WO2016136556A1 - パップ剤 - Google Patents
パップ剤 Download PDFInfo
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- WO2016136556A1 WO2016136556A1 PCT/JP2016/054570 JP2016054570W WO2016136556A1 WO 2016136556 A1 WO2016136556 A1 WO 2016136556A1 JP 2016054570 W JP2016054570 W JP 2016054570W WO 2016136556 A1 WO2016136556 A1 WO 2016136556A1
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- extract
- base fabric
- water
- plaster
- fabric
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
Definitions
- the present invention relates to a poultice.
- a poultice is a type of patch produced by applying a plaster containing a drug on a base fabric.
- the plaster layer contains a lot of water and the plaster layer has a thickness. Since the cataplasm has such a structure, the skin permeation of the active ingredient is promoted, and irritation to the skin is reduced.
- the components of the plaster layer greatly contribute to performance such as adhesive strength of the patch.
- adjustment of the dynamic viscoelasticity measurement value is studied in order to increase the adhesiveness of the patch or the adhesion to the skin.
- a tape agent in which a pressure-sensitive adhesive layer not containing moisture is laminated on a base fabric such as a knitted fabric has been studied. Such a tape agent has good follow-up to the skin and good adhesion.
- an object of the present invention is to produce a poultice that prevents the components of the plaster layer from exuding on the back side of the base fabric even when a base fabric such as a knitted fabric is laminated on the plaster layer containing a large amount of moisture. It is to provide a method.
- the present invention relates to a method for producing a poultice having a plaster layer on a base cloth, wherein a composition containing a physiologically active substance, a water-soluble polymer, glycerin and water is applied to the base cloth to form a plaster layer And a loss tangent in the dynamic viscoelasticity measurement at 1 Hz of the composition when applied to the base fabric is 0.75 to 1.
- the base fabric is a knitted fabric, and the elongation recovery rate of the knitted fabric is preferably 73 to 98% in the course direction and 83 to 98% in the wale direction.
- the base fabric is a knitted fabric, and the bending resistance of the knitted fabric is preferably 10 to 15 mm in the course direction and 10 to 18 mm in the wale direction.
- a loss tangent in a dynamic viscoelasticity measurement at 1 Hz at the time of application is 0.75 to 1 by using the base fabric having the above-described elongation recovery rate and / or bending resistance.
- the plaster layer made of the above composition is formed on the base fabric, the exudation of the components of the plaster layer is more reliably prevented.
- a methyl acrylate / 2-ethylhexyl acrylate copolymer resin also referred to as poly (methyl acrylate / 2-ethylhexyl acrylate)
- a methyl acrylate / 2-ethylhexyl acrylate copolymer resin also referred to as poly (methyl acrylate / 2-ethylhexyl acrylate)
- the content of the water-soluble polymer is preferably 3 to 18% by mass based on the total mass of the plaster layer.
- a poultice is obtained by the above production method. This poultice prevents bleeding of the plaster layer to the back side of the base fabric, so that uniform adhesiveness can be obtained, and the physiologically active substance is passed through.
- the skin absorbability is also stable. Furthermore, the plaster layer that oozes out on the back side of the base fabric eliminates inconveniences such as stickiness when sticking and sticking inside the packaging bag during storage.
- the loss tangent (tan ⁇ ) is a dynamic viscoelasticity measurement in which a composition containing a physiologically active substance, a water-soluble polymer, glycerin and water is sandwiched between two plates and placed on one plate. It is a value calculated from the following equation by measuring a change in stress when a strain that periodically vibrates is applied.
- the dynamic viscoelasticity measurement is performed, for example, using a rotary rheometer at a temperature of 32 ° C. and a frequency of 1 Hz.
- Loss tangent (tan ⁇ ) loss elastic modulus (G ′′) / storage elastic modulus (G ′)
- a composition containing a physiologically active substance, a water-soluble polymer, glycerin and water (hereinafter sometimes referred to as “plaster liquid” for convenience) is applied to the base fabric. Forming a plaster layer.
- Examples of the base fabric include a woven fabric, a nonwoven fabric, a resin film, a foam sheet, and paper.
- Examples of the woven fabric include a knitted fabric.
- examples of those materials include polyolefins such as polyethylene, polypropylene and polybutylene, polyesters such as polyethylene terephthalate, rayon, polyurethane and cotton.
