) ⁇ (B) is 0.9 or more, Nonionic interface instead of component (B) Compared with Comparative Example 7 using an active agent and Comparative Example 9 where the carbonic acid equivalent amount and pH value of component (A) are outside the above ranges, the liquid oral compositions of Examples 1 to 16 have a better feeling of use. It can be seen that both the effect of imparting the above and the excellent effect of removing colored stains are sufficiently combined.
  • Example 2 if it is a dentifrice, even if it is a dentifrice of the comparative example 11 with many compounding quantities of a component (A) and a component (B), although there is no problem in flavor and harm, Example It can be understood that the high color removal performance as in the liquid oral composition of 1 to 16 is not sufficiently exhibited.

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  • Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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Abstract

Cette invention concerne une composition liquide à usage oral qui exerce un excellent effet d'élimination des taches colorées tout en donnant une sensation agréable à l'utilisation. La composition liquide à usage oral comprend : (A) de 0,1 à 2 % en poids inclus, en termes d'acide carbonique, d'un ou de plusieurs types de sels d'acide carbonique choisis parmi l'hydrogénocarbonate de sodium, le carbonate de sodium et le sesquicarbonate de sodium, (B) de 0,2 à 1,7 % en poids inclus d'un tensioactif anionique, et (C) de 60 à 99,5 % en poids d'eau, où : un cation métal polyvalent (D) est contenu en une quantité inférieure à 0,1 fois en mol la quantité de composant (A); le produit de la quantité, en termes d'acide carbonique, du composant (A) avec la teneur en composant (B) [ (A) × (B)] est de 0,9 ou moins; et la valeur de pH à 25°C est de 8,5 à 10,5 inclus.
PCT/JP2016/087068 2015-12-14 2016-12-13 Composition liquide à usage oral WO2017104664A1 (fr)

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CN113274306A (zh) * 2021-05-28 2021-08-20 陕西省人民医院 一种日用健康环保口腔除味剂制备方法

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JP6742339B2 (ja) 2020-08-19
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CN108289800A (zh) 2018-07-17
TW201725028A (zh) 2017-07-16
TWI735490B (zh) 2021-08-11

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