- the base fabric may have a single layer structure or a multilayer structure. As the material for the base fabric, polyester is more preferable.
- the base fabric is preferably a knitted fabric or a non-woven fabric.
- the knitted fabrics are roughly classified into weft knitted fabrics and warp knitted fabrics.
- Flat knitted fabrics (knitted fabric, jersey), rubber knitted fabric (rib knitted fabric), pearl knitted fabric (garter knitted fabric) And smooth knitting (double-sided knitting).
- Examples of the warp knitted fabric include denby knitting, bandai knitting, cord knitting, atlas knitting, and multi-axis insertion knitting. Any of these knitted fabrics is preferably used, but a flat knitted fabric is particularly preferred.
- the plaster containing water may ooze out to the back side of the base fabric through the mesh of the woven fabric.
- 80 to 150 g / m 2 is preferable, and 95 to 125 g / m 2 is more preferable.
- the knitted fabric include a knitted fabric formed by combining one or two or more materials such as polyester, nylon, polypropylene, and rayon.
- a knitted fabric made of polyethylene terephthalate is more preferable.
- a knitted fabric having a predetermined elongation recovery rate is particularly preferable.
- the elongation recovery rate is a value measured according to “JIS L 1096: 2010 Fabric and knitted fabric test method”. It is preferable to use a knitted fabric having a predetermined elongation recovery rate because the base fabric expands and contracts according to the movement of the application site when it is applied to a movable part such as a joint.
- the 50% elongation recovery rate of the knitted fabric is 73 to 98% in the course direction, preferably 83 to 98% in the wale direction, and 75 to 97% in the course direction. More preferably 85 to 97% in the wale direction.
- the course direction and the wale direction in the knitted fabric will be described with reference to FIGS.
- FIG. 1 is a perspective view showing a course direction and a wale direction in a weft knitted fabric
- FIG. 2 is a perspective view showing a course direction and a wale direction in a warp knitted fabric.
- the direction represented by X in FIGS. 1 and 2 is the course direction, which means the weft direction of the knitted fabric.
- the direction represented by Y in FIGS. 1 and 2 is the wale direction, which means the warp direction of the knitted fabric.
- the bending resistance of the base fabric is 10 to 15 mm in the course direction, preferably 10 to 18 mm in the wale direction, 10 to 13 mm in the course direction, and 10 to 15 mm in the wale direction. More preferred.
- the measuring method of bending resistance is based on JIS L 1096: 2010 45 degree cantilever method.
- the knitted fabric preferably has a 50% modulus (load at 50% elongation) of 2 to 12 N / 5 cm in the course direction, a 50% modulus in the wale direction of 2 to 12 N / 5 cm, and 2 to 8 N / 5 cm in the course direction. More preferably, the 50% modulus in the wale direction is 2 to 12 N / 5 cm. The modulus is measured according to JIS L 1018: 1999. If the modulus is 50% modulus lower than 2 N / 5 cm in the course direction or the wale direction, the knitted fabric may extend when the plaster is applied, and the adhesive may soak into the mesh.
- the stretchability is inferior, and it may be difficult to follow the stretching of the skin when applied to the bent portion.
- the paste liquid (composition for forming a paste layer) contains a physiologically active substance, a water-soluble polymer, glycerin and water.
- Any physiologically active substance may be used as long as it has transdermal absorbability and exhibits pharmacological activity in vivo.
- ferbinac flurbiprofen, diclofenac, diclofenac sodium, methyl salicylate, glycol salicylate, indomethacin, ketoprofen ,
- Non-steroidal anti-inflammatory agents such as ibuprofen, or esters thereof, antihistamines such as diphenhydramine and chlorpheniramine, analgesics such as aspirin, acetaminophen, ibuprofen and loxoprofen sodium, local anesthetics such as lidocaine and dibucaine, and sisamethonium chloride
- Muscle relaxants such as clotrimazole, antifungal agents such as clonidine, antihypertensive agents such as clonidine, vasodilators such as nitroglycerin and isosorbide nitrate, vitamin A
- the plaster liquid contains a water-soluble polymer, and this water-soluble polymer means a polymer having a hydrophilic group.
- the hydrophilic group include a hydroxy group, a carboxy group, and an amino group.
- the water-soluble polymer preferably contains polyacrylic acid or a neutralized polyacrylic acid (sometimes referred to as “water-soluble acrylic polymer”).
- a poultice having a plaster layer that is more excellent in adhesion can be obtained.
- a water-soluble acrylic polymer is a polymer obtained by polymerizing an acryloyl group-containing compound having a functional group (hydrophilic group) that exhibits water-solubility, and exhibits adhesiveness when contained in water with a plaster layer.
- the water-soluble acrylic polymer is a polymer obtained by polymerizing a compound having an acryloyl group such as polyacrylic acid or a neutralized product thereof, an acrylic ester having a hydrophilic group, or an acrylic amide having a hydrophilic group.
- the water-soluble acrylic polymer may be a homopolymer obtained from a compound having one kind of acryloyl group or a copolymer obtained from a compound having two or more kinds of acryloyl groups.
- the hydrophilic group may be any of a cationic hydrophilic group, an anionic hydrophilic group, and a nonionic hydrophilic group.
- Examples of the cationic hydrophilic group include a quaternary ammonium group.
- Examples of the anionic hydrophilic group include a carboxy group, a sulfo group, and a phosphate group.
- Examples of the nonionic hydrophilic group include a hydroxy group and an amino group. Groups.
- the content is preferably adjusted to be 1 to 5% by mass based on the total mass of the plaster layer, and adjusted to be 2 to 6% by mass. More preferably.
- the content of the water-soluble polymer 1% by mass or more, the moldability and the shape retention of the plaster layer tend to be improved, and by making the content of polyacrylic acid 5% by mass or less, There is a tendency that the hardness of the plaster layer is not easily increased and the adhesion to the skin is further increased.
- the polyacrylic acid neutralized product may be a polyacrylic acid complete neutralized product, a polyacrylic acid partially neutralized product, or a mixture thereof.
- Examples of the polyacrylic acid neutralized product include polyacrylic acid salts, and for example, sodium salts, potassium salts, calcium salts, ammonium salts and the like can be used.
- the polyacrylic acid neutralized product is preferably a polyacrylic acid partially neutralized product because both the initial adhesive strength and the temporal adhesive strength are increased.
- the polyacrylic acid partial neutralized product is a polymer chain in which structural units derived from acrylic acid and structural units derived from acrylate are present in an arbitrary ratio.
- As the partially neutralized polyacrylic acid it is preferable to use a product obtained by neutralizing 20 to 80 mol% of carboxy groups in one polymer chain.
- the content is preferably adjusted to be 1 to 6% by mass based on the total mass of the plaster layer, and is 2 to 6% by mass. It is more preferable to adjust so.
- the content of the polyacrylic acid neutralized product 1% by mass or more, sufficient adhesion of the polyacrylic acid neutralized product can be obtained, and the content of the polyacrylic acid neutralized product is 6% by mass. By making it below, moldability and shape retention of the plaster layer are improved.
- the acrylic acid ester portion is preferably an acrylic acid alkyl ester.
- the alkyl moiety is preferably an alkyl having 1 to 10 carbon atoms, and more preferably an alkyl having 1 to 8 carbon atoms.
- the hydrophilic group is preferably present in the alkyl moiety.
- water-soluble polymers include those other than water-soluble acrylic polymers, such as gelatin, polyvinyl alcohol, polyvinyl pyrrolidone, sodium alginate, hydroxypropyl cellulose, sodium carboxymethyl cellulose (carmellose sodium), methyl cellulose, carrageenan, glucomannan, agar, guar gum. , Xanthan gum, gellan gum, pectin, locust bean gum. These may be used individually by 1 type and may be used in combination of 2 or more type.
- water-soluble polymer carmellose sodium, gelatin or polyvinyl alcohol is preferred. These may be used in combination with a water-soluble acrylic polymer.
- the content is preferably adjusted to 3 to 18% by mass based on the total mass of the plaster layer. It is more preferable to adjust so that it may become mass%. If the content of the water-soluble polymer is 3% by mass or more, the cohesive force of the paste layer tends to be high, and if it is 10% by mass or less, the physiologically active substance contained in the paste layer is uniformly dispersed. It tends to be easy to do.
- the content of glycerin is preferably adjusted to 5 to 50 mass%, more preferably 7 to 25 mass%, more preferably 10 to 20 mass%, based on the total mass of the plaster layer. More preferably.
- the plaster layer becomes softer and the adhesiveness of the poultice tends to be further improved.
- the content of glycerin is 5% by mass or more, drying of the plaster layer can be delayed while the poultice is used, and the adhesion of the poultice can be easily maintained for a longer time.
- content of glycerol is 50 mass% or less, glycerol is hard to isolate
- the paste liquid contains water, the skin permeability of the physiologically active substance is improved, and the pharmacological action of the physiologically active substance is more effectively exhibited.
- the water content is preferably 10 to 90% by mass, more preferably 15 to 88% by mass, and still more preferably 18 to 85% by mass based on the total mass of the paste liquid.
- the plaster liquid preferably contains a methyl acrylate / 2-ethylhexyl acrylate copolymer resin. If the weight of the plaster layer is small in the conventional poultice, the water content tends to decrease and the adhesive force tends to decrease. However, since the paste layer contains methyl acrylate / 2-ethylhexyl acrylate copolymer resin, the adhesive layer has sufficient adhesion even after a long time even if the mass of the paste layer is relatively small. It tends to be easily maintained.
- the methyl acrylate / 2-ethylhexyl acrylate copolymer resin is preferably an aqueous emulsion using water as a medium.
- the methyl acrylate / 2-ethylhexyl acrylate copolymer resin emulsion is also preferably an emulsion using polyoxyethylene nonylphenyl ether as a surfactant or protective colloid.
- the evaporation residue (nonvolatile content) due to heating above the boiling point of the medium is 57 to 61%.
- Nicazole TS-620 (trade name, manufactured by Nippon Carbide Industries Co., Ltd.). According to the Pharmaceutical Additives Standard (2013), when Nicazole TS-620 is evaporated to dryness on a water bath and then dried at 105 ° C. for 3 hours, the amount of evaporation residue is 57-61%.
- plaster liquid In addition, other chemicals, solubilizers, crosslinking agents, moisturizers, cooling agents, stabilizers, inorganic powders, coloring agents, flavoring agents, pH adjusting agents, etc. are added to the plaster liquid. Also good.
- the above composition includes the following: , Tomato extract, grape extract, loofah extract, lime juice, apple extract, apple juice, lemon extract, lemon juice and other fruit-derived ingredients, water-soluble placenta extract, allantoin, lecithin, amino acids, kojic acid, protein, sugar, hormone , Placenta extract, extract ingredients from various herbal medicines such as aloe and licorice, ashitaba extract, avocado extract, amacha extract, altea extract, arnica extract, ginkgo biloba extract, fennel extract Turmeric extract, Oolong tea extract, Ogon extract, Oat extract, Barley extract, Dutch mustard extract, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Chamomile extract, Kawara mugwort extract, Licorice extract, Calkade extract, Guanosine, Kumazasa Extract, Walnut Extract, Clematis Extract, Yeast Extract, Burdock Extract, Comfrey Extract, Peach
- the solubilizer is not particularly limited as long as it can dissolve the drug.
- crotamiton N-methylpyrrolidone
- polyalkylene glycol such as polyethylene glycol (PEG) and polybutylene glycol
- isopropyl myristate adipic acid
- Surfactants such as fatty acid esters such as diethyl; oxyalkylene fatty acid esters such as polyethylene glycol monostearate; fatty acid esters such as polyoxyalkylene sorbitan fatty acid ester; polyoxyethylene hydrogenated castor oil; polysorbate 80 and the like.
- These solubilizers may be used alone or in combination of two or more.
- the content of the solubilizer is preferably adjusted to be 0.1 to 10% by mass based on the total mass of the plaster layer.
- the moisturizing agent is not particularly limited as long as it can suppress the evaporation of moisture from the plaster layer over time.
- the humectant include polyhydric alcohols such as sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, liquid paraffin, 1,3-propanediol, and 1,4-butanediol.
- polyhydric alcohols such as sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, liquid paraffin, 1,3-propanediol, and 1,4-butanediol.
- One of these humectants may be used alone, or two or more thereof may be used in combination.
- the content of the humectant is preferably adjusted to 3 to 70% by mass based on the total mass of the plaster layer.
- Examples of the refreshing agent include thymol, l-menthol, dl-menthol, l-isopulegol, mint oil and the like, and it is preferable to use l-menthol.
- the content of the refreshing agent is preferably adjusted to 0.5 to 3% by mass based on the total mass of the plaster layer.
- the stabilizer examples include oxybenzone, dibutylhydroxytoluene (BHT), sodium edetate, UV absorber (for example, dibenzoylmethane derivative) and the like.
- the content of the stabilizer is preferably adjusted to be 0.01 to 3% by mass based on the total mass of the plaster layer.
- crosslinking agent inorganic powder, coloring agent, flavoring agent, and pH adjuster, those generally used as a poultice can be used.
- the viscosity of the paste liquid is preferably 50 to 90 Pa ⁇ s (50000 to 90000 cP), and more preferably 52 to 85 Pa ⁇ s (52000 to 85000 cP).
- the viscosity of the plaster liquid is 50 Pa ⁇ s (50000 cP) or more, when the plaster liquid is spread on the base fabric, the components of the plaster liquid tend not to leak into the base fabric, and 90 Pa ⁇ s (90000 cP). When it is below, it becomes easy to spread the plaster liquid on the base fabric because sufficient fluidity can be secured.
- the viscosity of the paste liquid can be adjusted to a desired value by those skilled in the art by changing the content of the physiologically active substance, water-soluble polymer, glycerin or water.
- the storage elastic modulus of the composition for forming the plaster layer is preferably 500 to 10,000 Pa, more preferably 600 to 9500 Pa when the composition is spread on the base fabric.
- the loss elastic modulus of the composition for forming the plaster layer is preferably 500 to 8500 Pa, and more preferably 600 to 8300 Pa when the composition is spread on the base fabric.
- the loss tangent (tan ⁇ ) of the composition for forming the plaster layer is 0.7 to 1.0 when the composition is spread on the base fabric. Preferably, it is 0.8 to 1.0.
- the above values are all values measured at a frequency of 1 Hz and 32 ° C.
- the loss tangent of the composition is preferably 0.75 to 1.0, more preferably 0.8 to 1.0. preferable.
- the loss tangent of the composition is preferably 0.75 to 1.0, and more preferably 0.8 to 1.0.
- the ratio of the course direction / wale direction of the 50% modulus of the base fabric is 0.8 to 1.2
- the composition The loss tangent is preferably 0.75 to 1.0, more preferably 0.8 to 1.0.
- the tan ⁇ value of the paste liquid can be adjusted to a desired value by those skilled in the art by changing the content of the physiologically active substance, water-soluble polymer, glycerin or water. In order to adjust the tan ⁇ value of the paste liquid, it is more effective to change the content of the water-soluble polymer. Moreover, since the tan ⁇ value of the plaster liquid tends to decrease with time as described later, by adjusting the time from preparation of the plaster liquid to spreading on the base cloth, The tan ⁇ value at the time of spreading may be adjusted to a desired value. In this case, for example, if a certain amount of time is required from the preparation of the plaster liquid to spreading on the base fabric, the content of water in the plaster liquid is increased in advance in accordance with the circumstances of the production site of the poultice. May be.
- the poultice may have a release liner.
- the release liner is laminated on the surface opposite to the base fabric with respect to the plaster layer.
- the release liner it is possible to suppress a decrease in the water content of the paste layer during storage, and to reduce adhesion of dust and the like to the paste layer.
- the material of the release liner is not particularly limited, and a liner generally known to those skilled in the art can be used.
- Examples of the material for the release liner include polyethylene, polypropylene, polyethylene terephthalate, and paper. One type may be used alone, or two or more types may be used in combination.
- the poultice may be stored inside the pouch.
- a decrease in the water content of the paste layer can be suppressed, and adhesion of dust and the like to the paste layer can be reduced.
- the mass of the plaster layer is preferably 300 g / m 2 or more, and more preferably 400 g / m 2 or more.
- the mass of a paste layer 750 g / m ⁇ 2 > or less is preferable, for example.
- a particularly suitable mass of the plaster layer is 400 to 450 g / m 2 , and by setting the mass within the above range, it is possible to improve the fit and maintain the adhesion over a longer period of time. If the mass of the plaster layer is in the above range, the thickness of the entire poultice can be reduced, and it is easy to follow the skin. It is in.
- Table 4 shows the results of calculating the loss tangent (tan ⁇ value) from the values of the storage modulus and loss modulus obtained by the dynamic viscoelasticity test.
- “Time” described in Table 4 means the time elapsed from the preparation of the paste liquid until the dynamic viscoelasticity test. With time, the loss tangent (tan ⁇ value) of the plaster fluid of Example 1 gradually decreased. After each time, when spreading to the base fabric, when the tan ⁇ value was 0.75 or more, the plaster liquid could be applied uniformly.
- the results are shown in Table 9.
- the poultice prepared from the plaster solution of Example 1 showed excellent adhesion even after 24 hours from application.
- the plaster liquid of Comparative Example 2 had a high viscosity and could not be spread uniformly on the base fabric.
- Example 1 the plaster solution of Examples 5 to 40 using Felbinac, diclofenac sodium, methyl salicylate, glycol salicylate, indomethacin, loxoprofen sodium, diphenhydramine, lidocaine or fentanyl instead of ketoprofen (Example 1)
- Examples 5 to 8 were obtained by replacing ketoprofen of ⁇ 4 with felbinac
- Examples 9 to 40 correspond to the order of description of physiologically active substances) to prepare cataplasms.
- the obtained poultice was subjected to a bleed-out test and an adhesion test, and all the poultices showed good results.
- Examples 41 to 44 were obtained by replacing gelatin of Examples 1 to 4 with agar.
- Examples 45 to 56 correspond to the order of description of the water-soluble polymer.
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Abstract
Description
損失正接(tanδ)=損失弾性率(G”)/貯蔵弾性率(G’)
基布A~Cを、編目に対してコース方向又はウェール方向に伸ばしたときの応力を測定した。すなわち、基布をコース方向又はウェール方向に対して、特定のモジュラスとなるまでの距離だけ伸ばした際に、基布にかかる応力を測定した。なお、「伸び」とは、例えば、「測定開始点」と記載された場合には、全く伸ばしていない状態の基布を意味し、「10%モジュラス」と記載された場合には、歪が10%になるように、基布を測定開始点からコース方向又はウェール方向に伸ばした状態を意味する。
基布A、B及びCを、編目に対してコース方向又はウェール方向に伸ばしたときの伸張回復率(%)、剛軟度(mm)、50%モジュラス(N/5cm)を測定した。伸張回復率、剛軟度の測定方法は、JIS L 1096:2010に記載の方法にしたがって、測定した。
試料として実施例1の膏体液を用いて、以下の条件により損失弾性率及び貯蔵弾性率を測定し、損失正接(tanδ値)を算出した。
[測定条件]
装置:回転式レオメータ(レオメトリック・サイエンティフィック・エフ・イー株式会社製)
試料部:直径25mmの平行平板
ギャップ間隔:7mm
試料量:2~3g
温度:32℃
周波数:1Hz
歪:1%
表5に記載の組成にしたがい、実施例2~4及び比較例1~2の膏体液を調製した。なお、表5中の数字は、質量部を意味する。
得られた実施例2~4及び比較例1~2の膏体液について、粘度測定及び動的粘弾性測定を行なった。なお、粘度測定は膏体液の調製直後に行い、動的粘弾性測定は膏体液の調製から2.5時間後及び1か月後に行った。
結果を表6に示す。ポリアクリル酸部分中和物の含有量を増加させることにより、膏体液の粘度は高くなり、動的粘弾性測定におけるtanδ値は減少した。
実施例1又は比較例1の膏体液を、基布B又はCにそれぞれ展延し、パップ剤を調製した。
得られたパップ剤の基布について、膏体層と接している面と反対側の面を指で触れた場合に、試験者の指に液体が付着し、べたつきを感じるかどうかで評価した。なお、評価結果については、べたつきを感じたときを「×」として記載し、べたつきを感じなかったときを「○」として記載した。
結果を表7に示す。比較例1の膏体液を用いると、染み出しが観察されたのに対し、実施例1の膏体液を用いると、染み出しは観察されなかった。
実施例1又は比較例2の膏体液を、基布A~Cにそれぞれ展延し、パップ剤を調製した。得られたパップ剤を、被験者15名の肘部または腰部の左右の皮膚に1枚ずつ貼付し、貼付から8時間後及び24時間後のパップ剤の剥離状態を、目視により評価した。なお、評価は、貼付してから8時間後又は24時間後において、パップ剤の皮膚から剥離している面積の、貼付した時の皮膚に接している面積に対する割合に基づいて、表8に記載の評価基準にしたがって、行った。
Claims (8)
- 基布上に膏体層を備えるパップ剤の製造方法であって、
生理活性物質、水溶性ポリマー、グリセリン及び水を含有する組成物を、前記基布に塗布して膏体層を形成する工程を含み、
前記基布に塗布する時点の、前記組成物の1Hzでの動的粘弾性測定における損失正接が0.75~1である、方法。 - 前記基布が編布であり、
該編布の伸長回復率は、コース方向で73~98%であり、ウェール方向で83~98%である、請求項1に記載の方法。 - 前記基布が編布であり、
該編布の剛軟度は、コース方向で10~15mmであり、ウェール方向で10~18mmである、請求項1又は2に記載の方法。 - 前記基布が編布であり、
該編布について、コース方向での50%モジュラスに対する、ウェール方向での50%モジュラスの値が、0.8~1.2である、請求項1~3のいずれか一項に記載の方法。 - 前記水溶性ポリマーが、ポリアクリル酸又はポリアクリル酸中和物を含有する、請求項1~4のいずれか一項に記載の方法。
- 前記組成物が、アクリル酸メチル・アクリル酸2-エチルヘキシル共重合体樹脂を含有する、請求項1~5のいずれか一項に記載の方法。
- 前記水溶性ポリマーの含有量が、前記膏体層の全質量基準で3~18質量%である、請求項1~6のいずれか一項に記載の方法。
- 請求項1~7のいずれか一項に記載の方法により得られるパップ剤。
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EP16755303.1A EP3263097B1 (en) | 2015-02-24 | 2016-02-17 | Adhesive skin poultice |
CN201680004916.1A CN107106513B (zh) | 2015-02-24 | 2016-02-17 | 泥罨剂 |
JP2017502295A JP6434123B2 (ja) | 2015-02-24 | 2016-02-17 | パップ剤 |
KR1020177022017A KR101913055B1 (ko) | 2015-02-24 | 2016-02-17 | 파프제 |
US15/551,916 US10940121B2 (en) | 2015-02-24 | 2016-02-17 | Gel patch |
BR112017017287-9A BR112017017287B1 (pt) | 2015-02-24 | 2016-02-17 | Curativo em gel e método para sua produção |
ES16755303T ES2894742T3 (es) | 2015-02-24 | 2016-02-17 | Cataplasma adhesiva a la piel |
HK18107226.1A HK1247819A1 (zh) | 2015-02-24 | 2018-06-01 | 泥罨劑 |
US17/167,498 US20210154152A1 (en) | 2015-02-24 | 2021-02-04 | Gel patch |
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US17/167,498 Continuation US20210154152A1 (en) | 2015-02-24 | 2021-02-04 | Gel patch |
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JP2020066592A (ja) * | 2018-10-24 | 2020-04-30 | 帝國製薬株式会社 | 水性貼付剤 |
WO2020241791A1 (en) * | 2019-05-31 | 2020-12-03 | Sumitomo Chemical Company, Limited | Liquid suspension concentrate formulation comprising mefentrifluconazole |
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CN107106513B (zh) * | 2015-02-24 | 2021-03-02 | 久光制药株式会社 | 泥罨剂 |
BR112021015884A2 (pt) * | 2019-02-14 | 2021-10-05 | Hisamitsu Pharmaceutical Co., Inc. | Cataplasma |
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HK1247819A1 (zh) | 2018-10-05 |
JPWO2016136556A1 (ja) | 2017-09-28 |
US10940121B2 (en) | 2021-03-09 |
US20180036255A1 (en) | 2018-02-08 |
CN107106513B (zh) | 2021-03-02 |
EP3263097A4 (en) | 2018-08-15 |
ES2894742T3 (es) | 2022-02-15 |
JP6434123B2 (ja) | 2018-12-05 |
KR20170102965A (ko) | 2017-09-12 |
KR101913055B1 (ko) | 2018-10-29 |
TW201642841A (zh) | 2016-12-16 |
BR112017017287A2 (pt) | 2018-04-10 |
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